Scholars@Duke

Noncoding RNAs Regulating Cancer Signaling Network.

Publication ,  Journal Article
Hu, J; Markowitz, GJ; Wang, X
Published in: Adv Exp Med Biol
2016
Published version (DOI) Link to item

The cellular signaling network plays a fundamental role during development and disease, especially cancer progression. By deregulating signaling pathways, cancer cells acquire hallmarks of the disease including uncontrolled proliferation, evasion from cell death, activation of angiogenesis, invasion, and metastasis. Noncoding RNAs make substantial contributions to regulating signal transduction in cancer, thereby promoting or suppressing different biological processes during tumorigenesis. This chapter provides an overview on the regulatory functions of noncoding RNAs in the signaling network in cancer cells. It summarizes examples of noncoding RNAs that act as oncogenes or tumor-suppressing genes involved in key signal pathways as well as signal crosstalk in cancer cells.

Duke Scholars

Xiao-Fan Wang
Author Xiao-Fan Wang Pharmacology & Cancer Biology
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Adv Exp Med Biol

DOI

10.1007/978-981-10-1498-7_11

ISSN

0065-2598

Publication Date

2016

Volume

927

Start / End Page

297 / 315

Location

United States

Related Subject Headings

  • Signal Transduction
  • RNA, Long Noncoding
  • Neovascularization, Pathologic
  • Neoplasms
  • Humans
  • General & Internal Medicine
  • Gene Expression Regulation, Neoplastic
  • Carcinogenesis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, J., Markowitz, G. J., & Wang, X. (2016). Noncoding RNAs Regulating Cancer Signaling Network. Adv Exp Med Biol, 927, 297–315. https://doi.org/10.1007/978-981-10-1498-7_11
Hu, Jing, Geoffrey J. Markowitz, and Xiaofan Wang. “Noncoding RNAs Regulating Cancer Signaling Network.” Adv Exp Med Biol 927 (2016): 297–315. https://doi.org/10.1007/978-981-10-1498-7_11.
Hu J, Markowitz GJ, Wang X. Noncoding RNAs Regulating Cancer Signaling Network. Adv Exp Med Biol. 2016;927:297–315.
Hu, Jing, et al. “Noncoding RNAs Regulating Cancer Signaling Network.” Adv Exp Med Biol, vol. 927, 2016, pp. 297–315. Pubmed, doi:10.1007/978-981-10-1498-7_11.
Hu J, Markowitz GJ, Wang X. Noncoding RNAs Regulating Cancer Signaling Network. Adv Exp Med Biol. 2016;927:297–315.

Published In

Adv Exp Med Biol

DOI

10.1007/978-981-10-1498-7_11

ISSN

0065-2598

Publication Date

2016

Volume

927

Start / End Page

297 / 315

Location

United States

Related Subject Headings

  • Signal Transduction
  • RNA, Long Noncoding
  • Neovascularization, Pathologic
  • Neoplasms
  • Humans
  • General & Internal Medicine
  • Gene Expression Regulation, Neoplastic
  • Carcinogenesis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences