Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501.
Published
Journal Article
Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.
Full Text
Duke Authors
Cited Authors
- Reed, AM; Pachman, L; Ober, C
Published Date
- December 1991
Published In
Volume / Issue
- 32 / 4
Start / End Page
- 235 - 240
PubMed ID
- 1783570
Pubmed Central ID
- 1783570
International Standard Serial Number (ISSN)
- 0198-8859
Digital Object Identifier (DOI)
- 10.1016/0198-8859(91)90085-n
Language
- eng
Conference Location
- United States