Xiao-Fan Wang
Donald and Elizabeth Cooke Distinguished Professor of Cancer Research, in the School of Medicine
The current research in the Wang laboratory mainly focuses on the elucidation of molecular nature and signaling mechanisms associated with the initiation of cellular senescence. In addition, we continue to study changes in tumor microenvironment that promotes tumor progression and metastasis, particularly how tumor cells interact with the immune system. Ultimately, we hope that our studies in these areas to lead to the development of novel therapeutics for the treatment of various types of human cancer.
Current Appointments & Affiliations
- Donald and Elizabeth Cooke Distinguished Professor of Cancer Research, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2009
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2003
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1992
Contact Information
- C218 Lev Sci Res Ctr, Durham, NC 27708
- Duke Box 3813, Durham, NC 27710
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wang0011@mc.duke.edu
(919) 681-4861
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Wang Lab Website
- Background
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Education, Training, & Certifications
- Ph.D., University of California - Los Angeles 1986
- B.S., Wuhan University (China) 1982
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Previous Appointments & Affiliations
- Associate Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 1998 - 2003
- Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 1998
- Recognition
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Awards & Honors
- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Roles of mitochondrial dynamics and mtDNA in senescence awarded by National Institutes of Health 2022 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- NGF recruits nerve fibers to reprogram an immunosuppressive microenvironment in melanoma awarded by National Institutes of Health 2020 - 2025
- Synthetic lethality by targeting the core senescent mechanism in lung cancer. awarded by National Institutes of Health 2020 - 2025
- Targeting UHRF1 in combinational immunotherapy awarded by National Institutes of Health 2019 - 2023
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- Examining Biosynthesis and NAD+ Demand in the Warburg Effect awarded by National Institutes of Health 2019 - 2022
- Understanding methionine metabolism and its therapeutic potential in cancer awarded by National Institutes of Health 2019 - 2021
- Role of hedgehog signaling in tumor-associated macrophage polarization awarded by National Institutes of Health 2017 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Analysis of mechanisms associated with Her2-positive breast cancer resistance to therapy awarded by Department of Defense 2016 - 2019
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- The anti-senescence activity of trefoil factor 1 awarded by National Institutes of Health 2012 - 2018
- The Roles of MicroRNAs in Glioblastoma awarded by National Institutes of Health 2012 - 2017
- Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Molecular determinants underlying herceptin sensitivity and resistance awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Determine the potential therapeutic effect of HDAC6 inhibitors in inhibiting breast cancer metastasis and glioblastoma growth in mouse models awarded by Acetylon Pharmaceuticals, Inc. 2014 - 2015
- The role of TGF-beta in tumorigenesis awarded by National Institutes of Health 2010 - 2015
- 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
- Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer awarded by National Institutes of Health 2011 - 2013
- The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma awarded by National Institutes of Health 2006 - 2012
- Mechanisms of TGF-B/Smad Signaling awarded by National Institutes of Health 2008 - 2012
- TGFBI and tumorigenesis awarded by National Institutes of Health 2006 - 2011
- Rad17- & p53-mediated apoptotic pathways in response to DNA damage awarded by National Institutes of Health 2006 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
- Molecular Mechanisms of SPARC Mediated Glioma Invasion awarded by National Institutes of Health 2006 - 2008
- TGF-Beta Signaling in MSCs and Osteoblast awarded by National Institutes of Health 2004 - 2008
- Analysis of Rad17-mediated Checkpoint Signaling awarded by National Institutes of Health 2002 - 2008
- Analysis of the Functional Role of TPF in Tumorigenesis awarded by National Institutes of Health 2000 - 2005
- The Role Of Tumor Supressor Smads In Tgf-B Signaling awarded by National Institutes of Health 1998 - 2004
- Same Same awarded by US Army Medical Research 1999 - 2002
- The Role Of Tgfb In Brain Tumors awarded by National Institutes of Health 1998 - 2001
- Tgf-Beta Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1995 - 2001
- Tgf-B Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1996 - 1999
- Examination Of Tgfb Induced Cell Death Pathway awarded by National Institutes of Health 1995 - 1998
- Analysis Of Tgf-B Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1994 - 1995
- Analysis Of Tgf Beta Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1993 - 1995
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External Relationships
- Cancer Science Institute of Singapore
- Cell Research, Nature Publishing Group
- Genetron Health Holdings Ltd
- Grant Review Panel, Starr Cancer Consortium, New York
- Institute of Immuno-chemistry, Shanghai Tech University
- Institute of Life Sciences, Zhejiang University
- Institute of Nutrition and Health, Chiese Academy of Sciences, Shanghai
- Joint Center for Life Sciences at Peking University and Tshinghua University
- Keymed Biosciences Inc.
- Laboratory of Basic Medical Research, Peking Union Medical College
- Laboratory of Regenerative Medicine, Guangdong Province
- Life and Medical Sciences Branch, University of Science and Technology of China
- National Science Review, Editorial Board
- Puhe Biophama
- Research Grants Council of Hong Kong
- Review Panel, Cancer Prevention & Research Institute of Texas
- Science China, Life Sciences
- Shanghai Epican Genetech
- TCRCure Biopharma
- Upstream Biotechnology
- Westlake University
- Wuhan University Taikang Medical Research Institute
- Xinchuang Foundation
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lin, Chao-Chieh, Jin Yan, Meghan D. Kapur, Kristi L. Norris, Cheng-Wei Hsieh, De Huang, Nicolas Vitale, et al. “Parkin coordinates mitochondrial lipid remodeling to execute mitophagy.” Embo Rep 23, no. 12 (December 6, 2022): e55191. https://doi.org/10.15252/embr.202255191.Full Text Link to Item
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Wang, E., K. Xiang, Y. Zhang, and X. F. Wang. “Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models.” Journal of the National Cancer Center 2, no. 4 (December 1, 2022): 263–76. https://doi.org/10.1016/j.jncc.2022.10.001.Full Text
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Long, Haixia, Qingzhu Jia, Liuyang Wang, Wenfeng Fang, Zhongyu Wang, Tao Jiang, Fei Zhou, et al. “Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy.” Cancer Cell 40, no. 6 (June 13, 2022): 674-693.e7. https://doi.org/10.1016/j.ccell.2022.04.018.Full Text Link to Item
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Huang, De, Yan Wang, J Will Thompson, Tao Yin, Peter B. Alexander, Diyuan Qin, Poorva Mudgal, et al. “Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.” Nat Cell Biol 24, no. 2 (February 2022): 230–41. https://doi.org/10.1038/s41556-021-00820-9.Full Text Open Access Copy Link to Item
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Huang, D., P. B. Alexander, Q. J. Li, and X. F. Wang. “GABAergic signaling beyond synapses: an emerging target for cancer therapy.” Trends in Cell Biology, January 1, 2022. https://doi.org/10.1016/j.tcb.2022.08.004.Full Text
