Rasheed Adebayo Gbadegesin

Rasheed Adebayo Gbadegesin
Professor of Pediatrics

Molecular genetics of glomerular disease
Genetic risk factors for childhood onset idiopathic nephrotic syndrome

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2018
Professor in Medicine, Medicine, Nephrology, Medicine 2018
Affiliate of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2014

Contact Information

Box 3959 Med Ctr, Durham, NC 27710
T0909-C Children's Hlth Ctr, Durham, NC 27710
rasheed.gbadegesin@duke.edu (919) 684-4246

Background
Education, Training, & Certifications
- Pediatric Nephrology Fellow, Pediatrics, University of Michigan at Ann Arbor 2004 - 2007
- Pediatric Resident, Pediatrics, New York Presbyterian Hospital 2002 - 2004
- Pediatric Resident, Pediatrics, University of Ibadan, College of Medicine (Nigeria) 1989 - 1995
- Medical Officer, National Service, University of Ibadan, College of Medicine (Nigeria) 1988 - 1989
- Intern, Med/Surg/Peds/Ob Gyn, University of Ibadan, College of Medicine (Nigeria) 1987 - 1988
- M.B.B.S., University of Ibadan, College of Medicine (Nigeria) 1987
Duke Appointment History
- Associate Professor in Medicine, Medicine, Nephrology, Medicine 2015 - 2018
- Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2016 - 2018
- Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2013 - 2016
- Assistant Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2007 - 2013
Expertise
Global Scholarship
- Research
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
- Postdoctoral training in genomic medicine research awarded by National Institutes of Health 2017 - 2022
- Alport Syndrome awarded by Reata Pharmaceuticals, Inc. 2018 - 2020
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2014 - 2019
- Genetics of childhood nephrotic syndrome awarded by Doris Duke Charitable Foundation 2017 - 2018
- FSGSabatacept awarded by Bristol-Myers Squibb Company 2016 - 2018
- H3 AFRICA KIDNEY DISEASE COHORT STUDY awarded by University of Arizona 2017 - 2018
- H3 Africa Kidney Disease Research Network awarded by University of Ghana 2017 - 2018
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- ACTH for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome in Children awarded by Emory University 2014 - 2018
- Gene Discovery in Autosomal Dominant Focal Segmental Glomerulosclerosis awarded by National Institutes of Health 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers awarded by Research Institute at Nationwide Children's Hospital 2014 - 2018
- H3Africa Kidney Disease Research Network awarded by University of Ghana 2015 - 2017
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Identification of New Non-invasive Diagnostic Tools for Vesicoureteric Reflux (VUR) awarded by Doris Duke Charitable Foundation 2014 - 2015
- IDENTIFICATION OF VUR GENES BY COMBINED LINKAGE ANALYSIS AND EXOME SEQUENCING awarded by National Institutes of Health 2013 - 2015
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2013 - 2014
- A New Locus for Hereditary FSGS on Chromosome 2p awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Adeyemo, A, Esezobor, C, Solarin, A, Abeyagunawardena, A, Kari, JA, El Desoky, S, Greenbaum, LA, Kamel, M, Kallash, M, Silva, C, Young, A, Hunley, TE, de Jesus-Gonzalez, N, Srivastava, T, and Gbadegesin, R. "HLA-DQA1 and APOL1 as Risk Loci for Childhood-Onset Steroid-Sensitive and Steroid-Resistant Nephrotic Syndrome." American journal of kidney diseases : the official journal of the National Kidney Foundation 71, no. 3 (March 2018): 399-406. Full Text
