Paloma Borrajo Liton
Associate Professor in Ophthalmology
Liton’s lab is focused on investigating a potential relationship between impairment of the autophagy lysosomal pathway and glaucoma in the aging eye.
Current Research Interests
- To investigate a role of autophagy in the physiology and pathophysiology of the trabecular meshwork (TM)/Schlemms’s canal (SC) outflow pathway: The TM/SC is a complex tissue located in the anterior segment of the eye responsible of maintaining proper levels of intraocular pressure (IOP). Failure of this tissue function is associated with increase risk in developing glaucoma, a potentially permanent blinding disease, affecting more than 70 million people worldwide. Liton’s lab is focused on studying the regulation of autophagy under mechanical stretch and shear stress conditions in TM cells.
- To investigate a role of autophagy neurodegeneration in glaucoma: The exact molecular mechanisms triggering retinal ganglion cell death and axonal degeneration in glaucoma are still not fully understood. Liton’s lab is investigating the independent contribution of autophagy to apoptotic RGC death and axonal degeneration in acute injury and chronic hypertensive experimental models of glaucoma. Identification of the early critical molecular events in RGCs in response to elevated IOP would add to our understanding of the nature of glaucomatous injury and provide potential targets for neuroprotective strategies for the treatment of glaucoma.
- Mechanisms of aging in the trabecular meshwork: Aging is the primary risk factor for ocular hypertension and glaucoma. Yet, the mechanisms by which aging predisposes to disease are not entirely understood. Liton’s lab previously reported the accumulation of senescent cells in the TM from glaucoma donors. Their goal now is to investigate the potential cellular mechanisms by which senescent cells accumulate in the outflow pathway and contribute to ocular hypertension and glaucoma.
Current Appointments & Affiliations
- Associate Professor in Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2017
- Associate Professor in Pathology, Pathology, Clinical Science Departments 2015
Contact Information
- 2351 Erwin Road, Aeri 4004, Durham, NC 27705
- DUMC 3802, Durham, NC 27710
-
paloma.liton@duke.edu
(919) 681-4085
-
Liton's lab
- Background
-
Education, Training, & Certifications
- Postdoctoral Associate, Department Of Ophthalmology, Duke University School of Medicine 2002 - 2006
- Ph.D., Universidad Autonoma de Madrid (Spain) 2001
- M.Sc., Universidad Autonoma de Madrid (Spain) 1995
-
Previous Appointments & Affiliations
- Associate Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2014 - 2017
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2009 - 2014
- Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2010 - 2014
- Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2007 - 2010
- Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2006 - 2007
- Recognition
-
Awards & Honors
- Expertise
-
Subject Headings
- Research
-
Selected Grants
- Autophagy and Retinal Ganglion Cell Death in Glaucoma awarded by National Institutes of Health 2022 - 2026
- Autophagy and Mechanotransduction in the Trabecular Meshwork awarded by National Institutes of Health 2016 - 2025
- Autophagy regulates endothelial nitric oxide (NO) synthase/NO in Schlemm¿s canal cells in response to shear stress awarded by BrightFocus Foundation 2022 - 2024
- Deciphering the local effect of glaucoma risk factors on axonal mitoproteome awarded by BrightFocus Foundation 2021 - 2023
- Phosphoinositide signaling in glaucoma: rescue strategies for Lowe syndrome awarded by Stanford University 2022 - 2023
- Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2023
- Primary cilia-mediated nitric oxide production in Schlemm's canal cells awarded by Glaucoma Research Foundation 2022 - 2023
- Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology awarded by National Institutes of Health 2017 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Analysis of DNA transport in electrotransfected cells awarded by National Science Foundation 2013 - 2017
- Lysosomal enzymes, Glycosaminoglycans and Outflow Pathway Physiology awarded by Glaucoma Research Foundation 2015 - 2016
