Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of California - Los Angeles 1986
  • B.S., Wuhan University (China) 1982
• 

  Duke Appointment History

  • Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1998 - 2003
  • Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 1998
• Recognition
• 

  Awards & Honors

  • International Scientific Cooperation Award. Chinese Academy of Sciences. 2013
  • Ray Wu Award. Chinese Biological Investigators Society, USA. 2013
  • Outstanding Alumni Award. Wuhan University, China. 2011
  • AAAS Fellows. American Association for the Advancement of Science, The. 2009
• Research
• 

  Selected Grants

  • Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
  • NGF recruits nerve fibers to reprogram an immunosuppressive microenvironment in melanoma awarded by National Institutes of Health 2020 - 2025
  • Synthetic lethality by targeting the core senescent mechanism in lung cancer. awarded by National Institutes of Health 2020 - 2025
  • Targeting UHRF1 in combinational immunotherapy awarded by National Institutes of Health 2019 - 2023
  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
  • Examining Biosynthesis and NAD+ Demand in the Warburg Effect awarded by National Institutes of Health 2019 - 2022
  • Understanding methionine metabolism and its therapeutic potential in cancer awarded by National Institutes of Health 2019 - 2021
  • Role of hedgehog signaling in tumor-associated macrophage polarization awarded by National Institutes of Health 2017 - 2021
  • Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
  • Characterization of the SGOC Metabolic Network in Cancer Pathogenesis awarded by National Institutes of Health 2015 - 2021
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
  • Analysis of mechanisms associated with Her2-positive breast cancer resistance to therapy awarded by Department of Defense 2016 - 2019
  • Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
  • The anti-senescence activity of trefoil factor 1 awarded by National Institutes of Health 2012 - 2018
  • The Roles of MicroRNAs in Glioblastoma awarded by National Institutes of Health 2012 - 2017
  • Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
  • Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
  • Molecular determinants underlying herceptin sensitivity and resistance awarded by National Institutes of Health 2014 - 2016
  • Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
  • Determine the potential therapeutic effect of HDAC6 inhibitors in inhibiting breast cancer metastasis and glioblastoma growth in mouse models awarded by Acetylon Pharmaceuticals, Inc. 2014 - 2015
  • The role of TGF-beta in tumorigenesis awarded by National Institutes of Health 2010 - 2015
  • 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
  • Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer awarded by National Institutes of Health 2011 - 2013
  • The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma awarded by National Institutes of Health 2006 - 2012
  • Mechanisms of TGF-B/Smad Signaling awarded by National Institutes of Health 2008 - 2012
  • TGFBI and tumorigenesis awarded by National Institutes of Health 2006 - 2011
  • Rad17- & p53-mediated apoptotic pathways in response to DNA damage awarded by National Institutes of Health 2006 - 2011
  • Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
  • TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
  • Molecular Mechanisms of SPARC Mediated Glioma Invasion awarded by National Institutes of Health 2006 - 2008
  • TGF-Beta Signaling in MSCs and Osteoblast awarded by National Institutes of Health 2004 - 2008
  • Analysis of Rad17-mediated Checkpoint Signaling awarded by National Institutes of Health 2002 - 2008
  • Analysis of the Functional Role of TPF in Tumorigenesis awarded by National Institutes of Health 2000 - 2005
  • The Role Of Tumor Supressor Smads In Tgf-B Signaling awarded by National Institutes of Health 1998 - 2004
  • Same Same awarded by US Army Medical Research 1999 - 2002
  • The Role Of Tgfb In Brain Tumors awarded by National Institutes of Health 1998 - 2001
  • Tgf-Beta Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1995 - 2001
  • Tgf-B Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1996 - 1999
  • Examination Of Tgfb Induced Cell Death Pathway awarded by National Institutes of Health 1995 - 1998
  • Analysis Of Tgf-B Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1994 - 1995
  • Analysis Of Tgf Beta Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1993 - 1995
• 

  External Relationships

  • Cell Research, Nature Publishing Group
  • Genetron Health Holdings Ltd
  • Grant Review Panel, Starr Cancer Consortium, New York
  • Institute of Immuno-chemistry, Shanghai Tech University
  • Institute of Life Sciences, Zhejiang University
  • Joint Center for Life Sciences at Peking University and Tshinghua University
  • Joint Center of Life Sciences, Peking University and Tsinghua University
  • Laboratory of Regenerative Medicine, Guangdong Province
  • Life and Medical Sciences Branch, University of Science and Technology of China
  • National Science Review, Editorial Board
  • Research Grants Council of Hong Kong
  • Research Grants Council, Hong Kong
  • Review Panel, Cancer Prevention & Research Institute of Texas
  • Science China, Life Sciences
  • Shanghai Epican Genetech
  • TCRCure Biopharma
  • Upstream Biotechnology
  • Westlake University
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chong, Mengyang, Tao Yin, Rui Chen, Handan Xiang, Lifeng Yuan, Yi Ding, Christopher C. Pan, et al. “CD36 initiates the secretory phenotype during the establishment of cellular senescence.” Embo Rep 19, no. 6 (June 2018). https://doi.org/10.15252/embr.201745274.
