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Paloma Borrajo Liton

Professor in Ophthalmology
Ophthalmology, Glaucoma
DUMC 3802, Durham, NC 27710
2351 Erwin Road, Aeri 4004, Durham, NC 27705

Overview


Liton’s lab is focused on investigating a potential relationship between impairment of the autophagy lysosomal pathway and glaucoma in the aging eye. 

Current Appointments & Affiliations


Professor in Ophthalmology · 2024 - Present Ophthalmology, Glaucoma, Ophthalmology
Professor in Pathology · 2024 - Present Pathology, Clinical Science Departments

Recent Publications


Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells.

Journal Article Cell Mol Life Sci · February 22, 2025 Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, a leading cause of irreversible blindness worldwide. IOP homeostasis is maintained through a balance between aqueous humor production and its drainage through the trabecular meshw ... Full text Link to item Cite

Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress.

Journal Article Invest Ophthalmol Vis Sci · January 2, 2025 PURPOSE: To study the roles of tubulin acetylation and cyclic mechanical stretch (CMS) in trabecular meshwork (TM) cells and their impact on outflow pathway physiology and pathology. METHODS: Primary TM cell cultures were subjected to CMS (8% elongation, 2 ... Full text Link to item Cite

Time-Lapse Live-Cell Imaging Using Fluorescent Protein Sensors in Outflow Pathway Cells Under Fluid Flow Conditions.

Journal Article Methods Mol Biol · 2025 The role of shear stress in regulating aqueous humor (AH) outflow and intraocular pressure (IOP) in the trabecular meshwork (TM) and Schlemm's canal (SC) of the eye is an emerging field. Shear stress has been shown to activate mechanosensitive ion channels ... Full text Link to item Cite
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Recent Grants


Autophagy and Retinal Ganglion Cell Death in Glaucoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026

Autophagy and Mechanotransduction in the Trabecular Meshwork

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2025

View All Grants

Education, Training & Certifications


Universidad Autonoma de Madrid (Spain) · 2001 Ph.D.
Universidad Autonoma de Madrid (Spain) · 1995 M.Sc.

External Links


Liton's lab