Skip to main content

Glenn Jay Jaffe

Robert Machemer M.D. Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
Box 3802 Med Ctr, Durham, NC 27710
Duke Eye Center, 2351 Erwin Ro, Durham, NC 27710

Selected Publications


Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study.

Journal Article Lancet · April 20, 2024 BACKGROUND: Frequent anti-vascular endothelial growth factor A (VEGF-A) injections reduce the risk of rapid and severe vision loss in patients with neovascular age-related macular degeneration (nAMD); however, due to undertreatment, many patients lose visi ... Full text Link to item Cite

Home OCT Imaging for Newly Diagnosed Neovascular Age-Related Macular Degeneration: A Feasibility Study.

Journal Article Ophthalmol Retina · April 2024 OBJECTIVE: To assess the feasibility of daily Home OCT imaging among patients with neovascular age-related macular degeneration (nAMD). DESIGN: Prospective observational study. PARTICIPANTS: Participants with ≥ 1 eye with previously untreated nAMD and visu ... Full text Link to item Cite

LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.

Journal Article Retina · March 1, 2024 PURPOSE: The LIGHTSITE III study evaluated multiwavelength photobiomodulation (PBM) therapy in nonexudative (dry) age-related macular degeneration (AMD) using the LumiThera Valeda Light Delivery System. METHODS: LIGHTSITE III is a randomized, controlled tr ... Full text Link to item Cite

Gradeability and Reproducibility of Geographic Atrophy Measurement in GATHER-1, a Phase II/III Randomized Interventional Trial.

Journal Article Ophthalmol Sci · 2024 OBJECTIVE: To validate GATHER-1 inclusion criteria and the study's primary anatomic end point by assessing the reproducibility of geographic atrophy (GA) measurements and factors that affect reproducibility. DESIGN: Post hoc analysis of phase II/III clinic ... Full text Link to item Cite

Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee.

Journal Article J Vitreoretin Dis · 2024 Purpose: To analyze post-marketing cases of retinal vasculitis after intravitreal pegcetacoplan. Methods: The American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee as well as an expert panel performed a retrospe ... Full text Link to item Cite

Faricimab Treat-and-Extend for Diabetic Macular Edema: Two-Year Results from the Randomized Phase 3 YOSEMITE and RHINE Trials.

Journal Article Ophthalmology · December 28, 2023 PURPOSE: To evaluate the 2-year efficacy, durability, and safety of dual angiopoietin-2 and vascular endothelial growth factor (VEGF) A pathway inhibition with intravitreal faricimab according to a personalized treat-and-extend (T&E)-based regimen with up ... Full text Link to item Cite

Reticular Pseudodrusen: Interreader Agreement of Evaluation on OCT Imaging in Age-Related Macular Degeneration.

Journal Article Ophthalmol Sci · December 2023 PURPOSE: To determine the interreader agreement for reticular pseudodrusen (RPD) assessment on combined infrared reflectance (IR) and OCT imaging in the early stages of age-related macular degeneration across a range of different criteria to define their p ... Full text Link to item Cite

Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial.

Journal Article Lancet · October 21, 2023 BACKGROUND: Geographic atrophy is an advanced form of dry age-related macular degeneration that can lead to irreversible vision loss and high burden of disease. We aimed to assess efficacy and safety of avacincaptad pegol 2 mg in reducing geographic atroph ... Full text Link to item Cite

Bilateral Panuveitis in an Adolescent with Autoimmune Lymphoproliferative Syndrome Due to CTLA4 Haploinsufficiency.

Journal Article Ocul Immunol Inflamm · September 13, 2023 PURPOSE: To describe a case of bilateral panuveitis in an 11-year-old girl with autoimmune lymphoproliferative syndrome (ALPS) due to CTLA4 haploinsufficiency. CASE DESCRIPTION: A 5-year-old girl developed cervical adenopathy, and autoimmune hemolytic anem ... Full text Link to item Cite

PSEUDOMONAS ENDOPHTHALMITIS AFTER 0.59 MG FLUOCINOLONE ACETONIDE SURGICAL IMPLANT IN A PATIENT WITH A LONG-STANDING CRAWFORD TUBE.

Journal Article Retin Cases Brief Rep · September 1, 2023 PURPOSE: The purpose of this study was to report a case of Pseudomonas aeruginosa endophthalmitis after surgical 0.59 mg fluocinolone acetonide implant in a patient with a long-standing Crawford tube. METHODS: This was a retrospective case review. RESULTS: ... Full text Link to item Cite

Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER.

Journal Article Ophthalmol Ther · August 2023 INTRODUCTION: The HAWK and HARRIER studies evaluated the efficacy and safety of brolucizumab versus aflibercept in treatment-naïve eyes with neovascular age-related macular degeneration. Based on the study design, brolucizumab-treated eyes adjusted to a q8 ... Full text Link to item Cite

Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial.

Journal Article Br J Ophthalmol · July 2023 BACKGROUND/AIMS: To describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular ... Full text Link to item Cite

0.18 MG FLUOCINOLONE ACETONIDE INSERT FOR THE TREATMENT OF CHRONIC POSTOPERATIVE PSEUDOPHAKIC CYSTOID MACULAR EDEMA.

Journal Article Retina · June 1, 2023 PURPOSE: To report the outcomes of the 0.18 mg fluocinolone acetonide insert (FAi) in the treatment of chronic (>6 months) postoperative cystoid macular edema after cataract surgery. METHODS: This was a retrospective consecutive case series of eyes with ch ... Full text Link to item Cite

Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.

Journal Article Am J Ophthalmol · December 2022 PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Natural history study METHODS: Setting: 16 clinical ... Full text Link to item Cite

Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity.

Journal Article Ophthalmol Retina · November 2022 OBJECTIVE: The purpose of the study was to perform a post hoc analysis to explore the effect of baseline anatomic characteristics identified on OCT on best-corrected visual acuity (BCVA) responses to risuteganib from the completed phase II study in subject ... Full text Link to item Cite

The standardisation of uveitis nomenclature (SUN) project.

Journal Article Clin Exp Ophthalmol · September 27, 2022 The uveitides are a collection of over 30 diseases characterised by intraocular inflammation. Previous work demonstrated that the agreement among uveitis experts on diagnosis was modest at best with some pairs of experts having chance alone agreement on se ... Full text Link to item Cite

Prevalence and Progression of Macular Atrophy in Eyes with Neovascular Age-Related Macular Degeneration in the Phase 2 Ladder Trial of the Port Delivery System with Ranibizumab.

Journal Article Ophthalmol Retina · September 2022 PURPOSE: To determine whether the rates of macular atrophy (MA) differ between eyes with neovascular age-related macular degeneration (nAMD) treated continuously with the Port Delivery System with ranibizumab (PDS) and those treated with ranibizumab given ... Full text Link to item Cite

MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid.