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Ma, Ning, Yi-Kang Wang, Sheng Xu, Qian-Zhi Ni, Qian-Wen Zheng, Bing Zhu, Hui-Jun Cao, et al. “PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.” Nat Commun 12, no. 1 (May 24, 2021): 3059. https://doi.org/10.1038/s41467-021-23285-8.Full Text Link to Item
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Christian, Laura S., Liuyang Wang, Bryan Lim, Dachuan Deng, Haiyang Wu, Xiao-Fan Wang, and Qi-Jing Li. “Resident memory T cells in tumor-distant tissues fortify against metastasis formation.” Cell Rep 35, no. 6 (May 11, 2021): 109118. https://doi.org/10.1016/j.celrep.2021.109118.Full Text Link to Item
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Wang, Guoping, Poorva Mudgal, Liuyang Wang, Timothy Wai Ho Shuen, Haiyang Wu, Peter B. Alexander, Who-Whong Wang, et al. “TCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinoma.” Oncoimmunology 10, no. 1 (2021): 1955545. https://doi.org/10.1080/2162402X.2021.1955545.Full Text Link to Item
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Yuan, Lifeng, Peter B. Alexander, and Xiao-Fan Wang. “Cellular senescence: from anti-cancer weapon to anti-aging target.” Sci China Life Sci 63, no. 3 (March 2020): 332–42. https://doi.org/10.1007/s11427-019-1629-6.Full Text Link to Item
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Yuan, Yan-Mei, Ning Ma, Er-Bin Zhang, Tian-Wei Chen, Hao Jiang, Fen-Fen Yin, Jing-Jing Wang, et al. “BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.” Oncogene 38, no. 48 (November 2019): 7281–93. https://doi.org/10.1038/s41388-019-0943-y.Full Text Link to Item
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Chen, Tian-Wei, Fen-Fen Yin, Yan-Mei Yuan, Dong-Xian Guan, Erbin Zhang, Feng-Kun Zhang, Hao Jiang, et al. “CHML promotes liver cancer metastasis by facilitating Rab14 recycle.” Nat Commun 10, no. 1 (June 7, 2019): 2510. https://doi.org/10.1038/s41467-019-10364-0.Full Text Link to Item
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Xiao, Fu-Hui, Xiao-Qiong Chen, Qin Yu, Yunshuang Ye, Yao-Wen Liu, Dongjing Yan, Li-Qin Yang, et al. “Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians.” Genome Research 28, no. 11 (November 2018): 1601–10. https://doi.org/10.1101/gr.220780.117.Full Text
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Ding, Yi, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H. Lin, Gehao Liang, et al. “Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.” Nat Commun 9, no. 1 (October 15, 2018): 4274. https://doi.org/10.1038/s41467-018-06651-x.Full Text Open Access Copy Link to Item
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Chong, Mengyang, Tao Yin, Rui Chen, Handan Xiang, Lifeng Yuan, Yi Ding, Christopher C. Pan, et al. “CD36 initiates the secretory phenotype during the establishment of cellular senescence.” Embo Rep 19, no. 6 (June 2018). https://doi.org/10.15252/embr.201745274.Full Text Link to Item
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Yuan, Lifeng, Linhui Zhai, Lili Qian, De Huang, Yi Ding, Handan Xiang, Xiaojing Liu, et al. “Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death.” Cell Res 28, no. 6 (June 2018): 625–43. https://doi.org/10.1038/s41422-018-0043-5.Full Text Link to Item
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Li, Jing-Jing, Hong-Kun Yin, Dong-Xian Guan, Jiang-Sha Zhao, Yu-Xiong Feng, Yue-Zhen Deng, Xiang Wang, et al. “Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.” Br J Cancer 118, no. 10 (May 2018): 1337–48. https://doi.org/10.1038/s41416-018-0077-y.Full Text Link to Item
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Deng, Yue-Zhen, Zhen Cai, Shuo Shi, Hao Jiang, Yu-Rong Shang, Ning Ma, Jing-Jing Wang, et al. “Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.” J Exp Med 215, no. 1 (January 2, 2018): 177–95. https://doi.org/10.1084/jem.20170399.Full Text Link to Item
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Zhang, Yun, Peter B. Alexander, and Xiao-Fan Wang. “TGF-β Family Signaling in the Control of Cell Proliferation and Survival.” Cold Spring Harb Perspect Biol 9, no. 4 (April 3, 2017). https://doi.org/10.1101/cshperspect.a022145.Full Text Link to Item
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Alexander, Peter B., Rui Chen, Chang Gong, Lifeng Yuan, Jeff S. Jasper, Yi Ding, Geoffrey J. Markowitz, et al. “Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.” J Biol Chem 292, no. 2 (January 13, 2017): 748–59. https://doi.org/10.1074/jbc.M116.754960.Full Text Open Access Copy Link to Item
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Xiang, Handan, Lifeng Yuan, Xia Gao, Peter B. Alexander, Omar Lopez, Calvin Lau, Yi Ding, et al. “UHRF1 is required for basal stem cell proliferation in response to airway injury.” Cell Discov 3 (2017): 17019. https://doi.org/10.1038/celldisc.2017.19.Full Text Open Access Copy Link to Item
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Liu, Zhengxue, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J. Barnard, et al. “Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.” Oncotarget 7, no. 40 (October 4, 2016): 64878–85. https://doi.org/10.18632/oncotarget.11713.Full Text Link to Item
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Hrgovic, Igor, Monika Doll, Johannes Kleemann, Xiao-Fan Wang, Nadja Zoeller, Andreas Pinter, Stefan Kippenberger, Roland Kaufmann, and Markus Meissner. “The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.” Bmc Cancer 16, no. 1 (September 30, 2016): 763. https://doi.org/10.1186/s12885-016-2807-y.Full Text Link to Item
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Hu, Jing, and Xiao-Fan Wang. “HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.” Cell Cycle 15, no. 15 (August 2, 2016): 1939–40. https://doi.org/10.1080/15384101.2016.1181877.Full Text Link to Item
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Bao, Wen-Dai, Yao Fan, Yue-Zhen Deng, Ling-Yun Long, Jing-Jing Wang, Dong-Xian Guan, Zhen-Yu Qian, et al. “Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis.” J Hepatol 65, no. 1 (July 2016): 137–45. https://doi.org/10.1016/j.jhep.2016.03.007.Full Text Link to Item
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Markowitz, Geoffrey J., Pengyuan Yang, Jing Fu, Gregory A. Michelotti, Rui Chen, Jianhua Sui, Bin Yang, et al. “Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.” Cancer Res 76, no. 8 (April 15, 2016): 2394–2405. https://doi.org/10.1158/0008-5472.CAN-15-1548.Full Text Link to Item
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Xu, Xin, Yun Zhang, Jeff Jasper, Erik Lykken, Peter B. Alexander, Geoffrey J. Markowitz, Donald P. McDonnell, Qi-Jing Li, and Xiao-Fan Wang. “MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.” Oncotarget 7, no. 15 (April 12, 2016): 20381–94. https://doi.org/10.18632/oncotarget.7953.Full Text Link to Item
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Valesky, Eva Maria, Igor Hrgovic, Monika Doll, Xiao-Fan Wang, Andreas Pinter, Johannes Kleemann, Roland Kaufmann, Stefan Kippenberger, and Markus Meissner. “Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.” Exp Dermatol 25, no. 3 (March 2016): 200–205. https://doi.org/10.1111/exd.12907.Full Text Link to Item
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Hu, Jing, Tao Sun, Hui Wang, Zhengxin Chen, Shuai Wang, Lifeng Yuan, Tingyu Liu, et al. “MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.” Cancer Cell 29, no. 1 (January 11, 2016): 49–60. https://doi.org/10.1016/j.ccell.2015.12.005.Full Text Open Access Copy Link to Item
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Hu, Jing, Geoffrey J. Markowitz, and Xiaofan Wang. “Noncoding RNAs Regulating Cancer Signaling Network.” Adv Exp Med Biol 927 (2016): 297–315. https://doi.org/10.1007/978-981-10-1498-7_11.Full Text Link to Item
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Hu, Jing, Geoffrey Markowitz, and Xiao-Fan Wang. “Isolation of Glioma-Initiating Cells for Biological Study.” Adv Exp Med Biol 899 (2016): 197–209. https://doi.org/10.1007/978-3-319-26666-4_11.Full Text Link to Item