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    • Yuan, Lifeng, Linhui Zhai, Lili Qian, De Huang, Yi Ding, Handan Xiang, Xiaojing Liu, et al. “Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death.” Cell Res 28, no. 6 (June 2018): 625–43. https://doi.org/10.1038/s41422-018-0043-5.
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    • Li, Jing-Jing, Hong-Kun Yin, Dong-Xian Guan, Jiang-Sha Zhao, Yu-Xiong Feng, Yue-Zhen Deng, Xiang Wang, et al. “Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.” Br J Cancer 118, no. 10 (May 2018): 1337–48. https://doi.org/10.1038/s41416-018-0077-y.
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    • Deng, Yue-Zhen, Zhen Cai, Shuo Shi, Hao Jiang, Yu-Rong Shang, Ning Ma, Jing-Jing Wang, et al. “Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.” J Exp Med 215, no. 1 (January 2, 2018): 177–95. https://doi.org/10.1084/jem.20170399.
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    • Zhang, Yun, Peter B. Alexander, and Xiao-Fan Wang. “TGF-β Family Signaling in the Control of Cell Proliferation and Survival.” Cold Spring Harbor Perspectives in Biology 9, no. 4 (April 3, 2017). https://doi.org/10.1101/cshperspect.a022145.
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    • Alexander, Peter B., Rui Chen, Chang Gong, Lifeng Yuan, Jeff S. Jasper, Yi Ding, Geoffrey J. Markowitz, et al. “Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.” J Biol Chem 292, no. 2 (January 13, 2017): 748–59. https://doi.org/10.1074/jbc.M116.754960.
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    • Xiang, Handan, Lifeng Yuan, Xia Gao, Peter B. Alexander, Omar Lopez, Calvin Lau, Yi Ding, et al. “UHRF1 is required for basal stem cell proliferation in response to airway injury.” Cell Discov 3 (2017): 17019. https://doi.org/10.1038/celldisc.2017.19.
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    • Liu, Zhengxue, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J. Barnard, et al. “Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.” Oncotarget 7, no. 40 (October 4, 2016): 64878–85. https://doi.org/10.18632/oncotarget.11713.
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    • Hrgovic, Igor, Monika Doll, Johannes Kleemann, Xiao-Fan Wang, Nadja Zoeller, Andreas Pinter, Stefan Kippenberger, Roland Kaufmann, and Markus Meissner. “The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.” Bmc Cancer 16, no. 1 (September 30, 2016): 763. https://doi.org/10.1186/s12885-016-2807-y.
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    • Hu, Jing, and Xiao-Fan Wang. “HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.” Cell Cycle 15, no. 15 (August 2, 2016): 1939–40. https://doi.org/10.1080/15384101.2016.1181877.
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    • Bao, Wen-Dai, Yao Fan, Yue-Zhen Deng, Ling-Yun Long, Jing-Jing Wang, Dong-Xian Guan, Zhen-Yu Qian, et al. “Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis.” J Hepatol 65, no. 1 (July 2016): 137–45. https://doi.org/10.1016/j.jhep.2016.03.007.
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    • Markowitz, Geoffrey J., Pengyuan Yang, Jing Fu, Gregory A. Michelotti, Rui Chen, Jianhua Sui, Bin Yang, et al. “Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.” Cancer Res 76, no. 8 (April 15, 2016): 2394–2405. https://doi.org/10.1158/0008-5472.CAN-15-1548.
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    • Xu, Xin, Yun Zhang, Jeff Jasper, Erik Lykken, Peter B. Alexander, Geoffrey J. Markowitz, Donald P. McDonnell, Qi-Jing Li, and Xiao-Fan Wang. “MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.” Oncotarget 7, no. 15 (April 12, 2016): 20381–94. https://doi.org/10.18632/oncotarget.7953.