Journal Article Ophthalmology · September 2022 PURPOSE: To assess the 52-week efficacy and safety of brolucizumab 6 mg administered every 4 weeks compared with aflibercept 2 mg dosed every 4 weeks in eyes with neovascular age-related macular degeneration (nAMD) and persistent retinal fluid. DESIGN: Mul ... Full text Link to item Cite

Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study.

Journal Article Lancet · April 20, 2024 BACKGROUND: Frequent anti-vascular endothelial growth factor A (VEGF-A) injections reduce the risk of rapid and severe vision loss in patients with neovascular age-related macular degeneration (nAMD); however, due to undertreatment, many patients lose visi ... Full text Link to item Cite

Home OCT Imaging for Newly Diagnosed Neovascular Age-Related Macular Degeneration: A Feasibility Study.

Journal Article Ophthalmol Retina · April 2024 OBJECTIVE: To assess the feasibility of daily Home OCT imaging among patients with neovascular age-related macular degeneration (nAMD). DESIGN: Prospective observational study. PARTICIPANTS: Participants with ≥ 1 eye with previously untreated nAMD and visu ... Full text Link to item Cite

LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.

Journal Article Retina · March 1, 2024 PURPOSE: The LIGHTSITE III study evaluated multiwavelength photobiomodulation (PBM) therapy in nonexudative (dry) age-related macular degeneration (AMD) using the LumiThera Valeda Light Delivery System. METHODS: LIGHTSITE III is a randomized, controlled tr ... Full text Link to item Cite

Gradeability and Reproducibility of Geographic Atrophy Measurement in GATHER-1, a Phase II/III Randomized Interventional Trial.

Journal Article Ophthalmol Sci · 2024 OBJECTIVE: To validate GATHER-1 inclusion criteria and the study's primary anatomic end point by assessing the reproducibility of geographic atrophy (GA) measurements and factors that affect reproducibility. DESIGN: Post hoc analysis of phase II/III clinic ... Full text Link to item Cite

Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee.

Journal Article J Vitreoretin Dis · 2024 Purpose: To analyze post-marketing cases of retinal vasculitis after intravitreal pegcetacoplan. Methods: The American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee as well as an expert panel performed a retrospe ... Full text Link to item Cite

Faricimab Treat-and-Extend for Diabetic Macular Edema: Two-Year Results from the Randomized Phase 3 YOSEMITE and RHINE Trials.

Journal Article Ophthalmology · December 28, 2023 PURPOSE: To evaluate the 2-year efficacy, durability, and safety of dual angiopoietin-2 and vascular endothelial growth factor (VEGF) A pathway inhibition with intravitreal faricimab according to a personalized treat-and-extend (T&E)-based regimen with up ... Full text Link to item Cite

Reticular Pseudodrusen: Interreader Agreement of Evaluation on OCT Imaging in Age-Related Macular Degeneration.

Journal Article Ophthalmol Sci · December 2023 PURPOSE: To determine the interreader agreement for reticular pseudodrusen (RPD) assessment on combined infrared reflectance (IR) and OCT imaging in the early stages of age-related macular degeneration across a range of different criteria to define their p ... Full text Link to item Cite

Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial.

Journal Article Lancet · October 21, 2023 BACKGROUND: Geographic atrophy is an advanced form of dry age-related macular degeneration that can lead to irreversible vision loss and high burden of disease. We aimed to assess efficacy and safety of avacincaptad pegol 2 mg in reducing geographic atroph ... Full text Link to item Cite

Bilateral Panuveitis in an Adolescent with Autoimmune Lymphoproliferative Syndrome Due to CTLA4 Haploinsufficiency.

Journal Article Ocul Immunol Inflamm · September 13, 2023 PURPOSE: To describe a case of bilateral panuveitis in an 11-year-old girl with autoimmune lymphoproliferative syndrome (ALPS) due to CTLA4 haploinsufficiency. CASE DESCRIPTION: A 5-year-old girl developed cervical adenopathy, and autoimmune hemolytic anem ... Full text Link to item Cite

PSEUDOMONAS ENDOPHTHALMITIS AFTER 0.59 MG FLUOCINOLONE ACETONIDE SURGICAL IMPLANT IN A PATIENT WITH A LONG-STANDING CRAWFORD TUBE.

Journal Article Retin Cases Brief Rep · September 1, 2023 PURPOSE: The purpose of this study was to report a case of Pseudomonas aeruginosa endophthalmitis after surgical 0.59 mg fluocinolone acetonide implant in a patient with a long-standing Crawford tube. METHODS: This was a retrospective case review. RESULTS: ... Full text Link to item Cite

Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER.

Journal Article Ophthalmol Ther · August 2023 INTRODUCTION: The HAWK and HARRIER studies evaluated the efficacy and safety of brolucizumab versus aflibercept in treatment-naïve eyes with neovascular age-related macular degeneration. Based on the study design, brolucizumab-treated eyes adjusted to a q8 ... Full text Link to item Cite

Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial.

Journal Article Br J Ophthalmol · July 2023 BACKGROUND/AIMS: To describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular ... Full text Link to item Cite

0.18 MG FLUOCINOLONE ACETONIDE INSERT FOR THE TREATMENT OF CHRONIC POSTOPERATIVE PSEUDOPHAKIC CYSTOID MACULAR EDEMA.

Journal Article Retina · June 1, 2023 PURPOSE: To report the outcomes of the 0.18 mg fluocinolone acetonide insert (FAi) in the treatment of chronic (>6 months) postoperative cystoid macular edema after cataract surgery. METHODS: This was a retrospective consecutive case series of eyes with ch ... Full text Link to item Cite

Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.

Journal Article Am J Ophthalmol · December 2022 PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Natural history study METHODS: Setting: 16 clinical ... Full text Link to item Cite

Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity.

Journal Article Ophthalmol Retina · November 2022 OBJECTIVE: The purpose of the study was to perform a post hoc analysis to explore the effect of baseline anatomic characteristics identified on OCT on best-corrected visual acuity (BCVA) responses to risuteganib from the completed phase II study in subject ... Full text Link to item Cite

The standardisation of uveitis nomenclature (SUN) project.

Journal Article Clin Exp Ophthalmol · September 27, 2022 The uveitides are a collection of over 30 diseases characterised by intraocular inflammation. Previous work demonstrated that the agreement among uveitis experts on diagnosis was modest at best with some pairs of experts having chance alone agreement on se ... Full text Link to item Cite

Prevalence and Progression of Macular Atrophy in Eyes with Neovascular Age-Related Macular Degeneration in the Phase 2 Ladder Trial of the Port Delivery System with Ranibizumab.

