Heather M. Stapleton
Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.
Current Appointments & Affiliations
- Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management, Environmental Sciences and Policy, Nicholas School of the Environment 2014
- Associate Professor of Environmental Sciences and Policy in the Nicholas School of the Environment, Environmental Sciences and Policy, Nicholas School of the Environment 2012
- Associate Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering, Pratt School of Engineering 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
Contact Information
- 9 Circuit Drive, Box 90328, LSRC Room A207, Durham, NC 27710
- Box 90328, Durham, NC 27708-0328
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heather.stapleton@duke.edu
(919) 613-8717
- Background
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Education, Training, & Certifications
- Ph.D., University of Maryland, College Park 2003
- M.S., University of Maryland, College Park 2000
- B.S., Long Island University Southhampton College 1997
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Duke Appointment History
- Assistant Professor of Environmental Sciences and Policy, Environmental Sciences and Policy, Nicholas School of the Environment 2005 - 2012
- Assist Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering, Pratt School of Engineering 2009 - 2012
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2007 - 2009
- Recognition
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In the News
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NOV 3, 2017 Nicholas School of the Environment -
JUL 11, 2017 -
MAY 18, 2016 Gear Junkie -
JAN 26, 2016 -
DEC 21, 2015 “CBS This Morning” -
DEC 14, 2015 -
OCT 20, 2015 Fox News -
JUL 30, 2015 Chemical Watch -
JUL 28, 2015 -
JUN 12, 2015 National Geographic -
SEP 29, 2014 The Atlantic -
SEP 22, 2014 The News & Observer
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Awards & Honors
- Expertise
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Global Scholarship
- Research
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Selected Grants
- The placenta: a novel target of sex specific neurotoxicity by fire retardants awarded by North Carolina State University 2017 - 2022
- Duke University Superfund Research Center awarded by National Institutes of Health 2000 - 2022
- Developmental Toxicity of Organophosphate-based Flame Retardants awarded by University of California - Riverside 2017 - 2022
- Interrogation of molecular mechanisms involved in driving adipogenesis in environmental mixtures and novel analytical techniques for identifying putative causative chemicals awarded by National Institutes of Health 2017 - 2020
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity awarded by National Institutes of Health 2007 - 2019
- Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and Pregnancy awarded by Harvard University 2014 - 2019
- Exposomics Reserach Project awarded by Wallace Genetic Foundation 2017 - 2018
- Residential Exposure of Young Children to SVOCs awarded by Environmental Protection Agency 2014 - 2018
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2018
- Prenatal Exposure to Organophosphates and Associations with Child Growth awarded by University of North Carolina - Chapel Hill 2014 - 2017
- Analysis of Flame Retardant Chemicals in Furniture Barriers awarded by Bureau of Electronic and Appliance Repair, Home Furnishings and Thermal Insulation 2016 - 2017
- Developmental Toxicity of Organophosphate-based Flame Retardants awarded by University of California - Riverside 2014 - 2017
- Evaluation of Changes in Flame Retardant Exposure in NYC awarded by Columbia University 2015 - 2016
- Urinary Concentrations of Flame Retardant Metabolites in Mothers and Children awarded by Environmental Working Group 2015 - 2016
- Toxicokinetics and Metabolic Disrupting Actions of the Flame Retardant Mixture Firemaster 550 awarded by North Carolina State University 2014 - 2016
- Exposure to Halogenated Aromatic Compounds and Risk of Thyroid Cancer awarded by Yale University 2016
- Evaluating Human Exposure to Triphenyl Phosphate from Nail Polish Applications awarded by Environmental Working Group 2015
- Developmental Toxicity of Organophosphate-based Flame Retardants awarded by University of South Carolina 2014 - 2015
- Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants awarded by National Institutes of Health 2011 - 2015
- Current-Use Flame Retardants: Maternal Exposure and Neurodevelopment in Children awarded by University of California - Berkeley 2013 - 2015
- Duke University Superfund Research Center (P42 ES010356) awarded by National Institute of Environmental Health Sciences 2000 - 2014
- Fate of Biosolid Derived Organic Contaminants in Soils and Effects on Soil Microbial Communities awarded by National Science Foundation 2009 - 2013
- Publications & Artistic Works
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Selected Publications
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Conference Papers
- Muzzio, AM, Noyes, PD, Stapleton, HM, and Lema, SC. "The Organic Anion Transporting Protein (OATP) Family in a Teleost Fish Model." April 2013. Link to Item
- Johnson, PI, Stapleton, HM, Hauser, R, and Meeker, JD. "Relationships Between Brominated Flame Retardant Concentrations in House Dust and Serum Hormone Levels in Men." November 2009. Full Text Link to Item
- Allen, JG, McClean, MD, Stapleton, HM, and Webster, TF. "Televisions as Sources of DecaBDE in House Dust." November 2008. Link to Item
- Huwe, JK, Hakk, H, Stapleton, HM, and Birnbaum, LS. "Tissue Distribution of Polybrominated Diphenyl Ethers in Rats Following Oral Exposure and the Relationship to Body Burdens." November 2008. Link to Item
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Journal Articles
- Bello, A, Carignan, CC, Xue, Y, Stapleton, HM, and Bello, D. "Exposure to organophosphate flame retardants in spray polyurethane foam applicators: Role of dermal exposure." Environment international 113 (April 2018): 55-65. Full Text
- Frederiksen, M, Stapleton, HM, Vorkamp, K, Webster, TF, Jensen, NM, Sørensen, JA, Nielsen, F, Knudsen, LE, Sørensen, LS, Clausen, PA, and Nielsen, JB. "Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model." Chemosphere 197 (April 2018): 185-192. Full Text
- Leonetti, CP, Butt, CM, and Stapleton, HM. "Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo." Chemosphere 197 (April 2018): 81-88. Full Text
- Kassotis, CD, Kollitz, EM, Ferguson, PL, and Stapleton, HM. "Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells." Toxicological sciences : an official journal of the Society of Toxicology 162, no. 1 (March 2018): 124-136. Full Text