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Yang, Pengyuan, Yun Zhang, Geoffrey J. Markowitz, Xing Guo, and Xiao-Fan Wang. “TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.” Methods Mol Biol 1344 (2016): 325–39. https://doi.org/10.1007/978-1-4939-2966-5_21.Full Text Link to Item
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Biernacka, Anna, Michele Cavalera, Junhong Wang, Ilaria Russo, Arti Shinde, Ping Kong, Carlos Gonzalez-Quesada, et al. “Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.” Circ Heart Fail 8, no. 4 (July 2015): 788–98. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001963.Full Text Link to Item
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Alexander, Peter B., and Xiao-Fan Wang. “Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies.” Front Med 9, no. 2 (June 2015): 134–38. https://doi.org/10.1007/s11684-015-0396-9.Full Text Link to Item
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Zhang, Yun, and Xiao-Fan Wang. “A niche role for cancer exosomes in metastasis.” Nat Cell Biol 17, no. 6 (June 2015): 709–11. https://doi.org/10.1038/ncb3181.Full Text Link to Item
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Dai, Xiaohua, Jianbin Shen, Neeraja Priyanka Annam, Hong Jiang, Edi Levi, Charles M. Schworer, Gerard Tromp, et al. “SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.” Sci Rep 5 (May 18, 2015): 10180. https://doi.org/10.1038/srep10180.Full Text Link to Item
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Markowitz, Geoffrey J., Gregory A. Michelotti, Anna Mae Diehl, and Xiao-Fan Wang. “Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma.” Sci Bull (Beijing) 60, no. 8 (April 1, 2015): 762–72. https://doi.org/10.1007/s11434-015-0772-5.Full Text Link to Item
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Alexander, Peter B., Lifeng Yuan, Pengyuan Yang, Tao Sun, Rui Chen, Handan Xiang, Jiekai Chen, Haoyu Wu, Daniel R. Radiloff, and Xiao-Fan Wang. “EGF promotes mammalian cell growth by suppressing cellular senescence.” Cell Res 25, no. 1 (January 2015): 135–38. https://doi.org/10.1038/cr.2014.141.Full Text Link to Item
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Zhang, Yun, and Xiao-Fan Wang. “Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.” Cancer Metastasis Rev 33, no. 4 (December 2014): 1011–16. https://doi.org/10.1007/s10555-014-9526-0.Full Text Link to Item
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Wang, Xiao-Fan, and Firouzeh Korangy. “Intrahepatic landscape of regulatory T-cell subsets in chronically HCV-infected patients with cirrhosis and HCC.” Hepatology (Baltimore, Md.) 60, no. 5 (November 2014): 1461–62. https://doi.org/10.1002/hep.27271.Full Text
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Wang, Hui, Tao Sun, Jing Hu, Rui Zhang, Yanhua Rao, Shuai Wang, Rui Chen, et al. “miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.” J Clin Invest 124, no. 10 (October 2014): 4489–4502. https://doi.org/10.1172/JCI75284.Full Text Link to Item
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Yang, Pengyuan, Geoffrey J. Markowitz, and Xiao-Fan Wang. “The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma.” Natl Sci Rev 1, no. 3 (July 14, 2014): 396–412. https://doi.org/10.1093/nsr/nwu038.Full Text Link to Item
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Wang, Qinhong, Michael Goldstein, Peter Alexander, Timothy P. Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B. Kastan, and Xiao-Fan Wang. “Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.” Embo J 33, no. 8 (April 16, 2014): 862–77. https://doi.org/10.1002/embj.201386064.Full Text Link to Item
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Zhang, Yun, Pengyuan Yang, and Xiao-Fan Wang. “Microenvironmental regulation of cancer metastasis by miRNAs.” Trends Cell Biol 24, no. 3 (March 2014): 153–60. https://doi.org/10.1016/j.tcb.2013.09.007.Full Text Link to Item
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Hu, Jim, and Xiao-Fan Wang. “COUP-TFII and AKT are cancer targets pursued by SCBA award winners.” Cell Biosci 4, no. 1 (2014): 57. https://doi.org/10.1186/2045-3701-4-57.Full Text Link to Item
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Kellenberger, Terese, Søren Krag, Carl Christian Danielsen, Xiao-Fan Wang, Jens Randel Nyengaard, Lea Pedersen, Chuanxu Yang, Shan Gao, and Lise Wogensen. “Differential effects of Smad3 targeting in a murine model of chronic kidney disease.” Physiol Rep 1, no. 7 (December 1, 2013): e00181. https://doi.org/10.1002/phy2.181.Full Text Link to Item
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Guo, Xing, and Xiao-Fan Wang. “A P(E)RM(I)T for BMP signaling.” Mol Cell 51, no. 1 (July 11, 2013): 1–2. https://doi.org/10.1016/j.molcel.2013.06.016.Full Text Link to Item
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Zhang, Yun, Pengyuan Yang, Tao Sun, Dong Li, Xin Xu, Yaocheng Rui, Chaoran Li, et al. “miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.” Nat Cell Biol 15, no. 3 (March 2013): 284–94. https://doi.org/10.1038/ncb2690.Full Text Link to Item
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Curtis, Valerie F., Hui Wang, Pengyuan Yang, Roger E. McLendon, Xiaohan Li, Qun-Yong Zhou, and Xiao-Fan Wang. “A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.” Plos One 8, no. 1 (2013): e54916. https://doi.org/10.1371/journal.pone.0054916.Full Text Link to Item
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Guo, Xing, and Xiao-Fan Wang. “A mediator lost in the war on cancer.” Cell 151, no. 5 (November 21, 2012): 927–29. https://doi.org/10.1016/j.cell.2012.11.003.Full Text Link to Item
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Zhang, Yuefan, Jun Chen, Fan Li, Dong Li, Qinhui Xiong, Yang Lin, Dazhi Zhang, Xiao-Fan Wang, Pengyuan Yang, and Yao-Cheng Rui. “A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway.” Stroke 43, no. 10 (October 2012): 2764–73. https://doi.org/10.1161/STROKEAHA.112.657908.Full Text Link to Item
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Yang, Pengyuan, Qi-Jing Li, Yuxiong Feng, Yun Zhang, Geoffrey J. Markowitz, Shanglei Ning, Yuezhen Deng, et al. “TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.” Cancer Cell 22, no. 3 (September 11, 2012): 291–303. https://doi.org/10.1016/j.ccr.2012.07.023.Full Text Link to Item
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Guo, Xing, and Xiao-Fan Wang. “New secrets behind bone metastasis.” Cell Res 22, no. 9 (September 2012): 1309–11. https://doi.org/10.1038/cr.2012.99.Full Text Link to Item
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Xu, Ying-Ping, Yuling Shi, Zhi-Zhong Cui, Hong H. Jiang, Li Li, Xiao-Fan Wang, Li Zhou, and Qing-Sheng Mi. “TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development.” J Invest Dermatol 132, no. 8 (August 2012): 2106–9. https://doi.org/10.1038/jid.2012.71.Full Text Link to Item
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Wakeman, Timothy P., Qinhong Wang, Junjie Feng, and Xiao-Fan Wang. “Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.” Embo J 31, no. 9 (May 2, 2012): 2169–81. https://doi.org/10.1038/emboj.2012.50.Full Text Link to Item
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Chen, Ye-Guang, Zhongwei Li, and Xiao-Fan Wang. “Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.” Cell Stem Cell 10, no. 3 (March 2, 2012): 231–32. https://doi.org/10.1016/j.stem.2012.02.008.Full Text Link to Item
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Yong, Sheila T., and Xiao-Fan Wang. “A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.” Plos One 7, no. 6 (2012): e38085. https://doi.org/10.1371/journal.pone.0038085.Full Text Link to Item
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Tapia-González, S., R. M. Giráldez-Pérez, M. I. Cuartero, M. J. Casarejos, M. A. Mena, X. F. Wang, and A. Sánchez-Capelo. “Dopamine and α-synuclein dysfunction in Smad3 null mice.” Molecular Neurodegeneration 6 (December 1, 2011): 72.
