Paul Joseph Mosca
Associate Professor of Surgery
My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.
Current Appointments & Affiliations
- Associate Professor of Surgery, Surgical Oncology, Surgery 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2011
Contact Information
- 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
- 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710
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paul.mosca@duke.edu
(919) 684-6858
- Background
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Education, Training, & Certifications
- M.B.A., Desales University 2011
- Chief Resident, Surgery, Duke University 2001 - 2002
- 2nd Year SAR, Surgery, Duke University 2000 - 2001
- Surgical Research Fellow, Surgery, Duke University 1998 - 2000
- Senior Assistant Resident, Surgery, Duke University 1997 - 1998
- Junior Assistant Resident, Surgery, Duke University 1996 - 1997
- Intern, Surgery, Duke University 1995 - 1996
- M.D., University of Virginia 1995
- Ph.D., University of Virginia 1994
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Previous Appointments & Affiliations
- Associate Professor of Surgery, Surgical Oncology, Surgery 2011 - 2021
- Instructor, Temporary in the Department of Surgery, Surgical Oncology, Surgery 2011
- Assistant Professor of Surgery, Surgery, Clinical Science Departments 2002 - 2004
- Assistant Research Professor of Surgery, Surgery, Surgical Sciences, Surgery 2001 - 2002
- Instructor, Temporary of Surgery, Surgery, Surgical Sciences, Surgery 2001
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Academic Positions Outside Duke
- Assistant Professor, Lehigh Valley Health Network. 2004 - 2010
- Expertise
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Subject Headings
- Research
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Selected Grants
- Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health 2013 - 2017
- Dendritic Cell Immunotherapy For Breast Cancer awarded by National Institutes of Health 1998 - 2000
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External Relationships
- Farrell, White, and Legg, PLLC
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Flynn, M Seth, and Paul J. Mosca. “The Sloop family: Addressing rural health disparities through service and education.” J Med Biogr, November 15, 2022, 9677720221137890. https://doi.org/10.1177/09677720221137890.Full Text Link to Item
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Farrow, Norma E., Jina Kim, Steven Wolf, Samantha M. Thomas, Lindsay Olson, Paul J. Mosca, Georgia M. Beasley, and Elisabeth T. Tracy. “Examining the role of wide excision margins in pediatric melanoma: A National Cancer Database analysis.” Pediatr Blood Cancer 69, no. 11 (November 2022): e29884. https://doi.org/10.1002/pbc.29884.Full Text Link to Item
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Penny, Caitlin L., Sean M. Tanino, and Paul J. Mosca. “ASO Visual Abstract: Racial Disparities in Surgery for Malignant Bowel Obstruction.” Ann Surg Oncol 29, no. 5 (May 2022): 3134–35. https://doi.org/10.1245/s10434-021-11248-8.Full Text Link to Item
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Penny, Caitlin L., Sean M. Tanino, and Paul J. Mosca. “Racial Disparities in Surgery for Malignant Bowel Obstruction.” Ann Surg Oncol 29, no. 5 (May 2022): 3122–33. https://doi.org/10.1245/s10434-021-11161-0.Full Text Link to Item
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Berger, Miles, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W Michael Bullock, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol 9, no. 2 (February 2022): 155–70. https://doi.org/10.1002/acn3.51499.Full Text Open Access Copy Link to Item
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Rodriguez-Homs, Larissa G., Sabran J. Masoud, Matthew J. Mosca, Oliver K. Jawitz, Cara O’Brien, and Paul J. Mosca. “Greater Compliance With Early Sepsis Management is Associated With Safer Care and Shorter Hospital Stay.” J Healthc Qual 43, no. 6 (November 2021): 347–54. https://doi.org/10.1097/JHQ.0000000000000295.Full Text Link to Item
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Farrow, Norma E., Eda K. Holl, Jeanne Jung, Junheng Gao, Sin-Ho Jung, Rami N. Al-Rohil, Maria A. Selim, et al. “Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma.” Ann Surg Oncol 28, no. 7 (July 2021): 3501–10. https://doi.org/10.1245/s10434-020-09277-w.Full Text Link to Item
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Salama, April K. S., Manisha Palta, Christel N. Rushing, M Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, et al. “Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.” Clin Cancer Res 27, no. 5 (March 1, 2021): 1287–95. https://doi.org/10.1158/1078-0432.CCR-20-2452.Full Text Link to Item
