Xiao-Fan Wang | Scholars@Duke

Xiao-Fan Wang
Donald and Elizabeth Cooke Professor of Cancer Research, in the School of Medicine

The current research in the Wang laboratory mainly focuses on the elucidation of molecular nature and signaling mechanisms associated with the initiation of cellular senescence. In addition, we continue to study changes in tumor microenvironment that promotes tumor progression and metastasis, particularly how tumor cells interact with the immune system. Ultimately, we hope that our studies in these areas to lead to the development of novel therapeutics for the treatment of various types of human cancer.

Current Appointments & Affiliations

Donald and Elizabeth Cooke Professor of Cancer Research, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2009
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2003
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1992

Contact Information

C218 Lev Sci Res Ctr, Durham, NC 27708
Duke Box 3813, Durham, NC 27710
wang0011@mc.duke.edu (919) 681-4861

Background
Education, Training, & Certifications
- Ph.D., University of California at Los Angeles 1986
- B.S., Wuhan University (China) 1982
Duke Appointment History
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1998 - 2003
- Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 1998
Recognition
Awards & Honors
Research
Selected Grants
- Targeting UHRF1 in combinational immunotherapy awarded by National Institutes of Health 2019 - 2023
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Analysis of mechanisms associated with Her2-positive breast cancer resistance to therapy awarded by Department of Defense 2016 - 2019
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment awarded by Susan G. Komen Breast Cancer Foundation 2015 - 2018
- The anti-senescence activity of trefoil factor 1 awarded by National Institutes of Health 2012 - 2018
- The Roles of MicroRNAs in Glioblastoma awarded by National Institutes of Health 2012 - 2017
- Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis awarded by National Institutes of Health 2011 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Molecular determinants underlying herceptin sensitivity and resistance awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Determine the potential therapeutic effect of HDAC6 inhibitors in inhibiting breast cancer metastasis and glioblastoma awarded by Acetylon Pharmaceuticals, Inc. 2014 - 2015
- The role of TGF-beta in tumorigenesis awarded by National Institutes of Health 2010 - 2015
- 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis awarded by National Institutes of Health 2013 - 2014
- Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer awarded by National Institutes of Health 2011 - 2013
- The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma awarded by National Institutes of Health 2006 - 2012
- Mechanisms of TGF-B/Smad Signaling awarded by National Institutes of Health 2008 - 2012
- TGFBI and tumorigenesis awarded by National Institutes of Health 2006 - 2011
- Rad17- & p53-mediated apoptotic pathways in response to DNA damage awarded by National Institutes of Health 2006 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
- Molecular Mechanisms of SPARC Mediated Glioma Invasion awarded by National Institutes of Health 2006 - 2008