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Tapia-González, Silvia, Rosa M. Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, and Amelia Sánchez-Capelo. “Dopamine and α-synuclein dysfunction in Smad3 null mice.” Mol Neurodegener 6 (October 13, 2011): 72. https://doi.org/10.1186/1750-1326-6-72.Full Text Link to Item
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Radiloff, Daniel R., Timothy P. Wakeman, Junjie Feng, Stephen Schilling, Edward Seto, and Xiao-Fan Wang. “Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.” Proc Natl Acad Sci U S A 108, no. 16 (April 19, 2011): 6591–96. https://doi.org/10.1073/pnas.1017269108.Full Text Link to Item
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Wakeman, Timothy P., Junjie Feng, and Xiao-fan Wang. “Abstract 2482: Bat3 facilitates histone H3 lysine 79 dimethylation by DOT1L to promote ionizing radiation-induced 53BP1 foci formation during G1- and G2-phases of the cell cycle.” Cancer Research 71, no. 8_Supplement (April 15, 2011): 2482–2482. https://doi.org/10.1158/1538-7445.am2011-2482.Full Text
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Wang, Hui, Xiao-Fan Wang, Jeremy Rich, Qinhong Wang, and Anita Hjelmeland. “Abstract 3311: IL6-Stat3 signaling promotes glioma stem cell (GSC) survival under hypoxia environment through inhibition of cell-death inducing gene Bnip3.” Cancer Research 71, no. 8_Supplement (April 15, 2011): 3311–3311. https://doi.org/10.1158/1538-7445.am2011-3311.Full Text
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Feng, Yu-Xiong, Tao Wang, Yue-Zhen Deng, Pengyuan Yang, Jing-Jing Li, Dong-Xian Guan, Fan Yao, et al. “Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model.” Hepatology 53, no. 2 (February 2011): 483–92. https://doi.org/10.1002/hep.24075.Full Text Link to Item
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D’Souza, C. A., J. W. Kronstad, G. Taylor, R. Warren, M. Yuen, G. Hu, W. H. Jung, et al. “Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.” Mbio 2, no. 1 (2011): e00342–e00310. https://doi.org/10.1128/mBio.00342-10.Full Text Link to Item
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Zhao, Jiang-Sha, Wen-Jie Li, Di Ge, Pei-Jing Zhang, Jing-Jing Li, Chun-Lai Lu, Xiao-Dan Ji, et al. “Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44.” Plos One 6, no. 6 (2011): e21419. https://doi.org/10.1371/journal.pone.0021419.Full Text Link to Item
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Dobaczewski, Marcin, Marcin Bujak, Na Li, Carlos Gonzalez-Quesada, Leonardo H. Mendoza, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.” Circ Res 107, no. 3 (August 6, 2010): 418–28. https://doi.org/10.1161/CIRCRESAHA.109.216101.Full Text Link to Item
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Zhang, Liyong, Chi-Hoon Park, Jing Wu, Hyun Kim, Weijun Liu, Takeo Fujita, Manimalha Balasubramani, Emanuel M. Schreiber, Xiao-Fan Wang, and Yong Wan. “Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.” Embo J 29, no. 10 (May 19, 2010): 1726–37. https://doi.org/10.1038/emboj.2010.55.Full Text Link to Item
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Feng, Yu-Xiong, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, and Dong Xie. “Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway.” Hepatology 51, no. 2 (February 2010): 535–44. https://doi.org/10.1002/hep.23313.Full Text Link to Item
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Wang, Jialiang, Timothy P. Wakeman, Justin D. Lathia, Anita B. Hjelmeland, Xiao-Fan Wang, Rebekah R. White, Jeremy N. Rich, and Bruce A. Sullenger. “Notch promotes radioresistance of glioma stem cells.” Stem Cells 28, no. 1 (January 2010): 17–28. https://doi.org/10.1002/stem.261.Full Text Link to Item
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Chen, Ye-Guang, and Xiao-Fan Wang. “Finale: the last minutes of Smads.” Cell 139, no. 4 (November 13, 2009): 658–60. https://doi.org/10.1016/j.cell.2009.10.038.Full Text Link to Item
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Feng, Junjie, Timothy Wakeman, Sheila Yong, Xiaohua Wu, Sally Kornbluth, and Xiao-Fan Wang. “Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress.” Mol Cell Biol 29, no. 21 (November 2009): 5696–5709. https://doi.org/10.1128/MCB.00191-09.Full Text Link to Item
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Hu, Guohong, Yibin Kang, and Xiao-Fan Wang. “From breast to the brain: unraveling the puzzle of metastasis organotropism.” J Mol Cell Biol 1, no. 1 (October 2009): 3–5. https://doi.org/10.1093/jmcb/mjp005.Full Text Link to Item
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Wang, Hui, Justin D. Lathia, Qiulian Wu, Jialiang Wang, Zhizhong Li, John M. Heddleston, Christine E. Eyler, et al. “Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.” Stem Cells 27, no. 10 (October 2009): 2393–2404. https://doi.org/10.1002/stem.188.Full Text Link to Item
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Schilling, Stephen H., Anita B. Hjelmeland, Daniel R. Radiloff, Irwin M. Liu, Timothy P. Wakeman, Jeffrey R. Fielhauer, Erika H. Foster, et al. “NDRG4 is required for cell cycle progression and survival in glioblastoma cells.” J Biol Chem 284, no. 37 (September 11, 2009): 25160–69. https://doi.org/10.1074/jbc.M109.012484.Full Text Link to Item
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Jardim, Melanie J., Qinhong Wang, Ryohei Furumai, Timothy Wakeman, Barbara K. Goodman, and Xiao-Fan Wang. “Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.” Mol Biol Cell 20, no. 17 (September 2009): 3801–9. https://doi.org/10.1091/mbc.e09-04-0303.Full Text Link to Item
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Liu, Irwin M., Stephen H. Schilling, Kristin A. Knouse, Lisa Choy, Rik Derynck, and Xiao-Fan Wang. “TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.” Embo J 28, no. 2 (January 21, 2009): 88–98. https://doi.org/10.1038/emboj.2008.266.Full Text Link to Item
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Chen, Ye-Guang, and Xiao-Fan Wang. “A special issue on TGF-beta signaling.” Cell Res 19, no. 1 (January 2009): 1–2. https://doi.org/10.1038/cr.2009.3.Full Text Link to Item
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Guo, Xing, and Xiao-Fan Wang. “Signaling cross-talk between TGF-beta/BMP and other pathways.” Cell Res 19, no. 1 (January 2009): 71–88. https://doi.org/10.1038/cr.2008.302.Full Text Link to Item
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Guo, X., D. S. Waddell, W. Wang, Z. Wang, N. T. Liberati, S. Yong, X. Liu, and X. -. F. Wang. “Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.” Oncogene 27, no. 58 (December 11, 2008): 7235–47. https://doi.org/10.1038/onc.2008.337.Full Text Link to Item
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Lee, Yi-Shan, Kian-Huat Lim, Xing Guo, Yoshiharu Kawaguchi, Yasheng Gao, Tomasa Barrientos, Peter Ordentlich, Xiao-Fan Wang, Christopher M. Counter, and Tso-Pang Yao. “The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.” Cancer Res 68, no. 18 (September 15, 2008): 7561–69. https://doi.org/10.1158/0008-5472.CAN-08-0188.Full Text Link to Item
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Ma, Chaoyu, and Xiao-Fan Wang. “In vitro assays for the extracellular matrix protein-regulated extravasation process.” Csh Protoc 2008 (August 1, 2008): pdb.prot5034. https://doi.org/10.1101/pdb.prot5034.Full Text Link to Item
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Guo, Jessie Yanxiang, Ayumi Yamada, Taisuke Kajino, Judy Qiju Wu, Wanli Tang, Christopher D. Freel, Junjie Feng, et al. “Aven-dependent activation of ATM following DNA damage.” Curr Biol 18, no. 13 (July 8, 2008): 933–42. https://doi.org/10.1016/j.cub.2008.05.045.Full Text Link to Item
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Ma, Chaoyu, Yu Rong, Daniel R. Radiloff, Michael B. Datto, Barbara Centeno, Shideng Bao, Anthony Wai Ming Cheng, et al. “Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.” Genes Dev 22, no. 3 (February 1, 2008): 308–21. https://doi.org/10.1101/gad.1632008.Full Text Link to Item
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Guo, Xing, Alejandro Ramirez, David S. Waddell, Zhizhong Li, Xuedong Liu, and Xiao-Fan Wang. “Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.” Genes Dev 22, no. 1 (January 1, 2008): 106–20. https://doi.org/10.1101/gad.1590908.Full Text Link to Item