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    • Valesky, Eva Maria, Igor Hrgovic, Monika Doll, Xiao-Fan Wang, Andreas Pinter, Johannes Kleemann, Roland Kaufmann, Stefan Kippenberger, and Markus Meissner. “Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.” Exp Dermatol 25, no. 3 (March 2016): 200–205. https://doi.org/10.1111/exd.12907.
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    • Hu, Jing, Tao Sun, Hui Wang, Zhengxin Chen, Shuai Wang, Lifeng Yuan, Tingyu Liu, et al. “MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.” Cancer Cell 29, no. 1 (January 11, 2016): 49–60. https://doi.org/10.1016/j.ccell.2015.12.005.
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    • Hu, Jing, Geoffrey J. Markowitz, and Xiaofan Wang. “Noncoding RNAs Regulating Cancer Signaling Network.” Adv Exp Med Biol 927 (2016): 297–315. https://doi.org/10.1007/978-981-10-1498-7_11.
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    • Hu, Jing, Geoffrey Markowitz, and Xiao-Fan Wang. “Isolation of Glioma-Initiating Cells for Biological Study.” Adv Exp Med Biol 899 (2016): 197–209. https://doi.org/10.1007/978-3-319-26666-4_11.
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    • Yang, Pengyuan, Yun Zhang, Geoffrey J. Markowitz, Xing Guo, and Xiao-Fan Wang. “TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.” Methods Mol Biol 1344 (2016): 325–39. https://doi.org/10.1007/978-1-4939-2966-5_21.
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    • Biernacka, Anna, Michele Cavalera, Junhong Wang, Ilaria Russo, Arti Shinde, Ping Kong, Carlos Gonzalez-Quesada, et al. “Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.” Circ Heart Fail 8, no. 4 (July 2015): 788–98. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001963.
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    • Alexander, Peter B., and Xiao-Fan Wang. “Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies.” Front Med 9, no. 2 (June 2015): 134–38. https://doi.org/10.1007/s11684-015-0396-9.
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    • Zhang, Yun, and Xiao-Fan Wang. “A niche role for cancer exosomes in metastasis.” Nat Cell Biol 17, no. 6 (June 2015): 709–11. https://doi.org/10.1038/ncb3181.
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    • Dai, Xiaohua, Jianbin Shen, Neeraja Priyanka Annam, Hong Jiang, Edi Levi, Charles M. Schworer, Gerard Tromp, et al. “SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.” Sci Rep 5 (May 18, 2015): 10180. https://doi.org/10.1038/srep10180.
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    • Markowitz, Geoffrey J., Gregory A. Michelotti, Anna Mae Diehl, and Xiao-Fan Wang. “Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma.” Sci Bull (Beijing) 60, no. 8 (April 1, 2015): 762–72. https://doi.org/10.1007/s11434-015-0772-5.
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    • Alexander, Peter B., Lifeng Yuan, Pengyuan Yang, Tao Sun, Rui Chen, Handan Xiang, Jiekai Chen, Haoyu Wu, Daniel R. Radiloff, and Xiao-Fan Wang. “EGF promotes mammalian cell growth by suppressing cellular senescence.” Cell Res 25, no. 1 (January 2015): 135–38. https://doi.org/10.1038/cr.2014.141.
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    • Zhang, Yun, and Xiao-Fan Wang. “Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.” Cancer Metastasis Rev 33, no. 4 (December 2014): 1011–16. https://doi.org/10.1007/s10555-014-9526-0.
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    • Wang, Xiao-Fan, and Firouzeh Korangy. “Intrahepatic landscape of regulatory T-cell subsets in chronically HCV-infected patients with cirrhosis and HCC.” Hepatology (Baltimore, Md.) 60, no. 5 (November 2014): 1461–62. https://doi.org/10.1002/hep.27271.
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    • Wang, Hui, Tao Sun, Jing Hu, Rui Zhang, Yanhua Rao, Shuai Wang, Rui Chen, et al. “miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.” J Clin Invest 124, no. 10 (October 2014): 4489–4502. https://doi.org/10.1172/JCI75284.
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    • Yang, Pengyuan, Geoffrey J. Markowitz, and Xiao-Fan Wang. “The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma.” Natl Sci Rev 1, no. 3 (July 14, 2014): 396–412. https://doi.org/10.1093/nsr/nwu038.
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    • Wang, Qinhong, Michael Goldstein, Peter Alexander, Timothy P. Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B. Kastan, and Xiao-Fan Wang. “Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.” Embo J 33, no. 8 (April 16, 2014): 862–77. https://doi.org/10.1002/embj.201386064.
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    • Zhang, Yun, Pengyuan Yang, and Xiao-Fan Wang. “Microenvironmental regulation of cancer metastasis by miRNAs.” Trends Cell Biol 24, no. 3 (March 2014): 153–60. https://doi.org/10.1016/j.tcb.2013.09.007.
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    • Hu, Jim, and Xiao-Fan Wang. “COUP-TFII and AKT are cancer targets pursued by SCBA award winners.” Cell Biosci 4, no. 1 (2014): 57. https://doi.org/10.1186/2045-3701-4-57.
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    • Kellenberger, Terese, Søren Krag, Carl Christian Danielsen, Xiao-Fan Wang, Jens Randel Nyengaard, Lea Pedersen, Chuanxu Yang, Shan Gao, and Lise Wogensen. “Differential effects of Smad3 targeting in a murine model of chronic kidney disease.” Physiol Rep 1, no. 7 (December 1, 2013): e00181. https://doi.org/10.1002/phy2.181.
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    • Guo, Xing, and Xiao-Fan Wang. “A P(E)RM(I)T for BMP signaling.” Molecular Cell 51, no. 1 (July 2013): 1–2. https://doi.org/10.1016/j.molcel.2013.06.016.
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    • Zhang, Yun, Pengyuan Yang, Tao Sun, Dong Li, Xin Xu, Yaocheng Rui, Chaoran Li, et al. “miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.” Nat Cell Biol 15, no. 3 (March 2013): 284–94. https://doi.org/10.1038/ncb2690.
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    • Curtis, Valerie F., Hui Wang, Pengyuan Yang, Roger E. McLendon, Xiaohan Li, Qun-Yong Zhou, and Xiao-Fan Wang. “A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.” Plos One 8, no. 1 (2013): e54916. https://doi.org/10.1371/journal.pone.0054916.
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    • Guo, Xing, and Xiao-Fan Wang. “A mediator lost in the war on cancer.” Cell 151, no. 5 (November 21, 2012): 927–29. https://doi.org/10.1016/j.cell.2012.11.003.
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    • Zhang, Yuefan, Jun Chen, Fan Li, Dong Li, Qinhui Xiong, Yang Lin, Dazhi Zhang, Xiao-Fan Wang, Pengyuan Yang, and Yao-Cheng Rui. “A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway.” Stroke 43, no. 10 (October 2012): 2764–73. https://doi.org/10.1161/strokeaha.112.657908.
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    • Yang, Pengyuan, Qi-Jing Li, Yuxiong Feng, Yun Zhang, Geoffrey J. Markowitz, Shanglei Ning, Yuezhen Deng, et al. “TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.” Cancer Cell 22, no. 3 (September 11, 2012): 291–303. https://doi.org/10.1016/j.ccr.2012.07.023.
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    • Guo, Xing, and Xiao-Fan Wang. “New secrets behind bone metastasis.” Cell Research 22, no. 9 (September 2012): 1309–11. https://doi.org/10.1038/cr.2012.99.
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    • Xu, Ying-Ping, Yuling Shi, Zhi-Zhong Cui, Hong H. Jiang, Li Li, Xiao-Fan Wang, Li Zhou, and Qing-Sheng Mi. “TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development.” J Invest Dermatol 132, no. 8 (August 2012): 2106–9. https://doi.org/10.1038/jid.2012.71.
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    • Wakeman, Timothy P., Qinhong Wang, Junjie Feng, and Xiao-Fan Wang. “Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.” The Embo Journal 31, no. 9 (May 2012): 2169–81. https://doi.org/10.1038/emboj.2012.50.
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    • Chen, Ye-Guang, Zhongwei Li, and Xiao-Fan Wang. “Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.” Cell Stem Cell 10, no. 3 (March 2, 2012): 231–32. https://doi.org/10.1016/j.stem.2012.02.008.
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    • Yong, Sheila T., and Xiao-Fan Wang. “A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.” Plos One 7, no. 6 (2012): e38085. https://doi.org/10.1371/journal.pone.0038085.
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    • Tapia-González, S., R. M. Giráldez-Pérez, M. I. Cuartero, M. J. Casarejos, M. A. Mena, X. F. Wang, and A. Sánchez-Capelo. “Dopamine and α-synuclein dysfunction in Smad3 null mice.” Molecular Neurodegeneration 6 (December 1, 2011): 72.
    • Tapia-González, Silvia, Rosa M. Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, and Amelia Sánchez-Capelo. “Dopamine and α-synuclein dysfunction in Smad3 null mice.” Mol Neurodegener 6 (October 13, 2011): 72. https://doi.org/10.1186/1750-1326-6-72.