- Holzem, RM, Gardner, CM, Stapleton, HM, and Gunsch, CK. "Using laboratory-generated biosolids to evaluate the microbial ecotoxicity of triclosan in a simulated land application scenario." Environmental science and pollution research international (February 6, 2018). Full Text
- Kollitz, EM, De Carbonnel, L, Stapleton, HM, and Ferguson, PL. "The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure." Toxicological sciences : an official journal of the Society of Toxicology (February 2, 2018). Full Text
- Carignan, CC, Mínguez-Alarcón, L, Williams, PL, Meeker, JD, Stapleton, HM, Butt, CM, Toth, TL, Ford, JB, Hauser, R, and EARTH Study Team, . "Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization." Environment international 111 (February 2018): 232-238. Full Text
- Rock, KD, Horman, B, Phillips, AL, McRitchie, SL, Watson, S, Deese-Spruill, J, Jima, D, Sumner, S, Stapleton, HM, and Patisaul, HB. "EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain." Endocrine connections 7, no. 2 (February 2018): 305-324. Full Text
- Lefèvre, E, Bossa, N, Gardner, CM, Gehrke, GE, Cooper, EM, Stapleton, HM, Hsu-Kim, H, and Gunsch, CK. "Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A." Water research 128 (January 2018): 102-110. Full Text
- Luz, AL, Kassotis, CD, Stapleton, HM, and Meyer, JN. "The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells." Toxicology 393 (January 2018): 150-159. Full Text
- Castorina, R, Bradman, A, Stapleton, HM, Butt, C, Avery, D, Harley, KG, Gunier, RB, Holland, N, and Eskenazi, B. "Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort." Chemosphere 189 (December 2017): 574-580. Full Text
- Phillips, AL, Hammel, SC, Konstantinov, A, and Stapleton, HM. "Characterization of Individual Isopropylated and tert-Butylated Triarylphosphate (ITP and TBPP) Isomers in Several Commercial Flame Retardant Mixtures and House Dust Standard Reference Material SRM 2585." Environmental science & technology 51, no. 22 (November 2017): 13443-13449. Full Text
- Hammel, SC, Hoffman, K, Lorenzo, AM, Chen, A, Phillips, AL, Butt, CM, Sosa, JA, Webster, TF, and Stapleton, HM. "Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels." Environment international 107 (October 2017): 181-189. Full Text
- Hoffman, K, Lorenzo, A, Butt, CM, Hammel, SC, Henderson, BB, Roman, SA, Scheri, RP, Stapleton, HM, and Sosa, JA. "Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: A case-control study." Environment international 107 (October 2017): 235-242. Full Text Open Access Copy
- Siebenaler, R, Cameron, R, Butt, CM, Hoffman, K, Higgins, CP, and Stapleton, HM. "Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes." Chemosphere 184 (October 2017): 687-693. Full Text
- Thomas, MB, Stapleton, HM, Dills, RL, Violette, HD, Christakis, DA, and Sathyanarayana, S. "Demographic and dietary risk factors in relation to urinary metabolites of organophosphate flame retardants in toddlers." Chemosphere 185 (October 2017): 918-925. Full Text
- Slotkin, TA, Skavicus, S, Stapleton, HM, and Seidler, FJ. "Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells." Toxicology 390 (September 2017): 32-42. Full Text
- Carignan, CC, Mínguez-Alarcón, L, Butt, CM, Williams, PL, Meeker, JD, Stapleton, HM, Toth, TL, Ford, JB, Hauser, R, and EARTH Study Team, . "Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization." Environmental health perspectives 125, no. 8 (August 25, 2017): 087018-. Full Text
- Hoffman, K, Gearhart-Serna, L, Lorber, M, Webster, TF, and Stapleton, HM. "Estimated Tris(1,3-dichloro-2-propyl) Phosphate Exposure Levels for U.S. Infants Suggest Potential Health Risks." Environmental Science & Technology Letters 4, no. 8 (August 8, 2017): 334-338. Full Text
- Baldwin, KR, Phillips, AL, Horman, B, Arambula, SE, Rebuli, ME, Stapleton, HM, and Patisaul, HB. "Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats." Scientific reports 7, no. 1 (August 2, 2017): 7118-. Full Text Open Access Copy
- Carignan, CC, Butt, CM, Stapleton, HM, Meeker, JD, Minguez-Alarcón, L, Williams, PL, and Hauser, R. "Influence of storage vial material on measurement of organophosphate flame retardant metabolites in urine." Chemosphere 181 (August 2017): 440-446. Full Text
- Kassotis, CD, Hoffman, K, and Stapleton, HM. "Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells." Environmental science & technology 51, no. 15 (August 2017): 8735-8745. Full Text
- Robel, AE, Marshall, K, Dickinson, M, Lunderberg, D, Butt, C, Peaslee, G, Stapleton, HM, and Field, JA. "Closing the Mass Balance on Fluorine on Papers and Textiles." Environmental science & technology 51, no. 16 (August 2017): 9022-9032. Full Text
- Castorina, R, Butt, C, Stapleton, HM, Avery, D, Harley, KG, Holland, N, Eskenazi, B, and Bradman, A. "Flame retardants and their metabolites in the homes and urine of pregnant women residing in California (the CHAMACOS cohort)." Chemosphere 179 (July 2017): 159-166. Full Text
- Smythe, TA, Butt, CM, Stapleton, HM, Pleskach, K, Ratnayake, G, Song, CY, Riddell, N, Konstantinov, A, and Tomy, GT. "Impacts of Unregulated Novel Brominated Flame Retardants on Human Liver Thyroid Deiodination and Sulfotransferation." Environmental science & technology 51, no. 12 (June 2017): 7245-7253. Full Text
- Preston, EV, McClean, MD, Claus Henn, B, Stapleton, HM, Braverman, LE, Pearce, EN, Makey, CM, and Webster, TF. "Associations between urinary diphenyl phosphate and thyroid function." Environment international 101 (April 2017): 158-164. Full Text
- Preston, EV, McClean, MD, Henn, BC, Stapleton, HM, Braverman, LE, Pearce, EN, Makey, CM, and Webster, TF. "Associations between urinary diphenyl phosphate and thyroid function." ENVIRONMENT INTERNATIONAL 101 (April 2017): 158-164. Full Text Link to Item
- Ferguson, PL, and Stapleton, HM. "Comment on "Mutagenic Azo Dyes, Rather Than Flame Retardants, Are the Predominant Brominated Compounds in House Dust"." Environmental science & technology 51, no. 6 (March 10, 2017): 3588-3590. Full Text
- Cowell, WJ, Stapleton, HM, Holmes, D, Calero, L, Tobon, C, Perzanowski, M, and Herbstman, JB. "Prevalence of historical and replacement brominated flame retardant chemicals in New York City homes." Emerging contaminants 3, no. 1 (March 2017): 32-39. Full Text
- Hoffman, K, Butt, CM, Webster, TF, Preston, EV, Hammel, SC, Makey, C, Lorenzo, AM, Cooper, EM, Carignan, C, Meeker, JD, Hauser, R, Soubry, A, Murphy, SK, Price, TM, Hoyo, C, Mendelsohn, E, Congleton, J, Daniels, JL, and Stapleton, HM. "Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States." Environmental science & technology letters 4, no. 3 (March 2017): 112-118. Full Text
