Skip to main content

Xiao-Fan Wang

Donald and Elizabeth Cooke Distinguished Professor of Cancer Research, in the School of Medicine
Pharmacology & Cancer Biology
Duke Box 3813, Durham, NC 27710
C218 Lev Sci Res Ctr, Durham, NC

Selected Grants


Targeting Hepatocyte Senescence to Improve NAFLD

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program

ResearchPreceptor · Awarded by National Institutes of Health · 2023 - 2028

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Roles of mitochondrial dynamics and mtDNA in senescence

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2022 - 2026

Targeting Hepatocyte Senescence to Improve NAFLD

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program

ResearchPreceptor · Awarded by National Institutes of Health · 2023 - 2028

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Roles of mitochondrial dynamics and mtDNA in senescence

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2022 - 2026

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Synthetic lethality by targeting the core senescent mechanism in lung cancer.

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025

NGF recruits nerve fibers to reprogram an immunosuppressive microenvironment in melanoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025

Targeting UHRF1 in combinational immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023

Translational Research in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022

Examining Biosynthesis and NAD+ Demand in the Warburg Effect

FellowshipSponsor · Awarded by National Institutes of Health · 2019 - 2022

Understanding methionine metabolism and its therapeutic potential in cancer

ResearchAdvisor · Awarded by National Institutes of Health · 2019 - 2021

Role of hedgehog signaling in tumor-associated macrophage polarization

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2021

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020

Analysis of mechanisms associated with Her2-positive breast cancer resistance to therapy

ResearchPrincipal Investigator · Awarded by Department of Defense · 2016 - 2019

Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment

ResearchKey Faculty · Awarded by Susan G. Komen Breast Cancer Foundation · 2015 - 2018

The anti-senescence activity of trefoil factor 1

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2018

The Roles of MicroRNAs in Glioblastoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2017

Kinase Target of Diverse Cell Surface Receptors in Cancer Invasion and Metastasis

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2017

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

Molecular determinants underlying herceptin sensitivity and resistance

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Cancer Institute · 1993 - 2016

The role of TGF-beta in tumorigenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2015

27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2013 - 2014

Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013

The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2012

Mechanisms of TGF-B/Smad Signaling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2012

TGFBI and tumorigenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2011

Rad17- & p53-mediated apoptotic pathways in response to DNA damage

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2011

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

TGFbeta-PTEN Interactions in Glioma Biology & Therapy

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

Molecular Mechanisms of SPARC Mediated Glioma Invasion

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

TGF-Beta Signaling in MSCs and Osteoblast

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2008

Analysis of Rad17-mediated Checkpoint Signaling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008

Analysis of the Functional Role of TPF in Tumorigenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2005

The Role Of Tumor Supressor Smads In Tgf-B Signaling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2004

Same Same

ResearchPrincipal Investigator · Awarded by US Army Medical Research · 1999 - 2002

The Role Of Tgfb In Brain Tumors

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Tgf-Beta Signaling Pathway And Cell Growth Regulation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2001

Tgf-B Signaling Pathway And Cell Growth Regulation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Examination Of Tgfb Induced Cell Death Pathway

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Analysis Of Tgf-B Receptor Ii Signalling Mechanism

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1995

Analysis Of Tgf Beta Receptor Ii Signalling Mechanism

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1995

External Relationships


  • Cancer Science Institute of Singapore
  • Cell Research, Nature Publishing Group
  • Feng Foundation
  • Institute of Life Sciences, Zhejiang University
  • Institute of Nutrition and Health, Chiese Academy of Sciences, Shanghai
  • Cancer Science Institute of Singapore
  • Cell Research, Nature Publishing Group
  • Feng Foundation
  • Institute of Life Sciences, Zhejiang University
  • Institute of Nutrition and Health, Chiese Academy of Sciences, Shanghai
  • Joint Center for Life Sciences at Peking University and Tshinghua University
  • Keymed Biosciences Inc.
  • National Science Review, Editorial Board
  • New Cornerstone Foundation
  • Research Grants Council of Hong Kong
  • Review Panel, Cancer Prevention & Research Institute of Texas
  • Science China, Life Sciences
  • TCRCure Biopharma
  • Upstream Biotechnology
  • Westlake University
  • Wuhan University Taikang Medical Research Institute

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.