Journal Article Ophthalmol Retina · September 2022 PURPOSE: To determine whether the rates of macular atrophy (MA) differ between eyes with neovascular age-related macular degeneration (nAMD) treated continuously with the Port Delivery System with ranibizumab (PDS) and those treated with ranibizumab given ... Full text Link to item Cite

MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid.

Journal Article Ophthalmology · September 2022 PURPOSE: To assess the 52-week efficacy and safety of brolucizumab 6 mg administered every 4 weeks compared with aflibercept 2 mg dosed every 4 weeks in eyes with neovascular age-related macular degeneration (nAMD) and persistent retinal fluid. DESIGN: Mul ... Full text Link to item Cite

Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK.

Journal Article Br J Ophthalmol · July 2022 PURPOSE: To compare the efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy (PCV) over 96 weeks in the HAWK study. DESIGN: HAWK was a global, 2-year, randomised, double-masked, multicentre phase III trial i ... Full text Link to item Cite

VALIDATION OF A DEEP LEARNING-BASED ALGORITHM FOR SEGMENTATION OF THE ELLIPSOID ZONE ON OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AN USH2A-RELATED RETINAL DEGENERATION CLINICAL TRIAL.

Journal Article Retina · July 1, 2022 PURPOSE: To assess the generalizability of a deep learning-based algorithm to segment the ellipsoid zone (EZ). METHODS: The dataset consisted of 127 spectral-domain optical coherence tomography volumes from eyes of participants with USH2A-related retinal d ... Full text Link to item Cite

OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement: Classification of Atrophy Meetings Report 6.

Journal Article Ophthalmol Retina · January 2022 PURPOSE: To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD). DESIG ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · December 2021 Full text Link to item Cite

Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema.

Journal Article Transl Vis Sci Technol · December 1, 2021 PURPOSE: The purpose of this study was to evaluate the safety and preliminary efficacy of a single intravitreal injection of 3 dose levels of THR-149 in adults with center-involved diabetic macular edema (DME). METHODS: A phase 1, open-label, multicenter 3 ... Full text Link to item Cite

Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments.

Journal Article Transl Vis Sci Technol · December 1, 2021 PURPOSE: Develop equations to convert Cirrus central subfield thickness (CST) to Spectralis CST equivalents and vice versa in eyes with diabetic macular edema (DME). METHODS: The DRCR Retina Network Protocol O data were split randomly to train (70% sample) ... Full text Link to item Cite

Pneumatic Vitreolysis with Perfluoropropane for Vitreomacular Traction with and without Macular Hole: DRCR Retina Network Protocols AG and AH.

Journal Article Ophthalmology · November 2021 PURPOSE: To evaluate pneumatic vitreolysis (PVL) in eyes with vitreomacular traction (VMT) with and without full-thickness macular hole (FTMH). DESIGN: Two multicenter (28 sites) studies: a randomized clinical trial comparing PVL with observation (sham inj ... Full text Link to item Cite

Predominantly Persistent Subretinal Fluid in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmol Retina · October 2021 OBJECTIVE: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and to compare visual acuity (VA) to eyes with nonpersistent SRF. DESIGN: Cohort within ran ... Full text Link to item Cite

SARILUMAB FOR RECALCITRANT CYSTOID MACULAR EDEMA IN NON-PARANEOPLASTIC AUTOIMMUNE RETINOPATHY.

Journal Article Retin Cases Brief Rep · September 1, 2021 PURPOSE: To demonstrate a rapid improvement of recalcitrant cystoid macular edema (CME) and perivascular leakage, in a patient with non-paraneoplastic autoimmune retinopathy and autoimmune optic neuropathy after treatment with sarilumab, a human anti-inter ... Full text Link to item Cite

Imaging Features Associated with Progression to Geographic Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 5.

Journal Article Ophthalmol Retina · September 2021 PURPOSE: To provide an image-based description of retinal features associated with risk for development of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD), as visualized with multimodal imaging anchored by structural OCT. DESIGN ... Full text Link to item Cite

Phase 1 Study of THR-687, a Novel, Highly Potent Integrin Antagonist for the Treatment of Diabetic Macular Edema.

Journal Article Ophthalmol Sci · September 2021 PURPOSE: To evaluate the safety and preliminary efficacy of THR-687 in patients with center-involved diabetic macular edema (DME). DESIGN: Phase 1, open-label, multicenter, 3 + 3 dose-escalation study with 3-month follow-up. PARTICIPANTS: Patients 18 years ... Full text Link to item Cite

COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retina · August 1, 2021 PURPOSE: To determine the relationship of drusen size as determined by spectral-domain optical coherence tomography (SD-OCT) with that measured on registered color fundus photography (CFP) images and to derive an OCT-based classification system that was co ... Full text Link to item Cite

Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.

Journal Article Ophthalmology · July 2021 PURPOSE: An independent Safety Review Committee (SRC), supported by Novartis Pharma AG, analyzed investigator-reported cases of intraocular inflammation (IOI), endophthalmitis, and retinal arterial occlusion in the phase 3 HAWK and HARRIER trials of broluc ... Full text Link to item Cite

Long-Term Safety and Efficacy of Adalimumab in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis.

Journal Article Ophthalmology · June 2021 PURPOSE: To evaluate long-term efficacy and safety of extended treatment with adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Open-label, multicenter, phase 3 extension study (VISUAL III). PARTICIPANTS: Adults who ... Full text Link to item Cite

Seven-Year Outcomes of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial and Follow-up Study Results.

Journal Article Ophthalmology · May 2021 PURPOSE: To evaluate the long-term outcomes of uveitic macular edema (ME). DESIGN: Longitudinal follow-up of a cohort of participants in a randomized clinical trial. PARTICIPANTS: A total of 248 eyes of 177 participants with uveitic ME enrolled in the Mult ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · May 2021 Full text Link to item Cite

C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.

Journal Article Ophthalmology · April 2021 PURPOSE: The complement pathway may play a key role in the pathogenesis of age-related macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura, IVERIC bio Inc, New York, NY), a C5 inhibitor, were assessed in participants with geog ... Full text Link to item Cite

Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Am J Ophthalmol · March 2021 PURPOSE: To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-vascular endothelial growth factor through pixel-mapping analysis of baseline optical coherence tomography (OCT). METHODS: Design: Cross-sectional a ... Full text Link to item Cite

Reply.

Journal Article Retina · March 1, 2021 Full text Link to item Cite

Complement-mediated release of fibroblast growth factor 2 from human RPE cells.

Journal Article Exp Eye Res · March 2021 PURPOSE: Complement activation is associated with choroidal neovascularization (CNV) in age-related macular degeneration (AMD). Fibroblast growth factor 2 (FGF2) and membrane attack complex (MAC) are present in eyes of patients with CNV. Herein, we investi ... Full text Link to item Cite

HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.