- Autophagic Lysosomal Pathway and Glaucoma awarded by National Institutes of Health 2010 - 2015
- Oxidative Stress and Lysosomal Function in the Outflow Pathway awarded by National Institutes of Health 2008 - 2011
-
External Relationships
- Brightfocus Grant Review Panel
- NIH Grant Review Panel
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Kaarniranta, Kai, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky, and Debasish Sinha. “Autophagy in age-related macular degeneration.” Autophagy 19, no. 2 (February 2023): 388–400. https://doi.org/10.1080/15548627.2022.2069437.Full Text Link to Item
-
Liton, Paloma B., Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, et al. “AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.” Autophagy Rep 2, no. 1 (2023). https://doi.org/10.1080/27694127.2023.2178996.Full Text Link to Item
-
Shim, Myoung Sup, and Paloma B. Liton. “The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up.” Prog Retin Eye Res 90 (September 2022): 101064. https://doi.org/10.1016/j.preteyeres.2022.101064.Full Text Link to Item
-
McDowell, Colleen M., Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J Cameron Millar, Markus H. Kuehn, et al. “Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.” Invest Ophthalmol Vis Sci 63, no. 2 (February 1, 2022): 12. https://doi.org/10.1167/iovs.63.2.12.Full Text Link to Item
-
Shyam, Rajalekshmy, Diego G. Ogando, Moonjung Choi, Paloma B. Liton, and Joseph A. Bonanno. “Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.” Invest Ophthalmol Vis Sci 62, no. 12 (September 2, 2021): 15. https://doi.org/10.1167/iovs.62.12.15.Full Text Link to Item
-
Shim, Myoung Sup, April Nettesheim, Angela Dixon, and Paloma B. Liton. “Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2021942118.Full Text Link to Item
-
Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.Full Text Link to Item
-
Nettesheim, April, Myoung Sup Shim, Angela Dixon, Urmimala Raychaudhuri, Haiyan Gong, and Paloma B. Liton. “Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma.” J Clin Med 10, no. 1 (December 28, 2020). https://doi.org/10.3390/jcm10010078.Full Text Link to Item
-
Nettesheim, April, Angela Dixon, Myoung Sup Shim, Aislyn Coyne, Molly Walsh, and Paloma B. Liton. “Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model.” Invest Ophthalmol Vis Sci 61, no. 10 (August 3, 2020): 31. https://doi.org/10.1167/iovs.61.10.31.Full Text Link to Item
-
Mao, Mao, Chun-Chi Chang, Adrian Pickar-Oliver, Lisa D. Cervia, Liangli Wang, Jing Ji, Paloma B. Liton, Charles A. Gersbach, and Fan Yuan. “Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo.” Adv Biosyst 4, no. 8 (August 2020): e2000059. https://doi.org/10.1002/adbi.202000059.Full Text Link to Item
-
Shim, Myoung Sup, April Nettesheim, Joshua Hirt, and Paloma B. Liton. “The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.” Autophagy 16, no. 7 (July 2020): 1248–61. https://doi.org/10.1080/15548627.2019.1662584.Full Text Link to Item
-
Nettesheim, April, Myoung Sup Shim, Josh Hirt, and Paloma B. Liton. “Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells.” Sci Rep 9, no. 1 (November 6, 2019): 16092. https://doi.org/10.1038/s41598-019-52627-2.Full Text Link to Item
-
Keller, Kate E., Sanjoy K. Bhattacharya, Theresa Borrás, Thomas M. Brunner, Sunee Chansangpetch, Abbott F. Clark, W Michael Dismuke, et al. “Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.” Exp Eye Res 171 (June 2018): 164–73. https://doi.org/10.1016/j.exer.2018.03.001.Full Text Link to Item
-
Hirt, Joshua, Kris Porter, Angela Dixon, Stuart McKinnon, and Paloma B. Liton. “Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model.” Cell Death Discov 4 (2018): 14. https://doi.org/10.1038/s41420-018-0077-y.Full Text Link to Item
-
Benischke, Anne-Sophie, Shivakumar Vasanth, Takashi Miyai, Kishore Reddy Katikireddy, Tomas White, Yuming Chen, Adna Halilovic, et al. “Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy.” Sci Rep 7, no. 1 (July 27, 2017): 6656. https://doi.org/10.1038/s41598-017-06523-2.Full Text Link to Item
-
