Xiao-Fan Wang | Scholars@Duke

Xiao-Fan Wang
Donald and Elizabeth Cooke Professor of Cancer Research, in the School of Medicine

The current research in the Wang laboratory mainly focuses on the elucidation of molecular nature and signaling mechanisms associated with the initiation of cellular senescence. In addition, we continue to study changes in tumor microenvironment that promotes tumor progression and metastasis, particularly how tumor cells interact with the immune system. Ultimately, we hope that our studies in these areas to lead to the development of novel therapeutics for the treatment of various types of human cancer.

Current Appointments & Affiliations

Donald and Elizabeth Cooke Professor of Cancer Research, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2009
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2003
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1992

Contact Information

C218 Lev Sci Res Ctr, Durham, NC 27708
Duke Box 3813, Durham, NC 27710
wang0011@mc.duke.edu (919) 681-4861

Background
Education, Training, & Certifications
- Ph.D., University of California at Los Angeles 1986
- B.S., Wuhan University (China) 1982
Duke Appointment History
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1998 - 2003
- Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 1998
Recognition
Awards & Honors
Research
Selected Grants
- Targeting UHRF1 in combinational immunotherapy awarded by National Institutes of Health 2019 - 2023
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Analysis of mechanisms associated with Her2-positive breast cancer resistance to therapy awarded by Department of Defense 2016 - 2019
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- The anti-senescence activity of trefoil factor 1 awarded by National Institutes of Health 2012 - 2018
- The Roles of MicroRNAs in Glioblastoma awarded by National Institutes of Health 2012 - 2017
- Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Molecular determinants underlying herceptin sensitivity and resistance awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Determine the potential therapeutic effect of HDAC6 inhibitors in inhibiting breast cancer metastasis and glioblastoma awarded by Acetylon Pharmaceuticals, Inc. 2014 - 2015
- The role of TGF-beta in tumorigenesis awarded by National Institutes of Health 2010 - 2015
- 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
- Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer awarded by National Institutes of Health 2011 - 2013
- Mechanisms of TGF-B/Smad Signaling awarded by National Institutes of Health 2008 - 2012
- TGFBI and tumorigenesis awarded by National Institutes of Health 2006 - 2011
- Rad17- & p53-mediated apoptotic pathways in response to DNA damage awarded by National Institutes of Health 2006 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
- Molecular Mechanisms of SPARC Mediated Glioma Invasion awarded by National Institutes of Health 2006 - 2008
- TGF-Beta Signaling in MSCs and Osteoblast awarded by National Institutes of Health 2004 - 2008
- Analysis of Rad17-mediated Checkpoint Signaling awarded by National Institutes of Health 2002 - 2008
- Analysis of the Functional Role of TPF in Tumorigenesis awarded by National Institutes of Health 2000 - 2005
- The Role Of Tumor Supressor Smads In Tgf-B Signaling awarded by National Institutes of Health 1998 - 2004
- Functional Analysis of TGFRP, A Putative Angiogenic Factor in Breast Carcinogenics awarded by US Army Medical Research 1999 - 2002
- The Role Of Tgfb In Brain Tumors awarded by National Institutes of Health 1998 - 2001
- Tgf-Beta Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1995 - 2001
- Tgf-B Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1996 - 1999
- Examination Of Tgfb Induced Cell Death Pathway awarded by National Institutes of Health 1995 - 1998
- Analysis Of Tgf-B Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1994 - 1995
- Analysis Of Tgf Beta Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1993 - 1995
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chong, M, Yin, T, Chen, R, Xiang, H, Yuan, L, Ding, Y, Pan, CC, Tang, Z, Alexander, PB, Li, Q-J, and Wang, X-F. "CD36 initiates the secretory phenotype during the establishment of cellular senescence." Embo Reports 19, no. 6 (June 2018). Full Text
  - Yuan, L, Zhai, L, Qian, L, Huang, D, Ding, Y, Xiang, H, Liu, X, Thompson, JW, Liu, J, He, Y-H, Chen, X-Q, Hu, J, Kong, Q-P, Tan, M, and Wang, X-F. "Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death." Cell Research 28, no. 6 (June 2018): 625-643. Full Text
  - Li, J-J, Yin, H-K, Guan, D-X, Zhao, J-S, Feng, Y-X, Deng, Y-Z, Wang, X, Li, N, Wang, X-F, Cheng, S-Q, Bao, Y, and Xie, D. "Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis." British Journal of Cancer 118, no. 10 (May 2, 2018): 1337-1348. Full Text
  - Deng, Y-Z, Cai, Z, Shi, S, Jiang, H, Shang, Y-R, Ma, N, Wang, J-J, Guan, D-X, Chen, T-W, Rong, Y-F, Qian, Z-Y, Zhang, E-B, Feng, D, Zhou, Q-L, Du, Y-N, Liu, D-P, Huang, X-X, Liu, L-M, Chin, E, Li, D-S, Wang, X-F, Zhang, X-L, and Xie, D. "Cilia loss sensitizes cells to transformation by activating the mevalonate pathway." The Journal of Experimental Medicine 215, no. 1 (January 2018): 177-195. Full Text
  - Zhang, Y, Alexander, PB, and Wang, X-F. "TGF-β Family Signaling in the Control of Cell Proliferation and Survival." Cold Spring Harbor perspectives in biology 9, no. 4 (April 2017). (Review) Full Text