Conference Ophthalmology · January 2021 PURPOSE: To report the 96-week outcomes from HAWK and HARRIER. DESIGN: Phase 3, prospective, randomized, double-masked, multicenter studies comparing efficacy and safety of brolucizumab 3 mg (HAWK only) and 6 mg with aflibercept 2 mg in eyes with neovascul ... Full text Link to item Cite

Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging: Report From a US Food and Drug Administration-Cosponsored Forum.

Journal Article JAMA Ophthalmol · January 1, 2021 In April 2019, the US Food and Drug Administration, in conjunction with 11 professional ophthalmic, vision science, and optometric societies, convened a forum on laser-based imaging. The forum brought together the Food and Drug Administration, clinicians, ... Full text Link to item Cite

The utility of CAM OCT criteria for AMD clinical trials

Journal Article Retina Today · January 1, 2021 Cite

The relationship between pigment epithelial detachment and visual outcome in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

Journal Article Eye (Lond) · December 2020 BACKGROUND/OBJECTIVES: To compare the detailed optical coherence tomography (OCT)-based morphological parameters of pigment epithelial detachment (PED) in eyes presenting with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vas ... Full text Link to item Cite

Preventing relapse in non-infectious uveitis affecting the posterior segment of the eye – evaluating the 0.2 μg/day fluocinolone acetonide intravitreal implant (ILUVIEN®)

Journal Article Journal of Ophthalmic Inflammation and Infection · December 1, 2020 Background: The current article is a short review of an Alimera Sciences-sponsored symposium held during The 15th International Ocular Inflammation Society Congress in Taiwan on the 14th November 2019 entitled, ‘Preventing relapse of non-infectious uveitis ... Full text Cite

Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity.

Journal Article Am J Ophthalmol · November 2020 PURPOSE: To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Cross-sectional study within a natural history study. METHODS: Setting: multicenter, international. STUDY POPULATION: Usher s ... Full text Open Access Link to item Cite

Effect of a Fluocinolone Acetonide Insert on Recurrence Rates in Noninfectious Intermediate, Posterior, or Panuveitis: Three-Year Results.

Journal Article Ophthalmology · October 2020 PURPOSE: To examine the 36-month efficacy and safety of a 0.2 μg/day fluocinolone acetonide insert (FAi) to treat noninfectious uveitis of the posterior segment (NIU-PS). DESIGN: Phase 3, prospective, double-masked, multicenter study (clinicaltrials.gov, N ... Full text Link to item Cite

Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells.

Journal Article Invest Ophthalmol Vis Sci · August 3, 2020 PURPOSE: Cigarette smoking has been implicated in the pathogenesis of AMD. Integrin dysfunctions have been associated with AMD. Herein, we investigate the effect of risuteganib (RSG), an integrin regulator, on RPE cell injury induced by hydroquinone (HQ), ... Full text Link to item Cite

BASELINE CHARACTERISTICS OF VITREOMACULAR TRACTION PROGRESSING TO FULL-THICKNESS MACULAR OR LAMELLAR HOLES IN THE PHASE III TRIALS OF ENZYMATIC VITREOLYSIS.

Conference Retina · August 2020 PURPOSE: To identify characteristics associated with progression from vitreomacular traction (VMT) to a full-thickness macular hole (FTMH) or lamellar hole (LH). METHODS: Post-hoc analysis of the Phase III clinical trial comparing ocriplasmin with placebo ... Full text Link to item Cite

CORRELATION OF SUBRETINAL HYPERREFLECTIVE MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Journal Article Retina · May 2020 PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) morphological features with visual acuity in eyes with neovascular age-related macular degeneration. METHODS: Retrospective analysis of treatment-naïve patients with neovasc ... Full text Link to item Cite

Anti-Vascular Endothelial Growth Factor Use and Atrophy in Neovascular Age-Related Macular Degeneration: Systematic Literature Review and Expert Opinion.

Journal Article Ophthalmology · May 2020 TOPIC: To summarize the rates of atrophy, risk factors, and atrophy-associated visual outcomes in patients with neovascular age-related macular degeneration (nAMD) who received anti-vascular endothelial growth factor (VEGF) treatment for macular neovascula ... Full text Link to item Cite

Time to disease recurrence in noninfectious uveitis following long-acting injectable fluocinolone acetonide implant.

Journal Article Graefes Arch Clin Exp Ophthalmol · May 2020 PURPOSE: To determine the time to disease recurrence with long-acting injectable fluocinolone acetonide implant (FAi) for noninfectious intermediate, posterior, and panuveitis. METHODS: This was a retrospective study of patients with at least 12 months of ... Full text Link to item Cite

Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells.

Journal Article Invest Ophthalmol Vis Sci · April 9, 2020 PURPOSE: Oxidative stress in retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD). Resveratrol exerts a range of protective biologic effects, but its mechanism(s) are not well understood. The aim of this study wa ... Full text Open Access Link to item Cite

Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration: Two-Year Results.

Journal Article Ophthalmology · April 2020 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4.

Journal Article Ophthalmology · March 2020 PURPOSE: To describe the defining features of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA), a consensus term referring to the OCT-based anatomic changes often identified before the development of complete RPE and outer reti ... Full text Link to item Cite

Characteristics of Eyes With Good Visual Acuity at 5 Years After Initiation of Treatment for Age-Related Macular Degeneration but Not Receiving Treatment From Years 3 to 5: Post Hoc Analysis of the CATT Randomized Clinical Trial.

Journal Article JAMA Ophthalmol · March 1, 2020 IMPORTANCE: Identifying the characteristics of eyes with neovascular age-related macular degeneration (nAMD) that maintain good vision without anti-vascular endothelial growth factor treatment for at least 3 years after management, as occurred in the Compa ... Full text Link to item Cite

RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY.

Journal Article Retin Cases Brief Rep · 2020 PURPOSE: To demonstrate improvement and stabilization of retinal findings, including recalcitrant cystoid macular edema, in a patient with nonparaneoplastic autoimmune retinopathy after treatment with tocilizumab, a humanized monoclonal antibody against so ... Full text Link to item Cite

HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmology · January 2020 PURPOSE: Two similarly designed phase 3 trials (HAWK and HARRIER) compared brolucizumab, a single-chain antibody fragment that inhibits vascular endothelial growth factor-A, with aflibercept to treat neovascular age-related macular degeneration (nAMD). DES ... Full text Link to item Cite

The Project Baseline Health Study: a step towards a broader mission to map human health.

Journal Article NPJ digital medicine · January 2020 The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical info ... Full text Open Access Cite

The Evolution of Fibrosis and Atrophy and Their Relationship with Visual Outcomes in Asian Persons with Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · December 2019 PURPOSE: To describe the rate of development and progression of fibrosis and macular atrophy (MA) and their relationship with 1-year visual outcomes in Asian participants with neovascular age-related macular degeneration (nAMD). DESIGN: Review of images co ... Full text Link to item Cite

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal Article Ophthalmology · December 2019 PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years ... Full text Open Access Link to item Cite

Reply.