Muñoz-Alía, Miguel Angel, José M. Casasnovas, María Luisa Celma, Juan Carabaña, Paloma B. Liton, and Rafael Fernandez-Muñoz. “Measles Virus Hemagglutinin epitopes immunogenic in natural infection and vaccination are targeted by broad or genotype-specific neutralizing monoclonal antibodies.” Virus Res 236 (May 15, 2017): 30–43. https://doi.org/10.1016/j.virusres.2017.04.018.Full Text Link to Item
-
Hirt, Joshua, and Paloma B. Liton. “Autophagy and mechanotransduction in outflow pathway cells.” Exp Eye Res 158 (May 2017): 146–53. https://doi.org/10.1016/j.exer.2016.06.021.Full Text Link to Item
-
Mao, Mao, Liangli Wang, Chun-Chi Chang, Katheryn E. Rothenberg, Jianyong Huang, Yingxiao Wang, Brenton D. Hoffman, Paloma B. Liton, and Fan Yuan. “Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection.” Mol Ther 25, no. 3 (March 1, 2017): 803–15. https://doi.org/10.1016/j.ymthe.2016.12.009.Full Text Link to Item
-
Williams, Andrew M., Kristin M. Perkumas, Isaac Perry, Joanne C. Wen, Janet Keeling, Michael Tramber, Paloma B. Liton, and W Daniel Stamer. “Successful Implementation of a Program for Increasing Donor Eyes for Research: The Duke-Miracles In Sight Program.” J Ocul Pharmacol Ther 32, no. 3 (April 2016): 145–49. https://doi.org/10.1089/jop.2015.0107.Full Text Link to Item
-
Liton, Paloma B. “The autophagic lysosomal system in outflow pathway physiology and pathophysiology.” Exp Eye Res 144 (March 2016): 29–37. https://doi.org/10.1016/j.exer.2015.07.013.Full Text Link to Item
-
“Erratum.” Autophagy 12, no. 2 (2016): 443. https://doi.org/10.1080/15548627.2016.1147886.Full Text Link to Item
-
Porter, Kristine, Joshua Hirt, W Daniel Stamer, and Paloma B. Liton. “Autophagic dysregulation in glaucomatous trabecular meshwork cells.” Biochim Biophys Acta 1852, no. 3 (March 2015): 379–85. https://doi.org/10.1016/j.bbadis.2014.11.021.Full Text Link to Item
-
Porter, Kristine M., Nallathambi Jeyabalan, and Paloma B. Liton. “MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.” Biochim Biophys Acta 1843, no. 6 (June 2014): 1054–62. https://doi.org/10.1016/j.bbamcr.2014.02.010.Full Text Link to Item
-
Xu, Ping, Yizhi Lin, Kristine Porter, and Paloma B. Liton. “Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells.” J Ocul Pharmacol Ther 30, no. 2–3 (2014): 246–53. https://doi.org/10.1089/jop.2013.0183.Full Text Link to Item
-
Gagen, Debjani, Mark S. Filla, Ross Clark, Paloma Liton, and Donna M. Peters. “Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells.” Invest Ophthalmol Vis Sci 54, no. 7 (July 24, 2013): 5000–5011. https://doi.org/10.1167/iovs.13-12084.Full Text Link to Item
-
Porter, Kristine, Jeyabalan Nallathambi, Yizhi Lin, and Paloma B. Liton. “Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.” Autophagy 9, no. 4 (April 2013): 581–94. https://doi.org/10.4161/auto.23568.Full Text Link to Item
-
Porter, Kristine, Yizhi Lin, and Paloma B. Liton. “Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge.” Plos One 8, no. 7 (2013): e68668. https://doi.org/10.1371/journal.pone.0068668.Full Text Link to Item
-
Klionsky, Daniel J., Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy 8, no. 4 (April 2012): 445–544. https://doi.org/10.4161/auto.19496.Full Text Link to Item
-
Porter, Kristine M., David L. Epstein, and Paloma B. Liton. “Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells.” Plos One 7, no. 4 (2012): e34792. https://doi.org/10.1371/journal.pone.0034792.Full Text Link to Item
-
Lin, Yizhi, David L. Epstein, and Paloma B. Liton. “Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.” Invest Ophthalmol Vis Sci 51, no. 12 (December 2010): 6483–95. https://doi.org/10.1167/iovs.10-5410.Full Text Link to Item
-
Liton, Paloma B., Pedro Gonzalez, and David L. Epstein. “The role of proteolytic cellular systems in trabecular meshwork homeostasis.” Exp Eye Res 88, no. 4 (April 2009): 724–28. https://doi.org/10.1016/j.exer.2008.11.002.Full Text Link to Item
-
Liton, Paloma B., Guorong Li, Coralia Luna, Pedro Gonzalez, and David L. Epstein. “Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.” Mol Vis 15 (2009): 326–34.Link to Item
-
Liton, Paloma B., Yizhi Lin, Pedro Gonzalez, and David L. Epstein. “Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma.” Autophagy 5, no. 1 (January 2009): 122–24. https://doi.org/10.4161/auto.5.1.7304.Full Text Link to Item
