Rasheed Adebayo Gbadegesin

Rasheed Adebayo Gbadegesin
Professor of Pediatrics

Molecular genetics of glomerular disease
Genetic risk factors for childhood onset idiopathic nephrotic syndrome

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2018
Professor in Medicine, Medicine, Nephrology, Medicine 2018
Affiliate of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2014

Contact Information

Box 3959 Med Ctr, Durham, NC 27710
T0909-C Children's Hlth Ctr, Durham, NC 27710
rasheed.gbadegesin@duke.edu (919) 684-4246

Background
Education, Training, & Certifications
- Pediatric Nephrology Fellow, Pediatrics, University of Michigan at Ann Arbor 2004 - 2007
- Pediatric Resident, Pediatrics, New York Presbyterian Hospital 2002 - 2004
- Pediatric Resident, Pediatrics, University of Ibadan, College of Medicine (Nigeria) 1989 - 1995
- Medical Officer, National Service, University of Ibadan, College of Medicine (Nigeria) 1988 - 1989
- Intern, Med/Surg/Peds/Ob Gyn, University of Ibadan, College of Medicine (Nigeria) 1987 - 1988
- M.B.B.S., University of Ibadan, College of Medicine (Nigeria) 1987
Duke Appointment History
- Associate Professor in Medicine, Medicine, Nephrology, Medicine 2015 - 2018
- Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2016 - 2018
- Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2013 - 2016
- Assistant Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2007 - 2013
Expertise
Global Scholarship
- Research
Research
Selected Grants
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- Duke Physician Scientist Development program awarded by Burroughs Wellcome Fund 2018 - 2023
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant awarded by University of Minnesota 2018 - 2022
- Duke Resident Physician-Scientist Program- NIAID awarded by National Institutes of Health 2018 - 2022
- Duke Resident Physician-Scientist Program- NHLBI awarded by National Institutes of Health 2018 - 2022
- The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2022
- Alport Syndrome 2018 - 2020
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2020
- H3 AFRICA KIDNEY DISEASE COHORT STUDY awarded by University of Kansas 2017 - 2020
- FSGSabatacept 2016 - 2020
- CUREGN 2.0 - Midwest Pediatric Nephrology Consortium - PCC 2019 - 2020
- Wake Forest Collaborative Application for an APOLLO Clinical Center 2018 - 2020
- H3 Africa Kidney Disease Research Network 2017 - 2019
- Pharmacokinetics of Cefepime in Children Receiving Continuous Renal Replacement Therapy 2018 - 2019
- Genetics of childhood nephrotic syndrome 2017 - 2019
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2014 - 2019
- Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers 2014 - 2019
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- ACTH for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome in Children awarded by Emory University 2014 - 2018
- Gene Discovery in Autosomal Dominant Focal Segmental Glomerulosclerosis awarded by National Institutes of Health 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- H3Africa Kidney Disease Research Network 2015 - 2017
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Identification of New Non-invasive Diagnostic Tools for Vesicoureteric Reflux (VUR) 2014 - 2015
- IDENTIFICATION OF VUR GENES BY COMBINED LINKAGE ANALYSIS AND EXOME SEQUENCING awarded by National Institutes of Health 2013 - 2015
- A New Locus for Hereditary FSGS on Chromosome 2p awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Tokhmafshan, Fatima, Jasmine El Andalousi, Vasikar Murugapoopathy, Marie-Lyne Fillion, Sarah Campillo, John-Paul Capolicchio, Roman Jednak, et al. “Children with vesico-ureteric reflux have joint hypermobility and occasional TNXB sequence variants..” Can Urol Assoc J, November 5, 2019. https://doi.org/10.5489/cuaj.6068.
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  - Bensimhon, Adam R., Anna E. Williams, and Rasheed A. Gbadegesin. “Treatment of steroid-resistant nephrotic syndrome in the genomic era..” Pediatr Nephrol 34, no. 11 (November 2019): 2279–93. https://doi.org/10.1007/s00467-018-4093-1.
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  - Sood, S., A. O. Ojo, D. Adu, K. Kannan, A. Ghassabian, T. Koshy, S. M. Vento, et al. “Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network.” Kidney International Reports 4, no. 11 (November 1, 2019): 1641–45. https://doi.org/10.1016/j.ekir.2019.07.017.
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  - Chambers, Eileen Tsai, and Rasheed A. Gbadegesin. “Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?.” Kidney Int 96, no. 4 (October 2019): 818–20. https://doi.org/10.1016/j.kint.2019.05.031.
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  - Blew, Kathryn H., Annabelle Chua, John Foreman, Rasheed Gbadegesin, Annette Jackson, Shashi Nagaraj, Rebecca Sadun, Del Wigfall, Allan D. Kirk, and Eileen T. Chambers. “Tailored use of belatacept in adolescent kidney transplantation..” Am J Transplant, September 24, 2019. https://doi.org/10.1111/ajt.15611.
