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Autophagy and mechanotransduction in outflow pathway cells.

Publication ,  Journal Article
Hirt, J; Liton, PB
Published in: Exp Eye Res
May 2017

Because of elevations in IOP and other forces, cells in the trabecular meshwork (TM) are constantly subjected to mechanical strain. In order to preserve cellular function and regain homeostasis, cells must sense and adapt to these morphological changes. We and others have already shown that mechanical stress can trigger a broad range of responses in TM cells; however, very little is known about the strategies that TM cells use to respond to this stress, so they can adapt and survive. Autophagy, a lysosomal degradation pathway, has emerged as an important cellular homeostatic mechanism promoting cell survival and adaptation to a number of cytotoxic stresses. Our laboratory has reported the activation of autophagy in TM cells in response to static biaxial strain and high pressure. Moreover, our newest data also suggest the activation of chaperon-assisted selective autophagy, a recently identified tension-induced autophagy essential for mechanotransduction, in TM cells under cyclic mechanical stress. In this review manuscript we will discuss autophagy as part of an integrated response triggered in TM cells in response to strain, exerting a dual role in repair and mechanotransduction, and the potential effects of dysregulated in outflow pathway pathophysiology.

Duke Scholars

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Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

May 2017

Volume

158

Start / End Page

146 / 153

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Stress, Mechanical
  • Ophthalmology & Optometry
  • Mechanotransduction, Cellular
  • Intraocular Pressure
  • Humans
  • Cells, Cultured
  • Cell Survival
  • Autophagy
  • Aqueous Humor
 

Citation

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MLA
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Hirt, J., & Liton, P. B. (2017). Autophagy and mechanotransduction in outflow pathway cells. Exp Eye Res, 158, 146–153. https://doi.org/10.1016/j.exer.2016.06.021
Hirt, Joshua, and Paloma B. Liton. “Autophagy and mechanotransduction in outflow pathway cells.Exp Eye Res 158 (May 2017): 146–53. https://doi.org/10.1016/j.exer.2016.06.021.
Hirt J, Liton PB. Autophagy and mechanotransduction in outflow pathway cells. Exp Eye Res. 2017 May;158:146–53.
Hirt, Joshua, and Paloma B. Liton. “Autophagy and mechanotransduction in outflow pathway cells.Exp Eye Res, vol. 158, May 2017, pp. 146–53. Pubmed, doi:10.1016/j.exer.2016.06.021.
Hirt J, Liton PB. Autophagy and mechanotransduction in outflow pathway cells. Exp Eye Res. 2017 May;158:146–153.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

May 2017

Volume

158

Start / End Page

146 / 153

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Stress, Mechanical
  • Ophthalmology & Optometry
  • Mechanotransduction, Cellular
  • Intraocular Pressure
  • Humans
  • Cells, Cultured
  • Cell Survival
  • Autophagy
  • Aqueous Humor