Journal Article Ophthalmology · December 2019 Full text Link to item Cite

Clinical outcomes following the triple procedure

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Luminate protects against hydroquinone-induced injury in human RPE cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

PERIVASCULAR THICKENING ON OPTICAL COHERENCE TOMOGRAPHY AS A MARKER OF INFLAMMATION IN BIRDSHOT RETINOCHOROIDITIS.

Journal Article Retina · May 2019 PURPOSE: In this study, we hypothesized that thickening along the major arcade vessels is a noninvasive marker of inflammation in eyes with birdshot retinochoroiditis (BRC). METHODS: In this single-center retrospective study, patients with BRC were identif ... Full text Link to item Cite

Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · May 2019 PURPOSE: To describe changes in visual acuity (VA) and macular morphologic features at 5 years in eyes with nonfibrotic scar (NFS) identified at 1 year in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective coho ... Full text Link to item Cite

MUST Beg to Differ.

Journal Article Ophthalmic Surg Lasers Imaging Retina · May 1, 2019 The authors provide a significant interpretation of the National Eye Institute-sponsored Multicenter Uveitis Steroid Treatment study, in which patients with severe, non-infectious intermediate, posterior, or panuveitis were randomly assigned to receive loc ... Full text Link to item Cite

Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial.

Journal Article Ophthalmology · April 2019 PURPOSE: To test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF), on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy. DESIGN: Rando ... Full text Link to item Cite

Effect of an Injectable Fluocinolone Acetonide Insert on Recurrence Rates in Chronic Noninfectious Uveitis Affecting the Posterior Segment: Twelve-Month Results.

Journal Article Ophthalmology · April 2019 PURPOSE: To assess the safety and efficacy of an intravitreal fluocinolone acetonide (FA) insert to manage inflammation associated with chronic noninfectious posterior uveitis. DESIGN: Multicenter, randomized, prospective, doubled-masked, sham-controlled, ... Full text Link to item Cite

Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.

Journal Article Ophthalmol Retina · April 2019 PURPOSE: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined feature ... Full text Link to item Cite

A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned.

Journal Article Transl Vis Sci Technol · April 2019 The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching ... Full text Link to item Cite

Macular Morphology and Visual Acuity in Year Five of the Comparison of Age-related Macular Degeneration Treatments Trials.

Conference Ophthalmology · February 2019 PURPOSE: To evaluate associations of morphologic features with 5-year visual acuity (VA) in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort study within a randomized clinical trial. PARTICIPANTS: Participants in ... Full text Link to item Cite

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17.

Journal Article Ophthalmology · February 2019 PURPOSE: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). DESIGN: Retrospective analysis of a prospective cohort study. PARTICIPANTS: Of th ... Full text Link to item Cite

Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial.

Journal Article Ophthalmology · February 2019 PURPOSE: To evaluate the comparative effectiveness of 3 regional corticosteroid injections for uveitic macular edema (ME): periocular triamcinolone acetonide (PTA), intravitreal triamcinolone acetonide (ITA), and the intravitreal dexamethasone implant (IDI ... Full text Link to item Cite

PANRETINAL PHOTOCOAGULATION VERSUS RANIBIZUMAB FOR PROLIFERATIVE DIABETIC RETINOPATHY: Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness in a Randomized Clinical Trial.

Journal Article Retina · January 2019 PURPOSE: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thick ... Full text Link to item Cite

Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials.

Journal Article Ocul Immunol Inflamm · 2019 PURPOSE: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis. METHODS: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active ... Full text Link to item Cite

Subfoveal Lucency after Treatment of Vitreomacular Traction without Macular Hole in the Phase 3 Trials of Ocriplasmin Vitreolysis.

Journal Article Ophthalmol Retina · January 2019 PURPOSE: To describe the clinical impact of subfoveal lucency (SFL) seen on OCT before and after treatment of vitreomacular traction (VMT) or symptomatic vitreomacular adhesion (VMA) without macular hole (MH) in the prospective phase 3 trials of ocriplasmi ... Full text Link to item Cite

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

Journal Article Ophthalmology · December 2018 PURPOSE: To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN: Prospective cohort study withi ... Full text Link to item Cite

Current role of optical coherence tomography angiography: Expert panel discussion.

Journal Article Indian J Ophthalmol · December 2018 Optical coherence tomography (OCT) angiography is a promising technique that provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging and offers several advantages ... Full text Link to item Cite

Diagnostic and Therapeutic Challenges.

Journal Article Retina · November 2018 Full text Link to item Cite

The role of cystoid macular edema as a marker in the progression of non-paraneoplastic autoimmune retinopathy.

Journal Article Graefes Arch Clin Exp Ophthalmol · October 2018 PURPOSE: To determine the relationship between cystoid macular edema (CME) and disease severity and progression in non-paraneoplastic autoimmune retinopathy (npAIR). METHODS: A retrospective study was conducted on patients seen between 2008 and 2016 with n ... Full text Link to item Cite

Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III.

Journal Article Ophthalmology · July 2018 PURPOSE: To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Phase 3, open-label, multicenter clinical trial extension (VISUAL III). PARTICIPANTS: Adults meeting treatment failure (TF ... Full text Link to item Cite

Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · July 2018 PURPOSE: To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Multicenter, prospective cohort study. PARTICIPANTS: A total of 1061 s ... Full text Link to item Cite

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.

Journal Article Ophthalmology · July 2018 PURPOSE: To assess systemic vascular endothelial growth factor (VEGF)-A levels after treatment with intravitreous aflibercept, bevacizumab, or ranibizumab. DESIGN: Comparative-effectiveness trial with participants randomly assigned to 2 mg aflibercept, 1.2 ... Full text Link to item Cite

Semi-Automated Segmentation of Hyperreflective Foci on Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Phase 2 Trial of Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Less invasive treatment for uveitis

Journal Article Retina Today · July 1, 2018 Cite

Baseline Predictors for Five-Year Visual Acuity Outcomes in the Comparison of AMD Treatment Trials.

Journal Article Ophthalmol Retina · June 2018 PURPOSE: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). DESIGN: Secondary analysis of data from a cohort study. P ... Full text Link to item Cite

Deep longitudinal transfer learning-based automatic segmentation of photoreceptor ellipsoid zone defects on optical coherence tomography images of macular telangiectasia type 2.