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Mosca, P. J., S. Zani, M. M. Haglund, B. H. Collins, S. Wasiolek, T. N. Pappas, A. D. Kirk, and L. C. Cendales. “The Legacy of Joseph A. Moylan, M.D.: "it's about Everyone Else".” Annals of Surgery, January 1, 2021. https://doi.org/10.1097/AS9.0000000000000051.Full Text
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Carr, Michael J., James Sun, Hidde M. Kroon, John T. Miura, Georgia M. Beasley, Norma E. Farrow, Paul J. Mosca, et al. “Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia.” Ann Surg Oncol 27, no. 13 (December 2020): 5107–18. https://doi.org/10.1245/s10434-020-09051-y.Full Text Link to Item
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Ravichandran, Surya, Neel Nath, David C. Jones, Gabriel Li, Visakha Suresh, Adam K. Brys, Brent A. Hanks, et al. “The utility of initial staging PET-CT as a baseline scan for surveillance imaging in stage II and III melanoma.” Surg Oncol 35 (December 2020): 533–39. https://doi.org/10.1016/j.suronc.2020.10.018.Full Text Link to Item
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Rodriguez-Homs, Larissa G., Bradley G. Hammill, Marc D. Ryser, Harry R. Phillips, and Paul J. Mosca. “Relationship Between HCAHPS Scores and Survey Response Rate Is Linked to Hospital Size.” J Patient Exp 7, no. 6 (December 2020): 1543–48. https://doi.org/10.1177/2374373520932458.Full Text Link to Item
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Hu, Janice, Sabran J. Masoud, Surya Ravichandran, Georgia M. Beasley, and Paul J. Mosca. “Retreatment with talimogene laherparepvec for advanced melanoma.” Immunotherapy 12, no. 16 (November 2020): 1167–72. https://doi.org/10.2217/imt-2020-0029.Full Text Link to Item
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Hu, Janice B., Surya Ravichandran, Christel Rushing, Georgia M. Beasley, Brent A. Hanks, Sin-Ho Jung, April K. S. Salama, Lisa Ho, and Paul J. Mosca. “Higher BMI, But Not Sarcopenia, Is Associated With Pembrolizumab-related Toxicity in Patients With Advanced Melanoma.” Anticancer Res 40, no. 9 (September 2020): 5245–54. https://doi.org/10.21873/anticanres.14528.Full Text Link to Item
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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.Full Text Link to Item
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Adair, Kathryn C., Larissa G. Rodriguez-Homs, Sabran Masoud, Paul J. Mosca, and J Bryan Sexton. “Gratitude at Work: Prospective Cohort Study of a Web-Based, Single-Exposure Well-Being Intervention for Health Care Workers.” J Med Internet Res 22, no. 5 (May 14, 2020): e15562. https://doi.org/10.2196/15562.Full Text Open Access Copy Link to Item
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Teras, Jüri, Hidde M. Kroon, John T. Miura, Tim Kenyon-Smith, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, et al. “International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients.” Ann Surg Oncol 27, no. 5 (May 2020): 1420–29. https://doi.org/10.1245/s10434-020-08312-0.Full Text Link to Item
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Puza, Charles J., Georgia M. Beasley, Andrew S. Barbas, and Paul J. Mosca. “Type of Organ Transplanted Impacts the Risk and Presentation of Cutaneous Squamous Cell Carcinoma in Transplant Recipients.” Exp Clin Transplant 18, no. 1 (February 2020): 93–97. https://doi.org/10.6002/ect.2018.0238.Full Text Link to Item
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VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.Full Text Open Access Copy Link to Item
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Masoud, Sabran J., Jennifer A. Perone, Norma E. Farrow, Paul J. Mosca, Douglas S. Tyler, and Georgia M. Beasley. “Correction to: Sentinel Lymph Node Biopsy and Completion Lymph Node Dissection for Melanoma.” Curr Treat Options Oncol 20, no. 10 (August 29, 2019): 76. https://doi.org/10.1007/s11864-019-0674-x.Full Text Link to Item
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Adair, Kathryn C., Larissa G. Rodriguez-Homs, Sabran Masoud, Paul J. Mosca, and J Bryan Sexton. “Gratitude at Work: Prospective Cohort Study of a Web-Based, Single-Exposure Well-Being Intervention for Health Care Workers (Preprint),” July 19, 2019. https://doi.org/10.2196/preprints.15562.Full Text Open Access Copy
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Puza, C. J., S. A. Myers, A. R. Cardones, G. M. Beasley, and P. J. Mosca. “The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients.” Clin Exp Dermatol 44, no. 3 (April 2019): 265–69. https://doi.org/10.1111/ced.13699.Full Text Link to Item