  - Alexander, PB, Chen, R, Gong, C, Yuan, L, Jasper, JS, Ding, Y, Markowitz, GJ, Yang, P, Xu, X, McDonnell, DP, Song, E, and Wang, X-F. "Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer." The Journal of Biological Chemistry 292, no. 2 (January 2017): 748-759. Full Text Open Access Copy
  - Xiang, H, Yuan, L, Gao, X, Alexander, PB, Lopez, O, Lau, C, Ding, Y, Chong, M, Sun, T, Chen, R, Liu, S-Q, Wu, H, Wan, Y, Randell, SH, Li, Q-J, and Wang, X-F. "UHRF1 is required for basal stem cell proliferation in response to airway injury." Cell Discovery 3 (January 2017): 17019-null. Full Text Open Access Copy
  - Liu, Z, Kundu-Roy, T, Matsuura, I, Wang, G, Lin, Y, Lou, Y-R, Barnard, NJ, Wang, X-F, Huang, M-T, Suh, N, and Liu, F. "Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice." Oncotarget 7, no. 40 (October 2016): 64878-64885. Full Text
  - Hrgovic, I, Doll, M, Kleemann, J, Wang, X-F, Zoeller, N, Pinter, A, Kippenberger, S, Kaufmann, R, and Meissner, M. "The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways." BMC cancer 16, no. 1 (September 30, 2016): 763-. Full Text
  - Hu, J, and Wang, X-F. "HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia." Cell Cycle (Georgetown, Tex.) 15, no. 15 (August 2016): 1939-1940. Full Text
  - Bao, W-D, Fan, Y, Deng, Y-Z, Long, L-Y, Wang, J-J, Guan, D-X, Qian, Z-Y, An, P, Feng, Y-Y, He, Z-Y, Wang, X-F, Phillip Koeffler, H, Hu, R, Wang, J, Wang, X, Wang, F, Li, J-J, and Xie, D. "Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis." Journal of hepatology 65, no. 1 (July 2016): 137-145. Full Text
  - Markowitz, GJ, Yang, P, Fu, J, Michelotti, GA, Chen, R, Sui, J, Yang, B, Qin, W-H, Zhang, Z, Wang, F-S, Diehl, AM, Li, Q-J, Wang, H, and Wang, X-F. "Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes." Cancer Research 76, no. 8 (April 2016): 2394-2405. Full Text
  - Xu, X, Zhang, Y, Jasper, J, Lykken, E, Alexander, PB, Markowitz, GJ, McDonnell, DP, Li, Q-J, and Wang, X-F. "MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer." Oncotarget 7, no. 15 (April 2016): 20381-20394. Full Text
  - Valesky, EM, Hrgovic, I, Doll, M, Wang, X-F, Pinter, A, Kleemann, J, Kaufmann, R, Kippenberger, S, and Meissner, M. "Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest." Experimental dermatology 25, no. 3 (March 2016): 200-205. Full Text
  - Hu, J, Markowitz, G, and Wang, X-F. "Isolation of Glioma-Initiating Cells for Biological Study." Advances in experimental medicine and biology 899 (January 2016): 197-209. Full Text
  - Hu, J, Markowitz, GJ, and Wang, X. "Noncoding RNAs Regulating Cancer Signaling Network." Advances in experimental medicine and biology 927 (January 2016): 297-315. (Review) Full Text
  - Hu, J, Sun, T, Wang, H, Chen, Z, Wang, S, Yuan, L, Liu, T, Li, H-R, Wang, P, Feng, Y, Wang, Q, McLendon, RE, Friedman, AH, Keir, ST, Bigner, DD, Rathmell, J, Fu, X-D, Li, Q-J, Wang, H, and Wang, X-F. "MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B." Cancer Cell 29, no. 1 (January 2016): 49-60. Full Text Open Access Copy
  - Yang, P, Zhang, Y, Markowitz, GJ, Guo, X, and Wang, X-F. "TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology." Methods in molecular biology (Clifton, N.J.) 1344 (January 2016): 325-339. Full Text
  - Biernacka, A, Cavalera, M, Wang, J, Russo, I, Shinde, A, Kong, P, Gonzalez-Quesada, C, Rai, V, Dobaczewski, M, Lee, D-W, Wang, X-F, and Frangogiannis, NG. "Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice." Circulation. Heart Failure 8, no. 4 (July 2015): 788-798. Full Text
  - Alexander, PB, and Wang, X-F. "Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies." Frontiers of Medicine 9, no. 2 (June 2015): 134-138. (Review) Full Text
  - Zhang, Y, and Wang, X-F. "A niche role for cancer exosomes in metastasis." Nature Cell Biology 17, no. 6 (June 2015): 709-711. Full Text
  - Dai, X, Shen, J, Annam, NP, Jiang, H, Levi, E, Schworer, CM, Tromp, G, Arora, A, Higgins, M, Wang, X-F, Yang, M, Li, HJ, Zhang, K, Kuivaniemi, H, and Li, L. "SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model." Scientific reports 5 (May 18, 2015): 10180-. Full Text
  - Markowitz, GJ, Michelotti, GA, Diehl, AM, and Wang, X-F. "Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma." Science bulletin 60, no. 8 (April 2015): 762-772. Full Text
  - Alexander, PB, Yuan, L, Yang, P, Sun, T, Chen, R, Xiang, H, Chen, J, Wu, H, Radiloff, DR, and Wang, X-F. "EGF promotes mammalian cell growth by suppressing cellular senescence." Cell Research 25, no. 1 (January 2015): 135-138. (Letter) Full Text
  - Zhang, Y, and Wang, X-F. "Post-transcriptional regulation of MTA family by microRNAs in the context of cancer." Cancer metastasis reviews 33, no. 4 (December 2014): 1011-1016. (Review) Full Text
  - Zhang, Y, and Wang, X-F. "Post-transcriptional regulation of MTA family by microRNAs in the context of cancer." Cancer and Metastasis Reviews 33, no. 4 (December 2014): 1011-1016. Full Text
  - Wang, X-F, and Korangy, F. "Intrahepatic landscape of regulatory T-cell subsets in chronically HCV-infected patients with cirrhosis and HCC." Hepatology (Baltimore, Md.) 60, no. 5 (November 2014): 1461-1462. Full Text
  - Wang, H, Sun, T, Hu, J, Zhang, R, Rao, Y, Wang, S, Chen, R, McLendon, RE, Friedman, AH, Keir, ST, Bigner, DD, Li, Q-J, Wang, H, and Wang, X-F. "miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4489-4502. Full Text
  - Yang, P, Markowitz, GJ, and Wang, X-F. "The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma." National science review 1, no. 3 (July 2014): 396-412. Full Text