Journal Article Biomed Opt Express · June 1, 2018 Photoreceptor ellipsoid zone (EZ) defects visible on optical coherence tomography (OCT) are important imaging biomarkers for the onset and progression of macular diseases. As such, accurate quantification of EZ defects is paramount to monitor disease progr ... Full text Link to item Cite

Linking OCT, Angiographic, and Photographic Lesion Components in Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · May 2018 PURPOSE: To develop methods to make precise comparisons of specific retinal features between and within spectral-domain (SD) OCT images, color fundus photography (CFP) images, and fluorescein angiography (FA) images in eyes treated with anti-vascular endot ... Full text Link to item Cite

Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3.

Journal Article Ophthalmology · April 2018 PURPOSE: To develop consensus terminology and criteria for defining atrophy based on OCT findings in the setting of age-related macular degeneration (AMD). DESIGN: Consensus meeting. PARTICIPANTS: Panel of retina specialists, image reading center experts, ... Full text Link to item Cite

Chronic Inflammation After YAG Capsulotomy.

Journal Article JAMA Ophthalmol · April 1, 2018 Full text Link to item Cite

Interobserver Agreement Among Uveitis Experts on Uveitic Diagnoses: The Standardization of Uveitis Nomenclature Experience.

Journal Article Am J Ophthalmol · February 2018 PURPOSE: To evaluate the interobserver agreement among uveitis experts on the diagnosis of the specific uveitic disease. DESIGN: Interobserver agreement analysis. METHODS: Five committees, each comprised of 9 individuals and working in parallel, reviewed c ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · January 2018 Full text Link to item Cite

Reply.

Journal Article Ophthalmology · January 2018 Full text Link to item Cite

Reply.

Journal Article Ophthalmology · January 2018 Full text Link to item Cite

Effect of Adding Dexamethasone to Continued Ranibizumab Treatment in Patients With Persistent Diabetic Macular Edema: A DRCR Network Phase 2 Randomized Clinical Trial.

Journal Article JAMA Ophthalmol · January 1, 2018 IMPORTANCE: Some eyes have persistent diabetic macular edema (DME) following anti-vascular endothelial growth factor (anti-VEGF) therapy for DME. Subsequently adding intravitreous corticosteroids to the treatment regimen might result in better outcomes tha ... Full text Link to item Cite

The Relationship of Vogt-Koyanagi-Harada Syndrome to Ocular Hypertension and Glaucoma.

Journal Article Ocul Immunol Inflamm · December 2017 PURPOSE: Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH. The purpose of this report is to examine the frequency and types of glaucoma a ... Full text Link to item Cite

Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience.

Journal Article Ophthalmology · September 2017 PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ... Full text Link to item Cite

Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial.

Journal Article Ophthalmology · September 2017 PURPOSE: To compare the efficacy and safety of brolucizumab with aflibercept to treat neovascular age-related macular degeneration (AMD). DESIGN: Prospective, randomized, double-masked, multicenter, 2-arm, phase 2 study. PARTICIPANTS: Eighty-nine treatment ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · August 2017 Full text Link to item Cite

Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.

Journal Article Invest Ophthalmol Vis Sci · August 1, 2017 PURPOSE: The purpose of this study was to describe fundus autofluorescence (FAF) findings in eyes with birdshot chorioretinitis (BSCR) and to compare findings to demographic, medical, and clinical characteristics. METHODS: In this multicenter, prospective, ... Full text Link to item Cite

Nepafenac 0.3% after Cataract Surgery in Patients with Diabetic Retinopathy: Results of 2 Randomized Phase 3 Studies.

Journal Article Ophthalmology · June 2017 PURPOSE: To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes. DESIGN: Two prospective, randomized, multicenter, double-masked ... Full text Link to item Cite

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.

Journal Article Invest Ophthalmol Vis Sci · June 1, 2017 PURPOSE: Complement activation is implicated in the pathogenesis of age-related macular degeneration (AMD). Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in eyes of individuals with AMD. Herein ... Full text Open Access Link to item Cite

Effect of Bax Inhibitor 1 overexpression on Tunicamycin-induced ER Stress in Human RPE Cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Complement Membrane Attack Complex Release Basic Fibroblast Growth Factor from Human RPE Cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Baseline Predictors of Five-Year Visual Acuity in the Comparison of AMD Treatment Trials (CATT)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Cystoid Macular Edema as a Marker in the Progression of Autoimmune Retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Association of Disorganization of Retinal Inner Layers With Visual Acuity In Eyes With Uveitic Cystoid Macular Edema.

Journal Article Am J Ophthalmol · May 2017 PURPOSE: To determine whether disorganization of retinal inner layers (DRIL) assessed by spectral-domain optical coherence tomography (SDOCT) correlates with visual acuity (VA) in eyes with uveitic cystoid macular edema (CME). DESIGN: Secondary analysis of ... Full text Link to item Cite

Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2.

Journal Article Invest Ophthalmol Vis Sci · May 1, 2017 PURPOSE: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). METHODS: Macular SD-OC ... Full text Link to item Cite

Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings.

Journal Article Ophthalmology · April 2017 PURPOSE: To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related macular de ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · April 2017 Full text Link to item Cite

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial.

Journal Article Lancet Neurol · March 2017 BACKGROUND: The human monoclonal antibody opicinumab (BIIB033, anti-LINGO-1) has shown remyelinating activity in preclinical studies. We therefore assessed the safety and tolerability, and efficacy of opicinumab given soon after a first acute optic neuriti ... Full text Link to item Cite

Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration: A Phase IIb, Multicenter, Randomized Controlled Trial.

Journal Article Ophthalmology · February 2017 PURPOSE: To assess the safety and efficacy of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, administered in combination with the anti-vascular endothelial growth factor (VEGF) agent ranibizumab (Lucentis; R ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · February 2017 Full text Link to item Cite

Platform-Independent Cirrus and Spectralis Thickness Measurements in Eyes with Diabetic Macular Edema Using Fully Automated Software.

Journal Article Transl Vis Sci Technol · February 2017 PURPOSE: We determine whether the automated segmentation software, Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can measure, in a platform-independent manner, retinal thickness on Cirrus and Spectralis spectral domain optical coher ... Full text Link to item Cite

Spontaneous Closure of Full-Thickness Macular Hole With Epiretinal Membrane in Vitrectomized Eyes: Case Series and Review of Literature.

Journal Article Ophthalmic Surg Lasers Imaging Retina · February 1, 2017 The authors describe three vitrectomized eyes that each subsequently developed a full-thickness macular hole (FTMH) that then spontaneously closed and summarize the current literature reporting these rare events. Clinical history, imaging, and course of th ... Full text Link to item Cite

Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · January 2017 PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PART ... Full text Link to item Cite

Retinal angiomatous proliferation.