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Puza, Charles J., Paul J. Mosca, and Adela R. Cardones. “Early-stage melanoma and hematopoietic stem cell transplantation outcomes.” J Am Acad Dermatol 80, no. 3 (March 2019): 786–88. https://doi.org/10.1016/j.jaad.2018.07.010.Full Text Link to Item
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Kwak, Minyoung, Norma E. Farrow, April K. S. Salama, Paul J. Mosca, Brent A. Hanks, Craig L. Slingluff, and Georgia M. Beasley. “Updates in adjuvant systemic therapy for melanoma.” J Surg Oncol 119, no. 2 (January 2019): 222–31. https://doi.org/10.1002/jso.25298.Full Text Link to Item
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Adair, Kathryn C., Krystina Quow, Allan Frankel, Paul J. Mosca, Jochen Profit, Allison Hadley, Michael Leonard, and J. Bryan Sexton. “The Improvement Readiness scale of the SCORE survey: a metric to assess capacity for quality improvement in healthcare.” Bmc Health Serv Res 18, no. 1 (December 17, 2018): 975. https://doi.org/10.1186/s12913-018-3743-0.Full Text Open Access Copy Link to Item
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Puza, Charles J., Andrew S. Barbas, and Paul J. Mosca. “Outcomes of patients with a pretransplant history of early-stage melanoma.” Melanoma Res 28, no. 5 (October 2018): 471–74. https://doi.org/10.1097/CMR.0000000000000471.Full Text Link to Item
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Masoud, Sabran J., Jennifer A. Perone, Norma E. Farrow, Paul J. Mosca, Douglas S. Tyler, and Georgia M. Beasley. “Sentinel Lymph Node Biopsy and Completion Lymph Node Dissection for Melanoma.” Curr Treat Options Oncol 19, no. 11 (September 19, 2018): 55. https://doi.org/10.1007/s11864-018-0575-4.Full Text Link to Item
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Puza, Charles J., Adela R. Cardones, and Paul J. Mosca. “Timing and Number of Cutaneous Squamous Cell Carcinomas in Transplant Recipients.” Jama Dermatol 154, no. 6 (June 1, 2018): 727–28. https://doi.org/10.1001/jamadermatol.2018.0856.Full Text Link to Item
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Puza, Charles J., Srirama Josyula, Alicia M. Terando, John H. Howard, Doreen M. Agnese, Paul J. Mosca, Walter T. Lee, and Georgia M. Beasley. “Does the number of sentinel lymph nodes removed affect the false negative rate for head and neck melanoma?” J Surg Oncol 117, no. 7 (June 2018): 1584–88. https://doi.org/10.1002/jso.25025.Full Text Link to Item
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Puza, Charles J., Adela R. Cardones, and Paul J. Mosca. “Examining the Incidence and Presentation of Melanoma in the Cardiothoracic Transplant Population.” Jama Dermatol 154, no. 5 (May 1, 2018): 589–91. https://doi.org/10.1001/jamadermatol.2018.0130.Full Text Link to Item
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Puza, Charles J., Warren S. Warren, and Paul J. Mosca. “Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy.” Lasers Med Sci 32, no. 9 (December 2017): 2173. https://doi.org/10.1007/s10103-017-2339-y.Full Text Link to Item
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Puza, Charles J., Warren S. Warren, and Paul J. Mosca. “The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy.” Lasers Med Sci 32, no. 8 (November 2017): 1935–39. https://doi.org/10.1007/s10103-017-2319-2.Full Text Link to Item
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Nath, Neel Som, Brian F. Gilmore, Richard K. McCann, and Paul J. Mosca. “Management of a cutaneous squamous cell carcinoma overlying an AV fistula.” Bmj Case Rep 2017 (May 6, 2017). https://doi.org/10.1136/bcr-2016-218932.Full Text Link to Item
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Gilmore, Brian F., Adam K. Brys, Neel S. Nath, Michael Barfield, Kristy L. Rialon, Tracy Truong, Gina-Maria Pomann, John Migaly, and Paul J. Mosca. “Clinical Acuity Shorthand System: a standardized classification tool to facilitate handoffs.” J Surg Res 211 (May 1, 2017): 163–71. https://doi.org/10.1016/j.jss.2016.10.033.Full Text Link to Item
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Mullinax, John E., Hidde M. Kroon, John F. Thompson, Neel Nath, Paul J. Mosca, Jeffrey M. Farma, Rajendra Bhati, et al. “Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma.” J Am Coll Surg 224, no. 4 (April 2017): 635–42. https://doi.org/10.1016/j.jamcollsurg.2016.12.035.Full Text Link to Item
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Kottschade, Lisa, Adam Brys, Tobias Peikert, Mabel Ryder, Laura Raffals, Jerry Brewer, Paul Mosca, Svetomir Markovic, and Svetomir Midwest Melanoma Partnership. “A multidisciplinary approach to toxicity management of modern immune checkpoint inhibitors in cancer therapy.” Melanoma Res 26, no. 5 (October 2016): 469–80. https://doi.org/10.1097/CMR.0000000000000273.Full Text Link to Item