-
Luna, Coralia, Guorong Li, Paloma B. Liton, David L. Epstein, and Pedro Gonzalez. “Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.” Mol Vis 15 (2009): 534–44.Link to Item
-
Luna, Coralia, Guorong Li, Paloma B. Liton, Jianming Qiu, David L. Epstein, Pratap Challa, and Pedro Gonzalez. “Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.” Food Chem Toxicol 47, no. 1 (January 2009): 198–204. https://doi.org/10.1016/j.fct.2008.10.029.Full Text Link to Item
-
Liton, Paloma B., Yizhi Lin, Coralia Luna, Guorong Li, Pedro Gonzalez, and David L. Epstein. “Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.” Invest Ophthalmol Vis Sci 49, no. 9 (September 2008): 3961–69. https://doi.org/10.1167/iovs.08-1915.Full Text Link to Item
-
Liton, Paloma B., and Pedro Gonzalez. “Stress response of the trabecular meshwork.” J Glaucoma 17, no. 5 (August 2008): 378–85. https://doi.org/10.1097/IJG.0b013e31815f52a8.Full Text Link to Item
-
Li, Guorong, Coralia Luna, Paloma B. Liton, Iris Navarro, David L. Epstein, and Pedro Gonzalez. “Sustained stress response after oxidative stress in trabecular meshwork cells.” Mol Vis 13 (December 17, 2007): 2282–88.Link to Item
-
Chow, Jessica, Paloma B. Liton, Coralia Luna, Fulton Wong, and Pedro Gonzalez. “Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells.” Mol Vis 13 (October 16, 2007): 1926–33.Link to Item
-
Liu, Yizhi, Xialin Liu, Tieying Zhang, Coralia Luna, Paloma B. Liton, and Pedro Gonzalez. “Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells.” Mol Vis 13 (January 16, 2007): 31–38.Link to Item
-
Liton, Paloma B., Coralia Luna, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.” Mol Vis 12 (July 12, 2006): 774–90.Link to Item
-
Gonzalez, P., D. L. Epstein, C. Luna, and P. B. Liton. “Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro.” Exp Eye Res 82, no. 6 (June 2006): 959–67. https://doi.org/10.1016/j.exer.2005.10.006.Full Text Link to Item
-
Liton, Paloma B., Coralia Luna, Marc Bodman, Anna Hong, David L. Epstein, and Pedro Gonzalez. “Induction of IL-6 expression by mechanical stress in the trabecular meshwork.” Biochem Biophys Res Commun 337, no. 4 (December 2, 2005): 1229–36. https://doi.org/10.1016/j.bbrc.2005.09.182.Full Text Link to Item
-
Liton, P. B., X. Liu, P. Challa, D. L. Epstein, and P. Gonzalez. “Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress.” J Cell Physiol 205, no. 3 (December 2005): 364–71. https://doi.org/10.1002/jcp.20404.Full Text Link to Item
-
Challa, Pratap, Coralia Luna, Paloma B. Liton, Beth Chamblin, John Wakefield, Ram Ramabhadran, David L. Epstein, and Pedro Gonzalez. “Lentiviral mediated gene delivery to the anterior chamber of rodent eyes.” Mol Vis 11 (June 21, 2005): 425–30.Link to Item
-
Liton, Paloma B., Pratap Challa, Sandra Stinnett, Coralia Luna, David L. Epstein, and Pedro Gonzalez. “Cellular senescence in the glaucomatous outflow pathway.” Exp Gerontol 40, no. 8–9 (2005): 745–48. https://doi.org/10.1016/j.exger.2005.06.005.Full Text Link to Item
-
Liton, Paloma B., Xialin Liu, W Daniel Stamer, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.” Invest Ophthalmol Vis Sci 46, no. 1 (January 2005): 183–90. https://doi.org/10.1167/iovs.04-0330.Full Text Link to Item
-
Caballero, Montserrat, Paloma B. Liton, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Effects of donor age on proteasome activity and senescence in trabecular meshwork cells.” Biochem Biophys Res Commun 323, no. 3 (October 22, 2004): 1048–54. https://doi.org/10.1016/j.bbrc.2004.08.195.Full Text Link to Item
-
Gonzalez, Pedro, Montserrat Caballero, Paloma B. Liton, W Daniel Stamer, and David L. Epstein. “Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.” Invest Ophthalmol Vis Sci 45, no. 5 (May 2004): 1389–95. https://doi.org/10.1167/iovs.03-0537.Full Text Link to Item
-
Caballero, Montserrat, Paloma B. Liton, David L. Epstein, and Pedro Gonzalez. “Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells.” Biochem Biophys Res Commun 308, no. 2 (August 22, 2003): 346–52. https://doi.org/10.1016/s0006-291x(03)01385-8.Full Text Link to Item
-