  - Pelletier, J, Gbadegesin, R, and Staples, B. "Renal Tubular Acidosis." Pediatrics in Review 38, no. 11 (November 2017): 537-539. Full Text
  - Karp, AM, and Gbadegesin, RA. "Genetics of childhood steroid-sensitive nephrotic syndrome." Pediatric nephrology (Berlin, Germany) 32, no. 9 (September 2017): 1481-1488. (Review) Full Text Open Access Copy
  - Pelletier, JH, Nagaraj, S, Gbadegesin, R, Wigfall, D, McGann, KA, and Foreman, J. "Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature." Pediatric transplantation 21, no. 6 (September 2017). Full Text
  - Selewski, DT, Troost, JP, Cummings, D, Massengill, SF, Gbadegesin, RA, Greenbaum, LA, Shatat, IF, Cai, Y, Kapur, G, Hebert, D, Somers, MJ, Trachtman, H, Pais, P, Seifert, ME, Goebel, J, Sethna, CB, Mahan, JD, Gross, HE, Herreshoff, E, Liu, Y, Carlozzi, NE, Reeve, BB, DeWalt, DA, and Gipson, DS. "Responsiveness of the PROMIS® measures to changes in disease status among pediatric nephrotic syndrome patients: a Midwest pediatric nephrology consortium study." Health and quality of life outcomes 15, no. 1 (August 23, 2017): 166-. Full Text Open Access Copy
  - Hall, G, Routh, JC, and Gbadegesin, RA. "Urinary Anomalies in 22q11.2 Deletion (DiGeorge syndrome): From Copy Number Variations to Single-Gene Determinants of Phenotype." American journal of kidney diseases : the official journal of the National Kidney Foundation 70, no. 1 (July 2017): 8-10. Full Text
  - Tokhmafshan, F, Brophy, PD, Gbadegesin, RA, and Gupta, IR. "Vesicoureteral reflux and the extracellular matrix connection." Pediatric nephrology (Berlin, Germany) 32, no. 4 (April 2017): 565-576. (Review) Full Text Open Access Copy
  - Hall, G, Lane, B, Chryst-Ladd, M, Wu, G, Lin, J-J, Qin, X, Hauser, ER, and Gbadegesin, R. "Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation." Scientific reports 7 (January 6, 2017): 39933-. Full Text
  - Rheault, MN, and Gbadegesin, RA. "The Genetics of Nephrotic Syndrome." Journal of pediatric genetics 5, no. 1 (March 2016): 15-24. (Review) Full Text
  - Elahi, S, Homstad, A, Vaidya, H, Stout, J, Hall, G, Wu, G, Conlon, P, Routh, JC, Wiener, JS, Ross, SS, Nagaraj, S, Wigfall, D, Foreman, J, Adeyemo, A, Gupta, IR, Brophy, PD, Rabinovich, CE, and Gbadegesin, RA. "Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux." Pediatric nephrology (Berlin, Germany) 31, no. 2 (February 2016): 247-253. Full Text
  - Wang, HHS, Gbadegesin, RA, Foreman, JW, Nagaraj, SK, Wigfall, DR, Wiener, JS, and Routh, JC. "Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: Systematic review and meta-analysis." Journal of Urology 193, no. 3 (January 1, 2016): 963-969. Full Text
  - Rheault, MN, Zhang, L, Selewski, DT, Kallash, M, Tran, CL, Seamon, M, Katsoufis, C, Ashoor, I, Hernandez, J, Supe-Markovina, K, D'Alessandri-Silva, C, DeJesus-Gonzalez, N, Vasylyeva, TL, Formeck, C, Woll, C, Gbadegesin, R, Geier, P, Devarajan, P, Carpenter, SL, Kerlin, BA, Smoyer, WE, and Midwest Pediatric Nephrology Consortium, . "AKI in Children Hospitalized with Nephrotic Syndrome." Clinical journal of the American Society of Nephrology : CJASN 10, no. 12 (December 2015): 2110-2118. Full Text
  - Phelan, PJ, Hall, G, Wigfall, D, Foreman, J, Nagaraj, S, Malone, AF, Winn, MP, Howell, DN, and Gbadegesin, R. "Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation." Clinical kidney journal 8, no. 5 (October 2015): 538-542. Full Text Open Access Copy