- TGF-Beta Signaling in MSCs and Osteoblast awarded by National Institutes of Health 2004 - 2008
- Analysis of Rad17-mediated Checkpoint Signaling awarded by National Institutes of Health 2002 - 2008
- Analysis of the Functional Role of TPF in Tumorigenesis awarded by National Institutes of Health 2000 - 2005
- The Role Of Tumor Supressor Smads In Tgf-B Signaling awarded by National Institutes of Health 1998 - 2004
- Functional Analysis of TGFRP, A Putative Angiogenic Factor in Breast Carcinogenics awarded by US Army Medical Research 1999 - 2002
- The Role Of Tgfb In Brain Tumors awarded by National Institutes of Health 1998 - 2001
- Tgf-Beta Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1995 - 2001
- Tgf-B Signaling Pathway And Cell Growth Regulation awarded by National Institutes of Health 1996 - 1999
- Examination Of Tgfb Induced Cell Death Pathway awarded by National Institutes of Health 1995 - 1998
- Analysis Of Tgf-B Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1994 - 1995
- Analysis Of Tgf Beta Receptor Ii Signalling Mechanism awarded by National Institutes of Health 1993 - 1995
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chong, M, Yin, T, Chen, R, Xiang, H, Yuan, L, Ding, Y, Pan, CC, Tang, Z, Alexander, PB, Li, Q-J, and Wang, X-F. "CD36 initiates the secretory phenotype during the establishment of cellular senescence." Embo Reports 19, no. 6 (June 2018). Full Text
  - Yuan, L, Zhai, L, Qian, L, Huang, D, Ding, Y, Xiang, H, Liu, X, Thompson, JW, Liu, J, He, Y-H, Chen, X-Q, Hu, J, Kong, Q-P, Tan, M, and Wang, X-F. "Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death." Cell Research 28, no. 6 (June 2018): 625-643. Full Text
  - Li, J-J, Yin, H-K, Guan, D-X, Zhao, J-S, Feng, Y-X, Deng, Y-Z, Wang, X, Li, N, Wang, X-F, Cheng, S-Q, Bao, Y, and Xie, D. "Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis." British Journal of Cancer 118, no. 10 (May 2, 2018): 1337-1348. Full Text
  - Deng, Y-Z, Cai, Z, Shi, S, Jiang, H, Shang, Y-R, Ma, N, Wang, J-J, Guan, D-X, Chen, T-W, Rong, Y-F, Qian, Z-Y, Zhang, E-B, Feng, D, Zhou, Q-L, Du, Y-N, Liu, D-P, Huang, X-X, Liu, L-M, Chin, E, Li, D-S, Wang, X-F, Zhang, X-L, and Xie, D. "Cilia loss sensitizes cells to transformation by activating the mevalonate pathway." The Journal of Experimental Medicine 215, no. 1 (January 2018): 177-195. Full Text
  - Zhang, Y, Alexander, PB, and Wang, X-F. "TGF-β Family Signaling in the Control of Cell Proliferation and Survival." Cold Spring Harbor perspectives in biology 9, no. 4 (April 2017). (Review) Full Text
  - Alexander, PB, Chen, R, Gong, C, Yuan, L, Jasper, JS, Ding, Y, Markowitz, GJ, Yang, P, Xu, X, McDonnell, DP, Song, E, and Wang, X-F. "Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer." The Journal of Biological Chemistry 292, no. 2 (January 2017): 748-759. Full Text Open Access Copy
  - Xiang, H, Yuan, L, Gao, X, Alexander, PB, Lopez, O, Lau, C, Ding, Y, Chong, M, Sun, T, Chen, R, Liu, S-Q, Wu, H, Wan, Y, Randell, SH, Li, Q-J, and Wang, X-F. "UHRF1 is required for basal stem cell proliferation in response to airway injury." Cell Discovery 3 (January 2017): 17019-null. Full Text Open Access Copy
  - Liu, Z, Kundu-Roy, T, Matsuura, I, Wang, G, Lin, Y, Lou, Y-R, Barnard, NJ, Wang, X-F, Huang, M-T, Suh, N, and Liu, F. "Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice." Oncotarget 7, no. 40 (October 2016): 64878-64885. Full Text
