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Remodeling and reparation of the cardiovascular system.

Publication ,  Journal Article
Weber, KT; Anversa, P; Armstrong, PW; Brilla, CG; Burnett, JC; Cruickshank, JM; Devereux, RB; Giles, TD; Korsgaard, N; Leier, CV
Published in: J Am Coll Cardiol
July 1992

Growth or altered metabolism of nonmyocyte cells (cardiac fibroblasts, vascular smooth muscle and endothelial cells) alters myocardial and vascular structure (remodeling) and function. However, the precise roles of circulating and locally generated factors such as angiotensin II, aldosterone and endothelin that regulate growth and metabolism of nonmyocyte cells have yet to be fully elucidated. Trials of pharmacologic therapy aimed at preventing structural remodeling and repairing altered myocardial structure to or toward normal in the setting of hypertension, heart failure and diabetes are reviewed. It is proposed that these are therapeutic goals that may reduce cardiovascular morbidity and mortality. Although this hypothesis remains unproved the primary goal of therapy should be to preserve or restore tissue structure and function.

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

July 1992

Volume

20

Issue

1

Start / End Page

3 / 16

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Rats
  • Peptidyl-Dipeptidase A
  • Myocardium
  • Muscle, Smooth, Vascular
  • Hypertension, Renovascular
  • Hypertension
  • Humans
  • Heart Failure
  • Heart
 

Citation

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Weber, K. T., Anversa, P., Armstrong, P. W., Brilla, C. G., Burnett, J. C., Cruickshank, J. M., … Leier, C. V. (1992). Remodeling and reparation of the cardiovascular system. J Am Coll Cardiol, 20(1), 3–16. https://doi.org/10.1016/0735-1097(92)90130-f
Weber, K. T., P. Anversa, P. W. Armstrong, C. G. Brilla, J. C. Burnett, J. M. Cruickshank, R. B. Devereux, T. D. Giles, N. Korsgaard, and C. V. Leier. “Remodeling and reparation of the cardiovascular system.J Am Coll Cardiol 20, no. 1 (July 1992): 3–16. https://doi.org/10.1016/0735-1097(92)90130-f.
Weber KT, Anversa P, Armstrong PW, Brilla CG, Burnett JC, Cruickshank JM, et al. Remodeling and reparation of the cardiovascular system. J Am Coll Cardiol. 1992 Jul;20(1):3–16.
Weber, K. T., et al. “Remodeling and reparation of the cardiovascular system.J Am Coll Cardiol, vol. 20, no. 1, July 1992, pp. 3–16. Pubmed, doi:10.1016/0735-1097(92)90130-f.
Weber KT, Anversa P, Armstrong PW, Brilla CG, Burnett JC, Cruickshank JM, Devereux RB, Giles TD, Korsgaard N, Leier CV. Remodeling and reparation of the cardiovascular system. J Am Coll Cardiol. 1992 Jul;20(1):3–16.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

July 1992

Volume

20

Issue

1

Start / End Page

3 / 16

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Rats
  • Peptidyl-Dipeptidase A
  • Myocardium
  • Muscle, Smooth, Vascular
  • Hypertension, Renovascular
  • Hypertension
  • Humans
  • Heart Failure
  • Heart