- Hoffman, K, Butt, CM, Webster, TF, Preston, EV, Hammel, SC, Makey, C, Lorenzo, AM, Cooper, EM, Carignan, C, Meeker, JD, Hauser, R, Soubry, A, Murphy, SK, Price, TM, Hoyo, C, Mendelsohn, E, Congleton, J, Daniels, JL, and Stapleton, HM. "Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States." ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 4, no. 3 (March 2017): 112-118. Full Text Link to Item
- Hoffman, K, Webster, TF, Sjödin, A, and Stapleton, HM. "Toddler's behavior and its impacts on exposure to polybrominated diphenyl ethers." Journal of exposure science & environmental epidemiology 27, no. 2 (March 2017): 193-197. Full Text
- Kassotis, CD, Masse, L, Kim, S, Schlezinger, JJ, Webster, TF, and Stapleton, HM. "Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling." Scientific reports 7 (February 8, 2017): 42104-. Full Text
- Hoffman, K, Lorenzo, A, Butt, CM, Adair, L, Herring, AH, Stapleton, HM, and Daniels, JL. "Predictors of urinary flame retardant concentration among pregnant women." Environment international 98 (January 2017): 96-101. Full Text
- Hoffman, K, Sosa, JA, and Stapleton, HM. "Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer?." Current opinion in oncology 29, no. 1 (January 2017): 7-13. (Review) Full Text
- Lewis, JJ, Hollingsworth, JW, Chartier, RT, Cooper, EM, Foster, WM, Gomes, GL, Kussin, PS, MacInnis, JJ, Padhi, BK, Panigrahi, P, Rodes, CE, Ryde, IT, Singha, AK, Stapleton, HM, Thornburg, J, Young, CJ, Meyer, JN, and Pattanayak, SK. "Biogas Stoves Reduce Firewood Use, Household Air Pollution, and Hospital Visits in Odisha, India." Environmental science & technology 51, no. 1 (January 2017): 560-569. Full Text
- Macaulay, LJ, Chernick, M, Chen, A, Hinton, DE, Bailey, JM, Kullman, SW, Levin, ED, and Stapleton, HM. "Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development." Environmental toxicology and chemistry 36, no. 1 (January 2017): 36-48. Full Text
- Leonetti, C, Butt, CM, Hoffman, K, Hammel, SC, Miranda, ML, and Stapleton, HM. "Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints." Environmental health : a global access science source 15, no. 1 (November 25, 2016): 113-. Full Text
- Cooper, EM, Kroeger, G, Davis, K, Clark, CR, Ferguson, PL, and Stapleton, HM. "Results from Screening Polyurethane Foam Based Consumer Products for Flame Retardant Chemicals: Assessing Impacts on the Change in the Furniture Flammability Standards." Environmental science & technology 50, no. 19 (October 2016): 10653-10660. Full Text
- Phillips, AL, Chen, A, Rock, KD, Horman, B, Patisaul, HB, and Stapleton, HM. "Editor's Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats." Toxicological sciences : an official journal of the Society of Toxicology 153, no. 2 (October 2016): 246-257. Full Text
- Butt, CM, Hoffman, K, Chen, A, Lorenzo, A, Congleton, J, and Stapleton, HM. "Regional comparison of organophosphate flame retardant (PFR) urinary metabolites and tetrabromobenzoic acid (TBBA) in mother-toddler pairs from California and New Jersey." Environment international 94 (September 2016): 627-634. Full Text
- Carignan, CC, Fang, M, Stapleton, HM, Heiger-Bernays, W, McClean, MD, and Webster, TF. "Urinary biomarkers of flame retardant exposure among collegiate U.S. gymnasts." Environment international 94 (September 2016): 362-368. Full Text
- Hammel, SC, Hoffman, K, Webster, TF, Anderson, KA, and Stapleton, HM. "Correction to Measuring Personal Exposure to Organophosphate Flame Retardants using Silicone Wristbands and Hand Wipes." Environmental science & technology 50, no. 18 (September 2016): 10291-. Full Text
- Volz, DC, Leet, JK, Chen, A, Stapleton, HM, Katiyar, N, Kaundal, R, Yu, Y, and Wang, Y. "Tris(1,3-dichloro-2-propyl)phosphate Induces Genome-Wide Hypomethylation within Early Zebrafish Embryos." Environmental science & technology 50, no. 18 (September 2016): 10255-10263. Full Text
- Gomes, G, Ward, P, Lorenzo, A, Hoffman, K, and Stapleton, HM. "Characterizing Flame Retardant Applications and Potential Human Exposure in Backpacking Tents." Environmental science & technology 50, no. 10 (May 2016): 5338-5345. Full Text
- Butt, CM, Miranda, ML, and Stapleton, HM. "Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum." Analytical and bioanalytical chemistry 408, no. 10 (April 2016): 2449-2459. Full Text
- Hammel, SC, Hoffman, K, Webster, TF, Anderson, KA, and Stapleton, HM. "Measuring Personal Exposure to Organophosphate Flame Retardants Using Silicone Wristbands and Hand Wipes." Environmental science & technology 50, no. 8 (April 2016): 4483-4491. Full Text
- Su, G, Letcher, RJ, Yu, H, Gooden, DM, and Stapleton, HM. "Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure." Chemosphere 149 (April 2016): 314-319. Full Text
- Leonetti, C, Butt, CM, Hoffman, K, Miranda, ML, and Stapleton, HM. "Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues." Environment international 88 (March 2016): 23-29. Full Text
- Czaplicki, LM, Cooper, E, Ferguson, PL, Stapleton, HM, Vilgalys, R, and Gunsch, CK. "A New Perspective on Sustainable Soil Remediation-Case Study Suggests Novel Fungal Genera Could Facilitate in situ Biodegradation of Hazardous Contaminants." Remediation (New York, N.Y.) 26, no. 2 (January 2016): 59-72. Full Text
- Lefevre, E, Cooper, E, Stapleton, HM, and Gunsch, CK. "Characterization and Adaptation of Anaerobic Sludge Microbial Communities Exposed to Tetrabromobisphenol A." PloS one 11, no. 7 (January 2016): e0157622-. Full Text
- Mendelsohn, E, Hagopian, A, Hoffman, K, Butt, CM, Lorenzo, A, Congleton, J, Webster, TF, and Stapleton, HM. "Nail polish as a source of exposure to triphenyl phosphate." Environment international 86 (January 2016): 45-51. Full Text
- Hoffman, K, Butt, CM, Chen, A, Limkakeng, AT, and Stapleton, HM. "High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products." Environmental science & technology 49, no. 24 (December 2015): 14554-14559. Full Text
- Miranda, ML, Anthopolos, R, Wolkin, A, and Stapleton, HM. "Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy." Environment international 85 (December 2015): 244-253. Full Text
- Macaulay, LJ, Bailey, JM, Levin, ED, and Stapleton, HM. "Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior." Neurotoxicology and teratology 52, no. Pt B (November 2015): 119-126. Full Text
- Macaulay, LJ, Chen, A, Rock, KD, Dishaw, LV, Dong, W, Hinton, DE, and Stapleton, HM. "Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β." Aquatic toxicology (Amsterdam, Netherlands) 168 (November 2015): 38-47. Full Text