  - Hrgovic, I, Doll, M, Kleemann, J, Wang, X-F, Zoeller, N, Pinter, A, Kippenberger, S, Kaufmann, R, and Meissner, M. "The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways." BMC cancer 16, no. 1 (September 30, 2016): 763-. Full Text
  - Hu, J, and Wang, X-F. "HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia." Cell Cycle (Georgetown, Tex.) 15, no. 15 (August 2016): 1939-1940. Full Text
  - Bao, W-D, Fan, Y, Deng, Y-Z, Long, L-Y, Wang, J-J, Guan, D-X, Qian, Z-Y, An, P, Feng, Y-Y, He, Z-Y, Wang, X-F, Phillip Koeffler, H, Hu, R, Wang, J, Wang, X, Wang, F, Li, J-J, and Xie, D. "Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis." Journal of hepatology 65, no. 1 (July 2016): 137-145. Full Text
  - Markowitz, GJ, Yang, P, Fu, J, Michelotti, GA, Chen, R, Sui, J, Yang, B, Qin, W-H, Zhang, Z, Wang, F-S, Diehl, AM, Li, Q-J, Wang, H, and Wang, X-F. "Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes." Cancer Research 76, no. 8 (April 2016): 2394-2405. Full Text
  - Xu, X, Zhang, Y, Jasper, J, Lykken, E, Alexander, PB, Markowitz, GJ, McDonnell, DP, Li, Q-J, and Wang, X-F. "MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer." Oncotarget 7, no. 15 (April 2016): 20381-20394. Full Text
  - Valesky, EM, Hrgovic, I, Doll, M, Wang, X-F, Pinter, A, Kleemann, J, Kaufmann, R, Kippenberger, S, and Meissner, M. "Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest." Experimental dermatology 25, no. 3 (March 2016): 200-205. Full Text
  - Hu, J, Markowitz, G, and Wang, X-F. "Isolation of Glioma-Initiating Cells for Biological Study." Advances in experimental medicine and biology 899 (January 2016): 197-209. Full Text
  - Hu, J, Markowitz, GJ, and Wang, X. "Noncoding RNAs Regulating Cancer Signaling Network." Advances in experimental medicine and biology 927 (January 2016): 297-315. (Review) Full Text
  - Hu, J, Sun, T, Wang, H, Chen, Z, Wang, S, Yuan, L, Liu, T, Li, H-R, Wang, P, Feng, Y, Wang, Q, McLendon, RE, Friedman, AH, Keir, ST, Bigner, DD, Rathmell, J, Fu, X-D, Li, Q-J, Wang, H, and Wang, X-F. "MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B." Cancer Cell 29, no. 1 (January 2016): 49-60. Full Text Open Access Copy
  - Yang, P, Zhang, Y, Markowitz, GJ, Guo, X, and Wang, X-F. "TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology." Methods in molecular biology (Clifton, N.J.) 1344 (January 2016): 325-339. Full Text
  - Biernacka, A, Cavalera, M, Wang, J, Russo, I, Shinde, A, Kong, P, Gonzalez-Quesada, C, Rai, V, Dobaczewski, M, Lee, D-W, Wang, X-F, and Frangogiannis, NG. "Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice." Circulation. Heart Failure 8, no. 4 (July 2015): 788-798. Full Text
  - Alexander, PB, and Wang, X-F. "Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies." Frontiers of Medicine 9, no. 2 (June 2015): 134-138. (Review) Full Text
  - Zhang, Y, and Wang, X-F. "A niche role for cancer exosomes in metastasis." Nature Cell Biology 17, no. 6 (June 2015): 709-711. Full Text
  - Dai, X, Shen, J, Annam, NP, Jiang, H, Levi, E, Schworer, CM, Tromp, G, Arora, A, Higgins, M, Wang, X-F, Yang, M, Li, HJ, Zhang, K, Kuivaniemi, H, and Li, L. "SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model." Scientific reports 5 (May 18, 2015): 10180-. Full Text