  - Wang, Q, Goldstein, M, Alexander, P, Wakeman, TP, Sun, T, Feng, J, Lou, Z, Kastan, MB, and Wang, X-F. "Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks." The Embo Journal 33, no. 8 (April 2014): 862-877. Full Text
  - Zhang, Y, Yang, P, and Wang, X-F. "Microenvironmental regulation of cancer metastasis by miRNAs." Trends in Cell Biology 24, no. 3 (March 2014): 153-160. (Review) Full Text
  - Zhang, Y, Yang, P, and Wang, XF. "Microenvironmental regulation of cancer metastasis by miRNAs." Trends in Cell Biology 24, no. 3 (March 1, 2014): 153-160. (Review) Full Text
  - Hu, J, and Wang, X-F. "COUP-TFII and AKT are cancer targets pursued by SCBA award winners." Cell & bioscience 4, no. 1 (January 2014): 57-. Full Text
  - Kellenberger, T, Krag, S, Danielsen, CC, Wang, X-F, Nyengaard, JR, Pedersen, L, Yang, C, Gao, S, and Wogensen, L. "Differential effects of Smad3 targeting in a murine model of chronic kidney disease." Physiological reports 1, no. 7 (December 15, 2013): e00181-. Full Text
  - Guo, X, and Wang, X-F. "A P(E)RM(I)T for BMP signaling." Molecular cell 51, no. 1 (July 2013): 1-2. Full Text
  - Zhang, Y, Yang, P, Sun, T, Li, D, Xu, X, Rui, Y, Li, C, Chong, M, Ibrahim, T, Mercatali, L, Amadori, D, Lu, X, Xie, D, Li, Q-J, and Wang, X-F. "miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis." Nat Cell Biol 15, no. 3 (March 2013): 284-294. Full Text Link to Item
  - Curtis, VF, Wang, H, Yang, P, McLendon, RE, Li, X, Zhou, Q-Y, and Wang, X-F. "A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer." Plos One 8, no. 1 (January 23, 2013): e54916-null. Full Text
  - Guo, X, and Wang, X-F. "New secrets behind bone metastasis." Cell Research 22, no. 9 (September 2012): 1309-1311. Full Text
  - Xu, Y-P, Shi, Y, Cui, Z-Z, Jiang, HH, Li, L, Wang, X-F, Zhou, L, and Mi, Q-S. "TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development." The Journal of Investigative Dermatology 132, no. 8 (August 2012): 2106-2109. (Letter) Full Text
  - Wakeman, TP, Wang, Q, Feng, J, and Wang, X-F. "Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases." The Embo Journal 31, no. 9 (May 2012): 2169-2181. Full Text
  - Chen, Y-G, Li, Z, and Wang, X-F. "Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate." Cell Stem Cell 10, no. 3 (March 2012): 231-232. Full Text
  - Guo, X, and Wang, X-F. "A mediator lost in the war on cancer." Cell 151, no. 5 (2012): 927-929. Full Text
  - Yang, P, Li, QJ, Feng, Y, Zhang, Y, Markowitz, GJ, Ning, S, Deng, Y, Zhao, J, Jiang, S, Yuan, Y, Wang, HY, Cheng, SQ, Xie, D, and Wang, XF. "TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma." Cancer Cell 22, no. 3 (2012): 291-303. Full Text
  - Yong, ST, and Wang, X-F. "A novel, non-apoptotic role for Scythe/BAT3: A functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle." PLoS ONE 7, no. 6 (2012). Full Text
  - Zhang, Y, Chen, J, Li, F, Li, D, Xiong, Q, Lin, Y, Zhang, D, Wang, X-F, Yang, P, and Rui, Y-C. "A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway." Stroke 43, no. 10 (2012): 2764-2773. Full Text
  - Wakeman, TP, Feng, J, and Wang, X-F. "Abstract 2482: Bat3 facilitates histone H3 lysine 79 dimethylation by DOT1L to promote ionizing radiation-induced 53BP1 foci formation during G1- and G2-phases of the cell cycle." Cancer Research 71, no. 8 Supplement (April 15, 2011): 2482-2482. Full Text
  - Wang, H, Wang, X-F, Rich, J, Wang, Q, and Hjelmeland, A. "Abstract 3311: IL6-Stat3 signaling promotes glioma stem cell (GSC) survival under hypoxia environment through inhibition of cell-death inducing gene Bnip3." Cancer Research 71, no. 8 Supplement (April 15, 2011): 3311-3311. Full Text
  - Radiloff, DR, Wakeman, TP, Feng, J, Schilling, S, Seto, E, and Wang, X-F. "Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process." Proceedings of the National Academy of Sciences of the United States of America 108, no. 16 (April 2011): 6591-6596. Full Text
  - Feng, Y-X, Wang, T, Deng, Y-Z, Yang, P, Li, J-J, Guan, D-X, Yao, F, Zhu, Y-Q, Qin, Y, Wang, H, Li, N, Wu, M-C, Wang, H-Y, Wang, X-F, Cheng, S-Q, and Xie, D. "Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model." Hepatology (Baltimore, Md.) 53, no. 2 (February 2011): 483-492. Full Text
  - D'Souza, CA, Kronstad, JW, Taylor, G, Warren, R, Yuen, M, Hu, G, Jung, WH, Sham, A, Kidd, SE, Tangen, K, Lee, N, Zeilmaker, T, Sawkins, J, McVicker, G, Shah, S, Gnerre, S, Griggs, A, Zeng, Q, Bartlett, K, Li, W, Wang, X, Heitman, J, Stajich, JE, Fraser, JA, Meyer, W, Carter, D, Schein, J, Krzywinski, M, Kwon-Chung, KJ, Varma, A, Wang, J, Brunham, R, Fyfe, M, Ouellette, BFF, Siddiqui, A, Marra, M, Jones, S, Holt, R, Birren, BW, Galagan, JE, and Cuomo, CA. "Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts." Mbio 2, no. 1 (January 2011): e00342-e00310. Full Text
  - Tapia-González, S, Giráldez-Pérez, RM, Cuartero, MI, Casarejos, MJ, Mena, MÁ, Wang, X-F, and Sánchez-Capelo, A. "Dopamine and α-synuclein dysfunction in Smad3 null mice." Molecular Neurodegeneration 6 (January 2011): 72-null. Full Text
  - Tapia-González, S, Giráldez-Pérez, RM, Cuartero, MI, Casarejos, MJ, Mena, MÁ, Wang, X-F, and Sánchez-Capelo, A. "Dopamine and α-synuclein dysfunction in Smad3 null mice." Molecular neurodegeneration 6 (2011): 72--. Full Text
  - Zhao, J-S, Li, W-J, Ge, D, Zhang, P-J, Li, J-J, Lu, C-L, Ji, X-D, Guan, D-X, Gao, H, Xu, L-Y, Li, E-M, Soukiasian, H, Koeffler, HP, Wang, X-F, and Xie, D. "Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44." PLoS One 6, no. 6 (2011): e21419-. Full Text Link to Item