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  - Dufek, Stephanie, Chris Cheshire, Adam P. Levine, Richard S. Trompeter, Naomi Issler, Matthew Stubbs, Monika Mozere, et al. “Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome..” J Am Soc Nephrol 30, no. 8 (August 2019): 1375–84. https://doi.org/10.1681/ASN.2018101054.
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  - Hurst, Jillian H., Katherine J. Barrett, Matthew S. Kelly, Betty B. Staples, Kathleen A. McGann, Coleen K. Cunningham, Ann M. Reed, Rasheed A. Gbadegesin, and Sallie R. Permar. “Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development..” Pediatrics 144, no. 2 (August 2019). https://doi.org/10.1542/peds.2019-0745.
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  - Zahr, Rima S., Marianne E. Yee, Jack Weaver, Katherine Twombley, Raed Bou Matar, Diego Aviles, Rajasree Sreedharan, et al. “Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study..” Pediatr Nephrol 34, no. 8 (August 2019): 1435–45. https://doi.org/10.1007/s00467-019-04237-3.
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  - Canetta, Pietro A., Jonathan P. Troost, Shannon Mahoney, Amy J. Kogon, Noelle Carlozzi, Sharon M. Bartosh, Yi Cai, et al. “Health-related quality of life in glomerular disease..” Kidney Int 95, no. 5 (May 2019): 1209–24. https://doi.org/10.1016/j.kint.2018.12.018.
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  - Troost, Jonathan P., Debbie S. Gipson, Noelle E. Carlozzi, Bryce B. Reeve, Patrick H. Nachman, Rasheed Gbadegesin, Jichuan Wang, et al. “Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients..” Health Psychol 38, no. 5 (May 2019): 410–21. https://doi.org/10.1037/hea0000679.
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  - Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study..” Pediatr Nephrol 34, no. 3 (March 2019). https://doi.org/10.1007/s00467-018-4103-3.
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  - Carpenter, Shannon L., Jennifer Goldman, Ashley K. Sherman, David T. Selewski, Mahmoud Kallash, Cheryl L. Tran, Meredith Seamon, et al. “Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome..” Pediatr Nephrol 34, no. 2 (February 2019): 261–67. https://doi.org/10.1007/s00467-018-4072-6.
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  - Mariani, Laura H., Andrew S. Bomback, Pietro A. Canetta, Michael F. Flessner, Margaret Helmuth, Michelle A. Hladunewich, Jonathan J. Hogan, et al. “CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease..” Am J Kidney Dis 73, no. 2 (February 2019): 218–29. https://doi.org/10.1053/j.ajkd.2018.07.020.
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  - Freischlag, Kyle W., Vivian Chen, Shashi K. Nagaraj, Annabelle N. Chua, Dongfeng Chen, Delbert R. Wigfall, John W. Foreman, Rasheed Gbadegesin, Deepak Vikraman, and Eileen T. Chambers. “Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation..” Front Pediatr 7 (2019). https://doi.org/10.3389/fped.2019.00102.
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  - Lane, Brandon M., Rachel Cason, Christopher Imokhuede Esezobor, and Rasheed A. Gbadegesin. “Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update..” Front Pediatr 7 (2019). https://doi.org/10.3389/fped.2019.00008.
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  - Wang, Chia-Shi, Curtis Travers, Courtney McCracken, Traci Leong, Rasheed Gbadegesin, Alejandro Quiroga, Mark R. Benfield, et al. “Adrenocorticotropic Hormone for Childhood Nephrotic Syndrome: The ATLANTIS Randomized Trial..” Clin J Am Soc Nephrol 13, no. 12 (December 7, 2018): 1859–65. https://doi.org/10.2215/CJN.06890618.
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  - Esezobor, Christopher I., Adanze O. Asinobi, Henrietta U. Okafor, Rosamund Akuse, and Rasheed Gbadegesin. “National survey found that managing childhood nephrotic syndrome in Nigeria varied widely and did not comply with the best evidence..” Acta Paediatr 107, no. 12 (December 2018): 2193–98. https://doi.org/10.1111/apa.14409.
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  - Selewski, David T., Josephine M. Ambruzs, Gerald B. Appel, Andrew S. Bomback, Raed Bou Matar, Yi Cai, Daniel C. Cattran, et al. “Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study..” Kidney Int Rep 3, no. 6 (November 2018): 1373–84. https://doi.org/10.1016/j.ekir.2018.07.021.
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  - Varner, Jennifer D., Ayo Matory, and Rasheed A. Gbadegesin. “Genetic Basis of Health Disparity in Childhood Nephrotic Syndrome..” Am J Kidney Dis 72, no. 5 Suppl 1 (November 2018): S22–25. https://doi.org/10.1053/j.ajkd.2018.06.022.
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  - Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings..” Pediatr Nephrol 33, no. 10 (October 2018): 1773–80. https://doi.org/10.1007/s00467-018-3994-3.