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Kim, Jina, Zhifei Sun, Brian C. Gulack, Mohamed A. Adam, Paul J. Mosca, Henry E. Rice, and Elisabeth T. Tracy. “Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma.” J Pediatr Surg 51, no. 6 (June 2016): 986–90. https://doi.org/10.1016/j.jpedsurg.2016.02.067.Full Text Link to Item
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Brys, Adam K., Lubna Bhatti, Mustafa R. Bashir, Tracy A. Jaffe, Georgia M. Beasley, Neel S. Nath, April K. S. Salama, Douglas S. Tyler, and Paul J. Mosca. “Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in Melanoma.” Ann Surg Oncol 23, no. 4 (April 2016): 1090–95. https://doi.org/10.1245/s10434-015-4972-7.Full Text Link to Item
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Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.Full Text Link to Item
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Brys, Adam K., Raghavendra Gowda, Daniel B. Loriaux, Gavin P. Robertson, and Paul J. Mosca. “Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy.” Biotechnol Adv 34, no. 5 (2016): 565–77. https://doi.org/10.1016/j.biotechadv.2016.01.004.Full Text Link to Item
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Brys, Adam K., Michelle M. Schneider, M Angelica Selim, and Paul J. Mosca. “Sentinel lymph node biopsy following a rotational flap.” Bmj Case Rep 2015 (July 14, 2015). https://doi.org/10.1136/bcr-2015-210762.Full Text Link to Item
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Jiang, Xiaoyin, H Bryan Anderson, Cynthia D. Guy, Paul J. Mosca, Richard F. Riedel, and Diana M. Cardona. “Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib.” Case Rep Oncol Med 2015 (2015): 317493. https://doi.org/10.1155/2015/317493.Full Text Link to Item
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Kamal, A., N. A. Bhavsar, S. Power, and P. J. Mosca. “Surgical interventions in cancer patients at the end of life: Experiences at an academic medical center.” J Clin Oncol 32, no. 30_suppl (October 20, 2014): 281. https://doi.org/10.1200/jco.2014.32.30_suppl.281.Full Text Link to Item
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Jiang, B. S., G. M. Beasley, P. J. Speicher, B. Hanks, P. J. Mosca, A. Salama, and D. S. Tyler. “Immunotherapy Following Disease Progression after Regional Treatment of Melanoma.” Journal of Surgical Research 186, no. 2 (February 2014): 682–682. https://doi.org/10.1016/j.jss.2013.11.925.Full Text
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Dannull, Jens, N Rebecca Haley, Gary Archer, Smita Nair, David Boczkowski, Mark Harper, Nicole De Rosa, et al. “Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.” J Clin Invest 123, no. 7 (July 2013): 3135–45. https://doi.org/10.1172/JCI67544.Full Text Link to Item
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Shetty, Gina, Georgia M. Beasley, Sara Sparks, Michael Barfield, Melanie Masoud, Paul J. Mosca, Scott K. Pruitt, et al. “Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion.” Ann Surg Oncol 20, no. 4 (April 2013): 1128–35. https://doi.org/10.1245/s10434-012-2785-5.Full Text Link to Item
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Rialon, K. L., A. P. Abernethy, and P. J. Mosca. “Integration of Palliative Surgery into the Palliative Care Delivery Team.” Journal of Palliative Care & Medicine 02, no. 02 (2013). https://doi.org/10.4172/2165-7386.1000e115.Full Text
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Beasley, Georgia M., Ketan Sharma, Joyce Wong, Mike Miller, Ryan S. Turley, Michael Lidsky, Melanie Masoud, et al. “A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion.” Cancer 118, no. 24 (December 15, 2012): 6136–43. https://doi.org/10.1002/cncr.27676.Full Text Link to Item
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Rialon, K. L., D. G. Blazer, A. P. Abernethy, and P. J. Mosca. “Surgery and the D-Word: Approaching the Topic of Death and Dying with Surgical Patients.” Journal of Palliative Care & Medicine 02, no. 03 (March 1, 2012): 108–108. https://doi.org/10.4172/2165-7386.1000108.Full Text
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Clawson, Gary A., Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Berg, et al. “Circulating tumor cells in melanoma patients.” Plos One 7, no. 7 (2012): e41052. https://doi.org/10.1371/journal.pone.0041052.Full Text Link to Item
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Hanna, J., D. G. Blazer, and P. J. Mosca. “Overview of Palliative Surgery: Principles and Priorities.” Journal of Palliative Care & Medicine 02, no. 07 (2012). https://doi.org/10.4172/2165-7386.1000132.Full Text
