Paul Joseph Mosca | Scholars@Duke

Paul Joseph Mosca
Associate Professor of Surgery

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Current Appointments & Affiliations

Associate Professor of Surgery, Surgical Oncology, Surgery 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2011

Contact Information

10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710
paul.mosca@duke.edu (919) 684-6858

Background
Education, Training, & Certifications
- M.B.A., Desales University 2011
- Assistant Professor, Surgery, Lehigh Valley Health Network 2004 - 2010
- Assistant Professor, Surgery, Duke University School of Medicine 2002 - 2004
- Chief Resident, Surgery, Duke University 2001 - 2002
- 2nd Year SAR, Surgery, Duke University 2000 - 2001
- Surgical Research Fellow, Surgery, Duke University 1998 - 2000
- Senior Assistant Resident, Surgery, Duke University 1997 - 1998
- Junior Assistant Resident, Surgery, Duke University 1996 - 1997
- Intern, Surgery, Duke University 1995 - 1996
- M.D., University of Virginia 1995
- Ph.D., University of Virginia 1994
Duke Appointment History
- Instructor, Temporary in the Department of Surgery, Surgical Oncology, Surgery 2011
- Assistant Professor of Surgery, Surgery, Clinical Science Departments 2002 - 2004
- Assistant Research Professor of Surgery, Surgery, Surgical Sciences, Surgery 2001 - 2002
- Instructor, Temporary of Surgery, Surgery, Surgical Sciences, Surgery 2001
Expertise
Subject Headings
Research
Selected Grants
- Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health 2013 - 2017
- Dendritic Cell Immunotherapy For Breast Cancer awarded by National Institutes of Health 1998 - 2000
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Puza, CJ, Mosca, PJ, and Cardones, AR. "Early-stage melanoma and hematopoietic stem cell transplantation outcomes." Journal of the American Academy of Dermatology 80, no. 3 (March 2019): 786-788. Full Text
  - Kwak, M, Farrow, NE, Salama, AKS, Mosca, PJ, Hanks, BA, Slingluff, CL, and Beasley, GM. "Updates in adjuvant systemic therapy for melanoma." Journal of Surgical Oncology 119, no. 2 (January 2019): 222-231. (Review) Full Text
  - Adair, KC, Quow, K, Frankel, A, Mosca, PJ, Profit, J, Hadley, A, Leonard, M, and Bryan Sexton, J. "The Improvement Readiness scale of the SCORE survey: a metric to assess capacity for quality improvement in healthcare." Bmc Health Services Research 18, no. 1 (December 17, 2018): 975-null. Full Text
  - Puza, CJ, Barbas, AS, and Mosca, PJ. "Outcomes of patients with a pretransplant history of early-stage melanoma." Melanoma Research 28, no. 5 (October 2018): 471-474. Full Text
  - Masoud, SJ, Perone, JA, Farrow, NE, Mosca, PJ, Tyler, DS, and Beasley, GM. "Sentinel Lymph Node Biopsy and Completion Lymph Node Dissection for Melanoma." Current Treatment Options in Oncology 19, no. 11 (September 19, 2018): 55-null. (Review) Full Text
  - Puza, CJ, Myers, SA, Cardones, AR, Beasley, GM, and Mosca, PJ. "The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients." Clinical and Experimental Dermatology (June 27, 2018). Full Text
  - Puza, CJ, Cardones, AR, and Mosca, PJ. "Timing and Number of Cutaneous Squamous Cell Carcinomas in Transplant Recipients." Jama Dermatology 154, no. 6 (June 2018): 727-728. Full Text
  - Puza, CJ, Josyula, S, Terando, AM, Howard, JH, Agnese, DM, Mosca, PJ, Lee, WT, and Beasley, GM. "Does the number of sentinel lymph nodes removed affect the false negative rate for head and neck melanoma?." Journal of surgical oncology (March 7, 2018). Full Text
  - Puza, CJ, Cardones, AR, and Mosca, PJ. "Examining the Incidence and Presentation of Melanoma in the Cardiothoracic Transplant Population." JAMA dermatology (February 16, 2018). Full Text