- Maley, AM, Falk, KA, Hoover, L, Earlywine, EB, Seymour, MD, DeYoung, PA, Blum, A, Stapleton, HM, and Peaslee, GF. "Detection of halogenated flame retardants in polyurethane foam by particle induced X-ray emission." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 358 (September 2015): 21-25. Full Text
- Fang, M, Webster, TF, and Stapleton, HM. "Effect-Directed Analysis of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) Ligands in Indoor Dust." Environmental science & technology 49, no. 16 (August 2015): 10065-10073. Full Text
- Fang, M, Webster, TF, and Stapleton, HM. "Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust." Environmental science & technology 49, no. 16 (August 2015): 10057-10064. Full Text
- Roberts, SC, Bianco, AC, and Stapleton, HM. "Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers." Chemical research in toxicology 28, no. 6 (June 2, 2015): 1265-1274. Full Text
- Scanlan, LD, Loguinov, AV, Teng, Q, Antczak, P, Dailey, KP, Nowinski, DT, Kornbluh, J, Lin, XX, Lachenauer, E, Arai, A, Douglas, NK, Falciani, F, Stapleton, HM, and Vulpe, CD. "Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants." Environmental science & technology 49, no. 12 (June 2015): 7400-7410. Full Text
- Davis, EF, Gunsch, CK, and Stapleton, HM. "Fate of flame retardants and the antimicrobial agent triclosan in planted and unplanted biosolid-amended soils." Environmental toxicology and chemistry 34, no. 5 (May 2015): 968-976. Full Text
- Su, G, Letcher, RJ, Crump, D, Gooden, DM, and Stapleton, HM. "In Vitro Metabolism of the Flame Retardant Triphenyl Phosphate in Chicken Embryonic Hepatocytes and the Importance of the Hydroxylation Pathway." Environmental Science & Technology Letters 2, no. 4 (April 14, 2015): 100-104. Full Text
- Isales, GM, Hipszer, RA, Raftery, TD, Chen, A, Stapleton, HM, and Volz, DC. "Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor." Aquatic toxicology (Amsterdam, Netherlands) 161 (April 2015): 221-230. Full Text
- Fang, M, Webster, TF, Ferguson, PL, and Stapleton, HM. "Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust." Environmental health perspectives 123, no. 2 (February 2015): 166-172. Full Text
- Hoffman, K, Garantziotis, S, Birnbaum, LS, and Stapleton, HM. "Monitoring indoor exposure to organophosphate flame retardants: hand wipes and house dust." Environmental health perspectives 123, no. 2 (February 2015): 160-165. Full Text
- Fang, M, Webster, TF, Ferguson, PL, and Stapleton, HM. "Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust." Environmental Health Perspectives 123, no. 2 (January 1, 2015): 166-172. Full Text
- Freitag, AR, Thayer, LR, Leonetti, C, Stapleton, HM, and Hamlin, HJ. "Effects of elevated nitrate on endocrine function in Atlantic salmon, Salmo salar." Aquaculture 436 (January 2015): 8-12. Full Text
- Macaulay, LJ, Bailey, JM, Levin, ED, and Stapleton, HM. "Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior." NEUROTOXICOLOGY AND TERATOLOGY 52 (2015): 119-126. Full Text Link to Item
- McIntyre, RL, Kenerson, HL, Subramanian, S, Wang, SA, Kazami, M, Stapleton, HM, and Yeung, RS. "Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency." BMC obesity 2 (January 2015): 3-. Full Text
- Dishaw, LV, Hunter, DL, Padnos, B, Padilla, S, and Stapleton, HM. "Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio)." Toxicological sciences : an official journal of the Society of Toxicology 142, no. 2 (December 2014): 445-454. Full Text
- Dishaw, LV, Macaulay, LJ, Roberts, SC, and Stapleton, HM. "Exposures, mechanisms, and impacts of endocrine-active flame retardants." Current opinion in pharmacology 19 (December 2014): 125-133. (Review) Full Text
- Fang, M, Getzinger, GJ, Cooper, EM, Clark, BW, Garner, LVT, Di Giulio, RT, Ferguson, PL, and Stapleton, HM. "Effect-directed analysis of Elizabeth River porewater: developmental toxicity in zebrafish (Danio rerio)." Environmental toxicology and chemistry 33, no. 12 (December 2014): 2767-2774. Full Text
- Stapleton, HM, Misenheimer, J, Hoffman, K, and Webster, TF. "Flame retardant associations between children's handwipes and house dust." Chemosphere 116 (December 2014): 54-60. Full Text
- Fang, M, and Stapleton, HM. "Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method." Environmental science & technology 48, no. 22 (November 5, 2014): 13323-13330. Full Text
- Pillai, HK, Fang, M, Beglov, D, Kozakov, D, Vajda, S, Stapleton, HM, Webster, TF, and Schlezinger, JJ. "Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro." Environmental health perspectives 122, no. 11 (November 2014): 1225-1232. Full Text
- Holzem, RM, Stapleton, HM, and Gunsch, CK. "Response to comment on "Determining the ecological impacts of organic contaminants in biosolids using a high-throughput colorimetric denitrification assay: a case study with antimicrobial agents"." Environmental science & technology 48, no. 20 (October 2014): 12470-12471. (Letter) Full Text
- Butt, CM, Congleton, J, Hoffman, K, Fang, M, and Stapleton, HM. "Metabolites of organophosphate flame retardants and 2-ethylhexyl tetrabromobenzoate in urine from paired mothers and toddlers." Environmental science & technology 48, no. 17 (September 2014): 10432-10438. Full Text
- Hoffman, K, Fang, M, Horman, B, Patisaul, HB, Garantziotis, S, Birnbaum, LS, and Stapleton, HM. "Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550." Environmental health perspectives 122, no. 9 (September 2014): 963-969. Full Text
- Martin, NP, Marron Fernandez de Velasco, E, Mizuno, F, Scappini, EL, Gloss, B, Erxleben, C, Williams, JG, Stapleton, HM, Gentile, S, and Armstrong, DL. "A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo." Endocrinology 155, no. 9 (September 2014): 3713-3724. Full Text
- Belcher, SM, Cookman, CJ, Patisaul, HB, and Stapleton, HM. "In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components." Toxicology letters 228, no. 2 (July 2014): 93-102. Full Text
- Wolf, CJ, Fang, M, Stapleton, HM, and Abbott, BD. "Activation of Human Peroxisome Proliferator-Activated Receptor-Gamma (PPAR gamma) by House Dust Extracts." BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY 100, no. 5 (May 2014): 393-393. Link to Item
- Hoffman, K, Daniels, JL, and Stapleton, HM. "Urinary metabolites of organophosphate flame retardants and their variability in pregnant women." Environ Int 63 (February 2014): 169-172. Full Text Link to Item
- Keller, AS, Raju, NP, Webster, TF, and Stapleton, HM. "Flame Retardant Applications in Camping Tents and Potential Exposure." Environmental science & technology letters 1, no. 2 (February 2014): 152-155. Full Text