Manchester, M., D. S. Eto, A. Valsamakis, P. B. Liton, R. Fernandez-Muñoz, P. A. Rota, W. J. Bellini, D. N. Forthal, and M. B. Oldstone. “Clinical isolates of measles virus use CD46 as a cellular receptor.” J Virol 74, no. 9 (May 2000): 3967–74. https://doi.org/10.1128/jvi.74.9.3967-3974.2000.Full Text Link to Item
-
-
Other Articles
-
Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.Full Text Link to Item
-
-
Conference Papers
-
Shyam, Raji, Diego Ogando, Moonjung Choi, Paloma Liton, and Joseph Bonanno. “Mitochondrial ROS leads to lysosomal dysfunction and autophagy impairment in an animal model of Congenital Hereditary Endothelial Dystrophy.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.Link to Item
-
Sim, Myoungsup, April Nettesheim, Angela Dixon, and Paloma Liton. “Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.Link to Item
-
Nettesheim, April, Angela Dixon, Aislyn Coyne, Molly Walsh, and Paloma Borrajo Liton. “Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.Link to Item
-
Raychaudhuri, Urmimala, April Nettesheim, Angela Dixon, and Paloma Borrajo Liton. “Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.Link to Item
-
Nettesheim, April, Myoungsup Sim, Urmimala Raychaudhuri, and Paloma Borrajo Liton. “Autophagy is a regulator of TGF beta-induced fibrogenesis in trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
-
Sim, Myoungsup, April Nettesheim, Angela Dixon, and Paloma Borrajo Liton. “Nuclear LC3 triggers ribophagy upon cyclic mechanical stretch in human trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
-
Liton, Paloma Borrajo, Myoungsup Sim, April Nettesheim, and Angela Dixon. “Cross-talk between autophagy and TGF-beta signaling in human trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.Link to Item
-
Hirt, Joshua, and Paloma Borrajo Liton. “New Role of Autophagy Genes in Trabecular Meshwork Mechanotransduction.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.Link to Item
-
Hirt, Joshua A. B., Alison Choi, and Paloma B. Liton. “Lysosomal Enzymes in Extracellular Matrix Remodeling and Outflow Pathway Function.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.Link to Item
-
Liton, Paloma B. “Autophagic dysregulation in glaucomatous trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.Link to Item
-
Dai, Yan, Audrey Hagiwara, Heba Ijaz, Christopher Uherek, Paloma Borrajo Liton, Elizabeth Cho, and Haiyan Gong. “SIRT1 Regulates Cell Survival, Collagen VI Expression of Human TM Cells and Permeability Of Endothelial Cells of Schlemm's Canal.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.Link to Item
-
Hirt, Joshua, Angela Dixon, Stuart J. McKinnon, and Paloma Borrajo Liton. “Autophagy in the Neuroretina and Angle Region of DBA/2J Mice.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.Link to Item
-
Liton, Paloma Borrajo, and Joshua Hirt. “Autophagy and Mechanotransduction in Trabecular Meshwork Cells.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.Link to Item
-
Liton, Paloma Borrajo, Joshua Hirt, and Kristine M. Porter. “Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.Link to Item
-
Gagen, Debjani, Ross Clark, Paloma Liton, and Donna Peters. “Integrins Modulate Phagocytosis in Human Trabecular Meshwork (TM) Cells.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.Link to Item
-
Porter, Kristine, Ping Xu, W Daniel Stamer, and Paloma Liton. “DIMINISHED AUTOPHAGIC CAPACITY OF GLAUCOMATOUS TRABECULAR MESHWORK CELLS.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.Link to Item
-
Liton, P. B., Y. Lin, and D. L. Epstein. “Cytosolic Release of Cathepsin D Resulting from Lysosomal Permeabilization is Involved in H2O2-Induced Cell Death in Porcine Trabecular Meshwork (TM) Cells: Potential Relevance to Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
-
Porter, K. M., Y. Lin, D. L. Epstein, and P. B. Liton. “Chronic Oxidative Stress Impairs Phagocytic Degradative Capacity in Cultured Trabecular Meshwork (TM) Cells.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
-
Hong, A., P. B. Liton, C. Luna, P. Gonzalez, and D. L. Epstein. “Induction of the interleukin-6 (IL-6) gene promoter in the trabecular meshwork (TM) after mechanical stress: Potential implications for aqueous humor outflow modulation and glaucoma pathophysiology.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.Link to Item