  - Selewski, DT, Troost, JP, Massengill, SF, Gbadegesin, RA, Greenbaum, LA, Shatat, IF, Cai, Y, Kapur, G, Hebert, D, Somers, MJ, Trachtman, H, Pais, P, Seifert, ME, Goebel, J, Sethna, CB, Mahan, JD, Gross, HE, Herreshoff, E, Liu, Y, Song, PX, Reeve, BB, DeWalt, DA, and Gipson, DS. "The impact of disease duration on quality of life in children with nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study." Pediatric Nephrology 30, no. 9 (September 18, 2015): 1467-1476. Full Text
  - Selewski, DT, Troost, JP, Massengill, SF, Gbadegesin, RA, Greenbaum, LA, Shatat, IF, Cai, Y, Kapur, G, Hebert, D, Somers, MJ, Trachtman, H, Pais, P, Seifert, ME, Goebel, J, Sethna, CB, Mahan, JD, Gross, HE, Herreshoff, E, Liu, Y, Song, PX, Reeve, BB, DeWalt, DA, and Gipson, DS. "The impact of disease duration on quality of life in children with nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study." Pediatric nephrology (Berlin, Germany) 30, no. 9 (September 2015): 1467-1476. Full Text
  - Jordan, DM, Frangakis, SG, Golzio, C, Cassa, CA, Kurtzberg, J, Task Force for Neonatal Genomics, , Davis, EE, Sunyaev, SR, and Katsanis, N. "Identification of cis-suppression of human disease mutations by comparative genomics." Nature 524, no. 7564 (August 2015): 225-229. Full Text
  - Gbadegesin, RA, Adeyemo, A, Webb, NJA, Greenbaum, LA, Abeyagunawardena, A, Thalgahagoda, S, Kale, A, Gipson, D, Srivastava, T, Lin, J-J, Chand, D, Hunley, TE, Brophy, PD, Bagga, A, Sinha, A, Rheault, MN, Ghali, J, Nicholls, K, Abraham, E, Janjua, HS, Omoloja, A, Barletta, G-M, Cai, Y, Milford, DD, O'Brien, C, Awan, A, Belostotsky, V, Smoyer, WE, Homstad, A, Hall, G, Wu, G, Nagaraj, S, Wigfall, D, Foreman, J, Winn, MP, and Mid-West Pediatric Nephrology Consortium, . "HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome." Journal of the American Society of Nephrology : JASN 26, no. 7 (July 2015): 1701-1710. Full Text
  - Hall, G, and Gbadegesin, RA. "Translating genetic findings in hereditary nephrotic syndrome: the missing loops." American journal of physiology. Renal physiology 309, no. 1 (July 2015): F24-F28. (Review) Full Text
  - Sadowski, CE, Lovric, S, Ashraf, S, Pabst, WL, Gee, HY, Kohl, S, Engelmann, S, Vega-Warner, V, Fang, H, Halbritter, J, Somers, MJ, Tan, W, Shril, S, Fessi, I, Lifton, RP, Bockenhauer, D, El-Desoky, S, Kari, JA, Zenker, M, Kemper, MJ, Mueller, D, Fathy, HM, Soliman, NA, SRNS Study Group, , and Hildebrandt, F. "A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome." Journal of the American Society of Nephrology : JASN 26, no. 6 (June 2015): 1279-1289. Full Text
  - Gbadegesin, RA. "The author replies." Kidney international 87, no. 4 (April 2015): 859-860. (Letter) Full Text
  - Hall, G, Gbadegesin, RA, Lavin, P, Wu, G, Liu, Y, Oh, EC, Wang, L, Spurney, RF, Eckel, J, Lindsey, T, Homstad, A, Malone, AF, Phelan, PJ, Shaw, A, Howell, DN, Conlon, PJ, Katsanis, N, and Winn, MP. "A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS." Journal of the American Society of Nephrology : JASN 26, no. 4 (April 2015): 831-843. Full Text
  - Wang, H-HS, Gbadegesin, RA, Foreman, JW, Nagaraj, SK, Wigfall, DR, Wiener, JS, and Routh, JC. "Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis." The Journal of urology 193, no. 3 (March 2015): 963-969. (Review) Full Text
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, and Gbadegesin, RA. "Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis." Kidney international 86, no. 6 (December 2014): 1253-1259. Full Text Open Access Copy
  - Selewski, DT, Massengill, SF, Troost, JP, Wickman, L, Messer, KL, Herreshoff, E, Bowers, C, Ferris, ME, Mahan, JD, Greenbaum, LA, MacHardy, J, Kapur, G, Chand, DH, Goebel, J, Barletta, GM, Geary, D, Kershaw, DB, Pan, CG, Gbadegesin, R, Hidalgo, G, Lane, JC, Leiser, JD, Song, PX, Thissen, D, Liu, Y, Gross, HE, DeWalt, DA, and Gipson, DS. "Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study." Pediatric nephrology (Berlin, Germany) 29, no. 12 (December 2014): 2347-2356. Full Text