  - Dobaczewski, M, Bujak, M, Li, N, Gonzalez-Quesada, C, Mendoza, LH, Wang, X-F, and Frangogiannis, NG. "Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction." Circulation Research 107, no. 3 (August 2010): 418-428. Full Text
  - Zhang, L, Park, C-H, Wu, J, Kim, H, Liu, W, Fujita, T, Balasubramani, M, Schreiber, EM, Wang, X-F, and Wan, Y. "Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress." The Embo Journal 29, no. 10 (May 2010): 1726-1737. Full Text
  - Feng, Y-X, Zhao, J-S, Li, J-J, Wang, T, Cheng, S-Q, Yuan, Y, Wang, F, Wang, X-F, and Xie, D. "Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-κB signaling pathway." Hepatology 51, no. 2 (2010): 535-544. Full Text
  - Wang, J, Wakeman, TP, Lathia, JD, Hjelmeland, AB, Wang, X-F, White, RR, Rich, JN, and Sullenger, BA. "Notch promotes radioresistance of glioma stem cells." Stem Cells (Dayton, Ohio) 28, no. 1 (January 2010): 17-28. Full Text
  - Feng, J, Wakeman, T, Yong, S, Wu, X, Kornbluth, S, and Wang, X-F. "Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress." Molecular and Cellular Biology 29, no. 21 (November 2009): 5696-5709. Full Text
  - Wang, H, Lathia, JD, Wu, Q, Wang, J, Li, Z, Heddleston, JM, Eyler, CE, Elderbroom, J, Gallagher, J, Schuschu, J, MacSwords, J, Cao, Y, McLendon, RE, Wang, X-F, Hjelmeland, AB, and Rich, JN. "Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth." Stem Cells (Dayton, Ohio) 27, no. 10 (October 2009): 2393-2404. Full Text
  - Jardim, MJ, Wang, Q, Furumai, R, Wakeman, T, Goodman, BK, and Wang, X-F. "Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells." Molecular Biology of the Cell 20, no. 17 (September 2009): 3801-3809. Full Text
  - Schilling, SH, Hjelmeland, AB, Radiloff, DR, Liu, IM, Wakeman, TP, Fielhauer, JR, Foster, EH, Lathia, JD, Rich, JN, Wang, X-F, and Datto, MB. "NDRG4 is required for cell cycle progression and survival in glioblastoma cells." The Journal of Biological Chemistry 284, no. 37 (September 2009): 25160-25169. Full Text
  - Chen, Y-G, and Wang, X-F. "Finale: The Last Minutes of Smads." Cell 139, no. 4 (2009): 658-660. Full Text
  - Chen, Y-G, and Wang, X-F. "A special issue on TGF-beta signaling." Cell Research 19, no. 1 (January 2009): 1-2. Full Text
  - Guo, X, and Wang, X-F. "Signaling cross-talk between TGF-beta/BMP and other pathways." Cell Research 19, no. 1 (January 2009): 71-88. (Review) Full Text
  - Hu, G, Kang, Y, and Wang, X-F. "From breast to the brain: Unraveling the puzzle of metastasis organotropism." Journal of Molecular Cell Biology 1, no. 1 (2009): 3-5. Full Text
  - Liu, IM, Schilling, SH, Knouse, KA, Choy, L, Derynck, R, and Wang, X-F. "TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch." The Embo Journal 28, no. 2 (January 2009): 88-98. Full Text
  - Guo, X, Waddell, DS, Wang, W, Wang, Z, Liberati, NT, Yong, S, Liu, X, and Wang, X-F. "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling." Oncogene 27, no. 58 (December 2008): 7235-7247. Full Text
  - Lee, Y-S, Lim, K-H, Guo, X, Kawaguchi, Y, Gao, Y, Barrientos, T, Ordentlich, P, Wang, X-F, Counter, CM, and Yao, T-P. "The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis." CANCER RESEARCH 68, no. 18 (September 15, 2008): 7561-7569. Full Text Link to Item
  - Lee, Y-S, Lim, K-H, Guo, X, Kawaguchi, Y, Gao, Y, Barrientos, T, Ordentlich, P, Wang, X-F, Counter, CM, and Yao, T-P. "The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis." Cancer Research 68, no. 18 (September 2008): 7561-7569. Full Text
  - Guo, JY, Yamada, A, Kajino, T, Wu, JQ, Tang, W, Freel, CD, Feng, J, Chau, BN, Wang, MZ, Margolis, SS, Yoo, HY, Wang, X-F, Dunphy, WG, Irusta, PM, Hardwick, JM, and Kornbluth, S. "Aven-dependent activation of ATM following DNA damage." Current Biology : Cb 18, no. 13 (July 2008): 933-942. Full Text
  - Ma, C, Rong, Y, Radiloff, DR, Datto, MB, Centeno, B, Bao, S, Cheng, AWM, Lin, F, Jiang, S, Yeatman, TJ, and Wang, X-F. "Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation." Genes & Development 22, no. 3 (February 2008): 308-321. Full Text
  - Guo, X, Ramirez, A, Waddell, DS, Li, Z, Liu, X, and Wang, X-F. "Axin and GSK3-beta control Smad3 protein stability and modulate TGF-beta signaling." Genes & Development 22, no. 1 (January 1, 2008): 106-120. (Academic Article) Full Text Link to Item
  - Guo, X, Ramirez, A, Waddell, DS, Li, Z, Liu, X, and Wang, X-F. "Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling." Genes & Development 22, no. 1 (January 2008): 106-120. Full Text
  - Ma, C, and Wang, X-F. "In vitro assays for the extracellular matrix protein-regulated extravasation process." Cold Spring Harbor Protocols 3, no. 8 (2008). Full Text
  - Bujak, M, Ren, G, Kweon, HJ, Dobaczewski, M, Reddy, A, Taffet, G, Wang, X-F, and Frangogiannis, NG. "Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling." Circulation 116, no. 19 (November 2007): 2127-2138. Full Text
  - Young, TW, Rosen, DG, Mei, FC, Li, N, Liu, J, Wang, X-F, and Cheng, X. "Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 13, no. 13 (July 2007): 3848-3854. Full Text
  - Margolis, SS, Perry, JA, Forester, CM, Nutt, LK, Guo, Y, Jardim, MJ, Thomenius, MJ, Freel, CD, Darbandi, R, Ahn, J-H, Arroyo, JD, Wang, X-F, Shenolikar, S, Nairn, AC, Dunphy, WG, Hahn, WC, Virshup, DM, and Kornbluth, S. "Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis." Cell 127, no. 4 (November 2006): 759-773. Full Text
  - Schilling, SH, Datto, MB, and Wang, X-F. "A phosphatase controls the fate of receptor-regulated Smads." Cell 125, no. 5 (June 2, 2006): 838-840. (Review) Full Text Link to Item
