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Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris.

Publication ,  Journal Article
Freeman, MR; Williams, AE; Chisholm, RJ; Patt, NL; Greyson, ND; Armstrong, PW
Published in: Am Heart J
February 1989

We performed quantitative thallium scintigraphy in 66 unstable angina patients, 5.6 +/- 5.1 hours after rest pain, to predict coronary anatomy, left ventricular wall motion, and hospital outcome. Thallium defects and/or washout abnormalities were present in 5 of 10 (50%) patients with coronary stenoses less than 50%, 27 of 33 (82%) patients with coronary stenosis greater than or equal to 50% and no history of previous myocardial infarction, and in 23 of 23 patients (100%) with histories of previous infarction. Defects were uncommon in the territory of vessels with less than 50% (13 of 61, 21%), but significantly more common in the territory of vessels with greater than or equal to 50% stenosis (57 of 137, 42%), p less than 0.005. With the addition of washout abnormalities to defect analysis, sensitivity for detection of coronary stenoses improved to 67% (92 of 137), p less than or equal to 0.005, but specificity fell to 59% (36 of 61), p less than 0.01. Segmental wall motion abnormalities were less common in segments with normal perfusion (21%) or in those with washout abnormalities alone (19%), than in segments with thallium defects (45%, p less than 0.005). Defects in patients with previous infarction were common in both segments, with normal (26 of 66, 40%) or abnormal (24 of 45, 53%) wall motion. Eleven of 18 patients with in-hospital cardiac events, but no history of myocardial infarction, had resting thallium defects, whereas only 8 of 25 patients without cardiac event had thallium defect (p = 0.056).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

February 1989

Volume

117

Issue

2

Start / End Page

306 / 314

Location

United States

Related Subject Headings

  • Thallium Radioisotopes
  • Rest
  • Radionuclide Imaging
  • Inpatients
  • Humans
  • Heart Ventricles
  • Heart
  • Forecasting
  • Coronary Vessels
  • Coronary Disease
 

Citation

APA
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ICMJE
MLA
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Freeman, M. R., Williams, A. E., Chisholm, R. J., Patt, N. L., Greyson, N. D., & Armstrong, P. W. (1989). Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris. Am Heart J, 117(2), 306–314. https://doi.org/10.1016/0002-8703(89)90773-4
Freeman, M. R., A. E. Williams, R. J. Chisholm, N. L. Patt, N. D. Greyson, and P. W. Armstrong. “Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris.Am Heart J 117, no. 2 (February 1989): 306–14. https://doi.org/10.1016/0002-8703(89)90773-4.
Freeman MR, Williams AE, Chisholm RJ, Patt NL, Greyson ND, Armstrong PW. Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris. Am Heart J. 1989 Feb;117(2):306–14.
Freeman, M. R., et al. “Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris.Am Heart J, vol. 117, no. 2, Feb. 1989, pp. 306–14. Pubmed, doi:10.1016/0002-8703(89)90773-4.
Freeman MR, Williams AE, Chisholm RJ, Patt NL, Greyson ND, Armstrong PW. Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris. Am Heart J. 1989 Feb;117(2):306–314.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

February 1989

Volume

117

Issue

2

Start / End Page

306 / 314

Location

United States

Related Subject Headings

  • Thallium Radioisotopes
  • Rest
  • Radionuclide Imaging
  • Inpatients
  • Humans
  • Heart Ventricles
  • Heart
  • Forecasting
  • Coronary Vessels
  • Coronary Disease