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  - Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes..” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.
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  - Adeyemo, Adebowale, Christopher Esezobor, Adaobi Solarin, Asiri Abeyagunawardena, Jameela A. Kari, Sherif El Desoky, Larry A. Greenbaum, et al. “HLA-DQA1 and APOL1 as Risk Loci for Childhood-Onset Steroid-Sensitive and Steroid-Resistant Nephrotic Syndrome..” Am J Kidney Dis 71, no. 3 (March 2018): 399–406. https://doi.org/10.1053/j.ajkd.2017.10.013.
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  - Esezobor, Christopher Imokhuede, Patricia Akintan, Uche Nwaogazie, Edna Akinwunmi, Edamisan Temiye, Adebola Akinsulie, and Rasheed Gbadegesin. “Enuresis in children and adolescents with sickle cell anaemia is more frequent and substantially different from the general population..” Plos One 13, no. 8 (2018). https://doi.org/10.1371/journal.pone.0201860.
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  - Varner, J. D., M. Chryst-Stangl, C. I. Esezobor, A. Solarin, G. Wu, B. Lane, G. Hall, et al. “Genetic testing for steroid-resistant-nephrotic syndrome in an outbred population.” Frontiers in Pediatrics 6 (January 1, 2018). https://doi.org/10.3389/fped.2018.00307.
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  - Pelletier, Jonathan, Rasheed Gbadegesin, and Betty Staples. “Renal Tubular Acidosis..” Pediatr Rev 38, no. 11 (November 2017): 537–39. https://doi.org/10.1542/pir.2016-0231.
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  - Karp, Alana M., and Rasheed A. Gbadegesin. “Genetics of childhood steroid-sensitive nephrotic syndrome..” Pediatr Nephrol 32, no. 9 (September 2017): 1481–88. https://doi.org/10.1007/s00467-016-3456-8.
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  - Pelletier, Jonathan H., Shashi Nagaraj, Rasheed Gbadegesin, Delbert Wigfall, Kathleen A. McGann, and John Foreman. “Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature..” Pediatr Transplant 21, no. 6 (September 2017). https://doi.org/10.1111/petr.13022.
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  - Selewski, David T., Jonathan P. Troost, Danyelle Cummings, Susan F. Massengill, Rasheed A. Gbadegesin, Larry A. Greenbaum, Ibrahim F. Shatat, et al. “Responsiveness of the PROMIS® measures to changes in disease status among pediatric nephrotic syndrome patients: a Midwest pediatric nephrology consortium study..” Health Qual Life Outcomes 15, no. 1 (August 23, 2017). https://doi.org/10.1186/s12955-017-0737-2.
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  - Hall, Gentzon, Jonathan C. Routh, and Rasheed A. Gbadegesin. “Urinary Anomalies in 22q11.2 Deletion (DiGeorge syndrome): From Copy Number Variations to Single-Gene Determinants of Phenotype..” Am J Kidney Dis 70, no. 1 (July 2017): 8–10. https://doi.org/10.1053/j.ajkd.2017.03.017.
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  - Tokhmafshan, Fatima, Patrick D. Brophy, Rasheed A. Gbadegesin, and Indra R. Gupta. “Vesicoureteral reflux and the extracellular matrix connection..” Pediatr Nephrol 32, no. 4 (April 2017): 565–76. https://doi.org/10.1007/s00467-016-3386-5.
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  - Hall, Gentzon, Brandon Lane, Megan Chryst-Ladd, Guanghong Wu, Jen-Jar Lin, XueJun Qin, Elizabeth R. Hauser, and Rasheed Gbadegesin. “Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation..” Sci Rep 7 (January 6, 2017). https://doi.org/10.1038/srep39933.
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  - Rheault, Michelle N., and Rasheed A. Gbadegesin. “The Genetics of Nephrotic Syndrome..” J Pediatr Genet 5, no. 1 (March 2016): 15–24. https://doi.org/10.1055/s-0035-1557109.
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  - Elahi, Shan, Alison Homstad, Himani Vaidya, Jennifer Stout, Gentzon Hall, Guanghong Wu, Peter Conlon, et al. “Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux..” Pediatr Nephrol 31, no. 2 (February 2016): 247–53. https://doi.org/10.1007/s00467-015-3203-6.
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  - Rheault, Michelle N., Lei Zhang, David T. Selewski, Mahmoud Kallash, Cheryl L. Tran, Meredith Seamon, Chryso Katsoufis, et al. “AKI in Children Hospitalized with Nephrotic Syndrome..” Clin J Am Soc Nephrol 10, no. 12 (December 7, 2015): 2110–18. https://doi.org/10.2215/CJN.06620615.
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  - Phelan, Paul J., Gentzon Hall, Delbert Wigfall, John Foreman, Shashi Nagaraj, Andrew F. Malone, Michelle P. Winn, David N. Howell, and Rasheed Gbadegesin. “Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation..” Clin Kidney J 8, no. 5 (October 2015): 538–42. https://doi.org/10.1093/ckj/sfv063.