  - Gbadegesin, RA, Hall, G, Adeyemo, A, Hanke, N, Tossidou, I, Burchette, J, Wu, G, Homstad, A, Sparks, MA, Gomez, J, Jiang, R, Alonso, A, Lavin, P, Conlon, P, Korstanje, R, Stander, MC, Shamsan, G, Barua, M, Spurney, R, Singhal, PC, Kopp, JB, Haller, H, Howell, D, Pollak, MR, Shaw, AS, Schiffer, M, and Winn, MP. "Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS." Journal of the American Society of Nephrology : JASN 25, no. 9 (September 2014): 1991-2002. Full Text
  - Hall, G, Rowell, J, Farinelli, F, Gbadegesin, RA, Lavin, P, Wu, G, Homstad, A, Malone, A, Lindsey, T, Jiang, R, Spurney, R, Tomaselli, GF, Kass, DA, and Winn, MP. "Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity." American journal of physiology. Renal physiology 306, no. 12 (June 2014): F1442-F1450. Full Text
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, and Gbadegesin, RA. "Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis." Kidney International 86, no. 6 (January 1, 2014): 1253-1259. Full Text
  - Rotimi, C, Abayomi, A, Abimiku, A, Adabayeri, VM, Adebamowo, C, Adebiyi, E, Ademola, AD, Adeyemo, A, Adu, D, Affolabi, D, Agongo, G, Ajayi, S, Akarolo-Anthony, S, Akinyemi, R, Akpalu, A, Alberts, M, Alonso Betancourt, O, Alzohairy, AM, Ameni, G, Amodu, O, Anabwani, G, Andersen, KG, Arogundade, F, Arulogun, O, Asogun, DA, Bakare, R, Balde, N, Baniecki, ML, Beiswanger, C, Benkahla, A, Bethke, L, Boehnke, M, Boima, V, Brandful, J, Brooks, AI, Brosius, FC, Brown, CW, Bucheton, B, and Burke, DT et al. "Research capacity. Enabling the genomic revolution in Africa." Science 344, no. 6190 (January 1, 2014): 1346-1348. Full Text
  - Selewski, DT, Massengill, SF, Troost, JP, Wickman, L, Messer, KL, Herreshoff, E, Bowers, C, Ferris, ME, Mahan, JD, Greenbaum, LA, MacHardy, J, Kapur, G, Chand, DH, Goebel, J, Barletta, GM, Geary, D, Kershaw, DB, Pan, CG, Gbadegesin, R, Hidalgo, G, Lane, JC, Leiser, JD, Song, PX, Thissen, D, Liu, Y, Gross, HE, DeWalt, DA, and Gipson, DS. "Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study." Pediatric Nephrology 29, no. 12 (2014): 2347-2356. Full Text
  - Gbadegesin, RA, Brophy, PD, Adeyemo, A, Hall, G, Gupta, IR, Hains, D, Bartkowiak, B, Rabinovich, CE, Chandrasekharappa, S, Homstad, A, Westreich, K, Wu, G, Liu, Y, Holanda, D, Clarke, J, Lavin, P, Selim, A, Miller, S, Wiener, JS, Ross, SS, Foreman, J, Rotimi, C, and Winn, MP. "TNXB mutations can cause vesicoureteral reflux." J Am Soc Nephrol 24, no. 8 (July 2013): 1313-1322. Full Text Link to Item
  - Gipson, DS, Selewski, DT, Massengill, SF, Wickman, L, Messer, KL, Herreshoff, E, Bowers, C, Ferris, ME, Mahan, JD, Greenbaum, LA, MacHardy, J, Kapur, G, Chand, DH, Goebel, J, Barletta, GM, Geary, D, Kershaw, DB, Pan, CG, Gbadegesin, R, Hidalgo, G, Lane, JC, Leiser, JD, Plattner, BW, Song, PX, Thissen, D, Liu, Y, Gross, HE, and DeWalt, DA. "Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study." HEALTH AND QUALITY OF LIFE OUTCOMES 11 (March 4, 2013). Full Text Link to Item
  - Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535))." Journal of the American Society of Nephrology 24, no. 1 (2013): 160--. Full Text
  - Straatmann, C, Ayoob, R, Gbadegesin, R, Gibson, K, Rheault, MN, Srivastava, T, Tran, CL, Gipson, DS, Greenbaum, LA, Smoyer, WE, and Vehaskari, VM. "Treatment outcome of late steroid-resistant nephrotic syndrome: A study by the Midwest Pediatric Nephrology Consortium." Pediatric Nephrology 28, no. 8 (2013): 1235-1241. Full Text