  - Jian, H, Shen, X, Liu, I, Semenov, M, He, X, and Wang, X-F. "Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells." Genes & Development 20, no. 6 (March 2006): 666-674. Full Text
  - Chow, EK, O'connell, RM, Schilling, S, Wang, X-F, Fu, X-Y, and Cheng, G. "TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk." The Embo Journal 24, no. 23 (December 2005): 4071-4081. Full Text
  - Hjelmeland, AB, Hjelmeland, MD, Shi, Q, Hart, JL, Bigner, DD, Wang, X-F, Kontos, CD, and Rich, JN. "Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity." Cancer Research 65, no. 24 (December 2005): 11276-11281. Full Text
  - Hjelmeland, AB, Schilling, SH, Guo, X, Quarles, D, and Wang, X-F. "Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination." Molecular and Cellular Biology 25, no. 21 (November 2005): 9460-9468. Full Text
  - Zhang, J, Bao, S, Furumai, R, Kucera, KS, Ali, A, Dean, NM, and Wang, X-F. "Protein phosphatase 5 is required for ATR-mediated checkpoint activation." Molecular and Cellular Biology 25, no. 22 (November 2005): 9910-9919. Full Text
  - Howard, BA, Furumai, R, Campa, MJ, Rabbani, ZN, Vujaskovic, Z, Wang, X-F, and Patz, EF. "Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo." Cancer Research 65, no. 19 (October 2005): 8853-8860. Full Text
  - Datto, M, and Wang, X-F. "Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling." Cell 121, no. 1 (April 8, 2005): 2-4. Full Text Link to Item
  - Chen, H, Sun, J, Buckley, S, Chen, C, Warburton, D, Wang, X-F, and Shi, W. "Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema." American Journal of Physiology. Lung Cellular and Molecular Physiology 288, no. 4 (April 2005): L683-L691. Full Text
  - Dang, T, Bao, S, and Wang, X-F. "Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability." Genes to Cells : Devoted to Molecular & Cellular Mechanisms 10, no. 4 (April 2005): 287-295. Full Text
  - Goudar, RK, Shi, Q, Hjelmeland, MD, Keir, ST, McLendon, RE, Wikstrand, CJ, Reese, ED, Conrad, CA, Traxler, P, Lane, HA, Reardon, DA, Cavenee, WK, Wang, X-F, Bigner, DD, Friedman, HS, and Rich, JN. "Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition." Molecular Cancer Therapeutics 4, no. 1 (January 2005): 101-112.
  - Shi, Q, Bao, S, Maxwell, JA, Reese, ED, Friedman, HS, Bigner, DD, Wang, X-F, and Rich, JN. "Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation." J Biol Chem 279, no. 50 (December 10, 2004): 52200-52209. Full Text Link to Item
  - Fang, Y, Tsao, C-C, Goodman, BK, Furumai, R, Tirado, CA, Abraham, RT, and Wang, X-F. "ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background." EMBO J 23, no. 15 (August 4, 2004): 3164-3174. Full Text Link to Item
  - Waddell, DS, Liberati, NT, Guo, X, Frederick, JP, and Wang, X-F. "Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway." The Journal of Biological Chemistry 279, no. 28 (July 2004): 29236-29246. Full Text
  - Hjelmeland, MD, Hjelmeland, AB, Sathornsumetee, S, Reese, ED, Herbstreith, MH, Laping, NJ, Friedman, HS, Bigner, DD, Wang, X-F, and Rich, JN. "SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility." Molecular Cancer Therapeutics 3, no. 6 (June 2004): 737-745.
  - Shao, R, Bao, S, Bai, X, Blanchette, C, Anderson, RM, Dang, T, Gishizky, ML, Marks, JR, and Wang, X-F. "Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression." Molecular and Cellular Biology 24, no. 9 (May 2004): 3992-4003. Full Text
  - Bao, S, Ouyang, G, Bai, X, Huang, Z, Ma, C, Liu, M, Shao, R, Anderson, RM, Rich, JN, and Wang, X-F. "Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway." Cancer Cell 5, no. 4 (April 2004): 329-339. Full Text
  - Feinberg, MW, Watanabe, M, Lebedeva, MA, Depina, AS, Hanai, J-I, Mammoto, T, Frederick, JP, Wang, X-F, Sukhatme, VP, and Jain, MK. "Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3." The Journal of Biological Chemistry 279, no. 16 (April 2004): 16388-16393. Full Text
  - Frederick, JP, Liberati, NT, Waddell, DS, Shi, Y, and Wang, X-F. "Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element." Molecular and Cellular Biology 24, no. 6 (March 2004): 2546-2559. Full Text
  - Ali, A, Zhang, J, Bao, S, Liu, I, Otterness, D, Dean, NM, Abraham, RT, and Wang, X-F. "Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation." Genes & Development 18, no. 3 (February 2004): 249-254. Full Text
  - Feinberg, MW, Shimizu, K, Lebedeva, M, Haspel, R, Takayama, K, Chen, Z, Frederick, JP, Wang, X-F, Simon, DI, Libby, P, Mitchell, RN, and Jain, MK. "Essential Role for Smad3 in Regulating MCP-1 Expression and Vascular Inflammation." Circulation Research 94, no. 5 (2004): 601-608. Full Text
  - Ho, J, Guise, CD, Kim, C, Lemay, S, Wang, X-F, and Lebrun, J-J. "Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15^INK4B and Sp1." Cellular Signalling 16, no. 6 (2004): 693-701. Full Text
  - Siervi, AD, Marinissen, M, Diggs, J, Wang, X-F, Pages, G, and Senderowicz, A. "Transcriptional Activation of p21^waf1/cip1 by Alkylphospholipids: Role of the Mitogen-Activated Protein Kinase Pathway in the Transactivation of the Human p21^waf1/cip1 Promoter by Sp1." Cancer Research 64, no. 2 (2004): 743-750. Full Text
  - Chen, W, Kirkbride, KC, How, T, Nelson, CD, Mo, J, Frederick, JP, Wang, X-F, Lefkowitz, RJ, and Blobe, GC. "Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling." Science (New York, N.Y.) 301, no. 5638 (September 2003): 1394-1397. Full Text
  - Rich, JN, Shi, Q, Hjelmeland, M, Cummings, TJ, Kuan, C-T, Bigner, DD, Counter, CM, and Wang, X-F. "Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model." The Journal of Biological Chemistry 278, no. 18 (May 2003): 15951-15957. Full Text