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    • Wakeman, Timothy P., Junjie Feng, and Xiao-fan Wang. “Abstract 2482: Bat3 facilitates histone H3 lysine 79 dimethylation by DOT1L to promote ionizing radiation-induced 53BP1 foci formation during G1- and G2-phases of the cell cycle.” Tumor Biology, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-2482.
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    • Wang, Hui, Xiao-Fan Wang, Jeremy Rich, Qinhong Wang, and Anita Hjelmeland. “Abstract 3311: IL6-Stat3 signaling promotes glioma stem cell (GSC) survival under hypoxia environment through inhibition of cell-death inducing gene Bnip3.” Tumor Biology, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-3311.
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    • Radiloff, Daniel R., Timothy P. Wakeman, Junjie Feng, Stephen Schilling, Edward Seto, and Xiao-Fan Wang. “Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.” Proceedings of the National Academy of Sciences of the United States of America 108, no. 16 (April 2011): 6591–96. https://doi.org/10.1073/pnas.1017269108.
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    • Feng, Yu-Xiong, Tao Wang, Yue-Zhen Deng, Pengyuan Yang, Jing-Jing Li, Dong-Xian Guan, Fan Yao, et al. “Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model.” Hepatology 53, no. 2 (February 2011): 483–92. https://doi.org/10.1002/hep.24075.
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    • D’Souza, C. A., J. W. Kronstad, G. Taylor, R. Warren, M. Yuen, G. Hu, W. H. Jung, et al. “Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.” Mbio 2, no. 1 (2011): e00342–e00310. https://doi.org/10.1128/mBio.00342-10.
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    • Zhao, Jiang-Sha, Wen-Jie Li, Di Ge, Pei-Jing Zhang, Jing-Jing Li, Chun-Lai Lu, Xiao-Dan Ji, et al. “Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44.” Plos One 6, no. 6 (2011): e21419. https://doi.org/10.1371/journal.pone.0021419.
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    • Dobaczewski, Marcin, Marcin Bujak, Na Li, Carlos Gonzalez-Quesada, Leonardo H. Mendoza, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.” Circ Res 107, no. 3 (August 6, 2010): 418–28. https://doi.org/10.1161/CIRCRESAHA.109.216101.
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    • Zhang, Liyong, Chi-Hoon Park, Jing Wu, Hyun Kim, Weijun Liu, Takeo Fujita, Manimalha Balasubramani, Emanuel M. Schreiber, Xiao-Fan Wang, and Yong Wan. “Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.” Embo J 29, no. 10 (May 19, 2010): 1726–37. https://doi.org/10.1038/emboj.2010.55.
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    • Feng, Yu-Xiong, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, and Dong Xie. “Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway.” Hepatology 51, no. 2 (February 2010): 535–44. https://doi.org/10.1002/hep.23313.
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    • Wang, Jialiang, Timothy P. Wakeman, Justin D. Lathia, Anita B. Hjelmeland, Xiao-Fan Wang, Rebekah R. White, Jeremy N. Rich, and Bruce A. Sullenger. “Notch promotes radioresistance of glioma stem cells.” Stem Cells 28, no. 1 (January 2010): 17–28. https://doi.org/10.1002/stem.261.
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    • Chen, Ye-Guang, and Xiao-Fan Wang. “Finale: the last minutes of Smads.” Cell 139, no. 4 (November 13, 2009): 658–60. https://doi.org/10.1016/j.cell.2009.10.038.
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    • Feng, Junjie, Timothy Wakeman, Sheila Yong, Xiaohua Wu, Sally Kornbluth, and Xiao-Fan Wang. “Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress.” Mol Cell Biol 29, no. 21 (November 2009): 5696–5709. https://doi.org/10.1128/MCB.00191-09.
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    • Hu, Guohong, Yibin Kang, and Xiao-Fan Wang. “From breast to the brain: unraveling the puzzle of metastasis organotropism.” J Mol Cell Biol 1, no. 1 (October 2009): 3–5. https://doi.org/10.1093/jmcb/mjp005.
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    • Wang, Hui, Justin D. Lathia, Qiulian Wu, Jialiang Wang, Zhizhong Li, John M. Heddleston, Christine E. Eyler, et al. “Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.” Stem Cells 27, no. 10 (October 2009): 2393–2404. https://doi.org/10.1002/stem.188.