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Bujak, Marcin, Guofeng Ren, Hyuk Jung Kweon, Marcin Dobaczewski, Anilkumar Reddy, George Taffet, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.” Circulation 116, no. 19 (November 6, 2007): 2127–38. https://doi.org/10.1161/CIRCULATIONAHA.107.704197.Full Text Link to Item
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Young, Travis W., Daniel G. Rosen, Fang C. Mei, Nan Li, Jinsong Liu, Xiao-Fan Wang, and Xiaodong Cheng. “Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.” Clin Cancer Res 13, no. 13 (July 1, 2007): 3848–54. https://doi.org/10.1158/1078-0432.CCR-07-0337.Full Text Link to Item
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Margolis, Seth S., Jennifer A. Perry, Craig M. Forester, Leta K. Nutt, Yanxiang Guo, Melanie J. Jardim, Michael J. Thomenius, et al. “Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.” Cell 127, no. 4 (November 17, 2006): 759–73. https://doi.org/10.1016/j.cell.2006.10.035.Full Text Link to Item
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Schilling, Stephen H., Michael B. Datto, and Xiao-Fan Wang. “A phosphatase controls the fate of receptor-regulated Smads.” Cell 125, no. 5 (June 2, 2006): 838–40. https://doi.org/10.1016/j.cell.2006.05.015.Full Text Link to Item
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Jian, Hongyan, Xing Shen, Irwin Liu, Mikhail Semenov, Xi He, and Xiao-Fan Wang. “Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.” Genes Dev 20, no. 6 (March 15, 2006): 666–74. https://doi.org/10.1101/gad.1388806.Full Text Link to Item
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Hjelmeland, Anita B., Mark D. Hjelmeland, Qing Shi, Janet L. Hart, Darell D. Bigner, Xiao-Fan Wang, Christopher D. Kontos, and Jeremy N. Rich. “Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.” Cancer Res 65, no. 24 (December 15, 2005): 11276–81. https://doi.org/10.1158/0008-5472.CAN-05-3016.Full Text Link to Item
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Chow, Edward K., Ryan M. O’connell, Stephen Schilling, Xiao-Fan Wang, Xin-Yuan Fu, and Genhong Cheng. “TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.” Embo J 24, no. 23 (December 7, 2005): 4071–81. https://doi.org/10.1038/sj.emboj.7600867.Full Text Link to Item
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Hjelmeland, Anita Borton, Stephen H. Schilling, Xing Guo, Darryl Quarles, and Xiao-Fan Wang. “Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination.” Mol Cell Biol 25, no. 21 (November 2005): 9460–68. https://doi.org/10.1128/MCB.25.21.9460-9468.2005.Full Text Link to Item
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Zhang, Ji, Shideng Bao, Ryohei Furumai, Katerina S. Kucera, Ambereen Ali, Nicolas M. Dean, and Xiao-Fan Wang. “Protein phosphatase 5 is required for ATR-mediated checkpoint activation.” Mol Cell Biol 25, no. 22 (November 2005): 9910–19. https://doi.org/10.1128/MCB.25.22.9910-9919.2005.Full Text Link to Item
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Howard, Brandon A., Ryohei Furumai, Michael J. Campa, Zahid N. Rabbani, Zeljko Vujaskovic, Xiao-Fan Wang, and Edward F. Patz. “Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.” Cancer Res 65, no. 19 (October 1, 2005): 8853–60. https://doi.org/10.1158/0008-5472.CAN-05-1219.Full Text Link to Item
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Datto, M., and X. -. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.” Cell 121, no. 1 (April 8, 2005): 2–4. https://doi.org/10.1016/j.cell.2005.03.017.Full Text Link to Item
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Chen, Hui, Jianping Sun, Sue Buckley, Cheng Chen, David Warburton, Xiao-Fan Wang, and Wei Shi. “Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema.” Am J Physiol Lung Cell Mol Physiol 288, no. 4 (April 2005): L683–91. https://doi.org/10.1152/ajplung.00298.2004.Full Text Link to Item
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Dang, Tongyun, Shideng Bao, and Xiao-Fan Wang. “Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability.” Genes Cells 10, no. 4 (April 2005): 287–95. https://doi.org/10.1111/j.1365-2443.2005.00840.x.Full Text Link to Item
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Goudar, Ranjit K., Qing Shi, Mark D. Hjelmeland, Stephen T. Keir, Roger E. McLendon, Carol J. Wikstrand, Elizabeth D. Reese, et al. “Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.” Mol Cancer Ther 4, no. 1 (January 2005): 101–12.Link to Item
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Shi, Qing, Shideng Bao, Jill A. Maxwell, Elizabeth D. Reese, Henry S. Friedman, Darell D. Bigner, Xiao-Fan Wang, and Jeremy N. Rich. “Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.” J Biol Chem 279, no. 50 (December 10, 2004): 52200–209. https://doi.org/10.1074/jbc.M409630200.Full Text Link to Item
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Fang, Yanan, Cheng-Chung Tsao, Barbara K. Goodman, Ryohei Furumai, Carlos A. Tirado, Robert T. Abraham, and Xiao-Fan Wang. “ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.” Embo J 23, no. 15 (August 4, 2004): 3164–74. https://doi.org/10.1038/sj.emboj.7600315.Full Text Link to Item
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Waddell, David S., Nicole T. Liberati, Xing Guo, Joshua P. Frederick, and Xiao-Fan Wang. “Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway.” J Biol Chem 279, no. 28 (July 9, 2004): 29236–46. https://doi.org/10.1074/jbc.M400880200.Full Text Link to Item
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Hjelmeland, Mark D., Anita B. Hjelmeland, Sith Sathornsumetee, Elizabeth D. Reese, Michael H. Herbstreith, Nicholas J. Laping, Henry S. Friedman, Darell D. Bigner, Xiao-Fan Wang, and Jeremy N. Rich. “SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.” Mol Cancer Ther 3, no. 6 (June 2004): 737–45.Link to Item
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Ho, Joanne, Chantal de Guise, Christie Kim, Serge Lemay, Xiao-Fan Wang, and Jean-Jacques Lebrun. “Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1.” Cell Signal 16, no. 6 (June 2004): 693–701. https://doi.org/10.1016/j.cellsig.2003.11.002.Full Text Link to Item
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Shao, Rong, Shideng Bao, Xuefang Bai, Carrie Blanchette, Ryan M. Anderson, Tongyun Dang, Mikhail L. Gishizky, Jeffrey R. Marks, and Xiao-Fan Wang. “Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.” Mol Cell Biol 24, no. 9 (May 2004): 3992–4003. https://doi.org/10.1128/MCB.24.9.3992-4003.2004.Full Text Link to Item
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Feinberg, Mark W., Masafumi Watanabe, Maria A. Lebedeva, Ana S. Depina, Jun-ichi Hanai, Tadanori Mammoto, Joshua P. Frederick, Xiao-Fan Wang, Vikas P. Sukhatme, and Mukesh K. Jain. “Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3.” J Biol Chem 279, no. 16 (April 16, 2004): 16388–93. https://doi.org/10.1074/jbc.M309664200.Full Text Link to Item
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Bao, Shideng, Gaoliang Ouyang, Xuefang Bai, Zhi Huang, Chaoyu Ma, Ming Liu, Rong Shao, Ryan M. Anderson, Jeremy N. Rich, and Xiao-Fan Wang. “Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.” Cancer Cell 5, no. 4 (April 2004): 329–39. https://doi.org/10.1016/s1535-6108(04)00081-9.Full Text Link to Item
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Feinberg, Mark W., Koichi Shimizu, Maria Lebedeva, Richard Haspel, Kiyoshi Takayama, Zhiping Chen, Joshua P. Frederick, et al. “Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation.” Circ Res 94, no. 5 (March 19, 2004): 601–8. https://doi.org/10.1161/01.RES.0000119170.70818.4F.Full Text Link to Item
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Frederick, Joshua P., Nicole T. Liberati, David S. Waddell, Yigong Shi, and Xiao-Fan Wang. “Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.” Mol Cell Biol 24, no. 6 (March 2004): 2546–59. https://doi.org/10.1128/MCB.24.6.2546-2559.2004.Full Text Link to Item
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Ali, Ambereen, Ji Zhang, Shideng Bao, Irene Liu, Diane Otterness, Nicholas M. Dean, Robert T. Abraham, and Xiao-Fan Wang. “Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.” Genes Dev 18, no. 3 (February 1, 2004): 249–54. https://doi.org/10.1101/gad.1176004.Full Text Link to Item
