Remodeling and reparation of the cardiovascular system.

Journal Article (Review)

Growth or altered metabolism of nonmyocyte cells (cardiac fibroblasts, vascular smooth muscle and endothelial cells) alters myocardial and vascular structure (remodeling) and function. However, the precise roles of circulating and locally generated factors such as angiotensin II, aldosterone and endothelin that regulate growth and metabolism of nonmyocyte cells have yet to be fully elucidated. Trials of pharmacologic therapy aimed at preventing structural remodeling and repairing altered myocardial structure to or toward normal in the setting of hypertension, heart failure and diabetes are reviewed. It is proposed that these are therapeutic goals that may reduce cardiovascular morbidity and mortality. Although this hypothesis remains unproved the primary goal of therapy should be to preserve or restore tissue structure and function.

Full Text

Duke Authors

Cited Authors

  • Weber, KT; Anversa, P; Armstrong, PW; Brilla, CG; Burnett, JC; Cruickshank, JM; Devereux, RB; Giles, TD; Korsgaard, N; Leier, CV

Published Date

  • July 1992

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 3 - 16

PubMed ID

  • 1318886

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

International Standard Serial Number (ISSN)

  • 0735-1097

Digital Object Identifier (DOI)

  • 10.1016/0735-1097(92)90130-f

Language

  • eng