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    • Schilling, Stephen H., Anita B. Hjelmeland, Daniel R. Radiloff, Irwin M. Liu, Timothy P. Wakeman, Jeffrey R. Fielhauer, Erika H. Foster, et al. “NDRG4 is required for cell cycle progression and survival in glioblastoma cells.” J Biol Chem 284, no. 37 (September 11, 2009): 25160–69. https://doi.org/10.1074/jbc.M109.012484.
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    • Jardim, Melanie J., Qinhong Wang, Ryohei Furumai, Timothy Wakeman, Barbara K. Goodman, and Xiao-Fan Wang. “Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.” Mol Biol Cell 20, no. 17 (September 2009): 3801–9. https://doi.org/10.1091/mbc.e09-04-0303.
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    • Liu, Irwin M., Stephen H. Schilling, Kristin A. Knouse, Lisa Choy, Rik Derynck, and Xiao-Fan Wang. “TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.” Embo J 28, no. 2 (January 21, 2009): 88–98. https://doi.org/10.1038/emboj.2008.266.
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    • Suzuki, A., C. Chang, J. M. Yingling, X. F. Wang, and A. Hemmati-Brivanlou. “Smad5 induces ventral fates in Xenopus embryo.” Dev Biol 184, no. 2 (April 15, 1997): 402–5. https://doi.org/10.1006/dbio.1997.8548.
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    • Datto, M. B., P. P. Hu, T. F. Kowalik, J. Yingling, and X. F. Wang. “The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.” Mol Cell Biol 17, no. 4 (April 1997): 2030–37. https://doi.org/10.1128/mcb.17.4.2030.
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    • Slotkin, T. A., X. F. Wang, H. S. Symonds, and F. J. Seidler. “Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain.” Brain Res Dev Brain Res 99, no. 1 (March 17, 1997): 61–65. https://doi.org/10.1016/s0165-3806(96)00199-x.
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    • Datto, M. B., C. H. Bassing, and X. F. Wang. “The TGFβ receptors and signaling pathways.” Growth Factors and Cytokines in Health and Disease 1, no. C (December 1, 1996): 395–432. https://doi.org/10.1016/S1874-5687(96)80017-6.
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    • Derynck, R., W. M. Gelbart, R. M. Harland, C. H. Heldin, S. E. Kern, J. Massagué, D. A. Melton, et al. “Nomenclature: vertebrate mediators of TGFbeta family signals.” Cell 87, no. 2 (October 18, 1996): 173. https://doi.org/10.1016/s0092-8674(00)81335-5.
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    • Yingling, J. M., P. Das, C. Savage, M. Zhang, R. W. Padgett, and X. F. Wang. “Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.” Proc Natl Acad Sci U S A 93, no. 17 (August 20, 1996): 8940–44. https://doi.org/10.1073/pnas.93.17.8940.
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    • Wang, J., W. Han, E. Zborowska, J. Liang, X. Wang, J. K. Willson, L. Sun, and M. G. Brattain. “Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells.” J Biol Chem 271, no. 29 (July 19, 1996): 17366–71. https://doi.org/10.1074/jbc.271.29.17366.
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    • Yingling, J. M., X. F. Wang, and C. H. Bassing. “Signaling by the transforming growth factor-beta receptors.” Biochim Biophys Acta 1242, no. 2 (December 18, 1995): 115–36. https://doi.org/10.1016/0304-419x(95)00007-2.
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    • Datto, M. B., Y. Yu, and X. F. Wang. “Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.” J Biol Chem 270, no. 48 (December 1, 1995): 28623–28. https://doi.org/10.1074/jbc.270.48.28623.
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    • Li, J. M., M. A. Nichols, S. Chandrasekharan, Y. Xiong, and X. F. Wang. “Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.” J Biol Chem 270, no. 45 (November 10, 1995): 26750–53. https://doi.org/10.1074/jbc.270.45.26750.
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    • Wang, J., L. Sun, L. Myeroff, X. Wang, L. E. Gentry, J. Yang, J. Liang, E. Zborowska, S. Markowitz, and J. K. Willson. “Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells.” J Biol Chem 270, no. 37 (September 15, 1995): 22044–49. https://doi.org/10.1074/jbc.270.37.22044.
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    • Wang, Y. Q., A. Sizeland, X. F. Wang, and D. Sassoon. “Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning.” Mech Dev 52, no. 2–3 (August 1995): 275–89. https://doi.org/10.1016/0925-4773(95)00408-s.
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    • Datto, M. B., Y. Li, J. F. Panus, D. J. Howe, Y. Xiong, and X. F. Wang. “Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.” Proc Natl Acad Sci U S A 92, no. 12 (June 6, 1995): 5545–49. https://doi.org/10.1073/pnas.92.12.5545.