  - Chowdhury, IH, Farhadi, A, Wang, X-F, Robb, ML, Birx, DL, and Kim, JH. "Human T-cell leukemia virus type 1 tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2." International Journal of Cancer 107, no. 4 (2003): 603-611. Full Text
  - Chowdhury, IH, Wang, X-F, Landau, NR, Robb, ML, Polonis, VR, Birx, DL, and Kim, JH. "HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest." Virology 305, no. 2 (January 2003): 371-377. Full Text
  - Hubbert, C, Guardiola, A, Shao, R, Kawaguchi, Y, Ito, A, Nixon, A, Yoshida, M, Wang, X-F, and Yao, T-P. "HDAC6 is a microtubule-associated deacetylase." Nature 417, no. 6887 (May 2002): 455-458. Full Text
  - Zhao, J, Shi, W, Wang, Y-L, Chen, H, Bringas, P, Datto, MB, Frederick, JP, Wang, X-F, and Warburton, D. "Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 3 (March 2002): L585-L593. Full Text
  - Frederick, JP, and Wang, X-F. "Smads "freeze" when they Ski." Structure 10, no. 12 (2002): 1607-1611. Full Text
  - Hsu, S, Borke, JL, Lewis, JB, Singh, B, Aiken, AC, Huynh, CT, Schuster, GS, Caughman, GB, Dickinson, DP, Smith, AK, Osaki, T, and Wang, XF. "Transforming growth factor β1 dysregulation in a human oral carcinoma tumour progression model." Cell Proliferation 35, no. 3 (2002): 183-192. Full Text
  - Borton, AJ, Frederick, JP, Datto, MB, Wang, XF, and Weinstein, RS. "The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 16, no. 10 (October 2001): 1754-1764. Full Text
  - Schnabl, B, Kweon, YO, Frederick, JP, Wang, XF, Rippe, RA, and Brenner, DA. "The role of Smad3 in mediating mouse hepatic stellate cell activation." Hepatology (Baltimore, Md.) 34, no. 1 (July 2001): 89-100. Full Text
  - Shen, X, Li, J, Hu, PP, Waddell, D, Zhang, J, and Wang, XF. "The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation." J Biol Chem 276, no. 18 (May 4, 2001): 15362-15368. Full Text Link to Item
  - Rich, JN, Guo, C, McLendon, RE, Bigner, DD, Wang, XF, and Counter, CM. "A genetically tractable model of human glioma formation." Cancer Research 61, no. 9 (May 2001): 3556-3560.
  - Rich, J, Borton, A, and Wang, X. "Transforming growth factor-beta signaling in cancer." Microscopy Research and Technique 52, no. 4 (February 2001): 363-373. (Review) Full Text
  - Bao, S, Tibbetts, RS, Brumbaugh, KM, Fang, Y, Richardson, DA, Ali, A, Chen, SM, Abraham, RT, and Wang, X-F. "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic responses." Nature 411, no. 6840 (2001): 969-974. Full Text
  - Liberati, NT, Moniwa, M, Borton, AJ, Davie, JR, and Wang, X-F. "An Essential Role for Mad Homology Domain 1 in the Association of Smad3 with Histone Deacetylase Activity." Journal of Biological Chemistry 276, no. 25 (2001): 22595-22603. Full Text
  - Datto, M, and Wang, XF. "The Smads: transcriptional regulation and mouse models." Cytokine & Growth Factor Reviews 11, no. 1-2 (March 2000): 37-48. (Review) Full Text
  - Lin, WW, Friedman, MA, Wang, XF, and Abou-Donia, MB. "Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells." Brain Res 852, no. 2 (January 10, 2000): 297-304. Link to Item
  - Hu, PP, Shen, X, Huang, D, Liu, Y, Counter, C, and Wang, XF. "The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta." J Biol Chem 274, no. 50 (December 10, 1999): 35381-35387. Link to Item
  - Hu, PP, Harvat, BL, Hook, SS, Shen, X, Wang, XF, and Means, AR. "c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA." Molecular Endocrinology (Baltimore, Md.) 13, no. 12 (December 1999): 2039-2048. Full Text
  - Rich, JN, Zhang, M, Datto, MB, Bigner, DD, and Wang, XF. "Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines." The Journal of Biological Chemistry 274, no. 49 (December 1999): 35053-35058. Full Text
  - Kivinen, L, Tsubari, M, Haapajärvi, T, Datto, MB, Wang, XF, and Laiho, M. "Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites." Oncogene 18, no. 46 (November 1999): 6252-6261. Full Text
  - Billon, N, Carlisi, D, Datto, MB, van Grunsven, LA, Watt, A, Wang, XF, and Rudkin, BB. "Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation." Oncogene 18, no. 18 (May 6, 1999): 2872-2882. Full Text Link to Item
  - Datto, MB, Frederick, JP, Pan, L, Borton, AJ, Zhuang, Y, and Wang, XF. "Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction." Molecular and Cellular Biology 19, no. 4 (April 1999): 2495-2504. Full Text
  - Haapajärvi, T, Kivinen, L, Heiskanen, A, des Bordes, C, Datto, MB, Wang, XF, and Laiho, M. "UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner." Experimental Cell Research 248, no. 1 (April 1999): 272-279. Full Text
  - Liberati, NT, Datto, MB, Frederick, JP, Shen, X, Wong, C, Rougier-Chapman, EM, and Wang, XF. "Smads bind directly to the Jun family of AP-1 transcription factors." Proceedings of the National Academy of Sciences of the United States of America 96, no. 9 (April 1999): 4844-4849. Full Text
  - Wong, C, Rougier-Chapman, EM, Frederick, JP, Datto, MB, Liberati, NT, Li, JM, and Wang, XF. "Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta." Mol Cell Biol 19, no. 3 (March 1999): 1821-1830. Link to Item
  - Bao, S, Shen, X, Shen, K, Liu, Y, and Wang, XF. "The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint." Cell Growth Differ 9, no. 12 (December 1998): 961-967. Link to Item
  - Wang, X, and Chen, J. "Quantitive estimates of outcrossing rates in a natural population of Sagittaria potamogetifolia." Wuhan Daxue Xuebao/Journal of Wuhan University 44, no. 2 (December 1, 1998).
