Renal oncocytosis presenting in childhood: a case report.
Renal oncocytosis is a rare condition in which a spectrum of oncocytic lesions, including oncocytomas, diffusely involve the kidney. Few cases have been reported and all were in adult patients. We report here such a case in a 12-year-old girl. In addition to the unusual age at presentation, this case is remarkable for its heterogeneous tumor morphology, with some areas containing chromophobe carcinoma-like cells. Electron microscopy, immunohistochemistry, Hale's colloidal iron staining, and cytogenetics were performed to further evaluate the different morphologic areas. Our results suggest that the cells in the chromophobe carcinoma-like areas do not fulfill all the diagnostic criteria of chromophobe carcinoma. We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients.
Duke Scholars
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Related Subject Headings
- Pathology
- Microscopy, Electron
- Kidney Neoplasms
- Immunohistochemistry
- Humans
- Female
- Diagnosis, Differential
- Child
- Adenoma, Oxyphilic
- Adenocarcinoma
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Pathology
- Microscopy, Electron
- Kidney Neoplasms
- Immunohistochemistry
- Humans
- Female
- Diagnosis, Differential
- Child
- Adenoma, Oxyphilic
- Adenocarcinoma