  - Straatmann, C, Ayoob, R, Gbadegesin, R, Gibson, K, Rheault, MN, Srivastava, T, Tran, CL, Gipson, DS, Greenbaum, LA, Smoyer, WE, and al, E. "Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium." Pediatric Nephrology (2013): 1-7. Full Text
  - Gbadegesin, RA, Lavin, PJ, Hall, G, Bartkowiak, B, Homstad, A, Jiang, R, Wu, G, Byrd, A, Lynn, K, Wolfish, N, Ottati, C, Stevens, P, Howell, D, Conlon, P, and Winn, MP. "Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis." Kidney Int 81, no. 1 (January 2012): 94-99. Full Text Link to Item
  - Akilesh, S, Suleiman, H, Yu, H, Stander, MC, Lavin, P, Gbadegesin, R, Antignac, C, Pollak, M, Kopp, JB, Winn, MP, and Shaw, AS. "Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis." J Clin Invest 121, no. 10 (October 2011): 4127-4137. Full Text Link to Item
  - Gbadegesin, R, Lavin, P, Foreman, J, and Winn, M. "Pathogenesis and therapy of focal segmental glomerulosclerosis: an update." Pediatr Nephrol 26, no. 7 (July 2011): 1001-1015. (Review) Full Text Link to Item
  - Heeringa, SF, Chernin, G, Chaki, M, Zhou, W, Sloan, AJ, Ji, Z, Xie, LX, Salviati, L, Hurd, TW, Vega-Warner, V, Killen, PD, Raphael, Y, Ashraf, S, Ovunc, B, Schoeb, DS, McLaughlin, HM, Airik, R, Vlangos, CN, Gbadegesin, R, Hinkes, B, Saisawat, P, Trevisson, E, Doimo, M, Casarin, A, Pertegato, V, Giorgi, G, Prokisch, H, Rötig, A, Nürnberg, G, Becker, C, Wang, S, Ozaltin, F, Topaloglu, R, Bakkaloglu, A, Bakkaloglu, SA, Müller, D, Beissert, A, Mir, S, Berdeli, A, Varpizen, S, Zenker, M, and Matejas, V et al. "COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness." The Journal of clinical investigation 121, no. 5 (May 2011): 2013-2024. Full Text
  - Eckel, J, Lavin, PJ, Finch, EA, Mukerji, N, Burch, J, Gbadegesin, R, Wu, G, Bowling, B, Byrd, A, Hall, G, Sparks, M, Zhang, ZS, Homstad, A, Barisoni, L, Birbaumer, L, Rosenberg, P, and Winn, MP. "TRPC6 enhances angiotensin II-induced albuminuria." J Am Soc Nephrol 22, no. 3 (March 2011): 526-535. Full Text Link to Item
  - Gbadegesin, RA, and Winn, MP. "Novel Insertion-Deletion Mutation in Uromodulin in a Large Kindred with Familial CKD and Nephrotic Range Proteinuria." PEDIATRIC NEPHROLOGY 25, no. 9 (September 2010): 1911-1912. Link to Item
  - Gbadegesin, R, Lavin, P, Janssens, L, Bartkowiak, B, Homstad, A, Wu, G, Bowling, B, Eckel, J, Potocky, C, Abbott, D, Conlon, P, Scott, WK, Howell, D, Hauser, E, and Winn, MP. "A new locus for familial FSGS on chromosome 2p." J Am Soc Nephrol 21, no. 8 (August 2010): 1390-1397. Full Text Link to Item
  - Gbadegesin, R, Zhao, S, Charpie, J, Brophy, PD, Smoyer, WE, and Lin, J-J. "Significance of hemolysis on extracorporeal life support after cardiac surgery in children." Pediatr Nephrol 24, no. 3 (March 2009): 589-595. Full Text Link to Item
  - Gbadegesin, R, Bartkowiak, B, Lavin, PJ, Mukerji, N, Wu, G, Bowling, B, Eckel, J, Damodaran, T, and Winn, MP. "Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS." Pediatr Nephrol 24, no. 2 (February 2009): 281-285. Full Text Link to Item
  - Heeringa, SF, Vlangos, CN, Chernin, G, Hinkes, B, Gbadegesin, R, Liu, J, Hoskins, BE, Ozaltin, F, Hildebrandt, F, and Members of the APN Study Group, . "Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome." Nephrol Dial Transplant 23, no. 11 (November 2008): 3527-3533. Full Text Link to Item
  - Chernin, G, Heeringa, SF, Gbadegesin, R, Liu, J, Hinkes, BG, Vlangos, CN, Vega-Warner, V, and Hildebrandt, F. "Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome." Pediatr Nephrol 23, no. 9 (September 2008): 1455-1460. Full Text Link to Item