  - Puza, CJ, Warren, WS, and Mosca, PJ. "Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy." Lasers in Medical Science 32, no. 9 (December 2017): 2173-null. Full Text
  - Puza, CJ, and Mosca, PJ. "The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy." Lasers in medical science 32, no. 8 (November 2017): 1935-1939. (Review) Full Text
  - Nath, NS, Gilmore, BF, McCann, RK, and Mosca, PJ. "Management of a cutaneous squamous cell carcinoma overlying an AV fistula." BMJ case reports 2017 (May 6, 2017). Full Text
  - Gilmore, BF, Brys, AK, Nath, NS, Barfield, M, Rialon, KL, Truong, T, Pomann, G-M, Migaly, J, and Mosca, PJ. "Clinical Acuity Shorthand System: a standardized classification tool to facilitate handoffs." The Journal of Surgical Research 211 (May 2017): 163-171. Full Text
  - Mullinax, JE, Kroon, HM, Thompson, JF, Nath, N, Mosca, PJ, Farma, JM, Bhati, R, Hardmann, D, Sileno, S, O'Donoghue, C, Perez, M, Naqvi, SMH, Chen, YA, Gonzalez, RJ, and Zager, JS. "Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma." Journal of the American College of Surgeons 224, no. 4 (April 2017): 635-642. Full Text
  - Kottschade, L, Brys, A, Peikert, T, Ryder, M, Raffals, L, Brewer, J, Mosca, P, Markovic, S, and Midwest Melanoma Partnership, . "A multidisciplinary approach to toxicity management of modern immune checkpoint inhibitors in cancer therapy." Melanoma research 26, no. 5 (October 2016): 469-480. Full Text
  - Brys, AK, Gowda, R, Loriaux, DB, Robertson, GP, and Mosca, PJ. "Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy." Biotechnology advances 34, no. 5 (September 2016): 565-577. (Review) Full Text
  - Kim, J, Sun, Z, Gulack, BC, Adam, MA, Mosca, PJ, Rice, HE, and Tracy, ET. "Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma." Journal of pediatric surgery 51, no. 6 (June 2016): 986-990. Full Text
  - Brys, AK, Bhatti, L, Bashir, MR, Jaffe, TA, Beasley, GM, Nath, NS, Salama, AKS, Tyler, DS, and Mosca, PJ. "Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in Melanoma." Annals of surgical oncology 23, no. 4 (April 2016): 1090-1095. Full Text
  - Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, C-L, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O'Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer." Science Translational Medicine 8, no. 320 (January 2016): 320ra4-null. Full Text
  - Robles, FE, Deb, S, Wilson, JW, Gainey, CS, Selim, MA, Mosca, PJ, Tyler, DS, Fischer, MC, and Warren, WS. "Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential." Biomedical Optics Express 6, no. 9 (September 2015): 3631-3645. Full Text
  - Brys, AK, Schneider, MM, Selim, MA, and Mosca, PJ. "Sentinel lymph node biopsy following a rotational flap." BMJ case reports 2015 (July 14, 2015). Full Text
  - Jiang, BS, Speicher, PJ, Thomas, S, Mosca, PJ, Abernethy, AP, and Tyler, DS. "Quality of life after isolated limb infusion for in-transit melanoma of the extremity." Annals of Surgical Oncology 22, no. 5 (May 2015): 1694-1700. Full Text
  - Jiang, X, Anderson, HB, Guy, CD, Mosca, PJ, Riedel, RF, and Cardona, DM. "Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib." Case reports in oncological medicine 2015 (January 28, 2015): 317493-. Full Text
  - Beasley, GM, Speicher, P, Augustine, CK, Dolber, PC, Peterson, BL, Sharma, K, Mosca, PJ, Royal, R, Ross, M, Zager, JS, and Tyler, DS. "A Multicenter Phase I Dose Escalation Trial to Evaluate Safety and Tolerability of Intra-arterial Temozolomide for Patients with Advanced Extremity Melanoma Using Normothermic Isolated Limb Infusion." Annals of Surgical Oncology 22, no. 1 (January 1, 2015): 287-294. Full Text
  - Kamal, A, Bhavsar, NA, Power, S, and Mosca, PJ. "Surgical interventions in cancer patients at the end of life: Experiences at an academic medical center." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 32, no. 30_suppl (October 2014): 281-null.
