Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure.

Published

Journal Article

In vitro studies using avian hepatocytes or human liver microsomes suggest that hydroxylation is an important pathway in the metabolism of triphenyl phosphate (TPHP), a chemical used as a flame retardant and plasticizer. TPHP metabolism can lead to the formation of para(p)- and meta(m)-hydroxyl-(OH-)TPHP products as well as their glucuronide conjugates. To determine whether the TPHP hydroxylation and depuration pathway also occurs in vivo in humans, the present study developed a sensitive method for quantification of p- and m-OH-TPHP glucuronides in human urine samples. In n = 1 pooled urine sample and n = 12 individual urine samples collected from four human volunteers from Ottawa (ON, Canada), p- and m-OH-TPHP glucuronides were detectable in 13 and 9 of the 13 analyzed samples and at concentrations ranging from

Full Text

Duke Authors

Cited Authors

  • Su, G; Letcher, RJ; Yu, H; Gooden, DM; Stapleton, HM

Published Date

  • April 2016

Published In

Volume / Issue

  • 149 /

Start / End Page

  • 314 - 319

PubMed ID

  • 26874059

Pubmed Central ID

  • 26874059

Electronic International Standard Serial Number (EISSN)

  • 1879-1298

International Standard Serial Number (ISSN)

  • 0045-6535

Digital Object Identifier (DOI)

  • 10.1016/j.chemosphere.2016.01.114

Language

  • eng