Glenn Jay Jaffe

I have an active basic and clinical research program. I have been principal investigator on several funded clinical studies including investigations of an oral ganciclovir prodrug to treat CMV retinitis and a study to determine the safety of a cyclosporine sustained drug delivery implant in the treatment of uveitis. I am principal investigator of an ongoing multicenter trial of a fluocinolone sustained drug delivery implant to treat patients with severe uveitis and a trial of this same implant to treat diabetic macular edema. Recently, I have investigated the use of ultrasonography and optical coherence tomography to diagnose macular edema in a variety of ocular diseases. I have maintained an ongoing basic research program to test the hypothesis that cytokines are important in the development of proliferative vitreoretinopathy, an important intraocular wound healing disorder. Education: I am actively involved in resident and fellow education. I give lectures to residents and fellows on a variety of topics related to uveitis and vitreoretinal diseases and train fellows to perform vitreoretinal surgery. I train post-doctoral students and medical students to conduct clinically relevant research. I serve as a mentor for the Duke third year medical school research program. I have served on a yearly basis as course faculty at many national and international meetings.

Current Appointments & Affiliations

Robert Machemer M.D. Distinguished Professor of Ophthalmology · 2013 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology

Professor of Ophthalmology · 1998 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology

Chief, Division of Retinal Ophthalmology · 2008 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology

In the News

Published September 8, 2016

Humira Provides Effective, Non-Steroid Alternative for Eye Inflammation

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Recent Publications

Returning Individual-Level Urgent or Emergent Research Results to Participants: The Project Baseline Health Study Experience.

Journal Article Am J Med Open · June 2025 BACKGROUND: Returning results to research participants is increasingly recognized as an ethical mandate, yet little is known about best practices to optimally communicate urgent or emergent results. METHODS: We describe the development of and experience wi ... Full text Link to item Cite

Corrigendum to "Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity" [Am J Ophthalmol 2020;219:87-100].

Journal Article Am J Ophthalmol · May 2025 Full text Link to item Cite

Designing the next generation of clinical trials in intermediate AMD-a consensus driven, pragmatic, proof of concept early intervention study.

Journal Article Exp Eye Res · March 14, 2025 A greater understanding of the pathophysiology of AMD has yielded potential therapeutic strategies for slowing vision loss. Structural imaging biomarkers and novel functional outcomes, both under intensive study as surrogate endpoints in AMD clinical trial ... Full text Link to item Cite

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Recent Grants

A Multi-Center, Randomized, Double-Masked Phase 2 Study to Assess Safety and Efficacy of ADVM-022 (AAV.7m8-aflibercept) in Anti-VEGF Treatment- Experienced Patients with Neovascular (Wet) Age-related Macular Degeneration (nAMD)

ResearchPrincipal Investigator · Awarded by Adverum Biotechnologies, Inc · 2022 - 2029

Ora_Sepul_DRC Ph3 Study of Sepofarsen in Subjects with Leber Congential Amaurosis (LCA)_HYPERION

ResearchPrincipal Investigator · Awarded by Ora LLC · 2024 - 2029

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A)

ResearchPrincipal Investigator · Awarded by Jaeb Center For Health Research · 2017 - 2028

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Education, Training & Certifications

University of California San Francisco, School of Medicine · 1983 M.D.