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De Siervi, Adriana, Maria Marinissen, Jessica Diggs, Xiao-Fan Wang, Gilles Pages, and Adrian Senderowicz. “Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.” Cancer Res 64, no. 2 (January 15, 2004): 743–50. https://doi.org/10.1158/0008-5472.can-03-2505.Full Text Link to Item
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Chowdhury, Iqbal H., Arash Farhadi, Xiao-Fan Wang, Merlin L. Robb, Deborah L. Birx, and Jerome H. Kim. “Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.” Int J Cancer 107, no. 4 (November 20, 2003): 603–11. https://doi.org/10.1002/ijc.11316.Full Text Link to Item
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Chen, Wei, Kellye C. Kirkbride, Tam How, Christopher D. Nelson, Jinyao Mo, Joshua P. Frederick, Xiao-Fan Wang, Robert J. Lefkowitz, and Gerard C. Blobe. “Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.” Science 301, no. 5638 (September 5, 2003): 1394–97. https://doi.org/10.1126/science.1083195.Full Text Link to Item
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Rich, Jeremy N., Qing Shi, Mark Hjelmeland, Thomas J. Cummings, Chien-Tsun Kuan, Darell D. Bigner, Christopher M. Counter, and Xiao-Fan Wang. “Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model.” J Biol Chem 278, no. 18 (May 2, 2003): 15951–57. https://doi.org/10.1074/jbc.M211498200.Full Text Link to Item
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Chowdhury, Iqbal H., Xiao-Fan Wang, Nathaniel R. Landau, Merlin L. Robb, Victoria R. Polonis, Deborah L. Birx, and Jerome H. Kim. “HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest.” Virology 305, no. 2 (January 20, 2003): 371–77. https://doi.org/10.1006/viro.2002.1777.Full Text Link to Item
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Frederick, Joshua P., and Xiao-Fan Wang. “Smads "freeze" when they ski.” Structure 10, no. 12 (December 2002): 1607–11. https://doi.org/10.1016/s0969-2126(02)00914-0.Full Text Link to Item
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Hsu, S., J. L. Borke, J. B. Lewis, B. Singh, A. C. Aiken, C. T. Huynh, G. S. Schuster, et al. “Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model.” Cell Prolif 35, no. 3 (June 2002): 183–92. https://doi.org/10.1046/j.1365-2184.2002.00237.x.Full Text Link to Item
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Hubbert, Charlotte, Amaris Guardiola, Rong Shao, Yoshiharu Kawaguchi, Akihiro Ito, Andrew Nixon, Minoru Yoshida, Xiao-Fan Wang, and Tso-Pang Yao. “HDAC6 is a microtubule-associated deacetylase.” Nature 417, no. 6887 (May 23, 2002): 455–58. https://doi.org/10.1038/417455a.Full Text Link to Item
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Zhao, Jingsong, Wei Shi, Yan-Ling Wang, Hui Chen, Pablo Bringas, Michael B. Datto, Joshua P. Frederick, Xiao-Fan Wang, and David Warburton. “Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice.” Am J Physiol Lung Cell Mol Physiol 282, no. 3 (March 2002): L585–93. https://doi.org/10.1152/ajplung.00151.2001.Full Text Link to Item
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Borton, A. J., J. P. Frederick, M. B. Datto, X. F. Wang, and R. S. Weinstein. “The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis.” J Bone Miner Res 16, no. 10 (October 2001): 1754–64. https://doi.org/10.1359/jbmr.2001.16.10.1754.Full Text Link to Item
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Schnabl, B., Y. O. Kweon, J. P. Frederick, X. F. Wang, R. A. Rippe, and D. A. Brenner. “The role of Smad3 in mediating mouse hepatic stellate cell activation.” Hepatology 34, no. 1 (July 2001): 89–100. https://doi.org/10.1053/jhep.2001.25349.Full Text Link to Item
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Liberati, N. T., M. Moniwa, A. J. Borton, J. R. Davie, and X. F. Wang. “An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.” J Biol Chem 276, no. 25 (June 22, 2001): 22595–603. https://doi.org/10.1074/jbc.M010778200.Full Text Link to Item
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Bao, S., R. S. Tibbetts, K. M. Brumbaugh, Y. Fang, D. A. Richardson, A. Ali, S. M. Chen, R. T. Abraham, and X. F. Wang. “ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.” Nature 411, no. 6840 (June 21, 2001): 969–74. https://doi.org/10.1038/35082110.Full Text Link to Item
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Shen, X., J. Li, P. P. Hu, D. Waddell, J. Zhang, and X. F. Wang. “The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.” J Biol Chem 276, no. 18 (May 4, 2001): 15362–68. https://doi.org/10.1074/jbc.M009534200.Full Text Link to Item
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Rich, J. N., C. Guo, R. E. McLendon, D. D. Bigner, X. F. Wang, and C. M. Counter. “A genetically tractable model of human glioma formation.” Cancer Res 61, no. 9 (May 1, 2001): 3556–60.Link to Item
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Rich, J., A. Borton, and X. Wang. “Transforming growth factor-beta signaling in cancer.” Microsc Res Tech 52, no. 4 (February 15, 2001): 363–73. https://doi.org/10.1002/1097-0029(20010215)52:4<363::AID-JEMT1021>3.0.CO;2-F.Full Text Link to Item
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Lin, W. W., M. A. Friedman, X. F. Wang, and M. B. Abou-Donia. “Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells.” Brain Res 852, no. 2 (January 10, 2000): 297–304. https://doi.org/10.1016/s0006-8993(99)02104-6.Full Text Link to Item
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Datto, M., and X. F. Wang. “The Smads: transcriptional regulation and mouse models.” Cytokine Growth Factor Rev 11, no. 1–2 (2000): 37–48. https://doi.org/10.1016/s1359-6101(99)00027-1.Full Text Link to Item
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Hu, P. P., X. Shen, D. Huang, Y. Liu, C. Counter, and X. F. Wang. “The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.” J Biol Chem 274, no. 50 (December 10, 1999): 35381–87. https://doi.org/10.1074/jbc.274.50.35381.Full Text Link to Item
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Rich, J. N., M. Zhang, M. B. Datto, D. D. Bigner, and X. F. Wang. “Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.” J Biol Chem 274, no. 49 (December 3, 1999): 35053–58. https://doi.org/10.1074/jbc.274.49.35053.Full Text Link to Item
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Hu, P. P., B. L. Harvat, S. S. Hook, X. Shen, X. F. Wang, and A. R. Means. “c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA.” Mol Endocrinol 13, no. 12 (December 1999): 2039–48. https://doi.org/10.1210/mend.13.12.0405.Full Text Link to Item
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Kivinen, L., M. Tsubari, T. Haapajärvi, M. B. Datto, X. F. Wang, and M. Laiho. “Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.” Oncogene 18, no. 46 (November 4, 1999): 6252–61. https://doi.org/10.1038/sj.onc.1203000.Full Text Link to Item
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Billon, N., D. Carlisi, M. B. Datto, L. A. van Grunsven, A. Watt, X. F. Wang, and B. B. Rudkin. “Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.” Oncogene 18, no. 18 (May 6, 1999): 2872–82. https://doi.org/10.1038/sj.onc.1202712.Full Text Link to Item
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Haapajärvi, T., L. Kivinen, A. Heiskanen, C. des Bordes, M. B. Datto, X. F. Wang, and M. Laiho. “UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.” Exp Cell Res 248, no. 1 (April 10, 1999): 272–79. https://doi.org/10.1006/excr.1999.4403.Full Text Link to Item
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Datto, M. B., J. P. Frederick, L. Pan, A. J. Borton, Y. Zhuang, and X. F. Wang. “Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.” Mol Cell Biol 19, no. 4 (April 1999): 2495–2504. https://doi.org/10.1128/MCB.19.4.2495.Full Text Link to Item
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Bao, S., X. Shen, K. Shen, Y. Liu, and X. F. Wang. “The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.” Cell Growth Differ 9, no. 12 (December 1998): 961–67.Link to Item
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Shen, X., P. P. Hu, N. T. Liberati, M. B. Datto, J. P. Frederick, and X. F. Wang. “TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.” Mol Biol Cell 9, no. 12 (December 1998): 3309–19. https://doi.org/10.1091/mbc.9.12.3309.Full Text Link to Item
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Wang, X., and J. Chen. “Quantitive estimates of outcrossing rates in a natural population of Sagittaria potamogetifolia.” Wuhan Daxue Xuebao/Journal of Wuhan University 44, no. 2 (December 1, 1998).