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  - Selewski, David T., Jonathan P. Troost, Susan F. Massengill, Rasheed A. Gbadegesin, Larry A. Greenbaum, Ibrahim F. Shatat, Yi Cai, et al. “The impact of disease duration on quality of life in children with nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study..” Pediatr Nephrol 30, no. 9 (September 2015): 1467–76. https://doi.org/10.1007/s00467-015-3074-x.
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  - Jordan, Daniel M., Stephan G. Frangakis, Christelle Golzio, Christopher A. Cassa, Joanne Kurtzberg, Joanne Task Force for Neonatal Genomics, Erica E. Davis, Shamil R. Sunyaev, and Nicholas Katsanis. “Identification of cis-suppression of human disease mutations by comparative genomics..” Nature 524, no. 7564 (August 13, 2015): 225–29. https://doi.org/10.1038/nature14497.
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  - Gbadegesin, Rasheed A., Adebowale Adeyemo, Nicholas J. A. Webb, Larry A. Greenbaum, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arundhati Kale, et al. “HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome..” J Am Soc Nephrol 26, no. 7 (July 2015): 1701–10. https://doi.org/10.1681/ASN.2014030247.
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  - Hall, Gentzon, and Rasheed A. Gbadegesin. “Translating genetic findings in hereditary nephrotic syndrome: the missing loops..” Am J Physiol Renal Physiol 309, no. 1 (July 1, 2015): F24–28. https://doi.org/10.1152/ajprenal.00683.2014.
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  - Sadowski, Carolin E., Svjetlana Lovric, Shazia Ashraf, Werner L. Pabst, Heon Yung Gee, Stefan Kohl, Susanne Engelmann, et al. “A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome..” J Am Soc Nephrol 26, no. 6 (June 2015): 1279–89. https://doi.org/10.1681/ASN.2014050489.
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  - Gbadegesin, Rasheed A. “The author replies..” Kidney Int 87, no. 4 (April 2015): 859–60. https://doi.org/10.1038/ki.2015.39.
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  - Hall, Gentzon, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Yangfan Liu, Edwin C. Oh, Liming Wang, et al. “A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS..” J Am Soc Nephrol 26, no. 4 (April 2015): 831–43. https://doi.org/10.1681/ASN.2013101053.
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  - Wang, Hsin-Hsiao S., Rasheed A. Gbadegesin, John W. Foreman, Shashi K. Nagaraj, Delbert R. Wigfall, John S. Wiener, and Jonathan C. Routh. “Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis..” J Urol 193, no. 3 (March 2015): 963–69. https://doi.org/10.1016/j.juro.2014.08.112.
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  - Malone, Andrew F., Paul J. Phelan, Gentzon Hall, Umran Cetincelik, Alison Homstad, Andrea S. Alonso, Ruiji Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis..” Kidney Int 86, no. 6 (December 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.
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  - Selewski, David T., Susan F. Massengill, Jonathan P. Troost, Larysa Wickman, Kassandra L. Messer, Emily Herreshoff, Corinna Bowers, et al. “Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study..” Pediatr Nephrol 29, no. 12 (December 2014): 2347–56. https://doi.org/10.1007/s00467-014-2858-8.
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  - Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS..” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.
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  - H3Africa Consortium, Heather, Charles Rotimi, Akin Abayomi, Alash’le Abimiku, Victoria May Adabayeri, Clement Adebamowo, Ezekiel Adebiyi, et al. “Research capacity. Enabling the genomic revolution in Africa..” Science 344, no. 6190 (June 20, 2014): 1346–48. https://doi.org/10.1126/science.1251546.
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  - Hall, Gentzon, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, et al. “Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity..” Am J Physiol Renal Physiol 306, no. 12 (June 15, 2014): F1442–50. https://doi.org/10.1152/ajprenal.00212.2013.
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  - Malone, A. F., P. J. Phelan, G. Hall, U. Cetincelik, A. Homstad, A. S. Alonso, R. Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.” Kidney International 86, no. 6 (January 1, 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.
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  - Eckel, J., P. J. Lavin, E. A. Finch, N. Mukerji, J. Burch, R. Gbadegesin, G. Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535)).” Journal of the American Society of Nephrology 24, no. 1 (December 28, 2013). https://doi.org/10.1681/ASN.2012111069.
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  - Straatmann, Caroline, Rose Ayoob, Rasheed Gbadegesin, Keisha Gibson, Michelle N. Rheault, Tarak Srivastava, Cheryl L. Tran, et al. “Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium..” Pediatr Nephrol 28, no. 8 (August 2013): 1235–41. https://doi.org/10.1007/s00467-013-2483-y.