  - Markowitz, GJ, Michelotti, GA, Diehl, AM, and Wang, X-F. "Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma." Science bulletin 60, no. 8 (April 2015): 762-772. Full Text
  - Alexander, PB, Yuan, L, Yang, P, Sun, T, Chen, R, Xiang, H, Chen, J, Wu, H, Radiloff, DR, and Wang, X-F. "EGF promotes mammalian cell growth by suppressing cellular senescence." Cell Research 25, no. 1 (January 2015): 135-138. (Letter) Full Text
  - Zhang, Y, and Wang, X-F. "Post-transcriptional regulation of MTA family by microRNAs in the context of cancer." Cancer metastasis reviews 33, no. 4 (December 2014): 1011-1016. (Review) Full Text
  - Zhang, Y, and Wang, X-F. "Post-transcriptional regulation of MTA family by microRNAs in the context of cancer." Cancer and Metastasis Reviews 33, no. 4 (December 2014): 1011-1016. Full Text
  - Wang, X-F, and Korangy, F. "Intrahepatic landscape of regulatory T-cell subsets in chronically HCV-infected patients with cirrhosis and HCC." Hepatology (Baltimore, Md.) 60, no. 5 (November 2014): 1461-1462. Full Text
  - Wang, H, Sun, T, Hu, J, Zhang, R, Rao, Y, Wang, S, Chen, R, McLendon, RE, Friedman, AH, Keir, ST, Bigner, DD, Li, Q-J, Wang, H, and Wang, X-F. "miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4489-4502. Full Text
  - Yang, P, Markowitz, GJ, and Wang, X-F. "The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma." National science review 1, no. 3 (July 2014): 396-412. Full Text
  - Wang, Q, Goldstein, M, Alexander, P, Wakeman, TP, Sun, T, Feng, J, Lou, Z, Kastan, MB, and Wang, X-F. "Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks." The Embo Journal 33, no. 8 (April 2014): 862-877. Full Text
  - "Microenvironmental regulation of cancer metastasis by miRNAs." Trends in Cell Biology 24, no. 3 (March 1, 2014): 153-160. (Review) Full Text
  - Zhang, Y, Yang, P, and Wang, X-F. "Microenvironmental regulation of cancer metastasis by miRNAs." Trends in Cell Biology 24, no. 3 (March 2014): 153-160. (Review) Full Text
  - Hu, J, and Wang, X-F. "COUP-TFII and AKT are cancer targets pursued by SCBA award winners." Cell & bioscience 4, no. 1 (January 2014): 57-. Full Text
  - Kellenberger, T, Krag, S, Danielsen, CC, Wang, X-F, Nyengaard, JR, Pedersen, L, Yang, C, Gao, S, and Wogensen, L. "Differential effects of Smad3 targeting in a murine model of chronic kidney disease." Physiological reports 1, no. 7 (December 15, 2013): e00181-. Full Text
  - Guo, X, and Wang, X-F. "A P(E)RM(I)T for BMP signaling." Molecular cell 51, no. 1 (July 2013): 1-2. Full Text
  - Zhang, Y, Yang, P, Sun, T, Li, D, Xu, X, Rui, Y, Li, C, Chong, M, Ibrahim, T, Mercatali, L, Amadori, D, Lu, X, Xie, D, Li, Q-J, and Wang, X-F. "miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis." Nature Cell Biology 15, no. 3 (March 2013): 284-294. Full Text
  - Curtis, VF, Wang, H, Yang, P, McLendon, RE, Li, X, Zhou, Q-Y, and Wang, X-F. "A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer." Plos One 8, no. 1 (January 23, 2013): e54916-null. Full Text
  - Guo, X, and Wang, X-F. "New secrets behind bone metastasis." Cell Research 22, no. 9 (September 2012): 1309-1311. Full Text
  - Yang, P, Li, Q-J, Feng, Y, Zhang, Y, Markowitz, GJ, Ning, S, Deng, Y, Zhao, J, Jiang, S, Yuan, Y, Wang, H-Y, Cheng, S-Q, Xie, D, and Wang, X-F. "TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma." Cancer Cell 22, no. 3 (September 2012): 291-303. Full Text