  - Lavin, PJ, Gbadegesin, R, Damodaran, TV, and Winn, MP. "Therapeutic targets in focal and segmental glomerulosclerosis." Curr Opin Nephrol Hypertens 17, no. 4 (July 2008): 386-392. (Review) Full Text Link to Item
  - Gbadegesin, R, Hinkes, BG, Hoskins, BE, Vlangos, CN, Heeringa, SF, Liu, J, Loirat, C, Ozaltin, F, Hashmi, S, Ulmer, F, Cleper, R, Ettenger, R, Antignac, C, Wiggins, RC, Zenker, M, and Hildebrandt, F. "Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)." Nephrol Dial Transplant 23, no. 4 (April 2008): 1291-1297. Full Text Link to Item
  - Amodu, OK, Oyedeji, SI, Ntoumi, F, Orimadegun, AE, Gbadegesin, RA, Olumese, PE, and Omotade, OO. "Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria." Ann Trop Med Parasitol 102, no. 2 (March 2008): 95-102. Full Text Link to Item
  - Hinkes, B, Vlangos, C, Heeringa, S, Mucha, B, Gbadegesin, R, Liu, J, Hasselbacher, K, Ozaltin, F, Hildebrandt, F, and APN Study Group, . "Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome." J Am Soc Nephrol 19, no. 2 (February 2008): 365-371. Full Text Link to Item
  - Gbadegesin, R, Kudelka, T, Gadegbeku, CA, Brophy, P, Smoyer, WE, and Lin, J-J. "Arterial compliance in adolescents and young adults receiving chronic hemodialysis." Ren Fail 30, no. 6 (2008): 591-596. Full Text Link to Item
  - Gbadegesin, R, and Smoyer, WE. "Nephrotic Syndrome." Comprehensive Pediatric Nephrology (2008): 205-218. Full Text
  - Gbadegesin, R, Hinkes, B, Vlangos, C, Mucha, B, Liu, J, Hopcian, J, and Hildebrandt, F. "Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome." Pediatr Nephrol 22, no. 4 (April 2007): 509-513. Full Text Link to Item
  - Hinkes, BG, Mucha, B, Vlangos, CN, Gbadegesin, R, Liu, J, Hasselbacher, K, Hangan, D, Ozaltin, F, Zenker, M, Hildebrandt, F, and Arbeitsgemeinschaft für Paediatrische Nephrologie Study Group, . "Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)." Pediatrics 119, no. 4 (April 2007): e907-e919. Full Text Link to Item
  - Hinkes, B, Wiggins, RC, Gbadegesin, R, Vlangos, CN, Seelow, D, Nürnberg, G, Garg, P, Verma, R, Chaib, H, Hoskins, BE, Ashraf, S, Becker, C, Hennies, HC, Goyal, M, Wharram, BL, Schachter, AD, Mudumana, S, Drummond, I, Kerjaschki, D, Waldherr, R, Dietrich, A, Ozaltin, F, Bakkaloglu, A, Cleper, R, Basel-Vanagaite, L, Pohl, M, Griebel, M, Tsygin, AN, Soylu, A, Müller, D, Sorli, CS, Bunney, TD, Katan, M, Liu, J, Attanasio, M, O'toole, JF, Hasselbacher, K, Mucha, B, Otto, EA, Airik, R, and Kispert, A et al. "Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible." Nat Genet 38, no. 12 (December 2006): 1397-1405. Full Text Link to Item
  - Amodu, OK, Olumese, PE, Gbadegesin, RA, Ayoola, OO, and Adeyemo, AA. "The influence of individual preventive measures on the clinical severity of malaria among Nigerian children." Acta Trop 97, no. 3 (March 2006): 370-372. Full Text Link to Item
  - Gbadegesin, RA, Cotton, SA, Watson, CJ, Brenchley, PEC, and Webb, NJA. "Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection." Int J Immunogenet 33, no. 1 (February 2006): 49-53. Full Text Link to Item
  - Amodu, OK, Adeyemo, AA, Ayoola, OO, Gbadegesin, RA, Orimadegun, AE, Akinsola, AK, Olumese, PE, and Omotade, OO. "Genetic diversity of the msp-1 locus and symptomatic malaria in south-west Nigeria." Acta Trop 95, no. 3 (September 2005): 226-232. Full Text Link to Item
  - Amodu, OK, Gbadegesin, RA, Ralph, SA, Adeyemo, AA, Brenchley, PEC, Ayoola, OO, Orimadegun, AE, Akinsola, AK, Olumese, PE, and Omotade, OO. "Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?." Acta Trop 95, no. 3 (September 2005): 248-255. Full Text Link to Item