  - Jiang, BS, Beasley, GM, Speicher, PJ, Mosca, PJ, Morse, MA, Hanks, B, Salama, A, and Tyler, DS. "Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma." Annals of Surgical Oncology 21, no. 8 (August 2014): 2525-2531. Full Text
  - Oldan, JD, James, OG, Mosca, PJ, Tyler, DS, and Borges-Neto, S. "Two-day lymphoscintigraphic imaging for melanoma." Nuclear medicine communications 35, no. 8 (August 2014): 870-875. Full Text
  - Speicher, PJ, Beasley, GM, Jiang, B, Lidsky, ME, Palmer, GM, Scarbrough, PM, Mosca, PJ, Dewhirst, MW, and Tyler, DS. "Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma." Annals of Surgical Oncology 21, no. 5 (May 2014): 1435-1440. Full Text
  - Beasley, GM, Speicher, P, Sharma, K, Seigler, H, Salama, A, Mosca, P, and Tyler, DS. "Efficacy of repeat sentinel lymph node biopsy in patients who develop recurrent melanoma." Journal of the American College of Surgeons 218, no. 4 (April 2014): 686-692. Full Text
  - Jiang, BS, Beasley, GM, Speicher, PJ, Hanks, B, Mosca, PJ, Salama, A, and Tyler, DS. "Immunotherapy Following Disease Progression after Regional Treatment of Melanoma." Journal of Surgical Research 186, no. 2 (February 2014): 682-682. Full Text
  - Speicher, PJ, Nussbaum, DP, White, RR, Zani, S, Mosca, PJ, Blazer, DG, Clary, BM, Pappas, TN, Tyler, DS, and Perez, A. "Defining the Learning Curve for Team-Based Laparoscopic Pancreaticoduodenectomy." Annals of Surgical Oncology 21, no. 12 (January 1, 2014): 4014-4019. Full Text
  - Shetty, G, Beasley, GM, Sparks, S, Barfield, M, Masoud, M, Mosca, PJ, Pruitt, SK, Salama, AKS, Chan, C, Tyler, DS, and Weinhold, KJ. "Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion." Ann Surg Oncol 20, no. 4 (April 2013): 1128-1135. Full Text Link to Item
  - Dannull, J, Haley, NR, Archer, G, Nair, S, Boczkowski, D, Harper, M, Rosa, ND, Pickett, N, Mosca, PJ, Burchette, J, Selim, MA, Mitchell, DA, Sampson, J, Tyler, DS, and Pruitt, SK. "Melanoma immunotherapy using mature DCs expressing the constitutive proteasome." Journal of Clinical Investigation 123, no. 7 (2013): 3135-3145. Full Text
  - L. Rialon, K. "Integration of Palliative Surgery into the Palliative Care Delivery Team." Journal of Palliative Care & Medicine 02, no. 02 (2013). Full Text
  - Rialon, K. "Surgery and the D-Word: Approaching the Topic of Death and Dying with Surgical Patients." Journal of Palliative Care & Medicine 02, no. 03 (2013). Full Text
  - Beasley, GM, Sharma, K, Wong, J, Miller, M, Turley, RS, Lidsky, M, Masoud, M, Dewhirst, MW, Mosca, PJ, Zager, JS, and Tyler, DS. "A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion." Cancer 118, no. 24 (December 15, 2012): 6136-6143. Full Text Link to Item
  - Clawson, GA, Kimchi, E, Patrick, SD, Xin, P, Harouaka, R, Zheng, S, Berg, A, Schell, T, Staveley-O'Carroll, KF, Neves, RI, Mosca, PJ, and Thiboutot, D. "Circulating tumor cells in melanoma patients." Plos One 7, no. 7 (2012): e41052-null. Full Text Link to Item
  - Hanna, J. "Overview of Palliative Surgery: Principles and Priorities." Journal of Palliative Care & Medicine 02, no. 07 (2012). Full Text