  - Xu, Y-P, Shi, Y, Cui, Z-Z, Jiang, HH, Li, L, Wang, X-F, Zhou, L, and Mi, Q-S. "TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development." The Journal of Investigative Dermatology 132, no. 8 (August 2012): 2106-2109. (Letter) Full Text
  - Wakeman, TP, Wang, Q, Feng, J, and Wang, X-F. "Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases." The Embo Journal 31, no. 9 (May 2012): 2169-2181. Full Text
  - Chen, Y-G, Li, Z, and Wang, X-F. "Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate." Cell Stem Cell 10, no. 3 (March 2012): 231-232. Full Text
  - Guo, X, and Wang, X-F. "A mediator lost in the war on cancer." Cell 151, no. 5 (2012): 927-929. Full Text
  - Yong, ST, and Wang, X-F. "A novel, non-apoptotic role for Scythe/BAT3: A functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle." PLoS ONE 7, no. 6 (2012). Full Text
  - Zhang, Y, Chen, J, Li, F, Li, D, Xiong, Q, Lin, Y, Zhang, D, Wang, X-F, Yang, P, and Rui, Y-C. "A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway." Stroke 43, no. 10 (2012): 2764-2773. Full Text
  - Wakeman, TP, Feng, J, and Wang, X-F. "Abstract 2482: Bat3 facilitates histone H3 lysine 79 dimethylation by DOT1L to promote ionizing radiation-induced 53BP1 foci formation during G1- and G2-phases of the cell cycle." Cancer Research 71, no. 8 Supplement (April 15, 2011): 2482-2482. Full Text
  - Wang, H, Wang, X-F, Rich, J, Wang, Q, and Hjelmeland, A. "Abstract 3311: IL6-Stat3 signaling promotes glioma stem cell (GSC) survival under hypoxia environment through inhibition of cell-death inducing gene Bnip3." Cancer Research 71, no. 8 Supplement (April 15, 2011): 3311-3311. Full Text
  - Radiloff, DR, Wakeman, TP, Feng, J, Schilling, S, Seto, E, and Wang, X-F. "Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process." Proceedings of the National Academy of Sciences of the United States of America 108, no. 16 (April 2011): 6591-6596. Full Text
  - Feng, Y-X, Wang, T, Deng, Y-Z, Yang, P, Li, J-J, Guan, D-X, Yao, F, Zhu, Y-Q, Qin, Y, Wang, H, Li, N, Wu, M-C, Wang, H-Y, Wang, X-F, Cheng, S-Q, and Xie, D. "Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model." Hepatology (Baltimore, Md.) 53, no. 2 (February 2011): 483-492. Full Text
  - D'Souza, CA, Kronstad, JW, Taylor, G, Warren, R, Yuen, M, Hu, G, Jung, WH, Sham, A, Kidd, SE, Tangen, K, Lee, N, Zeilmaker, T, Sawkins, J, McVicker, G, Shah, S, Gnerre, S, Griggs, A, Zeng, Q, Bartlett, K, Li, W, Wang, X, Heitman, J, Stajich, JE, Fraser, JA, Meyer, W, Carter, D, Schein, J, Krzywinski, M, Kwon-Chung, KJ, Varma, A, Wang, J, Brunham, R, Fyfe, M, Ouellette, BFF, Siddiqui, A, Marra, M, Jones, S, Holt, R, Birren, BW, Galagan, JE, and Cuomo, CA. "Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts." Mbio 2, no. 1 (January 2011): e00342-e00310. Full Text
  - Tapia-González, S, Giráldez-Pérez, RM, Cuartero, MI, Casarejos, MJ, Mena, MÁ, Wang, X-F, and Sánchez-Capelo, A. "Dopamine and α-synuclein dysfunction in Smad3 null mice." Molecular Neurodegeneration 6 (January 2011): 72-null. Full Text
  - Tapia-González, S, Giráldez-Pérez, RM, Cuartero, MI, Casarejos, MJ, Mena, MÁ, Wang, X-F, and Sánchez-Capelo, A. "Dopamine and α-synuclein dysfunction in Smad3 null mice." Molecular neurodegeneration 6 (2011): 72--. Full Text