Journal Article Surv Ophthalmol · 2017 Retinal angiomatous proliferation (RAP) is a unique variant of neovascular age-related macular degeneration. Published studies have estimated that up to 15% of patients with neovascular age-related macular degeneration have RAP. Clinical features frequentl ... Full text Link to item Cite

Visual and Morphologic Outcomes in Eyes with Hard Exudate in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmol Retina · 2017 PURPOSE: To compare baseline characteristics, visual acuity (VA) and morphological outcomes between eyes with baseline hard exudates (HE) and all other eyes among patients with neovascular age-related macular degeneration (NVAMD) treated with anti-vascular ... Full text Link to item Cite

Recovery of Foveal Anatomy and Subfoveal Lucency after Pharmacologic and Surgical Macular Hole Closure in the Ocriplasmin Phase III Trials.

Journal Article Ophthalmol Retina · 2017 PURPOSE: To compare foveal anatomic features on OCT after macular hole (MH) closure, and their association with visual function, in the ocriplasmin phase III trials. DESIGN: Randomized clinical trial. PARTICIPANTS: One hundred fifty-three participants. MET ... Full text Link to item Cite

Morphological assessment of the retina in uveitis.

Journal Article J Ophthalmic Inflamm Infect · December 2016 BACKGROUND: The objective of this study is to describe a system for color photograph evaluation in uveitis and report baseline morphologic findings for the Multicenter Uveitis Steroid Treatment (MUST) Trial. Four-hundred seventy-nine eyes of 255 subjects w ... Full text Link to item Cite

Intravitreal Aflibercept for Diabetic Macular Edema: 148-Week Results from the VISTA and VIVID Studies.

Conference Ophthalmology · November 2016 PURPOSE: To compare efficacy and safety of intravitreal aflibercept injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME) over 3 years. DESIGN: Two similarly designed phase 3 trials: VISTADME and VIVIDDME. PARTICIPANTS: Patie ... Full text Link to item Cite

Wide field of view swept-source optical coherence tomography for peripheral retinal disease.

Journal Article Br J Ophthalmol · October 2016 BACKGROUND/AIMS: To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. METHODS: A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-sou ... Full text Link to item Cite

Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.

Journal Article Lancet · September 17, 2016 BACKGROUND: Non-infectious uveitis is a potentially sight-threatening ocular disorder caused by chronic inflammation and its complications. Therapeutic success is limited by systemic adverse effects associated with long-term corticosteroid and immunomodula ... Full text Link to item Cite

Adalimumab in Patients with Active Noninfectious Uveitis.

Journal Article N Engl J Med · September 8, 2016 BACKGROUND: Patients with noninfectious uveitis are at risk for long-term complications of uncontrolled inflammation, as well as for the adverse effects of long-term glucocorticoid therapy. We conducted a trial to assess the efficacy and safety of adalimum ... Full text Link to item Cite

Differential Response to Anti-VEGF Regimens in Age-Related Macular Degeneration Patients with Early Persistent Retinal Fluid.

Journal Article Ophthalmology · September 2016 PURPOSE: To compare the effect of intravitreal aflibercept or ranibizumab drug type and frequency on visual acuity outcomes in eyes with neovascular age-related macular degeneration (NVAMD) and early persistent retinal fluid after 3 initial monthly injecti ... Full text Link to item Cite

Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results.

Journal Article Ophthalmology · September 2016 PURPOSE: To determine the effect of an injectable fluocinolone acetonide implant (FAi) in eyes with noninfectious intermediate uveitis, posterior uveitis, or panuveitis. DESIGN: Noncomparative, interventional, dose-randomized, dose-masked, prospective, ind ... Full text Link to item Cite

The Protective Effect of Bax Inhibitor 1 (BI-1) on Tunicamycin-induced Human RPE Cell Death

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

The Association of Apolipoprotein E and Membrane Attack Complex in Human RPE Cell

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Adalimumab in patients with active and inactive, non-infectious uveitis: VISUAL I and VISUAL II trials

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · August 2016 PURPOSE: To describe outcomes 5 years after initiating treatment with bevacizumab or ranibizumab for neovascular age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Patients enrolled in the Comparison of AMD Treatments Trials. METHO ... Full text Link to item Cite

Morphology and Visual Acuity in Aflibercept and Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration in the VIEW Trials.

Journal Article Ophthalmology · July 2016 PURPOSE: To compare the efficacy of intravitreal aflibercept and ranibizumab on the exudative activity of neovascular age-related macular degeneration (nAMD) using optical coherence tomography (OCT) and to correlate morphologic findings with visual acuity ... Full text Link to item Cite

Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The purposes of this study were to describe choroidal findings observed using optical coherence tomography with enhanced depth imaging (EDI-OCT) in eyes with birdshot chorioretinitis (BSCR) and to test the hypothesis that these findings are relate ... Full text Link to item Cite

Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article JAMA Ophthalmol · June 1, 2016 IMPORTANCE: Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD ... Full text Link to item Cite

Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · April 2016 PURPOSE: To describe the association between morphologic features on fundus photography (FP), fluorescein angiography (FA), and optical coherence tomography (OCT) and visual acuity (VA) in the second year of the Comparison of Age-related Macular Degenerati ... Full text Link to item Cite

Angiographic Cystoid Macular Edema and Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · April 2016 PURPOSE: To describe morphologic and visual outcomes in eyes with angiographic cystoid macular edema (CME) treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (nAMD). DESIGN: Prospective cohort study within a randomized ... Full text Link to item Cite

A Crossover Design for Comparative Efficacy: A 36-Week Randomized Trial of Bevacizumab and Ranibizumab for Diabetic Macular Edema.

Journal Article Ophthalmology · April 2016 PURPOSE: To investigate the comparative efficacy of bevacizumab (Avastin) and ranibizumab (Lucentis; both Genentech, Inc, South San Francisco, CA) for diabetic macular edema (DME) using a crossover study design. DESIGN: Randomized, double-masked, 36-week, ... Full text Link to item Cite

Analysis of Peripapillary Atrophy in Relation to Macular Geographic Atrophy in Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · April 1, 2016 PURPOSE: The purpose of this study was to investigate the presence, configuration, and progression of peripapillary atrophy (PPA) relative to macular geographic atrophy (GA) in AMD. METHODS: Confocal scanning laser ophthalmoscopy images of 413 eyes of 413 ... Full text Link to item Cite

Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study.

Journal Article Am J Ophthalmol · April 2016 PURPOSE: To describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial. DESIGN: Randomized clinical trial with extended follow-up. METHODS: Review of data collected on the first implant in the eye(s) of ... Full text Link to item Cite

Outcomes in Eyes with Retinal Angiomatous Proliferation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Journal Article Ophthalmology · March 2016 PURPOSE: To compare baseline characteristics, visual acuity (VA), and morphologic outcomes between eyes with retinal angiomatous proliferation (RAP) and all other eyes among patients with neovascular age-related macular degeneration (NVAMD) treated with an ... Full text Link to item Cite

Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study).