  - Sharma, K, Beasley, G, Turley, R, Raymond, AK, Broadwater, G, Peterson, B, Mosca, P, and Tyler, D. "Patterns of recurrence following complete response to regional chemotherapy for in-transit melanoma." Annals of Surgical Oncology 19, no. 8 (2012): 2563-2571. Full Text
  - Madhunapantula, SV, Mosca, PJ, and Robertson, GP. "The Akt signaling pathway: an emerging therapeutic target in malignant melanoma." Cancer Biology & Therapy 12, no. 12 (December 15, 2011): 1032-1049. (Review) Full Text
  - Santillan, AA, Delman, KA, Beasley, GM, Mosca, PJ, Hochwald, SN, Grobmyer, SR, Andtbacka, RH, Noyes, RD, Kane, JM, Ross, MI, Tyler, DS, and Zager, JS. "Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis." Ann Surg Oncol 16, no. 9 (September 2009): 2570-2578. Full Text Link to Item
  - Beasley, GM, Caudle, A, Petersen, RP, McMahon, NS, Padussis, J, Mosca, PJ, Zager, JS, Hochwald, SN, Grobmyer, SR, Delman, KA, Andtbacka, RH, Noyes, RD, Kane, JM, Seigler, H, Pruitt, SK, Ross, MI, and Tyler, DS. "A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US." J Am Coll Surg 208, no. 5 (May 2009): 706-715. Full Text Link to Item
  - Sharma, A, Sharma, AK, Madhunapantula, SV, Desai, D, Huh, SJ, Mosca, P, Amin, S, and Robertson, GP. "Targeting Akt3 signaling in malignant melanoma using isoselenocyanates." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 5 (March 2009): 1674-1685. Full Text
  - Padussis, JC, Steerman, SN, Tyler, DS, and Mosca, PJ. "Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI." Int J Hyperthermia 24, no. 3 (May 2008): 239-249. (Review) Full Text Link to Item
  - Mosca, PJ, Teicher, E, Nair, SP, and Pockaj, BA. "Can surgeons improve survival in stage IV melanoma?." J Surg Oncol 97, no. 5 (April 1, 2008): 462-468. (Review) Full Text Link to Item
  - Agostino, NM, Ali, A, Nair, SG, and Mosca, PJ. "Current immunotherapeutic strategies in malignant melanoma." Surg Oncol Clin N Am 16, no. 4 (October 2007): 945-xi. (Review) Full Text Link to Item
  - Mosca, PJ, Lyerly, HK, Clay, TM, and Morse, MA. "Dendritic cell vaccines." Frontiers in Bioscience : a Journal and Virtual Library 12 (January 2007): 4050-4060. (Review) Full Text
  - Posther, KE, Selim, MA, Mosca, PJ, Stanley, WE, Johnson, JL, Tyler, DS, and Seigler, HF. "Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma." Annals of Surgical Oncology 13, no. 5 (May 2006): 728-739. Full Text
  - Aloia, TA, Grubbs, E, Onaitis, M, Mosca, PJ, Cheng, T-Y, Seigler, H, and Tyler, DS. "Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response." Arch Surg 140, no. 11 (November 2005): 1115-1120. Full Text Link to Item
  - Ho, LM, Mosca, PJ, and Thompson, WM. "Pneumatosis intestinalis after lung transplant." Abdom Imaging 30, no. 5 (September 2005): 598-600. Full Text Link to Item
  - Hall, JG, Herman, C, Cook, JL, Tyler, D, Seigler, HF, and Mosca, PJ. "Melanoma arising in a skin graft." Ann Plast Surg 54, no. 1 (January 2005): 92-96. Link to Item
  - Mosca, PJ, Clay, TM, Morse, MA, and Lyerly, HK. "Immune monitoring." Cancer Treat Res 123 (2005): 369-388. (Review) Link to Item
  - Chui, S, Clay, TM, Mosca, PJ, Hobeika, AC, Osada, T, Galibert, L, Caron, D, Lyerly, HK, and Morse, MA. "Flt3-ligand as a vaccine adjuvant: Results in a study of Flt3-ligand plus tetanus toxoid immunization." Journal of Applied Research 4, no. 4 (December 1, 2004): 536-549.