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    • Schwarz, J. K., C. H. Bassing, I. Kovesdi, M. B. Datto, M. Blazing, S. George, X. F. Wang, and J. R. Nevins. “Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.” Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483–87. https://doi.org/10.1073/pnas.92.2.483.
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    • Sun, L., G. Wu, J. K. Willson, E. Zborowska, J. Yang, I. Rajkarunanayake, J. Wang, L. E. Gentry, X. F. Wang, and M. G. Brattain. “Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells.” J Biol Chem 269, no. 42 (October 21, 1994): 26449–55.
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    • Bassing, C. H., D. J. Howe, P. R. Segarini, P. K. Donahoe, and X. F. Wang. “A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.” J Biol Chem 269, no. 21 (May 27, 1994): 14861–64.
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    • Bassing, C. H., J. M. Yingling, D. J. Howe, T. Wang, W. W. He, M. L. Gustafson, P. Shah, P. K. Donahoe, and X. F. Wang. “A transforming growth factor beta type I receptor that signals to activate gene expression.” Science 263, no. 5143 (January 7, 1994): 87–89. https://doi.org/10.1126/science.8272871.
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    • Barnett, J. V., A. Moustakas, W. Lin, X. F. Wang, H. Y. Lin, J. B. Galper, and R. L. Maas. “Cloning and developmental expression of the chick type II and type III TGF beta receptors.” Dev Dyn 199, no. 1 (January 1994): 12–27. https://doi.org/10.1002/aja.1001990103.
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    • Bassing, C. H., J. M. Yingling, and X. F. Wang. “Receptors for the TGF-beta ligand family.” Vitam Horm 48 (1994): 111–56. https://doi.org/10.1016/s0083-6729(08)60497-5.
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    • Wang, X. F. “TGF-β activates gene expression.” Biomedicine and Pharmacotherapy 48, no. 8–9 (January 1, 1994): 410. https://doi.org/10.1016/0753-3322(94)90070-1.
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    • Wrana, J. L., L. Attisano, J. Cárcamo, A. Zentella, J. Doody, M. Laiho, X. F. Wang, and J. Massagué. “TGF beta signals through a heteromeric protein kinase receptor complex.” Cell 71, no. 6 (December 11, 1992): 1003–14. https://doi.org/10.1016/0092-8674(92)90395-s.
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    • Lin, H. Y., and X. F. Wang. “Expression cloning of TGF-beta receptors.” Mol Reprod Dev 32, no. 2 (June 1992): 105–10. https://doi.org/10.1002/mrd.1080320205.
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    • Lin, H. Y., X. F. Wang, E. Ng-Eaton, R. A. Weinberg, and H. F. Lodish. “Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.” Cell 68, no. 4 (February 21, 1992): 775–85. https://doi.org/10.1016/0092-8674(92)90152-3.
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    • Wang, X. F., H. Y. Lin, E. Ng-Eaton, J. Downward, H. F. Lodish, and R. A. Weinberg. “Expression cloning and characterization of the TGF-beta type III receptor.” Cell 67, no. 4 (November 15, 1991): 797–805. https://doi.org/10.1016/0092-8674(91)90074-9.
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    • Friend, S. H., J. M. Horowitz, M. R. Gerber, X. F. Wang, E. Bogenmann, F. P. Li, and R. A. Weinberg. “Erratum: Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein (Proc., Natl. Acad. Sci. USA, No. 24, Dec. 1987 (84, 9059-9063)).” Proceedings of the National Academy of Sciences of the United States of America 85, no. 7 (December 1, 1988): 2234. https://doi.org/10.1073/pnas.85.7.2234.
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    • Tsao, B. P., X. F. Wang, C. L. Peterson, and K. Calame. “In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.” Nucleic Acids Res 16, no. 8 (April 25, 1988): 3239–53. https://doi.org/10.1093/nar/16.8.3239.
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    • Kimchi, A., X. F. Wang, R. A. Weinberg, S. Cheifetz, and J. Massagué. “Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells.” Science 240, no. 4849 (April 8, 1988): 196–99. https://doi.org/10.1126/science.2895499.
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    • Kimchi, A., X. F. Wang, R. A. Weinberg, S. Cheifetz, and J. Massague. “Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells.” Science 239, no. 4849 (1988): 196–99.
    • Friend, S. H., J. M. Horowitz, M. R. Gerber, X. F. Wang, E. Bogenmann, F. P. Li, and R. A. Weinberg. “Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.” Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 9059–63. https://doi.org/10.1073/pnas.84.24.9059.
