The Relationship of Vogt-Koyanagi-Harada Syndrome to Ocular Hypertension and Glaucoma.

Journal Article (Journal Article)

PURPOSE: Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH. The purpose of this report is to examine the frequency and types of glaucoma associated with VKH. METHODS: This was a retrospective case series. Electronic medical records of patients with VKH were reviewed from two medical centers: Duke University and the University of North Carolina. RESULTS: Of 45 eyes with VKH, 28 (62%) developed ocular hypertension (OHT) or glaucoma. In the patients with VKH and OHT/glaucoma, 18/28 (64%) had posterior synechiae and/or peripheral anterior synechiae. CONCLUSIONS: We have shown a high prevalence of OHT and glaucoma in eyes with VKH. Furthermore, in addition to secondary open angle from corticosteroid treatment and uveitis, secondary angle closure resulting from posterior synechiae, frequently associated with iris bombé configuration, is an important cause of glaucoma in VKH eyes.

Full Text

Duke Authors

Cited Authors

  • Veerappan, M; Fleischman, D; Ulrich, JN; Stinnett, SS; Jaffe, GJ; Allingham, RR

Published Date

  • December 2017

Published In

Volume / Issue

  • 25 / 6

Start / End Page

  • 748 - 752

PubMed ID

  • 27438521

Electronic International Standard Serial Number (EISSN)

  • 1744-5078

Digital Object Identifier (DOI)

  • 10.1080/09273948.2016.1189578


  • eng

Conference Location

  • England