  - Morse, MA, Clay, TM, Hobeika, AC, Chui, S, Mosca, PJ, Caron, D, and Lyerly, HK. "Active immunotherapy with Flt3-ligand mobilized peripheral blood dendritic cells loaded with carcinoembryonic antigen peptide in patients with metastatic malignancies." Journal of Applied Research 4, no. 4 (December 1, 2004): 554-569.
  - Morse, MA, Lyerly, HK, Clay, TM, Abdel-Wahab, O, Chui, SY, Garst, J, Gollob, J, Grossi, PM, Kalady, M, Mosca, PJ, Onaitis, M, Sampson, JH, Seigler, HF, Toloza, EM, Tyler, D, Vieweg, J, and Yang, Y. "Immunotherapy of surgical malignancies." Current Problems in Surgery 41, no. 1 (January 2004): 15-132. (Review) Full Text
  - Morse, MA, Lyerly, HK, Clay, TM, Abdel-Wahab, O, Chui, SY, Garst, J, Gollob, J, Grossi, PM, Kalady, M, Mosca, PJ, Onaitis, M, Sampson, JH, Seigler, HF, Toloza, EM, Tyler, D, Vieweg, J, and Yang, Y. "How does the immune system attack cancer?." Current Problems in Surgery 41, no. 1 (January 1, 2004): 15-132. Full Text
  - Mosca, PJ, Tyler, DS, and Seigler, HF. "Surgical management of cutaneous melanoma: current practice and impact on prognosis." Adv Surg 38 (2004): 85-119. (Review) Link to Item
  - Morse, MA, Nair, SK, Mosca, PJ, Hobeika, AC, Clay, TM, Deng, Y, Boczkowski, D, Proia, A, Neidzwiecki, D, Clavien, P-A, Hurwitz, HI, Schlom, J, Gilboa, E, and Lyerly, HK. "Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA." Cancer Invest 21, no. 3 (June 2003): 341-349. Link to Item
  - Mosca, PJ, Clay, TM, Kim Lyerly, H, and Morse, MA. "Current status of dendritic cell immunotherapy of malignancies." Int Rev Immunol 22, no. 3-4 (May 2003): 255-281. (Review) Link to Item
  - Mosca, PJ, Lyerly, HK, Ching, CD, Hobeika, AC, Clay, TM, and Morse, MA. "Proteomics for monitoring immune responses to cancer vaccines." Curr Opin Mol Ther 5, no. 1 (February 2003): 39-43. (Review) Link to Item
  - Morse, MA, Clay, TM, Mosca, P, and Lyerly, HK. "Immunoregulatory T cells in cancer immunotherapy." Expert Opin Biol Ther 2, no. 8 (December 2002): 827-834. (Review) Full Text Link to Item
  - Morse, MA, Mosca, PJ, Clay, TM, and Lyerly, HK. "Dendritic cell-based vaccines in cancer: Clinical experience to date." American Journal of Cancer 1, no. 5 (December 1, 2002): 313-322. (Review) Full Text
  - Mosca, PJ, Hobeika, AC, Colling, K, Clay, TM, Thomas, EK, Caron, D, Lyerly, HK, and Morse, MA. "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand." Journal of Leukocyte Biology 72, no. 3 (September 2002): 546-553.