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  - Gbadegesin, Rasheed A., Patrick D. Brophy, Adebowale Adeyemo, Gentzon Hall, Indra R. Gupta, David Hains, Bartlomeij Bartkowiak, et al. “TNXB mutations can cause vesicoureteral reflux..” J Am Soc Nephrol 24, no. 8 (July 2013): 1313–22. https://doi.org/10.1681/ASN.2012121148.
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  - Gipson, Debbie S., David T. Selewski, Susan F. Massengill, Larysa Wickman, Kassandra L. Messer, Emily Herreshoff, Corinna Bowers, et al. “Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study..” Health Qual Life Outcomes 11 (March 4, 2013). https://doi.org/10.1186/1477-7525-11-30.
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  - Gbadegesin, Rasheed A., Michelle P. Winn, and William E. Smoyer. “Genetic testing in nephrotic syndrome--challenges and opportunities..” Nat Rev Nephrol 9, no. 3 (March 2013): 179–84. https://doi.org/10.1038/nrneph.2012.286.
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  - Gbadegesin, Rasheed A., Peter J. Lavin, Gentzon Hall, Bartlomiej Bartkowiak, Alison Homstad, Ruiji Jiang, Guanghong Wu, et al. “Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis..” Kidney Int 81, no. 1 (January 2012): 94–99. https://doi.org/10.1038/ki.2011.297.
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  - Akilesh, Shreeram, Hani Suleiman, Haiyang Yu, M Christine Stander, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, et al. “Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis..” J Clin Invest 121, no. 10 (October 2011): 4127–37. https://doi.org/10.1172/JCI46458.
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  - Gbadegesin, Rasheed, Peter Lavin, John Foreman, and Michelle Winn. “Pathogenesis and therapy of focal segmental glomerulosclerosis: an update..” Pediatr Nephrol 26, no. 7 (July 2011): 1001–15. https://doi.org/10.1007/s00467-010-1692-x.
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  - Heeringa, Saskia F., Gil Chernin, Moumita Chaki, Weibin Zhou, Alexis J. Sloan, Ziming Ji, Letian X. Xie, et al. “COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness..” J Clin Invest 121, no. 5 (May 2011): 2013–24. https://doi.org/10.1172/JCI45693.
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  - Eckel, Jason, Peter J. Lavin, Elizabeth A. Finch, Nirvan Mukerji, Jarrett Burch, Rasheed Gbadegesin, Guanghong Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria..” J Am Soc Nephrol 22, no. 3 (March 2011): 526–35. https://doi.org/10.1681/ASN.2010050522.
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  - Gbadegesin, R. A., and M. P. Winn. “Novel Insertion-Deletion Mutation in Uromodulin in a Large Kindred with Familial CKD and Nephrotic Range Proteinuria.” Pediatric Nephrology 25, no. 9 (September 1, 2010): 1911–12.
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  - Gbadegesin, Rasheed, Peter Lavin, Louis Janssens, Bartlomiej Bartkowiak, Alison Homstad, Guanghong Wu, Brandy Bowling, et al. “A new locus for familial FSGS on chromosome 2p..” J Am Soc Nephrol 21, no. 8 (August 2010): 1390–97. https://doi.org/10.1681/ASN.2009101046.
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  - Gbadegesin, Rasheed, Shuang Zhao, John Charpie, Patrick D. Brophy, William E. Smoyer, and Jen-Jar Lin. “Significance of hemolysis on extracorporeal life support after cardiac surgery in children..” Pediatr Nephrol 24, no. 3 (March 2009): 589–95. https://doi.org/10.1007/s00467-008-1047-z.
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  - Gbadegesin, Rasheed, Bartlomiej Bartkowiak, Peter J. Lavin, Nirvan Mukerji, Guanghong Wu, Brandy Bowling, Jason Eckel, Tirupapuliyur Damodaran, and Michelle P. Winn. “Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS..” Pediatr Nephrol 24, no. 2 (February 2009): 281–85. https://doi.org/10.1007/s00467-008-1025-5.
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  - Gbadegesin, R., and W. E. Smoyer. “Nephrotic Syndrome,” December 1, 2008, 205–18. https://doi.org/10.1016/B978-0-323-04883-5.50018-0.
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  - Heeringa, Saskia F., Christopher N. Vlangos, Gil Chernin, Bernward Hinkes, Rasheed Gbadegesin, Jinhong Liu, Bethan E. Hoskins, Fatih Ozaltin, Friedhelm Hildebrandt, and Friedhelm Members of the APN Study Group. “Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome..” Nephrol Dial Transplant 23, no. 11 (November 2008): 3527–33. https://doi.org/10.1093/ndt/gfn271.
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  - Chernin, Gil, Saskia F. Heeringa, Rasheed Gbadegesin, Jinhong Liu, Bernward G. Hinkes, Christopher N. Vlangos, Virginia Vega-Warner, and Friedhelm Hildebrandt. “Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome..” Pediatr Nephrol 23, no. 9 (September 2008): 1455–60. https://doi.org/10.1007/s00467-008-0861-7.
