Overview
The current research in the Wang laboratory mainly focuses on the elucidation of molecular nature and signaling mechanisms associated with the initiation of cellular senescence. In addition, we continue to study changes in tumor microenvironment that promotes tumor progression and metastasis, particularly how tumor cells interact with the immune system. Ultimately, we hope that our studies in these areas to lead to the development of novel therapeutics for the treatment of various types of human cancer.
Current Duke Appointments & Affiliations
Donald and Elizabeth Cooke Distinguished Professor of Cancer Research, in the School of Medicine
·
2009 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Pharmacology and Cancer Biology
·
2003 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Single-cell and spatial detection of senescent cells using DeepScence.
Journal article Cell Genom · December 10, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item CiteWSTF nuclear autophagy regulates chronic but not acute inflammation.
Journal article Nature · August 2025 Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmu ... Full text Open Access Link to item CiteSingle-cell and spatial detection of senescent cells using DeepScence.
Journal article bioRxiv · April 23, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Targeting Hepatocyte Senescence to Improve NAFLD
ResearchCo-Mentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029View All Grants
Education
University of California, Los Angeles ·
1986
Ph.D.
Wuhan University (China) ·
1982
B.S.