Morphometric Analysis of Predictors of Cervical Syrinx Formation in the Setting of Chiari I Malformation.

Journal Article (Journal Article)

BACKGROUND/AIMS: We performed a morphometric analysis of Chiari I malformations to look for predictors of cervical syrinx formation. METHODS: Eighteen patients with Chiari I malformation and associated cervical syrinx and 16 patients with Chiari I malformation without associated cervical syrinx were included in the study. Chiari I size was obtained from the radiology report; foramen magnum diameter, cerebellar volume, posterior fossa volume and intracranial volume were calculated using OsiriX software, and average measurements were compared between the two groups. RESULTS AND CONCLUSION: Patients with Chiari I with syrinx had an average tonsillar descent of 13.03 ± 5.31 mm compared to 9.25 ± 3.31 mm in the Chiari I without syrinx group (p < 0.05). Patients with Chiari I and syrinx also showed increased cerebellar crowding with a higher cerebellar volume to posterior fossa volume ratio; however, this difference was not significant (0.83 vs. 0.81; p = 0.1872). No difference between groups was found in posterior fossa volume, intracranial volume and foramen magnum diameter. Therefore, only Chiari I size based on the extent of tonsillar herniation was found to be a determinant of cervical syrinx formation.

Full Text

Duke Authors

Cited Authors

  • Halvorson, KG; Kellogg, RT; Keachie, KN; Grant, GA; Muh, CR; Waldau, B

Published Date

  • 2016

Published In

Volume / Issue

  • 51 / 3

Start / End Page

  • 137 - 141

PubMed ID

  • 26871424

Electronic International Standard Serial Number (EISSN)

  • 1423-0305

Digital Object Identifier (DOI)

  • 10.1159/000442991


  • eng

Conference Location

  • Switzerland