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  - Lavin, Peter J., Rasheed Gbadegesin, Tirupapuliyur V. Damodaran, and Michelle P. Winn. “Therapeutic targets in focal and segmental glomerulosclerosis..” Curr Opin Nephrol Hypertens 17, no. 4 (July 2008): 386–92. https://doi.org/10.1097/MNH.0b013e32830464f4.
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  - Gbadegesin, Rasheed, Bernward G. Hinkes, Bethan E. Hoskins, Christopher N. Vlangos, Saskia F. Heeringa, Jinhong Liu, Chantal Loirat, et al. “Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)..” Nephrol Dial Transplant 23, no. 4 (April 2008): 1291–97. https://doi.org/10.1093/ndt/gfm759.
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  - Amodu, O. K., S. I. Oyedeji, F. Ntoumi, A. E. Orimadegun, R. A. Gbadegesin, P. E. Olumese, and O. O. Omotade. “Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria..” Annals of Tropical Medicine and Parasitology 102, no. 2 (March 2008): 95–102. https://doi.org/10.1179/136485908x252340.
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  - Hinkes, Bernward, Christopher Vlangos, Saskia Heeringa, Bettina Mucha, Rasheed Gbadegesin, Jinhong Liu, Katrin Hasselbacher, Fatih Ozaltin, Friedhelm Hildebrandt, and Friedhelm APN Study Group. “Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome..” J Am Soc Nephrol 19, no. 2 (February 2008): 365–71. https://doi.org/10.1681/ASN.2007040452.
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  - Gbadegesin, Rasheed, Timothy Kudelka, Crystal A. Gadegbeku, Patrick Brophy, William E. Smoyer, and Jen-Jar Lin. “Arterial compliance in adolescents and young adults receiving chronic hemodialysis..” Ren Fail 30, no. 6 (2008): 591–96. https://doi.org/10.1080/08860220802132064.
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  - Gbadegesin, Rasheed, Bernward Hinkes, Christopher Vlangos, Bettina Mucha, Jinhong Liu, Jeff Hopcian, and Friedhelm Hildebrandt. “Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome..” Pediatr Nephrol 22, no. 4 (April 2007): 509–13. https://doi.org/10.1007/s00467-006-0377-y.
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  - Hinkes, Bernward G., Bettina Mucha, Christopher N. Vlangos, Rasheed Gbadegesin, Jinhong Liu, Katrin Hasselbacher, Daniela Hangan, et al. “Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)..” Pediatrics 119, no. 4 (April 2007): e907–19. https://doi.org/10.1542/peds.2006-2164.
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  - Hinkes, Bernward, Roger C. Wiggins, Rasheed Gbadegesin, Christopher N. Vlangos, Dominik Seelow, Gudrun Nürnberg, Puneet Garg, et al. “Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible..” Nat Genet 38, no. 12 (December 2006): 1397–1405. https://doi.org/10.1038/ng1918.
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  - Amodu, O. K., P. E. Olumese, R. A. Gbadegesin, O. O. Ayoola, and A. A. Adeyemo. “The influence of individual preventive measures on the clinical severity of malaria among Nigerian children..” Acta Trop 97, no. 3 (March 2006): 370–72. https://doi.org/10.1016/j.actatropica.2005.09.009.
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  - Gbadegesin, R. A., S. A. Cotton, C. J. Watson, P. E. C. Brenchley, and N. J. A. Webb. “Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection..” Int J Immunogenet 33, no. 1 (February 2006): 49–53. https://doi.org/10.1111/j.1744-313X.2006.00565.x.
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  - Amodu, O. K., A. A. Adeyemo, O. O. Ayoola, R. A. Gbadegesin, A. E. Orimadegun, A. K. Akinsola, P. E. Olumese, and O. O. Omotade. “Genetic diversity of the msp-1 locus and symptomatic malaria in south-west Nigeria..” Acta Trop 95, no. 3 (September 2005): 226–32. https://doi.org/10.1016/j.actatropica.2005.06.017.
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  - Amodu, O. K., R. A. Gbadegesin, S. A. Ralph, A. A. Adeyemo, P. E. Brenchley, O. O. Ayoola, A. E. Orimadegun, A. K. Akinsola, P. E. Olumese, and O. O. Omotade. “Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?.” Acta Tropica 95, no. 3 (September 2005): 248–55. https://doi.org/10.1016/j.actatropica.2005.05.011.
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  - Asinobi, A. O., R. A. Gbadegesin, and O. O. Ogunkunle. “Increased steroid responsiveness of young children with nephrotic syndrome in Nigeria..” Ann Trop Paediatr 25, no. 3 (September 2005): 199–203. https://doi.org/10.1179/146532805X58139.
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  - Asinobi, A. O., R. A. Gbadegesin, and O. B. Shittu. “A review of cases of posterior urethral valves seen at the University College Hospital, Ibadan (Nigeria)..” Pediatr Med Chir 26, no. 6 (November 2004): 430–33.