  - Hu, PP, Datto, MB, and Wang, XF. "Molecular mechanisms of transforming growth factor-beta signaling." Endocrine Reviews 19, no. 3 (June 1998): 349-363. (Review) Full Text
  - Li, JM, Datto, MB, Shen, X, Hu, PP, Yu, Y, and Wang, XF. "Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites." Nucleic Acids Res 26, no. 10 (May 15, 1998): 2449-2456. Link to Item
  - Lee, SJ, Ha, MJ, Lee, J, Nguyen, P, Choi, YH, Pirnia, F, Kang, WK, Wang, XF, Kim, SJ, and Trepel, JB. "Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells." The Journal of Biological Chemistry 273, no. 17 (April 1998): 10618-10623. Full Text
  - Bassing, CH, Shou, W, Muir, S, Heitman, J, Matzuk, MM, and Wang, XF. "FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes." Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research 9, no. 3 (March 1998): 223-228.
  - Li, JM, Shen, X, Hu, PP, and Wang, XF. "Transforming growth factor beta stimulates the human immunodeficiency virus 1 enhancer and requires NF-kappaB activity." Mol Cell Biol 18, no. 1 (January 1998): 110-121. Link to Item
  - Shen, X, Hu, PPC, Liberati, NT, Datto, MB, Frederick, JP, and Wang, XF. "TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein." Molecular Biology of the Cell 9, no. 12 (January 1, 1998): 3309-3319. Full Text
  - Yingling, JM, Datto, MB, Wong, C, Frederick, JP, Liberati, NT, and Wang, XF. "Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein." Mol Cell Biol 17, no. 12 (December 1997): 7019-7028. Link to Item
  - Li, JM, Hu, PP, Shen, X, Yu, Y, and Wang, XF. "E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites." Proc Natl Acad Sci U S A 94, no. 10 (May 13, 1997): 4948-4953. Link to Item
  - Datto, MB, Hu, PP, Kowalik, TF, Yingling, J, and Wang, XF. "The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B." Mol Cell Biol 17, no. 4 (April 1997): 2030-2037. Link to Item
  - Suzuki, A, Chang, C, Yingling, JM, Wang, XF, and Hemmati-Brivanlou, A. "Smad5 induces ventral fates in Xenopus embryo." Developmental Biology 184, no. 2 (April 1997): 402-405. Full Text
  - Slotkin, TA, Wang, XF, Symonds, HS, and Seidler, FJ. "Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain." Brain Res Dev Brain Res 99, no. 1 (March 17, 1997): 61-65. Link to Item
  - Chen, C, Wang, X-F, and Sun, L. "Expression of transforming growth factor β (TGFβ) type III receptor restores autocrine TGFβ₁ activity in human breast cancer MCF-7 cells." Journal of Biological Chemistry 272, no. 19 (1997): 12862-12867. Full Text
  - Datto, MB, Bassing, CH, and Wang, XF. "The TGFβ receptors and signaling pathways." Growth Factors and Cytokines in Health and Disease 1, no. C (December 1, 1996): 395-432. Full Text
  - Derynck, R, Gelbart, WM, Harland, RM, Heldin, CH, Kern, SE, Massagué, J, Melton, DA, Mlodzik, M, Padgett, RW, Roberts, AB, Smith, J, Thomsen, GH, Vogelstein, B, and Wang, XF. "Nomenclature: vertebrate mediators of TGFbeta family signals." Cell 87, no. 2 (October 1996): 173-null. (Letter) Full Text
  - Wang, J, Han, W, Zborowska, E, Liang, J, Wang, X, Willson, JK, Sun, L, and Brattain, MG. "Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells." The Journal of Biological Chemistry 271, no. 29 (July 1996): 17366-17371. Full Text
  - Yingling, JM, Das, P, Savage, C, Zhang, M, Padgett, RW, and Wang, X-F. "Mammalian dwarfins are phosphorylated in response to transforming growth factor β and are implicated in control of cell growth." Proceedings of the National Academy of Sciences of the United States of America 93, no. 17 (1996): 8940-8944. Full Text
  - Datto, MB, Yu, Y, and Wang, XF. "Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter." J Biol Chem 270, no. 48 (December 1, 1995): 28623-28628. Link to Item
  - Li, JM, Nichols, MA, Chandrasekharan, S, Xiong, Y, and Wang, XF. "Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site." The Journal of Biological Chemistry 270, no. 45 (November 1995): 26750-26753. Full Text
  - Wang, J, Sun, L, Myeroff, L, Wang, X, Gentry, LE, Yang, J, Liang, J, Zborowska, E, Markowitz, S, and Willson, JK. "Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells." The Journal of Biological Chemistry 270, no. 37 (September 1995): 22044-22049. Full Text
  - Datto, MB, Li, Y, Panus, JF, Howe, DJ, Xiong, Y, and Wang, XF. "Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism." Proceedings of the National Academy of Sciences of the United States of America 92, no. 12 (June 1995): 5545-5549. Full Text
  - Schwarz, JK, Bassing, CH, Kovesdi, I, Datto, MB, Blazing, M, George, S, Wang, XF, and Nevins, JR. "Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression." Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483-487. Link to Item
  - Wang, Y-Q, Sizeland, A, Wang, X-F, and Sassoon, D. "Restricted expression of type-II TGFβ receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning." Mechanisms of Development 52, no. 2-3 (1995): 275-289.
  - Yingling, JM, Wang, X-F, and Bassing, CH. "Signaling by the transforming growth factor-β receptor." BBA - Reviews on Cancer 1242, no. 2 (1995): 115-136.
  - Barnett, JV, Moustakas, A, Lin, W, Wang, XF, Lin, HY, Galper, JB, and Maas, RL. "Cloning and developmental expression of the chick type II and type III TGF beta receptors." Developmental Dynamics : an Official Publication of the American Association of Anatomists 199, no. 1 (January 1994): 12-27. Full Text
  - Bassing, CH, Howe, DJ, Segarini, PR, Donahoe, PK, and Wang, X-F. "A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-β ligands." Journal of Biological Chemistry 269, no. 21 (1994): 14861-14864.
  - Bassing, CH, Yingling, JM, Howe, DJ, Wang, T, He, WW, Gustafson, ML, Shah, P, Donahoe, PK, and Wang, XF. "A transforming growth factor beta type I receptor that signals to activate gene expression." Science (New York, N.Y.) 263, no. 5143 (January 1994): 87-89. Full Text
  - Bassing, CH, Yingling, JM, and Wang, XF. "Receptors for the TGF-beta ligand family." Vitamins and Hormones 48 (1994): 111-156.