  - Asinobi, AO, Gbadegesin, RA, and Ogunkunle, OO. "Increased steroid responsiveness of young children with nephrotic syndrome in Nigeria." Ann Trop Paediatr 25, no. 3 (September 2005): 199-203. Full Text Link to Item
  - Asinobi, AO, Gbadegesin, RA, and Shittu, OB. "A review of cases of posterior urethral valves seen at the University College Hospital, Ibadan (Nigeria)." Pediatr Med Chir 26, no. 6 (November 2004): 430-433. Link to Item
  - Olumese, PE, Amodu, OK, Björkman, A, Adeyemo, AA, Gbadegesin, RA, and Walker, O. "Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children." Trans R Soc Trop Med Hyg 96, no. 4 (July 2002): 418-420. Link to Item
  - Gbadegesin, RA, Watson, CJ, Cotton, SA, Brenchley, PEC, and Webb, NJA. "A PCR-RFLP typing method for adhesion molecule gene polymorphisms and allele frequencies in a normal UK population." Eur J Immunogenet 29, no. 2 (April 2002): 109-111. Link to Item
  - Gbadegesin, RA, Cotton, SA, Coupes, BM, Awan, A, Brenchley, PEC, and Webb, NJA. "Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis." Arch Dis Child 86, no. 3 (March 2002): 218-221. Link to Item
  - Cotton, SA, Gbadegesin, RA, Williams, S, Brenchley, PEC, and Webb, NJA. "Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection." Kidney Int 61, no. 1 (January 2002): 61-67. Full Text Link to Item
  - GBADEGESIN, R. "A PCR-RFLP typing method for adhesion molecule gene polymorphisms and allele frequencies in a normal UK population." Eur J Immunol 29 (2002): 109-111. Full Text
  - Omokhodion, SI, Ladipo, JK, Odebode, TO, Ajao, OG, Famewo, CE, Lagundoye, SB, Sanusi, A, and Gbadegesin, RA. "The Ibadan conjoined twins: a report of omphalopagus twins and a review of cases reported in Nigeria over 60 years." Ann Trop Paediatr 21, no. 3 (September 2001): 263-270. (Review) Link to Item
  - Olumese, PE, Gbadegesin, RA, Adeyemo, AA, Brown, B, and Walker, A. "Neurological features of cerebral malaria in Nigerian children." Ann Trop Paediatr 19, no. 4 (December 1999): 321-325. Link to Item
  - Olumese, PE, Björkman, A, Gbadegesin, RA, Adeyemo, AA, and Walker, O. "Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria." Acta Trop 73, no. 3 (October 15, 1999): 231-236. Link to Item
  - Asinobi, AO, Gbadegesin, RA, Adeyemo, AA, Akang, EE, Arowolo, FA, Abiola, OA, and Osinusi, K. "The predominance of membranoproliferative glomerulonephritis in childhood nephrotic syndrome in Ibadan, Nigeria." West Afr J Med 18, no. 3 (July 1999): 203-206. Link to Item
  - Adeyemo, AA, Sodeinde, O, Gbadegesin, RA, and Ademowo, OG. "Breastfeeding and bloody diarrhoea in young children." J Trop Pediatr 44, no. 1 (February 1998): 52-53. (Letter) Link to Item
  - Amodu, OK, Adeyemo, AA, Olumese, PE, and Gbadegesin, RA. "Intraleucocytic malaria pigment and clinical severity of malaria in children." Trans R Soc Trop Med Hyg 92, no. 1 (January 1998): 54-56. Link to Item
  - Sodeinde, O, Gbadegesin, RA, Ademowo, OG, and Adeyemo, AA. "Lack of association between falciparum malaria parasitemia and acute diarrhea in Nigerian children." Am J Trop Med Hyg 57, no. 6 (December 1997): 702-705. Link to Item
  - Adeyemo, AA, Gbadegesin, RA, and Omotade, OO. "Major congenital malformations among neonatal referrals to a Nigerian university hospital." East Afr Med J 74, no. 11 (November 1997): 699-701. Link to Item
  - Amodu, OK, Adeyemo, AA, Olumese, PE, Ketiku, O, and Gbadegesin, RA. "Intraleucocyte malaria pigment in asymptomatic and uncomplicated malaria." East Afr Med J 74, no. 11 (November 1997): 714-716. Link to Item