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  - Olumese, P. E., O. K. Amodu, A. Björkman, A. A. Adeyemo, R. A. Gbadegesin, and O. Walker. “Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children..” Trans R Soc Trop Med Hyg 96, no. 4 (July 2002): 418–20. https://doi.org/10.1016/s0035-9203(02)90378-0.
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  - Gbadegesin, R. A., C. J. Watson, S. A. Cotton, P. E. C. Brenchley, and N. J. A. Webb. “A PCR-RFLP typing method for adhesion molecule gene polymorphisms and allele frequencies in a normal UK population..” Eur J Immunogenet 29, no. 2 (April 2002): 109–11. https://doi.org/10.1046/j.1365-2370.2002.00277.x.
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  - Gbadegesin, R. A., S. A. Cotton, B. M. Coupes, A. Awan, P. E. C. Brenchley, and N. J. A. Webb. “Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis..” Arch Dis Child 86, no. 3 (March 2002): 218–21. https://doi.org/10.1136/adc.86.3.218.
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  - Cotton, Shirley A., Rasheed A. Gbadegesin, Shelley Williams, Paul E. C. Brenchley, and Nicholas J. A. Webb. “Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection..” Kidney Int 61, no. 1 (January 2002): 61–67. https://doi.org/10.1046/j.1523-1755.2002.00110.x.
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  - Omokhodion, S. I., J. K. Ladipo, T. O. Odebode, O. G. Ajao, C. E. Famewo, S. B. Lagundoye, A. Sanusi, and R. A. Gbadegesin. “The Ibadan conjoined twins: a report of omphalopagus twins and a review of cases reported in Nigeria over 60 years..” Ann Trop Paediatr 21, no. 3 (September 2001): 263–70. https://doi.org/10.1080/02724930120077853.
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  - Olumese, P. E., R. A. Gbadegesin, A. A. Adeyemo, B. Brown, and A. Walker. “Neurological features of cerebral malaria in Nigerian children..” Ann Trop Paediatr 19, no. 4 (December 1999): 321–25. https://doi.org/10.1080/02724939992149.
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  - Olumese, P. E., A. Björkman, R. A. Gbadegesin, A. A. Adeyemo, and O. Walker. “Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria..” Acta Trop 73, no. 3 (October 15, 1999): 231–36. https://doi.org/10.1016/s0001-706x(99)00031-5.
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  - Asinobi, A. O., R. A. Gbadegesin, A. A. Adeyemo, E. E. Akang, F. A. Arowolo, O. A. Abiola, and K. Osinusi. “The predominance of membranoproliferative glomerulonephritis in childhood nephrotic syndrome in Ibadan, Nigeria..” West Afr J Med 18, no. 3 (July 1999): 203–6.
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  - Adeyemo, A. A., O. Sodeinde, R. A. Gbadegesin, and O. G. Ademowo. “Breastfeeding and bloody diarrhoea in young children..” J Trop Pediatr 44, no. 1 (February 1998): 52–53. https://doi.org/10.1093/tropej/44.1.52.
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  - Amodu, O. K., A. A. Adeyemo, P. E. Olumese, and R. A. Gbadegesin. “Intraleucocytic malaria pigment and clinical severity of malaria in children..” Trans R Soc Trop Med Hyg 92, no. 1 (January 1998): 54–56. https://doi.org/10.1016/s0035-9203(98)90952-x.
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  - Sodeinde, O., R. A. Gbadegesin, O. G. Ademowo, and A. A. Adeyemo. “Lack of association between falciparum malaria parasitemia and acute diarrhea in Nigerian children..” Am J Trop Med Hyg 57, no. 6 (December 1997): 702–5. https://doi.org/10.4269/ajtmh.1997.57.702.
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  - Adeyemo, A. A., R. A. Gbadegesin, and O. O. Omotade. “Major congenital malformations among neonatal referrals to a Nigerian university hospital..” East Afr Med J 74, no. 11 (November 1997): 699–701.
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  - Amodu, O. K., A. A. Adeyemo, P. E. Olumese, O. Ketiku, and R. A. Gbadegesin. “Intraleucocyte malaria pigment in asymptomatic and uncomplicated malaria..” East Afr Med J 74, no. 11 (November 1997): 714–16.
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  - Sodeinde, O., A. A. Adeyemo, R. A. Gbadegesin, and O. G. Ademowo. “Persistent diarrhoea in Nigerian children aged less than five years: a hospital-based study..” J Diarrhoeal Dis Res 15, no. 3 (September 1997): 155–60.
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  - Adeyemo, A. A., O. Sodeinde, R. A. Gbadegesin, and O. G. Ademowo. “Breastfeeding and bloody diarrhoea in young children in Ibadan, Nigeria..” J Trop Pediatr 43, no. 4 (August 1997): 235–36. https://doi.org/10.1093/tropej/43.4.235.