  - Sun, L, Wu, G, Willson, JKV, Zborowska, E, Yang, J, Rajkarunanayake, I, Wang, J, Gentry, LE, Wang, X-F, and Brattain, MG. "Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells." Journal of Biological Chemistry 269, no. 42 (1994): 26449-26455.
  - Wang, XF. "TGF-β activates gene expression." Biomedicine and Pharmacotherapy 48, no. 8-9 (January 1, 1994): 410-null. Full Text
  - Wrana, JL, Attisano, L, Cárcamo, J, Zentella, A, Doody, J, Laiho, M, Wang, XF, and Massagué, J. "TGF beta signals through a heteromeric protein kinase receptor complex." Cell 71, no. 6 (December 1992): 1003-1014. Full Text
  - Lin, HY, Wang, XF, Ng-Eaton, E, Weinberg, RA, and Lodish, HF. "Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase." Cell 68, no. 4 (February 1992): 775-785. Full Text
  - Lin, HY, and Wang, X-F. "Expression cloning of TGF-β receptors." Molecular Reproduction and Development 32, no. 2 (1992): 105-110. Full Text
  - Wang, X-F, Lin, HY, Ng-Eaton, E, Downward, J, Lodish, HF, and Weinberg, RA. "Expression cloning and characterization of the TGF-β type III receptor." Cell 67, no. 4 (1991): 797-805.
  - Friend, SH, Horowitz, JM, Gerber, MR, Wang, XF, Bogenmann, E, Li, FP, and Weinberg, RA. "Erratum: Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein (Proc., Natl. Acad. Sci. USA, No. 24, Dec. 1987 (84, 9059-9063))." Proceedings of the National Academy of Sciences of the United States of America 85, no. 7 (December 1, 1988): 2234-null. Full Text
  - Kimchi, A, Wang, XF, Weinberg, RA, Cheifetz, S, and Massagué, J. "Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells." Science (New York, N.Y.) 240, no. 4849 (April 1988): 196-199. Full Text
  - Kimchi, A, Wang, X-F, Weinberg, RA, Cheifetz, S, and Massague, J. "Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells." Science 239, no. 4849 (1988): 196-199.
  - Tsao, BP, Wang, X-F, Peterson, CL, and Calame, K. "In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer." Nucleic Acids Research 16, no. 8 (1988): 3239-3253. Full Text
  - Friend, SH, Horowitz, JM, Gerber, MR, Wang, XF, Bogenmann, E, Li, FP, and Weinberg, RA. "Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein." Proceedings of the National Academy of Sciences of the United States of America 84, no. 24 (1987): 9059-9063.
  - Wang, XF, and Calame, K. "SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation." Cell 47, no. 2 (October 1986): 241-247. Full Text
  - Wang, X-F, and Calame, K. "The endogenous immunoglobulin heavy chain enhancer can activate tandem V_H promoters separated by a large distance." Cell 43, no. 3 PART 2 (1985): 659-665.
  - Mercola, M, Wang, XF, Olsen, J, and Calame, K. "Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus." Science 221, no. 4611 (1983): 663-665.
  - Zhao, J, Shi, W, Wang, YL, Chen, H, Bringas, P, Datto, MB, Frederick, JP, Wang, XF, and Warburton, D. "Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice." American Journal of Physiology Lung Cellular and Molecular Physiology 282, no. 3 26-3 (June 29, 2002).
- Conference Papers
  - Hu, J, Sun, T, Wang, H, Wang, P, Fu, X-D, Li, Q-J, and Wang, X-F. "Abstract 3536: Roles of miR-215 and regulatory mechanisms for its biogenesis in response to hypoxia in glioblastoma stem cells." October 1, 2014. Full Text
  - Biernacka, A, Gonzalez-Quesada, C, Kong, P, Rai, V, Christia, P, Dobaczewski, M, Lee, D-W, Wang, X-F, and Frangogiannis, NG. "Smad3 Loss is Associated with Aortic Dilation and Spontaneous Aortic Rupture in Lean and in Obese Diabetic Db/db Mice." November 20, 2012. Link to Item
  - Hrgovic, I, Doll, M, Kleemann, J, Wang, XF, Zoeller, N, Pinter, A, Kippenberger, S, Kaufmann, R, and Meissner, M. "The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways." September 11, 2012. Full Text
  - Biernacka, A, Gonzalez-Quesada, C, Tian, Q, Li, N, Dobaczewski, M, Wang, X-F, and Frangogiannis, NG. "TGF-beta/Smad3 Activation in the Diabetic Mouse Heart Induces Fibrotic Cardiac Remodeling and Diastolic Dysfunction While Protecting From Excessive Matrix Degradation and Preventing the Development of Systolic Dysfunction." November 22, 2011. Link to Item
  - Dobaczewski, M, Gonzalez-Ouesada, C, Bujak, M, Li, N, Wang, X-F, and Frangogiannis, NG. "Smad3-/- Fibroblasts Are Hyperproliferative Cells With Impaired Migratory Capacity, Reduced Contractile Activity and Diminished Synthetic Function: Implications for Cardiac Repair and Remodeling." November 3, 2009. Link to Item
  - Feng, J, Wakeman, T, Yong, S, Kornbluth, S, Wu, X-H, and Wang, X-F. "PP2A-dependent dephosphorylation of replication protein A (RPA) is required for the removal of DNA breaks induced by replication stress." May 1, 2009. Link to Item
  - Dobaczewski, M, Bujak, M, Gonzalez, C, Li, N, Wang, X-F, and Frangogiannis, NG. "The Smad3 Pathway Critically Regulates Myofibroblast Proliferation And Synthetic Activity In Healing Myocardial Infarcts." October 28, 2008. Link to Item
  - Bujak, MJ, Ren, G, Chatila, KF, Dobaczewski, M, Reddy, A, Taffet, G, Wang, X-F, and Frangogiannis, NG. "Smad3 signaling critically regulates infarct healing." April 2007. Link to Item
  - Buiak, MJ, Ren, G, Chatila, K, Dobaczewski, M, Reddy, A, Taffet, G, Wang, X-F, and Frangogiannis, NG. "Disruption of the Smad3 signaling pathway attenuates post-infarction remodeling." March 6, 2007. Link to Item
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