Gene expression profiling in human autoimmunity.

Published

Journal Article (Review)

Human autoimmune diseases are well suited for the application of gene expression profiling. Sampling of blood cells and target tissues has already revealed many important pathways contributing to this spectrum of disorders, and many commonalities are emerging. For instance, clinically distinct diseases such as systemic lupus erythematosus, Sjögren's syndrome, dermatomyositis, and psoriasis all show evidence for dysregulation of the type I interferon pathway. These data suggest that autoimmune diseases will eventually be categorized at the level of gene expression. This work has led to advances in our understanding of disease pathogenesis and in the future promises to facilitate assessments of disease activity and improve targeting of therapies. Here, we review the literature on gene profiling in human autoimmune diseases and provide perspective on the current state of the art.

Full Text

Duke Authors

Cited Authors

  • Baechler, EC; Batliwalla, FM; Reed, AM; Peterson, EJ; Gaffney, PM; Moser, KL; Gregersen, PK; Behrens, TW

Published Date

  • April 2006

Published In

Volume / Issue

  • 210 /

Start / End Page

  • 120 - 137

PubMed ID

  • 16623768

Pubmed Central ID

  • 16623768

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.0105-2896.2006.00367.x

Language

  • eng

Conference Location

  • England