Skip to main content
Journal cover image

PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.

Publication ,  Journal Article
Prencipe, G; Tabakman, SM; Welsher, K; Liu, Z; Goodwin, AP; Zhang, L; Henry, J; Dai, H
Published in: Journal of the American Chemical Society
April 2009

Nanomaterials have been actively pursued for biological and medical applications in recent years. Here, we report the synthesis of several new poly(ethylene glycol) grafted branched polymers for functionalization of various nanomaterials including carbon nanotubes, gold nanoparticles (NPs), and gold nanorods (NRs), affording high aqueous solubility and stability for these materials. We synthesize different surfactant polymers based upon poly(gamma-glutamic acid) (gammaPGA) and poly(maleic anhydride-alt-1-octadecene) (PMHC18). We use the abundant free carboxylic acid groups of gammaPGA for attaching lipophilic species such as pyrene or phospholipid, which bind to nanomaterials via robust physisorption. Additionally, the remaining carboxylic acids on gammaPGA or the amine-reactive anhydrides of PMHC18 are then PEGylated, providing extended hydrophilic groups, affording polymeric amphiphiles. We show that single-walled carbon nanotubes (SWNTs), Au NPs, and NRs functionalized by the polymers exhibit high stability in aqueous solutions at different pH values, at elevated temperatures, and in serum. Moreover, the polymer-coated SWNTs exhibit remarkably long blood circulation (t(1/2) = 22.1 h) upon intravenous injection into mice, far exceeding the previous record of 5.4 h. The ultralong blood circulation time suggests greatly delayed clearance of nanomaterials by the reticuloendothelial system (RES) of mice, a highly desired property for in vivo applications of nanomaterials, including imaging and drug delivery.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

April 2009

Volume

131

Issue

13

Start / End Page

4783 / 4787

Related Subject Headings

  • Solubility
  • Polyethylene Glycols
  • Nanostructures
  • Mice
  • Gold
  • General Chemistry
  • Carbon
  • Blood Circulation Time
  • Animals
  • 40 Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Prencipe, G., Tabakman, S. M., Welsher, K., Liu, Z., Goodwin, A. P., Zhang, L., … Dai, H. (2009). PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. Journal of the American Chemical Society, 131(13), 4783–4787. https://doi.org/10.1021/ja809086q
Prencipe, Giuseppe, Scott M. Tabakman, Kevin Welsher, Zhuang Liu, Andrew P. Goodwin, Li Zhang, Joy Henry, and Hongjie Dai. “PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.Journal of the American Chemical Society 131, no. 13 (April 2009): 4783–87. https://doi.org/10.1021/ja809086q.
Prencipe G, Tabakman SM, Welsher K, Liu Z, Goodwin AP, Zhang L, et al. PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. Journal of the American Chemical Society. 2009 Apr;131(13):4783–7.
Prencipe, Giuseppe, et al. “PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.Journal of the American Chemical Society, vol. 131, no. 13, Apr. 2009, pp. 4783–87. Epmc, doi:10.1021/ja809086q.
Prencipe G, Tabakman SM, Welsher K, Liu Z, Goodwin AP, Zhang L, Henry J, Dai H. PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. Journal of the American Chemical Society. 2009 Apr;131(13):4783–4787.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

April 2009

Volume

131

Issue

13

Start / End Page

4783 / 4787

Related Subject Headings

  • Solubility
  • Polyethylene Glycols
  • Nanostructures
  • Mice
  • Gold
  • General Chemistry
  • Carbon
  • Blood Circulation Time
  • Animals
  • 40 Engineering