-
Luna, C. C., P. B. Liton, A. Hong, D. L. Epstein, and P. Gonzalez. “Extension of life span and delay of stress-induced premature senescence of trabecular meshwork (TM) cells incubated at low oxygen tension.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.Link to Item
-
Gonzalez, P., P. B. Liton, C. Luna, P. Challa, and D. L. Epstein. “Genome-wide microarray analysis of the gene expression profile of normal and primary open angle glaucoma human trabecular meshwork (HTM) tissue and cultured HTM cells.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.Link to Item
-
Wang, W., P. Gonzalez, P. B. Liton, M. Caballero, and D. L. Epstein. “Effects of mutant TIGR/myocilin expression in trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, 45:U188–U188. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
-
Challa, P., P. Gonzalez, P. B. Liton, W. Wang, B. Chamblin, J. Wakefield, R. Ramabhadran, and D. L. Epstein. “Gene transfer to the trabecular meshwork and anterior segment of living rat eyes using lentiviral vectors.” In Investigative Ophthalmology & Visual Science, 45:U776–U776. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
-
Gonzalez, P., P. B. Liton, M. Caballero, P. Challa, W. Wang, and D. L. Epstein. “Stress-induced proteasome inhibition and cellular senescence in trabecular meshwork cells, and their potential roles in glaucoma pathophysiology.” In Investigative Ophthalmology & Visual Science, 45:U435–U435. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
-
Liton, P. B., P. Challa, X. Liu, M. Caballero, W. D. Stamer, and D. L. Epstein. “Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase-3-like-1 promoter in adenoviral-mediated gene transfer experiments.” In Investigative Ophthalmology & Visual Science, 45:U432–U432. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
-
Liu, X., P. Gonzalez, P. B. Liton, P. Challa, M. Bodman, and D. L. Epstein. “Induction of the TGF-beta-1 gene promoter in the trabecular meshwork after mechanical stress: potential implications in glaucoma pathophysiology.” In Investigative Ophthalmology & Visual Science, 45:U188–U188. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
-
Gonzalez, P., P. B. Liton, M. Caballero, D. W. Stamer, X. Liu, M. G. Bodman, and D. L. Epstein. “Search for promoters to target gene expression in selected cells of the outflow pathway.” In Investigative Ophthalmology & Visual Science, 44:U305–U305. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.Link to Item
-
Liton, P. B., M. Caballero, P. Gonzalez, and D. L. Epstein. “Induction of cytokine release after mechanical stress in trabecular meshwork cells.” In Investigative Ophthalmology & Visual Science, 44:U308–U308. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.Link to Item
-
Challa, P., P. Gonzalez, P. B. Liton, M. Caballero, and D. L. Epstein. “Gene expression profile in a novel cell type in primary cultures of human trabecular meshwork.” In Investigative Ophthalmology & Visual Science, 44:U131–U131. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.Link to Item
-
Liton, P. B., M. Caballero, P. Gonzalez, and D. L. Epstein. “Identification of a novel cell type in primary cultures of human trabecular meshwork.” In Investigative Ophthalmology & Visual Science, 43:U230–U230. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
-
-
- Teaching & Mentoring
-
Recent Courses
- PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2023
- PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2022
- PATHOL 793: Research Independent Study 2022
- PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2021
- PATHOL 793: Research Independent Study 2021
-
Advising & Mentoring
Available to mentor:
- PhD
- Scholarly, Clinical, & Service Activities
-
Service to the Profession
- ISER/Brightfocus Glaucoma Meeting Program Member. 2021 2021
- Women in Autophay Annual Meeting Program Committee Member. 2021 2021
- eLife Editorial. 2021 2021
- ARVO Annual Meeting Program Committee Member. 2020 2020
- Member Brightfocus Foundation Study Section. 2018 2018
- Member Biology of Visual Systems Study Section. 2017 2017
-
Service to Duke
- IACUC. 2006 2006
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