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Hu, P. P., M. B. Datto, and X. F. Wang. “Molecular mechanisms of transforming growth factor-beta signaling.” Endocr Rev 19, no. 3 (June 1998): 349–63. https://doi.org/10.1210/edrv.19.3.0333.Full Text Link to Item
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Li, J. M., M. B. Datto, X. Shen, P. P. Hu, Y. Yu, and X. F. Wang. “Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites.” Nucleic Acids Res 26, no. 10 (May 15, 1998): 2449–56. https://doi.org/10.1093/nar/26.10.2449.Full Text Link to Item
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Lee, S. J., M. J. Ha, J. Lee, P. Nguyen, Y. H. Choi, F. Pirnia, W. K. Kang, X. F. Wang, S. J. Kim, and J. B. Trepel. “Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.” J Biol Chem 273, no. 17 (April 24, 1998): 10618–23. https://doi.org/10.1074/jbc.273.17.10618.Full Text Link to Item
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Bassing, C. H., W. Shou, S. Muir, J. Heitman, M. M. Matzuk, and X. F. Wang. “FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.” Cell Growth Differ 9, no. 3 (March 1998): 223–28.Link to Item
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Li, J. M., X. Shen, P. P. Hu, and X. F. Wang. “Transforming growth factor beta stimulates the human immunodeficiency virus 1 enhancer and requires NF-kappaB activity.” Mol Cell Biol 18, no. 1 (January 1998): 110–21. https://doi.org/10.1128/MCB.18.1.110.Full Text Link to Item
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Yingling, J. M., M. B. Datto, C. Wong, J. P. Frederick, N. T. Liberati, and X. F. Wang. “Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.” Mol Cell Biol 17, no. 12 (December 1997): 7019–28. https://doi.org/10.1128/MCB.17.12.7019.Full Text Link to Item
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Li, J. M., P. P. Hu, X. Shen, Y. Yu, and X. F. Wang. “E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.” Proc Natl Acad Sci U S A 94, no. 10 (May 13, 1997): 4948–53. https://doi.org/10.1073/pnas.94.10.4948.Full Text Link to Item
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Chen, C., X. F. Wang, and L. Sun. “Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells.” J Biol Chem 272, no. 19 (May 9, 1997): 12862–67. https://doi.org/10.1074/jbc.272.19.12862.Full Text Link to Item
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Suzuki, A., C. Chang, J. M. Yingling, X. F. Wang, and A. Hemmati-Brivanlou. “Smad5 induces ventral fates in Xenopus embryo.” Dev Biol 184, no. 2 (April 15, 1997): 402–5. https://doi.org/10.1006/dbio.1997.8548.Full Text Link to Item
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Datto, M. B., P. P. Hu, T. F. Kowalik, J. Yingling, and X. F. Wang. “The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.” Mol Cell Biol 17, no. 4 (April 1997): 2030–37. https://doi.org/10.1128/MCB.17.4.2030.Full Text Link to Item
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Slotkin, T. A., X. F. Wang, H. S. Symonds, and F. J. Seidler. “Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain.” Brain Res Dev Brain Res 99, no. 1 (March 17, 1997): 61–65. https://doi.org/10.1016/s0165-3806(96)00199-x.Full Text Link to Item
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Datto, M. B., C. H. Bassing, and X. F. Wang. “The TGFβ receptors and signaling pathways.” Growth Factors and Cytokines in Health and Disease 1, no. C (December 1, 1996): 395–432. https://doi.org/10.1016/S1874-5687(96)80017-6.Full Text
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Derynck, R., W. M. Gelbart, R. M. Harland, C. H. Heldin, S. E. Kern, J. Massagué, D. A. Melton, et al. “Nomenclature: vertebrate mediators of TGFbeta family signals.” Cell 87, no. 2 (October 18, 1996): 173. https://doi.org/10.1016/s0092-8674(00)81335-5.Full Text Link to Item
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Yingling, J. M., P. Das, C. Savage, M. Zhang, R. W. Padgett, and X. F. Wang. “Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.” Proc Natl Acad Sci U S A 93, no. 17 (August 20, 1996): 8940–44. https://doi.org/10.1073/pnas.93.17.8940.Full Text Link to Item
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Wang, J., W. Han, E. Zborowska, J. Liang, X. Wang, J. K. Willson, L. Sun, and M. G. Brattain. “Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells.” J Biol Chem 271, no. 29 (July 19, 1996): 17366–71. https://doi.org/10.1074/jbc.271.29.17366.Full Text Link to Item
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Yingling, J. M., X. F. Wang, and C. H. Bassing. “Signaling by the transforming growth factor-beta receptors.” Biochim Biophys Acta 1242, no. 2 (December 18, 1995): 115–36. https://doi.org/10.1016/0304-419x(95)00007-2.Full Text Link to Item
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Datto, M. B., Y. Yu, and X. F. Wang. “Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.” J Biol Chem 270, no. 48 (December 1, 1995): 28623–28. https://doi.org/10.1074/jbc.270.48.28623.Full Text Link to Item
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Li, J. M., M. A. Nichols, S. Chandrasekharan, Y. Xiong, and X. F. Wang. “Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.” J Biol Chem 270, no. 45 (November 10, 1995): 26750–53. https://doi.org/10.1074/jbc.270.45.26750.Full Text Link to Item
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Wang, J., L. Sun, L. Myeroff, X. Wang, L. E. Gentry, J. Yang, J. Liang, E. Zborowska, S. Markowitz, and J. K. Willson. “Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells.” J Biol Chem 270, no. 37 (September 15, 1995): 22044–49. https://doi.org/10.1074/jbc.270.37.22044.Full Text Link to Item
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Wang, Y. Q., A. Sizeland, X. F. Wang, and D. Sassoon. “Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning.” Mech Dev 52, no. 2–3 (August 1995): 275–89. https://doi.org/10.1016/0925-4773(95)00408-s.Full Text Link to Item
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Datto, M. B., Y. Li, J. F. Panus, D. J. Howe, Y. Xiong, and X. F. Wang. “Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.” Proc Natl Acad Sci U S A 92, no. 12 (June 6, 1995): 5545–49. https://doi.org/10.1073/pnas.92.12.5545.Full Text Link to Item
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Schwarz, J. K., C. H. Bassing, I. Kovesdi, M. B. Datto, M. Blazing, S. George, X. F. Wang, and J. R. Nevins. “Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.” Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483–87. https://doi.org/10.1073/pnas.92.2.483.Full Text Link to Item
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Sun, L., G. Wu, J. K. Willson, E. Zborowska, J. Yang, I. Rajkarunanayake, J. Wang, L. E. Gentry, X. F. Wang, and M. G. Brattain. “Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells.” J Biol Chem 269, no. 42 (October 21, 1994): 26449–55.Link to Item
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Bassing, C. H., D. J. Howe, P. R. Segarini, P. K. Donahoe, and X. F. Wang. “A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.” J Biol Chem 269, no. 21 (May 27, 1994): 14861–64.Link to Item
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Bassing, C. H., J. M. Yingling, D. J. Howe, T. Wang, W. W. He, M. L. Gustafson, P. Shah, P. K. Donahoe, and X. F. Wang. “A transforming growth factor beta type I receptor that signals to activate gene expression.” Science 263, no. 5143 (January 7, 1994): 87–89. https://doi.org/10.1126/science.8272871.Full Text Link to Item
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Barnett, J. V., A. Moustakas, W. Lin, X. F. Wang, H. Y. Lin, J. B. Galper, and R. L. Maas. “Cloning and developmental expression of the chick type II and type III TGF beta receptors.” Dev Dyn 199, no. 1 (January 1994): 12–27. https://doi.org/10.1002/aja.1001990103.Full Text Link to Item
