Vesicoureteral reflux and the extracellular matrix connection.
Journal Article (Journal Article;Review)
Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.
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Duke Authors
Cited Authors
- Tokhmafshan, F; Brophy, PD; Gbadegesin, RA; Gupta, IR
Published Date
- April 2017
Published In
Volume / Issue
- 32 / 4
Start / End Page
- 565 - 576
PubMed ID
- 27139901
Pubmed Central ID
- PMC5376290
Electronic International Standard Serial Number (EISSN)
- 1432-198X
Digital Object Identifier (DOI)
- 10.1007/s00467-016-3386-5
Language
- eng
Conference Location
- Germany