Overview
Liton’s lab is focused on investigating a potential relationship between impairment of the autophagy lysosomal pathway and glaucoma in the aging eye.
Current Appointments & Affiliations
Professor in Ophthalmology
·
2024 - Present
Ophthalmology, Glaucoma,
Ophthalmology
Professor in Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Recent Publications
Comparative Multi-Omics Analysis of the Iridocorneal Angle Identifies an Immune-Fibrotic Profile in the DBA/2J Glaucoma Mouse Model.
Journal Article Mol Cell Proteomics · December 22, 2025 We present the first integrated transcriptomic and proteomic profiling of the iridocorneal region in the spontaneous murine glaucoma model DBA/2J and DBA/2J-Gpnmb+/Sj controls to define molecular changes associated with ocular hypertension and glaucoma. Us ... Full text Link to item CiteMatrine Reduces Intraocular Pressure in Corticosteroid-Induced Ocular Hypertensive Mouse Eyes.
Journal Article Invest Ophthalmol Vis Sci · August 1, 2025 PURPOSE: This study investigates the potential of matrine, a quinolizidine alkaloid, in regulating intraocular pressure (IOP) in normal and corticosteroid-induced ocular hypertension (OHT) mice. METHODS: Wild-type C57BL/6 mice were randomly divided into no ... Full text Link to item CiteClass I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells.
Journal Article Cell Mol Life Sci · February 22, 2025 Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, a leading cause of irreversible blindness worldwide. IOP homeostasis is maintained through a balance between aqueous humor production and its drainage through the trabecular meshw ... Full text Link to item CiteRecent Grants
Concepts and Breakthroughs in Glaucoma
ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2026Autophagy and Retinal Ganglion Cell Death in Glaucoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026Autophagy and Mechanotransduction in the Trabecular Meshwork
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2026View All Grants
Education, Training & Certifications
Universidad Autonoma de Madrid (Spain) ·
2001
Ph.D.
Universidad Autonoma de Madrid (Spain) ·
1995
M.Sc.