Striated muscle function, regeneration, and repair.


Journal Article (Review)

As the only striated muscle tissues in the body, skeletal and cardiac muscle share numerous structural and functional characteristics, while exhibiting vastly different size and regenerative potential. Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging. In contrast, the mammalian heart loses its regenerative capacity shortly after birth, leaving it susceptible to permanent damage by acute injury or chronic disease. In this review, we compare and contrast the physiology and regenerative potential of native skeletal and cardiac muscles, mechanisms underlying striated muscle dysfunction, and bioengineering strategies to treat muscle disorders. We focus on different sources for cellular therapy, biomaterials to augment the endogenous regenerative response, and progress in engineering and application of mature striated muscle tissues in vitro and in vivo. Finally, we discuss the challenges and perspectives in translating muscle bioengineering strategies to clinical practice.

Full Text

Duke Authors

Cited Authors

  • Shadrin, IY; Khodabukus, A; Bursac, N

Published Date

  • November 2016

Published In

Volume / Issue

  • 73 / 22

Start / End Page

  • 4175 - 4202

PubMed ID

  • 27271751

Pubmed Central ID

  • 27271751

Electronic International Standard Serial Number (EISSN)

  • 1420-9071

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-016-2285-z


  • eng