  - Morse, MA, Rizzieri, D, Stenzel, TT, Hobeika, AC, Vredenburgh, JJ, Chao, NJ, Clay, TM, Mosca, PJ, and Lyerly, HK. "Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants." J Hematother Stem Cell Res 11, no. 4 (August 2002): 659-668. Full Text Link to Item
  - Morse, MA, Mosca, PJ, Clay, TM, and Lyerly, HK. "Dendritic cell maturation in active immunotherapy strategies." Expert Opin Biol Ther 2, no. 1 (January 2002): 35-43. (Review) Full Text Link to Item
  - Clay, TM, Hobeika, AC, Mosca, PJ, Lyerly, HK, and Morse, MA. "Assays for monitoring cellular immune responses to active immunotherapy of cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 7, no. 5 (May 2001): 1127-1135. (Review)
  - Mosca, PJ, Hobeika, AC, Clay, TM, Morse, MA, and Lyerly, HK. "Direct detection of cellular immune responses to cancer vaccines." Surgery 129, no. 3 (March 2001): 248-254. (Review) Full Text
  - Morse, MA, Clay, TM, Hobeika, AC, Mosca, PJ, and Lyerly, HK. "Monitoring cellular immune responses to cancer immunotherapy." Curr Opin Mol Ther 3, no. 1 (February 2001): 45-52. (Review) Link to Item
  - Hobeika, AC, Clay, TM, Mosca, PJ, Lyerly, HK, and Morse, MA. "Quantitating therapeutically relevant T-cell responses to cancer vaccines." Critical Reviews in Immunology 21, no. 1-3 (January 2001): 287-297. (Review)
  - Morse, MA, Nair, S, Fernandez-Casal, M, Deng, Y, St Peter, M, Williams, R, Hobeika, A, Mosca, P, Clay, T, Cumming, RI, Fisher, E, Clavien, P, Proia, AD, Niedzwiecki, D, Caron, D, and Lyerly, HK. "Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer." J Clin Oncol 18, no. 23 (December 1, 2000): 3883-3893. Full Text Link to Item
  - Mosca, PJ, Hobeika, AC, Clay, TM, Nair, SK, Thomas, EK, Morse, MA, and Lyerly, HK. "A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment." Blood 96, no. 10 (November 2000): 3499-3504.
  - Mosca, PJ, Morse, MA, D'Amico, TA, Crawford, J, and Lyerly, HK. "Gene therapy for lung cancer." Clin Lung Cancer 1, no. 3 (February 2000): 218-226. Link to Item
  - Lin, HB, Falchetto, R, Mosca, PJ, Shabanowitz, J, Hunt, DF, and Hamlin, JL. "Mimosine targets serine hydroxymethyltransferase." J Biol Chem 271, no. 5 (February 2, 1996): 2548-2556. Link to Item
  - Mosca, PJ, Lin, HB, and Hamlin, JL. "Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells." Nucleic Acids Res 23, no. 2 (January 25, 1995): 261-268. Link to Item
  - Hamlin, JL, Mosca, PJ, and Levenson, VV. "Defining origins of replication in mammalian cells." Biochim Biophys Acta 1198, no. 2-3 (December 30, 1994): 85-111. (Review) Link to Item
  - Hamlin, JL, Mosca, PJ, Dijkwel, PA, and Lin, HB. "Initiation of replication at a mammalian chromosomal origin." Cold Spring Harbor Symposia on Quantitative Biology 58 (January 1993): 467-474. Full Text
  - Mosca, PJ, Dijkwel, PA, and Hamlin, JL. "The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells." Mol Cell Biol 12, no. 10 (October 1992): 4375-4383. Link to Item
- Book Sections
  - Hobeika, AC, Morse, MA, Clay, TM, Osada, T, Mosca, PJ, and Lyerly, HK. "Intracellular Cytokine Assays." In Measuring Immunity, 336-340.: Elsevier, 2005. Full Text