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Madhunapantula, SubbaRao V., Paul J. Mosca, and Gavin P. Robertson. “The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.” Cancer Biol Ther 12, no. 12 (December 15, 2011): 1032–49. https://doi.org/10.4161/cbt.12.12.18442.Full Text Link to Item
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Santillan, Alfredo A., Keith A. Delman, Georgia M. Beasley, Paul J. Mosca, Steven N. Hochwald, Stephen R. Grobmyer, Robert H. Andtbacka, et al. “Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis.” Ann Surg Oncol 16, no. 9 (September 2009): 2570–78. https://doi.org/10.1245/s10434-009-0563-9.Full Text Link to Item
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Beasley, Georgia M., Abigail Caudle, Rebecca P. Petersen, Nicole S. McMahon, James Padussis, Paul J. Mosca, Jonathan S. Zager, et al. “A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.” J Am Coll Surg 208, no. 5 (May 2009): 706–15. https://doi.org/10.1016/j.jamcollsurg.2008.12.019.Full Text Link to Item
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Sharma, Arati, Arun K. Sharma, Subbarao V. Madhunapantula, Dhimant Desai, Sung Jin Huh, Paul Mosca, Shantu Amin, and Gavin P. Robertson. “Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.” Clin Cancer Res 15, no. 5 (March 1, 2009): 1674–85. https://doi.org/10.1158/1078-0432.CCR-08-2214.Full Text Link to Item
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Padussis, James C., Samuel N. Steerman, Douglas S. Tyler, and Paul J. Mosca. “Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI.” Int J Hyperthermia 24, no. 3 (May 2008): 239–49. https://doi.org/10.1080/02656730701816410.Full Text Link to Item
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Mosca, Paul J., Erik Teicher, Suresh P. Nair, and Barbara A. Pockaj. “Can surgeons improve survival in stage IV melanoma?” J Surg Oncol 97, no. 5 (April 1, 2008): 462–68. https://doi.org/10.1002/jso.20950.Full Text Link to Item
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Agostino, Nicole M., Arjumand Ali, Suresh G. Nair, and Paul J. Mosca. “Current immunotherapeutic strategies in malignant melanoma.” Surg Oncol Clin N Am 16, no. 4 (October 2007): 945–xi. https://doi.org/10.1016/j.soc.2007.07.010.Full Text Link to Item
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Mosca, Paul J., H Kim Lyerly, Timothy M. Clay, and Michael A. Morse. “Dendritic cell vaccines.” Front Biosci 12 (May 1, 2007): 4050–60. https://doi.org/10.2741/2371.Full Text Link to Item
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Posther, Katherine E., M Angelica Selim, Paul J. Mosca, Wilma E. Stanley, Jeffrey L. Johnson, Douglas S. Tyler, and Hilliard F. Seigler. “Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.” Ann Surg Oncol 13, no. 5 (May 2006): 728–39. https://doi.org/10.1245/ASO.2006.03.091.Full Text Link to Item
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Aloia, Thomas A., Elizabeth Grubbs, Mark Onaitis, Paul J. Mosca, Tsung-Yen Cheng, Hilliard Seigler, and Douglas S. Tyler. “Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response.” Arch Surg 140, no. 11 (November 2005): 1115–20. https://doi.org/10.1001/archsurg.140.11.1115.Full Text Link to Item
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Hall, Jennifer G., Christopher Herman, Jonathan L. Cook, Douglas Tyler, Hilliard F. Seigler, and Paul J. Mosca. “Melanoma arising in a skin graft.” Ann Plast Surg 54, no. 1 (January 2005): 92–96. https://doi.org/10.1097/01.sap.0000136974.62109.01.Full Text Link to Item
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Ho, L. M., P. J. Mosca, and W. M. Thompson. “Pneumatosis intestinalis after lung transplant.” Abdom Imaging 30, no. 5 (2005): 598–600. https://doi.org/10.1007/s00261-005-0311-y.Full Text Link to Item
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Mosca, Paul J., Timothy M. Clay, Michael A. Morse, and H Kim Lyerly. “Immune monitoring.” Cancer Treat Res 123 (2005): 369–88. https://doi.org/10.1007/0-387-27545-2_16.Full Text Link to Item
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Chui, S., T. M. Clay, P. J. Mosca, A. C. Hobeika, T. Osada, L. Galibert, D. Caron, H. K. Lyerly, and M. A. Morse. “Flt3-ligand as a vaccine adjuvant: Results in a study of Flt3-ligand plus tetanus toxoid immunization.” Journal of Applied Research 4, no. 4 (December 1, 2004): 536–49.
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Morse, M. A., T. M. Clay, A. C. Hobeika, S. Chui, P. J. Mosca, D. Caron, and H. K. Lyerly. “Active immunotherapy with Flt3-ligand mobilized peripheral blood dendritic cells loaded with carcinoembryonic antigen peptide in patients with metastatic malignancies.” Journal of Applied Research 4, no. 4 (December 1, 2004): 554–69.
