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Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma.

Publication ,  Journal Article
Kim, J; Sun, Z; Gulack, BC; Adam, MA; Mosca, PJ; Rice, HE; Tracy, ET
Published in: J Pediatr Surg
June 2016

BACKGROUND/PURPOSE: Sentinel lymph node biopsy (SLNB)-based management has been shown to improve disease-free survival in adult melanoma, but there is scant evidence regarding the utility of SLNB in pediatric melanoma. METHODS: The 2004-2011 Surveillance, Epidemiology, and End Results database was queried for patients with primary cutaneous melanoma of Breslow depth>0.75mm and clinically negative nodes. Pediatric patients, defined as less than 20years of age, were grouped by whether they underwent SLNB or not. Kaplan-Meier analysis was performed to compare melanoma-specific survival (MSS) in propensity-matched groups. RESULTS: 310 pediatric patients met study criteria: 261 (84%) underwent SLNB, while 49 (16%) did not. There was no difference in MSS between matched children who received SLNB and those who did not (p=0.36). Among children who received SLNB, a positive SLNB was associated with worse MSS compared to a negative SLNB (89% vs. 100% at 84months, p=0.04). However, children with a positive SLNB had more favorable survival compared to patients >20years of age (88% vs. 66% at 84months, p=0.02). CONCLUSIONS: SLNB does not confer a survival benefit to children with melanoma, but it provides valuable prognostic information regarding MSS.

Duke Scholars

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

June 2016

Volume

51

Issue

6

Start / End Page

986 / 990

Location

United States

Related Subject Headings

  • United States
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Sentinel Lymph Node
  • SEER Program
  • Prognosis
  • Pediatrics
  • Melanoma, Cutaneous Malignant
  • Melanoma
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, J., Sun, Z., Gulack, B. C., Adam, M. A., Mosca, P. J., Rice, H. E., & Tracy, E. T. (2016). Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma. J Pediatr Surg, 51(6), 986–990. https://doi.org/10.1016/j.jpedsurg.2016.02.067
Kim, Jina, Zhifei Sun, Brian C. Gulack, Mohamed A. Adam, Paul J. Mosca, Henry E. Rice, and Elisabeth T. Tracy. “Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma.J Pediatr Surg 51, no. 6 (June 2016): 986–90. https://doi.org/10.1016/j.jpedsurg.2016.02.067.
Kim J, Sun Z, Gulack BC, Adam MA, Mosca PJ, Rice HE, et al. Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma. J Pediatr Surg. 2016 Jun;51(6):986–90.
Kim, Jina, et al. “Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma.J Pediatr Surg, vol. 51, no. 6, June 2016, pp. 986–90. Pubmed, doi:10.1016/j.jpedsurg.2016.02.067.
Kim J, Sun Z, Gulack BC, Adam MA, Mosca PJ, Rice HE, Tracy ET. Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma. J Pediatr Surg. 2016 Jun;51(6):986–990.
Journal cover image

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

June 2016

Volume

51

Issue

6

Start / End Page

986 / 990

Location

United States

Related Subject Headings

  • United States
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Sentinel Lymph Node
  • SEER Program
  • Prognosis
  • Pediatrics
  • Melanoma, Cutaneous Malignant
  • Melanoma
  • Male