  - Zhao, J-S, Li, W-J, Ge, D, Zhang, P-J, Li, J-J, Lu, C-L, Ji, X-D, Guan, D-X, Gao, H, Xu, L-Y, Li, E-M, Soukiasian, H, Koeffler, HP, Wang, X-F, and Xie, D. "Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44." PLoS One 6, no. 6 (2011): e21419-. Full Text Link to Item
  - Dobaczewski, M, Bujak, M, Li, N, Gonzalez-Quesada, C, Mendoza, LH, Wang, X-F, and Frangogiannis, NG. "Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction." Circulation Research 107, no. 3 (August 2010): 418-428. Full Text
  - Zhang, L, Park, C-H, Wu, J, Kim, H, Liu, W, Fujita, T, Balasubramani, M, Schreiber, EM, Wang, X-F, and Wan, Y. "Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress." The Embo Journal 29, no. 10 (May 2010): 1726-1737. Full Text
  - Feng, Y-X, Zhao, J-S, Li, J-J, Wang, T, Cheng, S-Q, Yuan, Y, Wang, F, Wang, X-F, and Xie, D. "Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-κB signaling pathway." Hepatology 51, no. 2 (2010): 535-544. Full Text
  - Wang, J, Wakeman, TP, Lathia, JD, Hjelmeland, AB, Wang, X-F, White, RR, Rich, JN, and Sullenger, BA. "Notch promotes radioresistance of glioma stem cells." Stem Cells (Dayton, Ohio) 28, no. 1 (January 2010): 17-28. Full Text
  - Feng, J, Wakeman, T, Yong, S, Wu, X, Kornbluth, S, and Wang, X-F. "Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress." Molecular and Cellular Biology 29, no. 21 (November 2009): 5696-5709. Full Text
  - Wang, H, Lathia, JD, Wu, Q, Wang, J, Li, Z, Heddleston, JM, Eyler, CE, Elderbroom, J, Gallagher, J, Schuschu, J, MacSwords, J, Cao, Y, McLendon, RE, Wang, X-F, Hjelmeland, AB, and Rich, JN. "Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth." Stem Cells (Dayton, Ohio) 27, no. 10 (October 2009): 2393-2404. Full Text
  - Jardim, MJ, Wang, Q, Furumai, R, Wakeman, T, Goodman, BK, and Wang, X-F. "Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells." Molecular Biology of the Cell 20, no. 17 (September 2009): 3801-3809. Full Text
  - Schilling, SH, Hjelmeland, AB, Radiloff, DR, Liu, IM, Wakeman, TP, Fielhauer, JR, Foster, EH, Lathia, JD, Rich, JN, Wang, X-F, and Datto, MB. "NDRG4 is required for cell cycle progression and survival in glioblastoma cells." The Journal of Biological Chemistry 284, no. 37 (September 2009): 25160-25169. Full Text
  - Chen, Y-G, and Wang, X-F. "Finale: The Last Minutes of Smads." Cell 139, no. 4 (2009): 658-660. Full Text
  - Chen, Y-G, and Wang, X-F. "A special issue on TGF-beta signaling." Cell Research 19, no. 1 (January 2009): 1-2. Full Text
  - Guo, X, and Wang, X-F. "Signaling cross-talk between TGF-beta/BMP and other pathways." Cell Research 19, no. 1 (January 2009): 71-88. (Review) Full Text
  - Hu, G, Kang, Y, and Wang, X-F. "From breast to the brain: Unraveling the puzzle of metastasis organotropism." Journal of Molecular Cell Biology 1, no. 1 (2009): 3-5. Full Text
  - Liu, IM, Schilling, SH, Knouse, KA, Choy, L, Derynck, R, and Wang, X-F. "TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch." The Embo Journal 28, no. 2 (January 2009): 88-98. Full Text
  - Guo, X, Waddell, DS, Wang, W, Wang, Z, Liberati, NT, Yong, S, Liu, X, and Wang, X-F. "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling." Oncogene 27, no. 58 (December 2008): 7235-7247. Full Text
