Overview
Liton’s lab is focused on investigating a potential relationship between impairment of the autophagy lysosomal pathway and glaucoma in the aging eye.
Current Appointments & Affiliations
Professor in Ophthalmology
·
2024 - Present
Ophthalmology, Glaucoma,
Ophthalmology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Publications
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells.
Journal Article Cell Mol Life Sci · February 22, 2025 Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, a leading cause of irreversible blindness worldwide. IOP homeostasis is maintained through a balance between aqueous humor production and its drainage through the trabecular meshw ... Full text Link to item CiteTubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress.
Journal Article Invest Ophthalmol Vis Sci · January 2, 2025 PURPOSE: To study the roles of tubulin acetylation and cyclic mechanical stretch (CMS) in trabecular meshwork (TM) cells and their impact on outflow pathway physiology and pathology. METHODS: Primary TM cell cultures were subjected to CMS (8% elongation, 2 ... Full text Link to item CiteTime-Lapse Live-Cell Imaging Using Fluorescent Protein Sensors in Outflow Pathway Cells Under Fluid Flow Conditions.
Journal Article Methods Mol Biol · 2025 The role of shear stress in regulating aqueous humor (AH) outflow and intraocular pressure (IOP) in the trabecular meshwork (TM) and Schlemm's canal (SC) of the eye is an emerging field. Shear stress has been shown to activate mechanosensitive ion channels ... Full text Link to item CiteRecent Grants
Autophagy and Retinal Ganglion Cell Death in Glaucoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026Autophagy and Mechanotransduction in the Trabecular Meshwork
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2025Autophagy regulates endothelial nitric oxide (NO) synthase/NO in Schlemm¿s canal cells in response to shear stress
ResearchCollaborator · Awarded by BrightFocus Foundation · 2022 - 2025View All Grants
Education, Training & Certifications
Universidad Autonoma de Madrid (Spain) ·
2001
Ph.D.
Universidad Autonoma de Madrid (Spain) ·
1995
M.Sc.