Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure.


Journal Article

In vitro studies using avian hepatocytes or human liver microsomes suggest that hydroxylation is an important pathway in the metabolism of triphenyl phosphate (TPHP), a chemical used as a flame retardant and plasticizer. TPHP metabolism can lead to the formation of para(p)- and meta(m)-hydroxyl-(OH-)TPHP products as well as their glucuronide conjugates. To determine whether the TPHP hydroxylation and depuration pathway also occurs in vivo in humans, the present study developed a sensitive method for quantification of p- and m-OH-TPHP glucuronides in human urine samples. In n = 1 pooled urine sample and n = 12 individual urine samples collected from four human volunteers from Ottawa (ON, Canada), p- and m-OH-TPHP glucuronides were detectable in 13 and 9 of the 13 analyzed samples and at concentrations ranging from

Full Text

Duke Authors

Cited Authors

  • Su, G; Letcher, RJ; Yu, H; Gooden, DM; Stapleton, HM

Published Date

  • April 2016

Published In

Volume / Issue

  • 149 /

Start / End Page

  • 314 - 319

PubMed ID

  • 26874059

Pubmed Central ID

  • 26874059

Electronic International Standard Serial Number (EISSN)

  • 1879-1298

International Standard Serial Number (ISSN)

  • 0045-6535

Digital Object Identifier (DOI)

  • 10.1016/j.chemosphere.2016.01.114


  • eng