- Holzem, RM, Stapleton, HM, and Gunsch, CK. "Determining the ecological impacts of organic contaminants in biosolids using a high-throughput colorimetric denitrification assay: a case study with antimicrobial agents." Environmental science & technology 48, no. 3 (January 23, 2014): 1646-1655. Full Text
- Dong, W, Macaulay, LJ, Kwok, KW, Hinton, DE, Ferguson, PL, and Stapleton, HM. "The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos." Endocrine disruptors (Austin, Tex.) 2, no. 1 (January 2014). Full Text
- Levin, ED, Cauley, M, Johnson, JE, Cooper, EM, Stapleton, HM, Ferguson, PL, Seidler, FJ, and Slotkin, TA. "Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor." Neurotoxicol Teratol 41 (January 2014): 35-42. Full Text Link to Item
- Muzzio, AM, Noyes, PD, Stapleton, HM, and Lema, SC. "Tissue distribution and thyroid hormone effects on mRNA abundance for membrane transporters Mct8, Mct10, and organic anion-transporting polypeptides (Oatps) in a teleost fish." Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 167 (January 1, 2014): 77-89. Full Text
- Noyes, PD, Lema, SC, Roberts, SC, Cooper, EM, and Stapleton, HM. "Rapid method for the measurement of circulating thyroid hormones in low volumes of teleost fish plasma by LC-ESI/MS/MS." Anal Bioanal Chem 406, no. 3 (January 2014): 715-726. Full Text Link to Item
- Noyes, PD, and Stapleton, HM. "PBDE flame retardants." Endocrine Disruptors 2, no. 1 (January 2014): e29430-e29430. Full Text
- Stapleton, HM, Misenheimer, J, Hoffman, K, and Webster, TF. "Flame retardant associations between children's handwipes and house dust." Chemosphere 116 (January 1, 2014): 54-60. Full Text
- Carignan, CC, Heiger-Bernays, W, McClean, MD, Roberts, SC, Stapleton, HM, Sjödin, A, and Webster, TF. "Flame retardant exposure among collegiate United States gymnasts." Environmental Science and Technology 47, no. 23 (December 3, 2013): 13848-13856. Full Text
- Butt, CM, and Stapleton, HM. "Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics." Chem Res Toxicol 26, no. 11 (November 18, 2013): 1692-1702. Full Text Link to Item
- Meeker, JD, Cooper, EM, Stapleton, HM, and Hauser, R. "Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health." Endocrine disruptors (Austin, Tex.) 1, no. 1 (October 2013): e26306-. Full Text
- Clark, BW, Cooper, EM, Stapleton, HM, and Di Giulio, RT. "Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA)." Environ Sci Technol 47, no. 18 (September 17, 2013): 10556-10566. Full Text Link to Item
- Noyes, PD, Lema, SC, Macaulay, LJ, Douglas, NK, and Stapleton, HM. "Low level exposure to the flame retardant BDE-209 reduces thyroid hormone levels and disrupts thyroid signaling in fathead minnows." Environ Sci Technol 47, no. 17 (September 3, 2013): 10012-10021. Full Text Link to Item
- Slotkin, TA, Cooper, EM, Stapleton, HM, and Seidler, FJ. "Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?." Environ Toxicol Pharmacol 36, no. 2 (September 2013): 284-287. Full Text Link to Item
- Lohmann, R, Stapleton, HM, and Hites, RA. "Science Should Guide TSCA Reform." ENVIRONMENTAL SCIENCE & TECHNOLOGY 47, no. 16 (August 20, 2013): 8995-8996. Full Text Link to Item
- Lohmann, R, Stapleton, HM, and Hites, RA. "Science In TSCA Reform." CHEMICAL & ENGINEERING NEWS 91, no. 32 (August 12, 2013): 3-3. Link to Item
- Dong, W, Macaulay, LJ, Kwok, KWH, Hinton, DE, and Stapleton, HM. "Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages." Aquat Toxicol 132-133 (May 15, 2013): 190-199. Full Text Link to Item
- Fang, M, Webster, TF, Gooden, D, Cooper, EM, McClean, MD, Carignan, C, Makey, C, and Stapleton, HM. "Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust." Environ Sci Technol 47, no. 9 (May 7, 2013): 4449-4454. Full Text Link to Item
- McGee, SP, Konstantinov, A, Stapleton, HM, and Volz, DC. "Aryl Phosphate Esters Within a Major PentaBDE Replacement Product Induce Cardiotoxicity in Developing Zebrafish Embryos: Potential Role of the Aryl Hydrocarbon Receptor." TOXICOLOGICAL SCIENCES 133, no. 1 (May 2013): 144-156. Full Text Link to Item
- Allen, JG, Stapleton, HM, Vallarino, J, McNeely, E, McClean, MD, Harrad, SJ, Rauert, CB, and Spengler, JD. "Exposure to flame retardant chemicals on commercial airplanes." ENVIRONMENTAL HEALTH 12 (February 16, 2013). Full Text Link to Item
- Buttke, DE, Wolkin, A, Stapleton, HM, and Miranda, ML. "Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women." Journal of Exposure Science and Environmental Epidemiology 23, no. 2 (2013): 176-182. Full Text
- Carignan, CC, McClean, MD, Cooper, EM, Watkins, DJ, Fraser, AJ, Heiger-Bernays, W, Stapleton, HM, and Webster, TF. "Predictors of tris(1,3-dichloro-2-propyl) phosphate metabolite in the urine of office workers." Environment International 55 (2013): 56-61. Full Text
- Meeker, JD, Cooper, EM, Stapleton, HM, and Hauser, R. "Urinary metabolites of organophosphate flame retardants: Temporal variability and correlations with house dust concentrations." Environmental Health Perspectives 121, no. 5 (2013): 580-585. Full Text
- Patisaul, HB, Roberts, SC, Mabrey, N, Mccaffrey, KA, Gear, RB, Braun, J, Belcher, SM, and Stapleton, HM. "Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment." Journal of Biochemical and Molecular Toxicology 27, no. 2 (2013): 124-136. Full Text
- Watkins, DJ, McClean, MD, Fraser, AJ, Weinberg, J, Stapleton, HM, and Webster, TF. "Associations between PBDEs in office air, dust, and surface wipes." Environment International 59 (2013): 124-132. Full Text
- Webster, TF, Stapleton, HM, and McClean, MD. "Exposure to Polybrominated Diphenyl Ethers in the Indoor Environment." Fire Technology 51, no. 1 (January 1, 2013): 85-95. Full Text
- Webster, TF, Stapleton, HM, and McClean, MD. "Exposure to Polybrominated Diphenyl Ethers in the Indoor Environment." Fire Technology (2013): 1-11. Full Text
- Webster, TF, and Stapleton, HM. "Human exposure assessment of indoor dust: Webster and Stapleton respond." Environmental health perspectives 121, no. 4 (2013): A110-A111. Full Text
- Webster, TF, and Stapleton, HM. "Human exposure assessment of indoor dust: Webster and stapleton respond." Environmental Health Perspectives 121, no. 4 (2013): A109-A110. Full Text
- Stapleton, HM, Sharma, S, Getzinger, G, Ferguson, PL, Gabriel, M, Webster, TF, and Blum, A. "Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out." Environ Sci Technol 46, no. 24 (December 18, 2012): 13432-13439. Full Text Link to Item
- Springer, C, Dere, E, Hall, SJ, McDonnell, EV, Roberts, SC, Butt, CM, Stapleton, HM, Watkins, DJ, McClean, MD, Webster, TF, Schlezinger, JJ, and Boekelheide, K. "Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust." ENVIRONMENTAL HEALTH PERSPECTIVES 120, no. 12 (December 2012): 1711-1719. Full Text Link to Item