  - Lee, Y-S, Lim, K-H, Guo, X, Kawaguchi, Y, Gao, Y, Barrientos, T, Ordentlich, P, Wang, X-F, Counter, CM, and Yao, T-P. "The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis." CANCER RESEARCH 68, no. 18 (September 15, 2008): 7561-7569. Full Text Link to Item
  - Lee, Y-S, Lim, K-H, Guo, X, Kawaguchi, Y, Gao, Y, Barrientos, T, Ordentlich, P, Wang, X-F, Counter, CM, and Yao, T-P. "The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis." Cancer Research 68, no. 18 (September 2008): 7561-7569. Full Text
  - Guo, JY, Yamada, A, Kajino, T, Wu, JQ, Tang, W, Freel, CD, Feng, J, Chau, BN, Wang, MZ, Margolis, SS, Yoo, HY, Wang, X-F, Dunphy, WG, Irusta, PM, Hardwick, JM, and Kornbluth, S. "Aven-dependent activation of ATM following DNA damage." Current Biology : Cb 18, no. 13 (July 2008): 933-942. Full Text
  - Ma, C, Rong, Y, Radiloff, DR, Datto, MB, Centeno, B, Bao, S, Cheng, AWM, Lin, F, Jiang, S, Yeatman, TJ, and Wang, X-F. "Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation." Genes & Development 22, no. 3 (February 2008): 308-321. Full Text
  - Guo, X, Ramirez, A, Waddell, DS, Li, Z, Liu, X, and Wang, X-F. "Axin and GSK3-beta control Smad3 protein stability and modulate TGF-beta signaling." Genes & Development 22, no. 1 (January 1, 2008): 106-120. (Academic Article) Full Text Link to Item
  - Guo, X, Ramirez, A, Waddell, DS, Li, Z, Liu, X, and Wang, X-F. "Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling." Genes & Development 22, no. 1 (January 2008): 106-120. Full Text
  - Ma, C, and Wang, X-F. "In vitro assays for the extracellular matrix protein-regulated extravasation process." Cold Spring Harbor Protocols 3, no. 8 (2008). Full Text
  - Bujak, M, Ren, G, Kweon, HJ, Dobaczewski, M, Reddy, A, Taffet, G, Wang, X-F, and Frangogiannis, NG. "Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling." Circulation 116, no. 19 (November 2007): 2127-2138. Full Text
  - Young, TW, Rosen, DG, Mei, FC, Li, N, Liu, J, Wang, X-F, and Cheng, X. "Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 13, no. 13 (July 2007): 3848-3854. Full Text
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  - Biernacka, A, Gonzalez-Quesada, C, Tian, Q, Li, N, Dobaczewski, M, Wang, X-F, and Frangogiannis, NG. "TGF-beta/Smad3 Activation in the Diabetic Mouse Heart Induces Fibrotic Cardiac Remodeling and Diastolic Dysfunction While Protecting From Excessive Matrix Degradation and Preventing the Development of Systolic Dysfunction." November 22, 2011. Link to Item
  - Dobaczewski, M, Gonzalez-Ouesada, C, Bujak, M, Li, N, Wang, X-F, and Frangogiannis, NG. "Smad3-/- Fibroblasts Are Hyperproliferative Cells With Impaired Migratory Capacity, Reduced Contractile Activity and Diminished Synthetic Function: Implications for Cardiac Repair and Remodeling." November 3, 2009. Link to Item
  - Feng, J, Wakeman, T, Yong, S, Kornbluth, S, Wu, X-H, and Wang, X-F. "PP2A-dependent dephosphorylation of replication protein A (RPA) is required for the removal of DNA breaks induced by replication stress." May 1, 2009. Link to Item
  - Dobaczewski, M, Bujak, M, Gonzalez, C, Li, N, Wang, X-F, and Frangogiannis, NG. "The Smad3 Pathway Critically Regulates Myofibroblast Proliferation And Synthetic Activity In Healing Myocardial Infarcts." October 28, 2008. Link to Item
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