Immune evasion pathways and the design of dendritic cell-based cancer vaccines.

Journal Article (Journal Article;Review)

Emerging data is suggesting that the process of dendritic cell (DC) tolerization is an important step in tumorigenesis. Our understanding of the networks within the tumor microenvironment that functionally tolerize DC function is evolving while methods for genetically manipulating DC populations in situ continue to develop. A more intimate understanding of the paracrine signaling pathways which mediate immune evasion by subverting DC function promises to provide novel strategies for improving the clinical efficacy of DC-based cancer vaccines. This will likely require a better understanding of both the antigen expression profile and the immune evasion network of the tumor and its associated stromal tissues.

Full Text

Duke Authors

Cited Authors

  • Hanks, BA

Published Date

  • February 2016

Published In

Volume / Issue

  • 21 / 114

Start / End Page

  • 135 - 142

PubMed ID

  • 27011049

Pubmed Central ID

  • PMC4934601

Electronic International Standard Serial Number (EISSN)

  • 1944-7930


  • eng

Conference Location

  • United States