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  - Gbadegesin, R. A., A. A. Adeyemo, and A. O. Asinobi. “Deaths in childhood nephrotic syndrome in Ibadan, Nigeria..” J Trop Pediatr 43, no. 4 (August 1997): 248–49. https://doi.org/10.1093/tropej/43.4.248.
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  - Gbadegesin, R. A., A. A. Adeyemo, A. O. Asinobi, and K. Osinusi. “Inaccuracy of the Schwartz formula in estimating glomerular filtration rate in Nigerian children..” Ann Trop Paediatr 17, no. 2 (June 1997): 179–85. https://doi.org/10.1080/02724936.1997.11747884.
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  - Nafiu, O. O., P. E. Olumese, R. A. Gbadegesin, and K. Osinusi. “Intraosseous infusion in an emergency situation: a case report..” Ann Trop Paediatr 17, no. 2 (June 1997): 175–77. https://doi.org/10.1080/02724936.1997.11747883.
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  - Olumese, P. E., A. A. Adeyemo, O. G. Ademowo, R. A. Gbadegesin, O. Sodeinde, and O. Walker. “The clinical manifestations of cerebral malaria among Nigerian children with the sickle cell trait..” Ann Trop Paediatr 17, no. 2 (June 1997): 141–45. https://doi.org/10.1080/02724936.1997.11747877.
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  - Olumese, P. E., A. A. Adeyemo, R. A. Gbadegesin, and O. Walker. “Retinal haemorrhage in cerebral malaria..” East Afr Med J 74, no. 5 (May 1997): 285–87.
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  - Gbadegesin, R. A., O. Sodeinde, A. A. Adeyemo, and O. G. Ademowo. “Body temperature is a poor predictor of malaria parasitaemia in children with acute diarrhoea..” Ann Trop Paediatr 17, no. 1 (March 1997): 89–94. https://doi.org/10.1080/02724936.1997.11747869.
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  - Sodeinde, O., A. A. Adeyemo, R. A. Gbadegesin, B. O. Olaleye, K. E. Ajayi-Obe, and O. G. Ademowo. “Interaction between acute diarrhoea and falciparum malaria in Nigerian children..” J Diarrhoeal Dis Res 14, no. 4 (December 1996): 269–73.
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  - Olumese, P. E., O. Sodeinde, R. A. Gbadegesin, O. Nafiu, S. Oguche, and O. Walker. “Respiratory distress adversely affects the outcome of childhood cerebral malaria..” Trans R Soc Trop Med Hyg 89, no. 6 (November 1995). https://doi.org/10.1016/0035-9203(95)90421-2.
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  - Gbadegesin, R. A., A. O. Asinobi, K. Osinusi, and A. A. Adeyemo. “Is the height/plasma creatinine formula of Schwartz useful as a screening test in detecting Nigeria children with low GFR?.” West Afr J Med 14, no. 4 (October 1995): 242–45.
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  - Adeyemo, A. A., R. A. Gbadegesin, T. N. Onyemenem, and C. C. Ekweozor. “Urinary tract pathogens and antimicrobial sensitivity patterns in children in Ibadan, Nigeria..” Ann Trop Paediatr 14, no. 4 (1994): 271–74. https://doi.org/10.1080/02724936.1994.11747728.
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  - Akindele, J. A., and R. A. Gbadegesin. “Outbreak of neonatal Klebsiella septicaemia at the University College Hospital, Ibadan, Nigeria. Appraisal of predisposing factors and preventive measures..” Trop Geogr Med 46, no. 3 (1994): 151–53.
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  - Akindele, J. A. “Trends in newborn mortality over a ten year period at the University College Hospital, Ibadan, Nigeria.” Early Child Development and Care 80, no. 1 (January 1, 1992): 31–41. https://doi.org/10.1080/0300443920800105.
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- Book Sections
  - Gbadegesin, R., K. L. Gibson, and W. E. Smoyer. “Steroid resistant nephrotic syndrome.” In Pediatric Kidney Disease: Second Edition, 455–78, 2017. https://doi.org/10.1007/978-3-662-52972-0_16.
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- Conference Papers
  - Hall, Gentzon, G Michelle Ducasa, Brandon M. Lane, Max Lagas, Maria E. Kovalik, Olivia G. Gregory, Guanghong Wu, et al. “THE LMX1 beta R246Q MUTATION INDUCES PODOCYTE INJURY THROUGH DYSREGULATION OF CHOLESTEROL TRANSPORT GENE EXPRESSION.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.
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  - Hall, Gentzon, Sidharth K. Sethi, Brandon M. Lane, Matthew G. Sampson, Olivia G. Gregory, Maria E. Kovalik, Megan Chryst-Stangl, et al. “A NOVEL HETEROZYGOUS MISSENSE MUTATION OF WILMS' TUMOR 1 MAY CAUSE FSGS THROUGH DYSREGULATED EXPRESSION OF ARHGAP24.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.
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Teaching & Mentoring
Recent Courses
- HGP 301B: Research in HGP 2020

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