- Roberts, SC, Macaulay, LJ, and Stapleton, HM. "In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues." Chem Res Toxicol 25, no. 7 (July 16, 2012): 1435-1441. Full Text Link to Item
- Stapleton, HM, Eagle, S, Sjödin, A, and Webster, TF. "Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables." Environ Health Perspect 120, no. 7 (July 2012): 1049-1054. Full Text Link to Item
- Davis, EF, Klosterhaus, SL, and Stapleton, HM. "Measurement of flame retardants and triclosan in municipal sewage sludge and biosolids." Environ Int 40 (April 2012): 1-7. Full Text Link to Item
- Webster, TF, and Stapleton, HM. "Flame Retardants: Polybrominated Diphenyl Ethers and their Replacements." (March 30, 2012): 89-108. (Chapter) Full Text
- Ashley, JTF, Vasquez, MA, Zelanko, P, McKinley, E, Schafer, M, Zaoudeh, L, Horwitz, R, Stapleton, HM, and Velinsky, DJ. "Trophic transfer of polybrominated diphenyl ethers and polychlorinated biphenyls in a tidal freshwater marsh." Chemistry and Ecology 28, no. 4 (2012): 305-325. Full Text
- Bearr, JS, Mitchelmore, CL, Roberts, SC, and Stapleton, HM. "Species specific differences in the in vitro metabolism of the flame retardant mixture, Firemaster® BZ-54." Aquatic Toxicology 124-125 (2012): 41-47. Full Text
- Buttke, DE, Wolkin, A, Stapleton, HM, and Miranda, ML. "Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women." Journal of Exposure Science and Environmental Epidemiology (2012). Full Text
- Fraser, AJ, Webster, TF, Watkins, DJ, Nelson, JW, Stapleton, HM, Calafat, AM, Kato, K, Shoeib, M, Vieira, VM, and McClean, MD. "Polyfluorinated compounds in serum linked to indoor air in office environments." Environmental Science and Technology 46, no. 2 (2012): 1209-1215. Full Text
- Johnson, PJ, Stapleton, HM, Mukherjee, B, Hauser, R, and Meeker, JD. "Associations between brominated flame retardants in house dust and hormone levels in men. (Accepted)" Sci Total Environ (2012). (Academic Article)
- Klosterhaus, SL, Stapleton, HM, Guardia, MJL, and Greig, DJ. "Brominated and chlorinated flame retardants in San Francisco Bay sediments and wildlife." Environment International 47 (2012): 56-65. Full Text
- McClain, V, Stapleton, HM, Tilton, F, and Gallagher, EP. "BDE 49 and developmental toxicity in zebrafish." Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 155, no. 2 (2012): 253-258. Full Text
- McGee, SP, Cooper, E, Stapleton, HM, and Volz, D. "Early Zebrafish Embryogenesis Is Susceptible to Developmental TDCPP Exposure." Environmental Health Perspectives 120, no. 11 (2012): 1586-1591. (Academic Article)
- McGee, SP, Cooper, EM, Stapleton, HM, and Volz, DC. "Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure." Environmental Health Perspectives 120, no. 11 (2012): 1585-1591. Full Text
- Patisaul, HB, Roberts, SC, Mabrey, N, Mccaffrey, KA, Gear, RB, Braun, J, Belcher, SM, and Stapleton, HM. "Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster ® 550 in Rats: An Exploratory Assessment." Journal of Biochemical and Molecular Toxicology (2012). Full Text
- Watkins, DJ, McClean, MD, Fraser, AJ, Weinberg, J, Stapleton, HM, Sjödin, A, and Webster, TF. "Impact of dust from multiple microenvironments and diet on PentaBDE body burden." Environmental Science and Technology 46, no. 2 (2012): 1192-1200. Full Text
- Butt, CM, Wang, D, and Stapleton, HM. "Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver." Toxicol Sci 124, no. 2 (December 2011): 339-347. Full Text Link to Item
- Dishaw, LV, Powers, CM, Ryde, IT, Roberts, SC, Seidler, FJ, Slotkin, TA, and Stapleton, HM. "Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells." Toxicol Appl Pharmacol 256, no. 3 (November 1, 2011): 281-289. Full Text Link to Item
- Jung, D, Matson, CW, Collins, LB, Laban, G, Stapleton, HM, Bickham, JW, Swenberg, JA, and Di Giulio, RT. "Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia." Ecotoxicology 20, no. 8 (November 2011): 1890-1899. Full Text Link to Item
- Cooper, EM, Covaci, A, van Nuijs, ALN, Webster, TF, and Stapleton, HM. "Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry." Anal Bioanal Chem 401, no. 7 (October 2011): 2123-2132. Full Text Link to Item
- Stapleton, HM, Eagle, S, Anthopolos, R, Wolkin, A, and Miranda, ML. "Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy." Environ Health Perspect 119, no. 10 (October 2011): 1454-1459. Full Text Link to Item
- Noyes, PD, Hinton, DE, and Stapleton, HM. "Accumulation and debromination of decabromodiphenyl ether (BDE-209) in juvenile fathead minnows (Pimephales promelas) induces thyroid disruption and liver alterations." Toxicol Sci 122, no. 2 (August 2011): 265-274. Full Text Link to Item
- Stapleton, HM, Klosterhaus, S, Keller, A, Ferguson, PL, van Bergen, S, Cooper, E, Webster, TF, and Blum, A. "Identification of flame retardants in polyurethane foam collected from baby products." Environ Sci Technol 45, no. 12 (June 15, 2011): 5323-5331. Full Text Link to Item
- Roberts, SC, Noyes, PD, Gallagher, EP, and Stapleton, HM. "Species-specific differences and structure-activity relationships in the debromination of PBDE congeners in three fish species." Environ Sci Technol 45, no. 5 (March 1, 2011): 1999-2005. Full Text Link to Item
- Stapleton, HM, Eagle, SD, Sjodin, A, and Webster, TF. "Serum PBDEs in US Toddlers: Associations with Hand Wipes, House Dust and Socioeconomic Variables (Submitted)." Environmental Health Perspectives (2011). (Academic Article)
- Tomy, GT, Palace, V, Marvin, C, Stapleton, HM, Covaci, A, and Harrad, S. "Biotransformation of HBCD in biological systems can confound temporal-trend studies." Environmental Science and Technology 45, no. 2 (2011): 364-365. Full Text
- Watkins, DJ, McClean, MD, Fraser, AJ, Weinberg, J, Stapleton, HM, Sjödin, A, and Webster, TF. "Exposure to PBDEs in the office environment: Evaluating the relationships between dust, handwipes, and serum." Environmental Health Perspectives 119, no. 9 (2011): 1247-1252. Full Text
- Cooper, EM, Stapleton, HM, Matson, CW, Di Giulio, RT, and Schuler, AJ. "Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products." Environ Toxicol Chem 29, no. 11 (November 2010): 2409-2416. Full Text Link to Item
- Wang, D, and Stapleton, HM. "Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry." Anal Bioanal Chem 397, no. 5 (July 2010): 1831-1839. Full Text Link to Item
- Noyes, PD, Kelly, SM, Mitchelmore, CL, and Stapleton, HM. "Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp." Aquat Toxicol 97, no. 2 (April 15, 2010): 142-150. Full Text Link to Item