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Mosca, Paul J., Douglas S. Tyler, and Hilliard F. Seigler. “Surgical management of cutaneous melanoma: current practice and impact on prognosis.” Adv Surg 38 (2004): 85–119.Link to Item
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Morse, Michael A., H Kim Lyerly, Timothy M. Clay, Omar Abdel-Wahab, Stephen Y. Chui, Jennifer Garst, Jared Gollob, et al. “Immunotherapy of surgical malignancies.” Curr Probl Surg 41, no. 1 (January 2004): 15–132. https://doi.org/10.1016/S0011384003001321.Full Text Link to Item
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Morse, Michael A., Smita K. Nair, Paul J. Mosca, Amy C. Hobeika, Timothy M. Clay, Yuping Deng, David Boczkowski, et al. “Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.” Cancer Invest 21, no. 3 (June 2003): 341–49. https://doi.org/10.1081/cnv-120018224.Full Text Link to Item
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Mosca, Paul J., H Kim Lyerly, C Denise Ching, Amy C. Hobeika, Timothy M. Clay, and Michael A. Morse. “Proteomics for monitoring immune responses to cancer vaccines.” Curr Opin Mol Ther 5, no. 1 (February 2003): 39–43.Link to Item
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Mosca, Paul J., Timothy M. Clay, H. Kim Lyerly, and Michael A. Morse. “Current status of dendritic cell immunotherapy of malignancies.” Int Rev Immunol 22, no. 3–4 (2003): 255–81. https://doi.org/10.1080/08830180305223.Full Text Link to Item
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Morse, M. A., P. J. Mosca, T. M. Clay, and H. K. Lyerly. “Dendritic cell-based vaccines in cancer: Clinical experience to date.” American Journal of Cancer 1, no. 5 (December 1, 2002): 313–22. https://doi.org/10.2165/00024669-200201050-00002.Full Text
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Morse, Michael A., Timothy M. Clay, Paul Mosca, and H Kim Lyerly. “Immunoregulatory T cells in cancer immunotherapy.” Expert Opin Biol Ther 2, no. 8 (December 2002): 827–34. https://doi.org/10.1517/14712598.2.8.827.Full Text Link to Item
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Mosca, Paul J., Amy C. Hobeika, Kirsten Colling, Timothy M. Clay, Elaine K. Thomas, Dania Caron, H Kim Lyerly, and Michael A. Morse. “Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.” J Leukoc Biol 72, no. 3 (September 2002): 546–53.Link to Item
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Morse, Michael A., David Rizzieri, Timothy T. Stenzel, Amy C. Hobeika, James J. Vredenburgh, Nelson J. Chao, Timothy M. Clay, Paul J. Mosca, and H Kim Lyerly. “Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants.” J Hematother Stem Cell Res 11, no. 4 (August 2002): 659–68. https://doi.org/10.1089/15258160260194802.Full Text Link to Item
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Morse, Michael A., Paul J. Mosca, Timothy M. Clay, and H Kim Lyerly. “Dendritic cell maturation in active immunotherapy strategies.” Expert Opin Biol Ther 2, no. 1 (January 2002): 35–43. https://doi.org/10.1517/14712598.2.1.35.Full Text Link to Item
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Clay, T. M., A. C. Hobeika, P. J. Mosca, H. K. Lyerly, and M. A. Morse. “Assays for monitoring cellular immune responses to active immunotherapy of cancer.” Clin Cancer Res 7, no. 5 (May 2001): 1127–35.Link to Item
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Mosca, P. J., A. C. Hobeika, T. M. Clay, M. A. Morse, and H. K. Lyerly. “Direct detection of cellular immune responses to cancer vaccines.” Surgery 129, no. 3 (March 2001): 248–54. https://doi.org/10.1067/msy.2001.108609.Full Text Link to Item
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Morse, M. A., T. M. Clay, A. C. Hobeika, P. J. Mosca, and H. K. Lyerly. “Monitoring cellular immune responses to cancer immunotherapy.” Curr Opin Mol Ther 3, no. 1 (February 2001): 45–52.Link to Item
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Hobeika, A. C., T. M. Clay, P. J. Mosca, H. K. Lyerly, and M. A. Morse. “Quantitating therapeutically relevant T-cell responses to cancer vaccines.” Crit Rev Immunol 21, no. 1–3 (2001): 287–97.Link to Item
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Morse, M. A., S. Nair, M. Fernandez-Casal, Y. Deng, M. St Peter, R. Williams, A. Hobeika, et al. “Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer.” J Clin Oncol 18, no. 23 (December 1, 2000): 3883–93. https://doi.org/10.1200/JCO.2000.18.23.3883.Full Text Link to Item