  - Speicher, P, Tyler, DS, and Mosca, P. "Management of In-transit Malignant Melanoma." In Melanoma From Early Detection to Treatment. . (Chapter)
- Other Articles
  - Mosca, PJ, Blazer, DG, Wheeler, JL, and Abernethy, AP. "When a chance to cut is not a chance to cure: a future for palliative surgery?." Ann Surg Oncol 18, no. 12 (November 2011): 3235-3239. Full Text Link to Item
  - Mosca, PJ, and Robertson, GP. "Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression." Cancer Biology & Therapy 11, no. 6 (March 15, 2011): 581-583. Full Text
  - Madhunapantula, SV, Mosca, P, and Robertson, GP. "Steroid hormones drive cancer development." Cancer Biology and Therapy 10, no. 8 (2010): 765-766. Full Text
  - Morse, MA, Clay, TM, Hobeika, AC, Mosca, PJ, and Lyerly, HK. "Surrogate markers of response to cancer immunotherapy." Expert Opinion on Biological Therapy 1, no. 2 (March 2001): 153-158. Full Text
  - Mosca, PJ, Loyd, GE, and Tsueda, K. "Effects of ThermH2Osorb carbon dioxide absorber on temperature and humidity in the anesthetic circuit." Anesth Analg 84, no. 5 (May 1997): 1164-1165. (Letter) Link to Item
  - Mosca, PJ, Dijkwel, PA, and Hamlin, JL. "Erratum: The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells (Mol. Cell. Biol., Vol. 12, No. 10, p. 4375, (1992))." Molecular and Cellular Biology 13, no. 3 (1993): 1981--.
- Conference Papers
  - Masoud, SJ, Hu, JB, Beasley, G, Stewart, JH, and Mosca, PJ. "Efficacy of Talimogene Laherparepvec (T-VEC) Therapy in Patients with In-Transit Melanoma Metastasis Decreases with Increasing Lesion Size." 72nd Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO). San Diego, CA. March 27, 2019 - March 30, 2019.: SPRINGER, February 1, 2019. Link to Item
  - Miura, JT, Kroon, HM, Beasley, G, Farrow, NE, Mosca, PJ, Lowe, M, Farley, C, Kim, Y, Naqvi, S, Potdar, A, Daou, H, Sun, J, Mullen, D, Farma, J, Henderson, M, Serpell, J, Delman, KA, Smithers, M, Coventry, B, Tyler, DS, Thompson, J, and Zager, J. "Long-term Oncologic Outcomes Following Isolated Limb Infusion for Locoregional Metastatic Melanoma: An International Multi-Center Analysis." 72nd Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO). San Diego, CA. March 27, 2019 - March 30, 2019.: SPRINGER, February 1, 2019. Link to Item
  - Puza, CJ, and Mosca, PJ. "Examining the incidence and presentation of melanoma in thoracic transplant patients." Annual Meeting of the American-Academy-of-Dermatology (AAD). San Diego, CA. February 16, 2018 - February 20, 2018.: MOSBY-ELSEVIER, September 1, 2018. Link to Item
  - Puza, CJ, and Mosca, PJ. "Incidence and presentation of squamous cell carcinoma in renal transplant patients after rejection episodes." Annual Meeting of the American-Academy-of-Dermatology (AAD). San Diego, CA. February 16, 2018 - February 20, 2018.: MOSBY-ELSEVIER, September 1, 2018. Link to Item
  - Puza, CJ, Myers, SA, Cardones, AR, Beasley, GM, and Mosca, PJ. "The effect of rejection episodes on squamous cell carcinoma (SCC) in transplant patients." International Investigative Dermatology (IID) Meeting. Orlando, FL. May 16, 2018 - May 19, 2018.: ELSEVIER SCIENCE INC, May 1, 2018. Link to Item