- Ashley, JTF, Ward, JS, Schafer, MW, Stapleton, HM, and Velinsky, DJ. "Evaluating daily exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in fish oil supplements." Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 27, no. 8 (2010): 1177-1185. Full Text
- Bearr, JS, Stapleton, HM, and Mitchelmore, CL. "Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, firemaster® 550 and firemaster® BZ-54." Environmental Toxicology and Chemistry 29, no. 3 (2010): 722-729. Full Text
- Johnson, PI, Stapleton, HM, Sjodin, A, and Meeker, JD. "Relationships between polybrominated diphenyl ether concentrations in house dust and serum." Environmental Science and Technology 44, no. 14 (2010): 5627-5632. Full Text Open Access Copy
- Kim, GB, and Stapleton, HM. "PBDEs, methoxylated PBDEs and HBCDs in Japanese common squid (Todarodes pacificus) from Korean offshore waters." Marine Pollution Bulletin 60, no. 6 (2010): 935-940. Full Text
- Meeker, JD, and Stapleton, HM. "House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters." Environmental Health Perspectives 118, no. 3 (2010): 318-323. Full Text
- Stapleton, HM, and Davis, EF. "Response to "Comment on 'Photodegradation Pathways of Nonabrominated Diphenyl Ethers, 2-Ethylhexyltetrabromobenzoate, and Di(2-ethylhexyl)tetrabromophthalate: Identifying Potential Markers of Photodegradation'"." Environ Sci Technol 43, no. 20 (October 15, 2009): 7994-. Full Text Link to Item
- Stapleton, HM, Klosterhaus, S, Eagle, S, Fuh, J, Meeker, JD, Blum, A, and Webster, TF. "Detection of organophosphate flame retardants in furniture foam and U.S. house dust." Environ Sci Technol 43, no. 19 (October 1, 2009): 7490-7495. Link to Item
- Davis, EF, and Stapleton, HM. "Photodegradation pathways of nonabrominated diphenyl ethers, 2-ethylhexyltetrabromobenzoate and di(2-ethylhexyl)tetrabromophthalate: identifying potential markers of photodegradation." Environ Sci Technol 43, no. 15 (August 1, 2009): 5739-5746. Link to Item
- Stapleton, HM, Kelly, SM, Pei, R, Letcher, RJ, and Gunsch, C. "Metabolism of polybrominated diphenyl ethers (PBDEs) by human hepatocytes in vitro." Environ Health Perspect 117, no. 2 (February 2009): 197-202. Full Text Link to Item
- Browne, EP, Stapleton, HM, Kelly, SM, Tilton, SC, and Gallagher, EP. "In vitro hepatic metabolism of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE 99) in Chinook Salmon (Onchorhynchus tshawytscha)." Aquatic Toxicology 92, no. 4 (2009): 281-287. Full Text
- Webster, TF, Harrad, S, Millette, JR, Holbrook, RD, Davis, JM, Stapleton, HM, Allen, JG, McClean, MD, Ibarra, C, Abdallah, MA-E, and Covaci, A. "Identifying transfer mechanisms and sources of decabromodiphenyl ether (BDE 209) in indoor environments using environmental forensic microscopy." Environmental Science and Technology 43, no. 9 (2009): 3067-3072. Full Text
- Stapleton, HM, Allen, JG, Kelly, SM, Konstantinov, A, Klosterhaus, S, Watkins, D, McClean, MD, and Webster, TF. "Alternate and new brominated flame retardants detected in U.S. house dust." Environ Sci Technol 42, no. 18 (September 15, 2008): 6910-6916. Link to Item
- Stapleton, HM, Kelly, SM, Allen, JG, Mcclean, MD, and Webster, TF. "Measurement of polybrominated diphenyl ethers on hand wipes: estimating exposure from hand-to-mouth contact." Environ Sci Technol 42, no. 9 (May 1, 2008): 3329-3334. Link to Item
- Stapleton, HM, Sjödin, A, Jones, RS, Niehüser, S, Zhang, Y, and Patterson, DG. "Serum levels of polybrominated diphenyl ethers (PBDEs) in foam recyclers and carpet installers working in the United States." Environ Sci Technol 42, no. 9 (May 1, 2008): 3453-3458. Link to Item
- Stapleton, HM, and Dodder, NG. "Photodegradation of decabromodiphenyl ether in house dust by natural sunlight." Environ Toxicol Chem 27, no. 2 (February 2008): 306-312. Full Text Link to Item
- Allen, JG, McClean, MD, Stapleton, HM, and Webster, TF. "Longitudinal Analysis of Polybrominated Diphenyl Ethers (PBDEs) in Household Microenvironments: Characterization of Dust and Relationship to Indoor Air." Environment International 34, no. 8 (2008): 1085-1091. (Academic Article)
- Allen, JG, McClean, MD, Stapleton, HM, and Webster, TF. "Critical factors in assessing exposure to PBDEs via house dust." Environment International 34, no. 8 (2008): 1085-1091. Full Text
- Allen, JG, Mcclean, MD, Stapleton, HM, and Webster, TF. "Linking PBDEs in house dust to consumer products using X-ray fluorescence." Environmental Science and Technology 42, no. 11 (2008): 4222-4228. Full Text
- Huwe, JK, Hakk, H, Smith, DJ, Diliberto, JJ, Richardson, V, Stapleton, HM, and Birnbaum, LS. "Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats." Environmental Science and Technology 42, no. 7 (2008): 2694-2700. Full Text
- Stapleton, HM, Kelly, SM, Allen, JG, McClean, MD, and Webster, TF. "Measurement of Polybrominated Diphenyl Ethers on Hand Wipes: Estimating Exposure from Hand to Mouth Contact." Environ Sci & Technol 49, no. 9 (2008): 3329-3334. (Academic Article)
- Stapleton, HM, Kelly, SM, Allen, JG, Watkins, DJ, Heiger-Bernays, WJ, McClean, MD, Webster, TF, Konstantinov, A, and Klosterhaus, S. "Response to comment on "Altemate and new brominated flame retardants detected in U.S. house dust"." Environmental Science and Technology 42, no. 24 (2008): 9455-9456. Full Text
- Stapleton, HM, Sjodin, A, Jones, RS, Niehauser, S, Zhang, Y, and Patterson, DG. "Serum PBDE Levels in Occupationally Exposed Individuals in the United States." Environ Sci & Technol 42, no. 9 (2008): 3453-3458. (Academic Article)
- Stapleton, HM, Keller, JM, Schantz, MM, Kucklick, JR, Leigh, SD, and Wise, SA. "Determination of polybrominated diphenyl ethers in environmental standard reference materials." Anal Bioanal Chem 387, no. 7 (April 2007): 2365-2379. Full Text Link to Item
- Allen, JG, Mcclean, MD, Stapleton, HM, Nelson, JW, and Webster, TF. "Personal exposure to Polybrominated Diphenyl Ethers (PBDEs) in residential indoor air." Environmental Science and Technology 41, no. 13 (2007): 4574-4579. Full Text
- Ashley, JTF, Libero, D, Halscheid, E, Zaoudeh, L, and Stapleton, HM. "Polybrominated diphenyl ethers in American eels (Anguilla rostrata) from the Delaware River, USA." Bulletin of Environmental Contamination and Toxicology 79, no. 1 (2007): 99-103. Full Text
- Benedict, RT, Stapleton, HM, Letcher, RJ, and Mitchelmore, CL. "Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes." Chemosphere 69, no. 6 (2007): 987-993. Full Text
- Schantz, BMM, Keller, JM, Kucklick, JR, Poster, DL, Stapleton, HM, Pol, SSV, and Wise, SA. "New standard reference material (srm) 2585: Organic contaminants in house dust to support exposure assessment measurements." American Laboratory 39, no. 15 (2007): 22-28.