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Mosca, P. J., A. C. Hobeika, T. M. Clay, S. K. Nair, E. K. Thomas, M. A. Morse, and H. K. Lyerly. “A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.” Blood 96, no. 10 (November 15, 2000): 3499–3504.Link to Item
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Mosca, P. J., M. A. Morse, T. A. D’Amico, J. Crawford, and H. K. Lyerly. “Gene therapy for lung cancer.” Clin Lung Cancer 1, no. 3 (February 2000): 218–26. https://doi.org/10.3816/clc.2000.n.005.Full Text Link to Item
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Lin, H. B., R. Falchetto, P. J. Mosca, J. Shabanowitz, D. F. Hunt, and J. L. Hamlin. “Mimosine targets serine hydroxymethyltransferase.” J Biol Chem 271, no. 5 (February 2, 1996): 2548–56. https://doi.org/10.1074/jbc.271.5.2548.Full Text Link to Item
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Mosca, P. J., H. B. Lin, and J. L. Hamlin. “Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells.” Nucleic Acids Res 23, no. 2 (January 25, 1995): 261–68. https://doi.org/10.1093/nar/23.2.261.Full Text Link to Item
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Hamlin, J. L., P. J. Mosca, and V. V. Levenson. “Defining origins of replication in mammalian cells.” Biochim Biophys Acta 1198, no. 2–3 (December 30, 1994): 85–111. https://doi.org/10.1016/0304-419x(94)90008-6.Full Text Link to Item
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Hamlin, J. L., P. J. Mosca, P. A. Dijkwel, and H. B. Lin. “Initiation of replication at a mammalian chromosomal origin.” Cold Spring Harb Symp Quant Biol 58 (1993): 467–74. https://doi.org/10.1101/sqb.1993.058.01.053.Full Text Link to Item
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Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. “The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells.” Mol Cell Biol 12, no. 10 (October 1992): 4375–83. https://doi.org/10.1128/mcb.12.10.4375-4383.1992.Full Text Link to Item
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Book Sections
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Hobeika, A. C., M. A. Morse, T. M. Clay, T. Osada, P. J. Mosca, and H. K. Lyerly. “Intracellular Cytokine Assays.” In Measuring Immunity: Basic Biology and Clinical Assessment, 336–40, 2005. https://doi.org/10.1016/B978-012455900-4/50290-7.Full Text
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Hobeika, A. C., M. A. Morse, T. M. Clay, T. Osada, P. J. Mosca, and H. K. Lyerly. “Intracellular Cytokine Assays.” In Measuring Immunity: Basic Science and Clinical Practice, 336–40, 2004. https://doi.org/10.1016/B978-012455900-4/50290-7.Full Text
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Speicher, P., D. S. Tyler, and paul Mosca. “Management of In-transit Malignant Melanoma.” In Melanoma From Early Detection to Treatment, n.d.
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Other Articles
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Mosca, Paul J., Dan G. Blazer, Jane L. Wheeler, and Amy P. Abernethy. “When a chance to cut is not a chance to cure: a future for palliative surgery?” Ann Surg Oncol, November 2011. https://doi.org/10.1245/s10434-011-1787-z.Full Text Link to Item
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Mosca, Paul J., and Gavin P. Robertson. “Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression.” Cancer Biol Ther, March 15, 2011. https://doi.org/10.4161/cbt.11.6.14697.Full Text Link to Item
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Madhunapantula, SubbaRao V., Paul Mosca, and Gavin P. Robertson. “Steroid hormones drive cancer development.” Cancer Biol Ther, October 15, 2010. https://doi.org/10.4161/cbt.10.8.13531.Full Text Link to Item
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Morse, M. A., T. M. Clay, A. C. Hobeika, P. J. Mosca, and H. K. Lyerly. “Surrogate markers of response to cancer immunotherapy.” Expert Opin Biol Ther, March 2001. https://doi.org/10.1517/14712598.1.2.153.Full Text Link to Item
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Mosca, P. J., G. E. Loyd, and K. Tsueda. “Effects of ThermH2Osorb carbon dioxide absorber on temperature and humidity in the anesthetic circuit.” Anesth Analg, May 1997. https://doi.org/10.1097/00000539-199705000-00044.Full Text Link to Item
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Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. “Erratum: The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells (Mol. Cell. Biol., Vol. 12, No. 10, p. 4375, (1992)).” Molecular and Cellular Biology, January 1, 1993.