  - Puza, CJ, Josyula, S, Agnese, DM, Howard, J, Terando, AM, Mosca, PJ, Lee, WT, and Beasley, G. "Is the Number of Sentinel Lymph Nodes Important for Head and Neck Melanoma Staging?." 71st Annual Cancer Symposium of the Society-of-Surgical-Oncology. Chicago, IL. March 21, 2018 - March 24, 2018.: SPRINGER, February 1, 2018. Link to Item
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, S, Greenup, RA, Mosca, PJ, Cahill, J, Mito, JK, Cuneo, KC, Larrier, N, O'Reilly, E, Spasojevic, I, Riedel, RF, Eward, WC, Griffith, LG, Bawendi, MG, Ferrer, J, Strasfeld, DB, Lee, WD, Brigman, B, and Kirsch, DG. "Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents." : American Association for Cancer Research (AACR), August 1, 2015. Full Text
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, E, Greenup, RA, Mosca, PJ, Cahill, J, Mito, JK, Cuneo, KC, Larrier, N, O'Reilly, E, Spasojevic, I, Riedel, RF, Eward, WC, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery." February 2015. Link to Item
  - Beasley, GM, Speicher, P, Augustine, CK, Dolber, PC, Peterson, BL, Sharma, K, Mosca, PJ, Royal, R, Ross, M, Zager, JS, and Tyler, DS. "A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion." January 2015. Full Text
  - Speicher, PJ, Nussbaum, DP, White, RR, Zani, S, Mosca, PJ, Blazer, DG, Clary, BM, Pappas, TN, Tyler, DS, and Perez, A. "Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy." November 2014. Full Text
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, SE, Mosca, PJ, Cahill, J, Ferrer, JM, Strasfeld, DB, Mito, JK, Cuneo, KC, Larrier, N, Williams, N, Spasojevic, I, Riedel, RF, Eward, W, Lee, WD, Griffith, LG, Bawendi, M, Kirsch, DG, and Brigman, BE. "A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015." : American Society of Clinical Oncology (ASCO), May 20, 2014. Full Text
  - Posther, KE, Mosca, PJ, Selim, MA, Stanley, WE, Johnson, JL, Tyler, DS, and Seigler, HF. "Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma." : Springer Nature, February 2004. Full Text
  - Colling, KL, Hobeika, AC, Mosca, PJ, Clay, TM, Lyerly, HK, and Morse, MA. "Enumerating functionally mature monocyte-derived dendritic cells for use in cancer immunotherapy." November 16, 2001. Link to Item
  - Hobeika, AC, Peplinski, S, Morse, MA, Mosca, PJ, Clay, TC, and Lyerly, HK. "Quantitating antigen specific T cell responses in peripheral blood: A comparison of peptide MHC tetramer, ELISpot and intracellular cytokine analysis." November 16, 2001. Link to Item
  - Mosca, PJ, Hobeika, AC, Clay, TM, Nair, SK, Thomas, EK, Caron, DA, Lyerly, HK, and Morse, MA. "Multiple signals are required for IL-12 production by Flt-3 ligand mobilized dendritic cells." November 16, 2000. Link to Item
  - MOSCA, PJ, DIJKWEL, PA, and HAMLIN, JL. "THE PLANT AMINO-ACID MIMOSINE MAY INHIBIT INITIATION AT ORIGINS OF REPLICATION IN CHINESE-HAMSTER CELLS (MOLECULAR AND CELLULAR BIOLOGY, VOL 12, PG 4375, 1992)." March 1993. Link to Item

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