Vesicoureteral reflux and the extracellular matrix connection.

Journal Article (Journal Article;Review)

Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.

Full Text

Duke Authors

Cited Authors

  • Tokhmafshan, F; Brophy, PD; Gbadegesin, RA; Gupta, IR

Published Date

  • April 2017

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 565 - 576

PubMed ID

  • 27139901

Pubmed Central ID

  • PMC5376290

Electronic International Standard Serial Number (EISSN)

  • 1432-198X

Digital Object Identifier (DOI)

  • 10.1007/s00467-016-3386-5


  • eng

Conference Location

  • Germany