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    • Wang, X. F., and K. Calame. “SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation.” Cell 47, no. 2 (October 24, 1986): 241–47. https://doi.org/10.1016/0092-8674(86)90446-0.
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    • Wang, X. F., and K. Calame. “The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.” Cell 43, no. 3 Pt 2 (December 1985): 659–65. https://doi.org/10.1016/0092-8674(85)90238-7.
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    • Mercola, M., X. F. Wang, J. Olsen, and K. Calame. “Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.” Science 221, no. 4611 (August 12, 1983): 663–65. https://doi.org/10.1126/science.6306772.
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  • Conference Papers

    • Hu, Jing, Tao Sun, Hui Wang, Pingping Wang, Xiang-Dong Fu, Qi-Jing Li, and Xiao-Fan Wang. “Abstract 3536: Roles of miR-215 and regulatory mechanisms for its biogenesis in response to hypoxia in glioblastoma stem cells.” In Molecular and Cellular Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-3536.
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    • Biernacka, Anna, Carlos Gonzalez-Quesada, Ping Kong, Vikrant Rai, Panagiota Christia, Marcin Dobaczewski, Dong-Wook Lee, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 Loss is Associated with Aortic Dilation and Spontaneous Aortic Rupture in Lean and in Obese Diabetic Db/db Mice.” In Circulation, Vol. 126. LIPPINCOTT WILLIAMS & WILKINS, 2012.
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    • Hrgovic, I., M. Doll, J. Kleemann, X. F. Wang, N. Zoeller, A. Pinter, S. Kippenberger, R. Kaufmann, and M. Meissner. “The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.” In Bmc Bioinformatics, Vol. 13, 2012. https://doi.org/10.1186/s12885-016-2807-y.
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    • Biernacka, Anna, Carlos Gonzalez-Quesada, Qi Tian, Na Li, Marcin Dobaczewski, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “TGF-beta/Smad3 Activation in the Diabetic Mouse Heart Induces Fibrotic Cardiac Remodeling and Diastolic Dysfunction While Protecting From Excessive Matrix Degradation and Preventing the Development of Systolic Dysfunction.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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    • Dobaczewski, Marcin, Carlos Gonzalez-Ouesada, Marcin Bujak, Na Li, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3-/- Fibroblasts Are Hyperproliferative Cells With Impaired Migratory Capacity, Reduced Contractile Activity and Diminished Synthetic Function: Implications for Cardiac Repair and Remodeling.” In Circulation, 120:S792–S792. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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    • Feng, Junjie, Timothy Wakeman, Sheila Yong, Sally Kornbluth, Xiao-Hua Wu, and Xiao-Fan Wang. “PP2A-dependent dephosphorylation of replication protein A (RPA) is required for the removal of DNA breaks induced by replication stress.” In Cancer Research, Vol. 69. AMER ASSOC CANCER RESEARCH, 2009.
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    • Dobaczewski, Marcin, Marcin Bujak, Carlos Gonzalez, Na Li, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “The Smad3 Pathway Critically Regulates Myofibroblast Proliferation And Synthetic Activity In Healing Myocardial Infarcts.” In Circulation, 118:S293–S293. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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    • Bujak, Marcin J., Guofeng Ren, Khaled F. Chatila, Marcin Dobaczewski, Anilkumar Reddy, George Taffet, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Smad3 signaling critically regulates infarct healing.” In Faseb Journal, 21:A11–A11. FEDERATION AMER SOC EXP BIOL, 2007.
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    • Buiak, Marcin J., Guofeng Ren, Khaled Chatila, Marcin Dobaczewski, Anilkumar Reddy, George Taffet, Xiao-Fan Wang, and Nikolaos G. Frangogiannis. “Disruption of the Smad3 signaling pathway attenuates post-infarction remodeling.” In Journal of the American College of Cardiology, 49:210A-210A. ELSEVIER SCIENCE INC, 2007.
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• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 393: Research Independent Study 2021
  • PHARM 394: Research Independent Study 2021
  • PHARM 493: Research Independent Study 2021
  • PHARM 494: Research Independent Study 2021
  • PHARM 393: Research Independent Study 2020
  • PHARM 394: Research Independent Study 2020
  • PHARM 493: Research Independent Study 2020
  • PHARM 494: Research Independent Study 2020
  • PHARM 393: Research Independent Study 2019
  • PHARM 394: Research Independent Study 2019
  • PHARM 493: Research Independent Study 2019
  • PHARM 494: Research Independent Study 2019

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