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Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Publication ,  Journal Article
Sato, S; Tang, YJ; Wei, Q; Hirata, M; Weng, A; Han, I; Okawa, A; Takeda, S; Whetstone, H; Nadesan, P; Kirsch, DG; Wunder, JS; Alman, BA
Published in: Cell Rep
July 26, 2016

The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using lineage tracing, we demonstrated that bone and soft tissue sarcomas driven by the deletion of the Trp53 tumor suppressor, or desmoid tumors driven by a mutation in Apc, can derive from cells expressing Ng2/Cspg4. Deletion of the Trp53 tumor suppressor gene in these cells resulted in the bone and soft tissue sarcomas that closely resemble human sarcomas, while stabilizing β-catenin in this same cell type caused desmoid tumors. Comparing expression between Ng2/Cspg4-expressing pericytes lacking Trp53 and sarcomas that arose from deletion of Trp53 showed inhibition of β-catenin signaling in the sarcomas. Activation of β-catenin inhibited the formation and growth of sarcomas. Thus, pericytes can be a cell of origin for mesenchymal tumors, and β-catenin dysregulation plays an important role in the neoplastic phenotype.

Duke Scholars

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

July 26, 2016

Volume

16

Issue

4

Start / End Page

917 / 927

Location

United States

Related Subject Headings

  • beta Catenin
  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Sarcoma
  • Proteoglycans
  • Phenotype
  • Pericytes
  • Neoplasms
  • Mutation
  • Mice, Knockout
 

Citation

APA
Chicago
ICMJE
MLA
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Sato, S., Tang, Y. J., Wei, Q., Hirata, M., Weng, A., Han, I., … Alman, B. A. (2016). Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. Cell Rep, 16(4), 917–927. https://doi.org/10.1016/j.celrep.2016.06.058
Sato, Shingo, Yuning J. Tang, Qingxia Wei, Makoto Hirata, Angela Weng, Ilkyu Han, Atsushi Okawa, et al. “Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.Cell Rep 16, no. 4 (July 26, 2016): 917–27. https://doi.org/10.1016/j.celrep.2016.06.058.
Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, et al. Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. Cell Rep. 2016 Jul 26;16(4):917–27.
Sato, Shingo, et al. “Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.Cell Rep, vol. 16, no. 4, July 2016, pp. 917–27. Pubmed, doi:10.1016/j.celrep.2016.06.058.
Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P, Kirsch DG, Wunder JS, Alman BA. Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. Cell Rep. 2016 Jul 26;16(4):917–927.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

July 26, 2016

Volume

16

Issue

4

Start / End Page

917 / 927

Location

United States

Related Subject Headings

  • beta Catenin
  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Sarcoma
  • Proteoglycans
  • Phenotype
  • Pericytes
  • Neoplasms
  • Mutation
  • Mice, Knockout