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Ventriculoperitoneal shunt placement for POEMS syndrome.

Publication ,  Journal Article
Alvarez-Breckenridge, CA; Attiah, MA; Zachariah, M; Gummadavelli, A; Yang, J; Codd, PJ
Published in: J Clin Neurosci
October 2015

We report a 41-year-old woman with a history of an uncomplicated spinal hemangioma resection, who developed acute onset sensory-motor polyneuropathy following influenza vaccine administration. With extensive workup she was diagnosed with POEMS syndrome with progressive headaches, visual loss with papilledema, and repeated elevated lumbar puncture opening pressures despite treatment with acetazolamide and immunosuppressive therapy. Her symptoms dramatically improved following ventriculoperitoneal shunt placement. POEMS syndrome is a paraneoplastic disorder involving a constellation of clinical symptoms including polyneuropathy, organomegaly, endocrinopathy, monoclonal protein elevation, and skin changes. The progression of the disease involves a number of neurovascular sequelae, including symmetric sensory-motor polyneuropathy resembling chronic inflammatory demyelinating polyneuropathy, cerebrovascular accidents, and papilledema associated with increased intracranial pressure. Despite the association of POEMS with papilledema, treatment for this finding typically includes acetazolamide and therapeutic large volume lumbar punctures. To our knowledge, this is the first report of cerebrospinal fluid shunting for the symptomatic management of hydrocephalus associated with POEMS syndrome.

Duke Scholars

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

October 2015

Volume

22

Issue

10

Start / End Page

1672 / 1674

Location

Scotland

Related Subject Headings

  • Ventriculoperitoneal Shunt
  • POEMS Syndrome
  • Neurology & Neurosurgery
  • Intracranial Hypertension
  • Humans
  • Headache
  • Female
  • Adult
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alvarez-Breckenridge, C. A., Attiah, M. A., Zachariah, M., Gummadavelli, A., Yang, J., & Codd, P. J. (2015). Ventriculoperitoneal shunt placement for POEMS syndrome. J Clin Neurosci, 22(10), 1672–1674. https://doi.org/10.1016/j.jocn.2015.03.042
Alvarez-Breckenridge, Christopher A., Mark A. Attiah, Marcus Zachariah, Abhijeet Gummadavelli, Jimmy Yang, and Patrick J. Codd. “Ventriculoperitoneal shunt placement for POEMS syndrome.J Clin Neurosci 22, no. 10 (October 2015): 1672–74. https://doi.org/10.1016/j.jocn.2015.03.042.
Alvarez-Breckenridge CA, Attiah MA, Zachariah M, Gummadavelli A, Yang J, Codd PJ. Ventriculoperitoneal shunt placement for POEMS syndrome. J Clin Neurosci. 2015 Oct;22(10):1672–4.
Alvarez-Breckenridge, Christopher A., et al. “Ventriculoperitoneal shunt placement for POEMS syndrome.J Clin Neurosci, vol. 22, no. 10, Oct. 2015, pp. 1672–74. Pubmed, doi:10.1016/j.jocn.2015.03.042.
Alvarez-Breckenridge CA, Attiah MA, Zachariah M, Gummadavelli A, Yang J, Codd PJ. Ventriculoperitoneal shunt placement for POEMS syndrome. J Clin Neurosci. 2015 Oct;22(10):1672–1674.
Journal cover image

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

October 2015

Volume

22

Issue

10

Start / End Page

1672 / 1674

Location

Scotland

Related Subject Headings

  • Ventriculoperitoneal Shunt
  • POEMS Syndrome
  • Neurology & Neurosurgery
  • Intracranial Hypertension
  • Humans
  • Headache
  • Female
  • Adult
  • 5202 Biological psychology
  • 3209 Neurosciences