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Bassing, C. H., J. M. Yingling, and X. F. Wang. “Receptors for the TGF-beta ligand family.” Vitam Horm 48 (1994): 111–56. https://doi.org/10.1016/s0083-6729(08)60497-5.Full Text Link to Item
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Wang, X. F. “TGF-β activates gene expression.” Biomedicine and Pharmacotherapy 48, no. 8–9 (January 1, 1994): 410. https://doi.org/10.1016/0753-3322(94)90070-1.Full Text
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Wrana, J. L., L. Attisano, J. Cárcamo, A. Zentella, J. Doody, M. Laiho, X. F. Wang, and J. Massagué. “TGF beta signals through a heteromeric protein kinase receptor complex.” Cell 71, no. 6 (December 11, 1992): 1003–14. https://doi.org/10.1016/0092-8674(92)90395-s.Full Text Link to Item
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Lin, H. Y., and X. F. Wang. “Expression cloning of TGF-beta receptors.” Mol Reprod Dev 32, no. 2 (June 1992): 105–10. https://doi.org/10.1002/mrd.1080320205.Full Text Link to Item
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Lin, H. Y., X. F. Wang, E. Ng-Eaton, R. A. Weinberg, and H. F. Lodish. “Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.” Cell 68, no. 4 (February 21, 1992): 775–85. https://doi.org/10.1016/0092-8674(92)90152-3.Full Text Link to Item
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Wang, X. F., H. Y. Lin, E. Ng-Eaton, J. Downward, H. F. Lodish, and R. A. Weinberg. “Expression cloning and characterization of the TGF-beta type III receptor.” Cell 67, no. 4 (November 15, 1991): 797–805. https://doi.org/10.1016/0092-8674(91)90074-9.Full Text Link to Item
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Friend, S. H., J. M. Horowitz, M. R. Gerber, X. F. Wang, E. Bogenmann, F. P. Li, and R. A. Weinberg. “Erratum: Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein (Proc., Natl. Acad. Sci. USA, No. 24, Dec. 1987 (84, 9059-9063)).” Proceedings of the National Academy of Sciences of the United States of America 85, no. 7 (December 1, 1988): 2234. https://doi.org/10.1073/pnas.85.7.2234.Full Text
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Tsao, B. P., X. F. Wang, C. L. Peterson, and K. Calame. “In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.” Nucleic Acids Res 16, no. 8 (April 25, 1988): 3239–53. https://doi.org/10.1093/nar/16.8.3239.Full Text Link to Item
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Kimchi, A., X. F. Wang, R. A. Weinberg, S. Cheifetz, and J. Massagué. “Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells.” Science 240, no. 4849 (April 8, 1988): 196–99. https://doi.org/10.1126/science.2895499.Full Text Link to Item
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Kimchi, A., X. F. Wang, R. A. Weinberg, S. Cheifetz, and J. Massague. “Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells.” Science 239, no. 4849 (1988): 196–99.
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Friend, S. H., J. M. Horowitz, M. R. Gerber, X. F. Wang, E. Bogenmann, F. P. Li, and R. A. Weinberg. “Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.” Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 9059–63. https://doi.org/10.1073/pnas.84.24.9059.Full Text Link to Item
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Wang, X. F., and K. Calame. “SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation.” Cell 47, no. 2 (October 24, 1986): 241–47. https://doi.org/10.1016/0092-8674(86)90446-0.Full Text Link to Item
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Wang, X. F., and K. Calame. “The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.” Cell 43, no. 3 Pt 2 (December 1985): 659–65. https://doi.org/10.1016/0092-8674(85)90238-7.Full Text Link to Item
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Mercola, M., X. F. Wang, J. Olsen, and K. Calame. “Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.” Science 221, no. 4611 (August 12, 1983): 663–65. https://doi.org/10.1126/science.6306772.Full Text Link to Item
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Conference Papers
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Hu, Jing, Tao Sun, Hui Wang, Pingping Wang, Xiang-Dong Fu, Qi-Jing Li, and Xiao-Fan Wang. “Abstract 3536: Roles of miR-215 and regulatory mechanisms for its biogenesis in response to hypoxia in glioblastoma stem cells.” In Cancer Research, 74:3536–3536. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-3536.Full Text
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Biernacka, Anna, Carlos Gonzalez-Quesada, Ping Kong, Vikrant Rai, Panagiota Christia, Marcin Dobaczewski, Dong-Wook Lee, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 Loss is Associated with Aortic Dilation and Spontaneous Aortic Rupture in Lean and in Obese Diabetic Db/db Mice.” In Circulation, Vol. 126. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
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Hrgovic, I., M. Doll, J. Kleemann, X. F. Wang, N. Zoeller, A. Pinter, S. Kippenberger, R. Kaufmann, and M. Meissner. “The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.” In Bmc Bioinformatics, Vol. 13, 2012. https://doi.org/10.1186/s12885-016-2807-y.Full Text
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Biernacka, Anna, Carlos Gonzalez-Quesada, Qi Tian, Na Li, Marcin Dobaczewski, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “TGF-beta/Smad3 Activation in the Diabetic Mouse Heart Induces Fibrotic Cardiac Remodeling and Diastolic Dysfunction While Protecting From Excessive Matrix Degradation and Preventing the Development of Systolic Dysfunction.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.Link to Item
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Dobaczewski, Marcin, Carlos Gonzalez-Ouesada, Marcin Bujak, Na Li, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3-/- Fibroblasts Are Hyperproliferative Cells With Impaired Migratory Capacity, Reduced Contractile Activity and Diminished Synthetic Function: Implications for Cardiac Repair and Remodeling.” In Circulation, 120:S792–S792. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Feng, Junjie, Timothy Wakeman, Sheila Yong, Sally Kornbluth, Xiao-Hua Wu, and Xiao-Fan Wang. “PP2A-dependent dephosphorylation of replication protein A (RPA) is required for the removal of DNA breaks induced by replication stress.” In Cancer Research, Vol. 69. AMER ASSOC CANCER RESEARCH, 2009.Link to Item
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Dobaczewski, Marcin, Marcin Bujak, Carlos Gonzalez, Na Li, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “The Smad3 Pathway Critically Regulates Myofibroblast Proliferation And Synthetic Activity In Healing Myocardial Infarcts.” In Circulation, 118:S293–S293. LIPPINCOTT WILLIAMS & WILKINS, 2008.Link to Item
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Bujak, Marcin J., Guofeng Ren, Khaled F. Chatila, Marcin Dobaczewski, Anilkumar Reddy, George Taffet, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 signaling critically regulates infarct healing.” In Faseb Journal, 21:A11–A11. FEDERATION AMER SOC EXP BIOL, 2007.Link to Item
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Buiak, Marcin J., Guofeng Ren, Khaled Chatila, Marcin Dobaczewski, Anilkumar Reddy, George Taffet, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Disruption of the Smad3 signaling pathway attenuates post-infarction remodeling.” In Journal of the American College of Cardiology, 49:210A-210A. ELSEVIER SCIENCE INC, 2007.Link to Item
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Shao, Rong, Wei Yan, Brooke Pazik, Ann Marie Pendergast, and Xiao-Fan Wang. “Cytoplasmic tyrosine kinase c-Abl is required for bFGF but not VEGF-induced tumor angiogenesis.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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