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Conference Papers
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Kenyon-Smith, Timothy J., Hidde M. Kroon, John T. Miura, Jüri Teras, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, et al. “Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study.” In Eur J Surg Oncol, 46:2140–46, 2020. https://doi.org/10.1016/j.ejso.2020.06.040.Full Text Link to Item
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Masoud, Sabran J., Janice B. Hu, Georgia M. Beasley, John H. Stewart, and Paul J. Mosca. “Efficacy of Talimogene Laherparepvec (T-VEC) Therapy in Patients with In-Transit Melanoma Metastasis Decreases with Increasing Lesion Size.” In Ann Surg Oncol, 26:4633–41, 2019. https://doi.org/10.1245/s10434-019-07691-3.Full Text Link to Item
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Miura, John T., Hidde M. Kroon, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, Paul J. Mosca, Michael C. Lowe, et al. “Long-Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis.” In Ann Surg Oncol, 26:2486–94, 2019. https://doi.org/10.1245/s10434-019-07288-w.Full Text Link to Item
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Puza, Charles J., and Paul J. Mosca. “Examining the incidence and presentation of melanoma in thoracic transplant patients.” In Journal of the American Academy of Dermatology, 79:AB138–AB138. MOSBY-ELSEVIER, 2018.Link to Item
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Puza, Charles J., and Paul J. Mosca. “Incidence and presentation of squamous cell carcinoma in renal transplant patients after rejection episodes.” In Journal of the American Academy of Dermatology, 79:AB165–AB165. MOSBY-ELSEVIER, 2018.Link to Item
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Puza, C. J., S. A. Myers, A. R. Cardones, G. M. Beasley, and P. J. Mosca. “291 The effect of rejection episodes on squamous cell carcinoma (SCC) in transplant patients.” In Journal of Investigative Dermatology, 138:S50–S50. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.297.Full Text
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Puza, C. J., S. Josyula, D. M. Agnese, J. Howard, A. M. Terando, P. J. Mosca, W. T. Lee, and G. Beasley. “Is the Number of Sentinel Lymph Nodes Important for Head and Neck Melanoma Staging?” In Annals of Surgical Oncology, 25:S172–S172. SPRINGER, 2018.Link to Item
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Whitley, Melodi J., Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, et al. “Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents.” In Cancer Research, Vol. 75. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-sy36-03.Full Text
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Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.Link to Item
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Beasley, Georgia M., Paul Speicher, Christina K. Augustine, Paul C. Dolber, Bercedis L. Peterson, Ketan Sharma, Paul J. Mosca, et al. “A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.” In Ann Surg Oncol, 22:287–94, 2015. https://doi.org/10.1245/s10434-014-3887-z.Full Text Link to Item
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Speicher, Paul J., Daniel P. Nussbaum, Rebekah R. White, Sabino Zani, Paul J. Mosca, Dan G. Blazer, Bryan M. Clary, Theodore N. Pappas, Douglas S. Tyler, and Alexander Perez. “Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy.” In Ann Surg Oncol, 21:4014–19, 2014. https://doi.org/10.1245/s10434-014-3839-7.Full Text Link to Item
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Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.Full Text
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Posther, K. E., P. J. Mosca, M. A. Selim, W. E. Stanley, J. L. Johnson, D. S. Tyler, and H. F. Seigler. “Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.” In Annals of Surgical Oncology, 11:S78–S78. Springer Science and Business Media LLC, 2004. https://doi.org/10.1007/bf02524057.Full Text
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Colling, K. L., A. C. Hobeika, P. J. Mosca, T. M. Clay, H. K. Lyerly, and M. A. Morse. “Enumerating functionally mature monocyte-derived dendritic cells for use in cancer immunotherapy.” In Blood, 98:851A-851A. AMER SOC HEMATOLOGY, 2001.Link to Item
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Hobeika, A. C., S. Peplinski, M. A. Morse, P. J. Mosca, T. C. Clay, and H. K. Lyerly. “Quantitating antigen specific T cell responses in peripheral blood: A comparison of peptide MHC tetramer, ELISpot and intracellular cytokine analysis.” In Blood, 98:23A-23A. AMER SOC HEMATOLOGY, 2001.Link to Item
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Mosca, P. J., A. C. Hobeika, T. M. Clay, S. K. Nair, E. K. Thomas, D. A. Caron, H. K. Lyerly, and M. A. Morse. “Multiple signals are required for IL-12 production by Flt-3 ligand mobilized dendritic cells.” In Blood, 96:295A-295A. AMER SOC HEMATOLOGY, 2000.Link to Item
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MOSCA, P. J., P. A. DIJKWEL, and J. L. HAMLIN. “THE PLANT AMINO-ACID MIMOSINE MAY INHIBIT INITIATION AT ORIGINS OF REPLICATION IN CHINESE-HAMSTER CELLS (MOLECULAR AND CELLULAR BIOLOGY, VOL 12, PG 4375, 1992).” In Molecular and Cellular Biology, 13:1981–1981. AMER SOC MICROBIOLOGY, 1993.Link to Item
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