- Schantz, MM, Keller, JM, Leigh, S, Jr, DGP, Sharpless, KE, Sjödin, A, Stapleton, HM, Swarthout, R, Turner, WE, and Wise, SA. "Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum." Analytical and Bioanalytical Chemistry 389, no. 4 (2007): 1201-1208. Full Text
- Stapleton, HM. "Instrumental methods and challenges in quantifying polybrominated diphenyl ethers in environmental extracts: a review." Anal Bioanal Chem 386, no. 4 (October 2006): 807-817. Link to Item
- Stapleton, HM, Brazil, B, Holbrook, RD, Mitchelmore, CL, Benedict, R, Konstantinov, A, and Potter, D. "In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp." Environ Sci Technol 40, no. 15 (August 1, 2006): 4653-4658. Link to Item
- Stapleton, HM, Dodder, NG, Kucklick, JR, Reddy, CM, Schantz, MM, Becker, PR, Gulland, F, Porter, BJ, and Wise, SA. "Determination of HBCD, PBDEs and MeO-BDEs in California sea lions (Zalophus californianus) stranded between 1993 and 2003." Mar Pollut Bull 52, no. 5 (May 2006): 522-531. Full Text Link to Item
- Stapleton, HM, Harner, T, Shoeib, M, Keller, JM, Schantz, MM, Leigh, SD, and Wise, SA. "Determination of polybrominated diphenyl ethers in indoor dust standard reference materials." Anal Bioanal Chem 384, no. 3 (February 2006): 791-800. Full Text Link to Item
- Stapleton, HM, Dodder, NG, Offenberg, JH, Schantz, MM, and Wise, SA. "Polybrominated diphenyl ethers in house dust and clothes dryer lint." Environmental Science and Technology 39, no. 4 (2005): 925-931. Full Text
- Tuerk, KJS, Kucklick, JR, Becker, PR, Stapleton, HM, and Baker, JE. "Persistent organic pollutants in two dolphin species with focus on toxaphene and polybrominated diphenyl ethers." Environmental Science and Technology 39, no. 3 (2005): 692-698. Full Text
- Stapleton, HM, Alaee, M, Letcher, RJ, and Baker, JE. "Debromination of the Flame Retardant Decabromodiphenyl Ether by Juvenile Carp (Cyprinus carpio) following Dietary Exposure." Environmental Science and Technology 38, no. 1 (2004): 112-119. Full Text
- Stapleton, HM, Letcher, RJ, Li, J, and Baker, JE. "Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)." Environmental Toxicology and Chemistry 23, no. 8 (2004): 1939-1946. Full Text
- Stapleton, HM, Letcher, RJ, and Baker, JE. "Debromination of Polybrominated Diphenyl Ether Congeners BDE 99 and BDE 183 in the Intestinal Tract of the Common Carp (Cyprinus carpio)." Environmental Science and Technology 38, no. 4 (2004): 1054-1061.
- Ashley, JTF, Moore, A, Stapleton, HM, Velinsky, DJ, and Wilhelm, MP. "Sedimentary nonylphenol contamination in an urbanized, industrialized segment of the Delaware River estuary, USA." Bulletin of Environmental Contamination and Toxicology 70, no. 5 (2003): 978-984. Full Text
- Hale, RC, Alaee, M, Manchester-Neesvig, JB, Stapleton, HM, and Ikonomou, MG. "Polybrominated diphenyl ether flame retardants in the North American environment." Environment International 29, no. 6 (2003): 771-779. Full Text
- Stapleton, HM, and Baker, JE. "Comparing polybrominated diphenyl ether and polychlorinated biphenyl bioaccumulation in a food web in Grand Traverse Bay, Lake Michigan." Archives of Environmental Contamination and Toxicology 45, no. 2 (2003): 227-234. Full Text
- Stapleton, HM, Skubinna, J, and Baker, JE. "Seasonal dynamics of PCB and toxaphene bioaccumulation within a Lake Michigan food web." Journal of Great Lakes Research 28, no. 1 (2002): 52-64.
- Schneider, AR, Stapleton, HM, Cornwell, J, and Baker, JE. "Recent declines in PAH, PCB, and toxaphene levels in the Northern Great Lakes as determined from high resolution sediment cores." Environmental Science and Technology 35, no. 19 (2001): 3809-3815. Full Text
- Stapleton, HM, Letcher, RJ, and Baker, JE. "Metabolism of highly chlorinated PCBs by a Lake Michigan fish." Environ. Sci. Technol. 35, no. 24 (2001): 4747-4752. (Academic Article)
- Stapleton, HM, Letcher, RJ, and Baker, JE. "Metabolism of PCBs by the deepwater sculpin (Myoxocephalus thompsoni)." Environmental Science and Technology 35, no. 24 (2001): 4747-4752. Full Text
- Stapleton, HM, Masterson, C, Skubinna, J, Ostrom, P, Ostrom, NE, and Baker, JE. "Accumulation of atmospheric and sedimentary PCBs and toxaphene in a Lake Michigan food web." Environmental Science and Technology 35, no. 16 (2001): 3287-3293. Full Text
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- Teaching & Mentoring
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Recent Courses
- CEE 563: Chemical Fate of Organic Compounds 2018
- ENVIRON 393: Research Independent Study 2018
- ENVIRON 394: Research Independent Study 2018
- ENVIRON 540: Chemical Fate of Organic Compounds 2018
- ENVIRON 593: Independent Studies and Projects 2018
- ENVIRON 898: Program Area Seminar 2018
- ENVIRON 899: Master's Project 2018
- ENVIRON 780: Environmental Exposure Analysis 2017
- ENVIRON 360: Environmental Chemistry and Toxicology 2016
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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