  - Sodeinde, O, Adeyemo, AA, Gbadegesin, RA, and Ademowo, OG. "Persistent diarrhoea in Nigerian children aged less than five years: a hospital-based study." J Diarrhoeal Dis Res 15, no. 3 (September 1997): 155-160. Link to Item
  - Adeyemo, AA, Sodeinde, O, Gbadegesin, RA, and Ademowo, OG. "Breastfeeding and bloody diarrhoea in young children in Ibadan, Nigeria." J Trop Pediatr 43, no. 4 (August 1997): 235-236. Link to Item
  - Gbadegesin, RA, Adeyemo, AA, and Asinobi, AO. "Deaths in childhood nephrotic syndrome in Ibadan, Nigeria." J Trop Pediatr 43, no. 4 (August 1997): 248-249. (Letter) Link to Item
  - Gbadegesin, RA, Adeyemo, AA, Asinobi, AO, and Osinusi, K. "Inaccuracy of the Schwartz formula in estimating glomerular filtration rate in Nigerian children." Ann Trop Paediatr 17, no. 2 (June 1997): 179-185. Link to Item
  - Nafiu, OO, Olumese, PE, Gbadegesin, RA, and Osinusi, K. "Intraosseous infusion in an emergency situation: a case report." Ann Trop Paediatr 17, no. 2 (June 1997): 175-177. Link to Item
  - Olumese, PE, Adeyemo, AA, Ademowo, OG, Gbadegesin, RA, Sodeinde, O, and Walker, O. "The clinical manifestations of cerebral malaria among Nigerian children with the sickle cell trait." Ann Trop Paediatr 17, no. 2 (June 1997): 141-145. Link to Item
  - Olumese, PE, Adeyemo, AA, Gbadegesin, RA, and Walker, O. "Retinal haemorrhage in cerebral malaria." East Afr Med J 74, no. 5 (May 1997): 285-287. Link to Item
  - Gbadegesin, RA, Sodeinde, O, Adeyemo, AA, and Ademowo, OG. "Body temperature is a poor predictor of malaria parasitaemia in children with acute diarrhoea." Ann Trop Paediatr 17, no. 1 (March 1997): 89-94. Link to Item
  - Sodeinde, O, Adeyemo, AA, Gbadegesin, RA, Olaleye, BO, Ajayi-Obe, KE, and Ademowo, OG. "Interaction between acute diarrhoea and falciparum malaria in Nigerian children." J Diarrhoeal Dis Res 14, no. 4 (December 1996): 269-273. Link to Item
  - Olumese, PE, Sodeinde, O, Gbadegesin, RA, Nafiu, O, Oguche, S, and Walker, O. "Respiratory distress adversely affects the outcome of childhood cerebral malaria." Trans R Soc Trop Med Hyg 89, no. 6 (November 1995): 634-. Link to Item
  - Gbadegesin, RA, Asinobi, AO, Osinusi, K, and Adeyemo, AA. "Is the height/plasma creatinine formula of Schwartz useful as a screening test in detecting Nigeria children with low GFR?." West Afr J Med 14, no. 4 (October 1995): 242-245. Link to Item
  - Adeyemo, AA, Gbadegesin, RA, Onyemenem, TN, and Ekweozor, CC. "Urinary tract pathogens and antimicrobial sensitivity patterns in children in Ibadan, Nigeria." Ann Trop Paediatr 14, no. 4 (1994): 271-274. Link to Item
  - Akindele, JA, and Gbadegesin, RA. "Outbreak of neonatal Klebsiella septicaemia at the University College Hospital, Ibadan, Nigeria. Appraisal of predisposing factors and preventive measures." Trop Geogr Med 46, no. 3 (1994): 151-153. Link to Item
  - Akindele, J, Oyejide, C, and Gbadegesin, R. "Trends in newborn mortality over a ten year period at the University College Hospital, Ibadan, Nigeria." Early Child Development and Care 80, no. 1 (January 1992): 31-41. Full Text
  - Gbadegesin, RA, Winn, MP, and Smoyer, WE. "Genetic testing in nephrotic syndrome--challenges and opportunities." Nat Rev Nephrol 9, no. 3: 179-184. (Review) Full Text Link to Item
Teaching & Mentoring
Recent Courses
- HGP 301B: RESEARCH IN HGP 2018

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Global Scholarship

Research

Selected Grants

Selected Publications

Journal Articles

Recent Courses