Journal Article Ophthalmology · February 2016 PURPOSE: The Geographic Atrophy Progression (GAP) study was designed to assess the rate of geographic atrophy (GA) progression and to identify prognostic factors by measuring the enlargement of the atrophic lesions using fundus autofluorescence (FAF) and c ... Full text Link to item Cite

A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmology · January 2016 PURPOSE: To assess the safety and tolerability of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, when administered in combination with an anti-vascular endothelial growth factor (VEGF) agent, ranibizumab (Lu ... Full text Link to item Cite

Prevalence of vitreomacular adhesion: an optical coherence tomography analysis in the retina clinic setting.

Journal Article Clin Ophthalmol · 2016 PURPOSE: The aims of this study were to determine the prevalence of vitreomacular adhesion (VMA) in a random sample of clinical patients at three US retina clinics and to assess comorbid retinal conditions, ocular diseases, prior treatment history, and oth ... Full text Link to item Cite

Randomized Trial to Evaluate Tandospirone in Geographic Atrophy Secondary to Age-Related Macular Degeneration: The GATE Study.

Journal Article Am J Ophthalmol · December 2015 PURPOSE: To determine the safety and efficacy of AL-8309B (tandospirone) in the management of patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and obtain standardized data on GA lesion growth progression. DESIGN: Pr ... Full text Link to item Cite

Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).

Journal Article Ophthalmology · December 2015 PURPOSE: To evaluate the association of baseline characteristics and early visual acuity (VA) response with visual outcomes at years 1 or 2 in the Comparison of Age-Related Macular Degeneration (AMD) Treatments Trials (CATT). DESIGN: Secondary analysis of ... Full text Link to item Cite

Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial.

Journal Article Am J Ophthalmol · December 2015 PURPOSE: To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. DESIGN: Cohort study using randomized controlled trial data. METHODS: Multicenter Uveitis ... Full text Link to item Cite

Improved Surgical Success of Combined Glaucoma Tube Shunt and Retisert(®) Implantation in Uveitic Eyes: A Retrospective Study.

Journal Article Ophthalmol Ther · December 2015 INTRODUCTION: The purpose of this study was to determine whether the outcomes following placement of a fluocinolone acetonide implant (Retisert(®); Bausch & Lomb, Inc.) combined with an Ahmed™ glaucoma valve (New World Medical, Inc.) in eyes with uveitic g ... Full text Link to item Cite

Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results.

Journal Article Ophthalmology · November 2015 PURPOSE: To evaluate the 2-year outcomes of uveitic macular edema. DESIGN: Longitudinal follow-up of a randomized cohort. PARTICIPANTS: At baseline, 148 eyes of 117 patients enrolled in the Multicenter Uveitis Steroid Treatment (MUST) Trial had macular ede ... Full text Link to item Cite

Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography.

Journal Article Invest Ophthalmol Vis Sci · October 2015 PURPOSE: To differentiate diabetic macular edema (DME) from pseudophakic cystoid macular edema (PCME) based solely on spectral-domain optical coherence tomography (SD-OCT). METHODS: This cross-sectional study included 134 participants: 49 with PCME, 60 wit ... Full text Link to item Cite

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · September 2015 PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective cohort study w ... Full text Link to item Cite

IDENTIFICATION OF FLUID ON OPTICAL COHERENCE TOMOGRAPHY BY TREATING OPHTHALMOLOGISTS VERSUS A READING CENTER IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS.

Journal Article Retina · July 2015 PURPOSE: To examine treatment decisions by ophthalmologists versus reading center fluid identification from optical coherence tomography in Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). METHODS: Fluid in 6,210 optical coherence t ... Full text Link to item Cite

Association between anatomical resolution and functional outcomes in the mivi-trust studies using ocriplasmin to treat symptomatic vitreomacular adhesion/vitreomacular traction, including when associated with macular hole.

Journal Article Retina · June 2015 PURPOSE: To evaluate visual function in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction including when associated with macular hole after ocriplasmin treatment, and the association between resolution of the underlying conditio ... Full text Link to item Cite

Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · June 2015 OBJECTIVE: To assess the association of the vitreomacular interface with outcomes of eyes treated with anti-vascular endothelial growth factor drugs for neovascular age-related macular degeneration (AMD). DESIGN: Prospective cohort study within a multicent ... Full text Link to item Cite

Complement-mediated Apolipoprotein E Accumulation in Cultured Human RPE Cell

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema.

Journal Article N Engl J Med · March 26, 2015 BACKGROUND: The relative efficacy and safety of intravitreous aflibercept, bevacizumab, and ranibizumab in the treatment of diabetic macular edema are unknown. METHODS: At 89 clinical sites, we randomly assigned 660 adults (mean age, 61±10 years) with diab ... Full text Link to item Cite

Lack of consensus in the diagnosis and treatment for ocular tuberculosis among uveitis specialists.

Journal Article Ocul Immunol Inflamm · February 2015 PURPOSE: To assess the approach of specialists to ocular tuberculosis (TB). METHODS: The American Uveitis Society (AUS) Listserv was surveyed using two clinical cases and general questions. RESULTS: Of 196 members, 87 responded (44.4%), of whom 64 were aff ... Full text Link to item Cite

Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials.

Journal Article Ophthalmology · January 2015 PURPOSE: To evaluate the efficacy of a single intravitreal injection of ocriplasmin 125 μg across relevant subpopulations of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT), including when associated with macular hole. D ... Full text Link to item Cite

Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema.

Journal Article Transl Vis Sci Technol · January 2015 PURPOSE: To evaluate the reproducibility of central subfield thickness (CST) and volume measurements from optical coherence tomography (OCT) images obtained with Zeiss Stratus and Optovue RTVue, and formulate equations to convert these measurements from RT ... Full text Link to item Cite

Lab-on-a-disk immunoassay for ocular diagnostics

Conference Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC · December 2, 2014 Monitoring of angiogenic cytokines in the eyes of patients with diabetic retinopathy (DR) and age-related macular degeneration (AMD) is crucial to confirm efficacy of treatment. We present a novel 'lab-on-a-disk' immunoassay for monitoring vascular endothe ... Full text Cite

Intravitreal aflibercept for diabetic macular edema.

Journal Article Ophthalmology · November 2014 PURPOSE: A head-to-head comparison was performed between vascular endothelial growth factor blockade and laser for treatment of diabetic macular edema (DME). DESIGN: Two similarly designed, double-masked, randomized, phase 3 trials, VISTA(DME) and VIVID(DM ... Full text Link to item Cite

Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema.

Journal Article JAMA Ophthalmol · September 2014 IMPORTANCE: Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. OBJECTIVE: To evaluate the reproducibility of ... Full text Link to item Cite

A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate.

Journal Article Lab Chip · August 7, 2014 We present a novel "Lab-on-a-Disk" platform and demonstrate its capability for rapid and sensitive measurement of vascular endothelial growth factor (VEGF) intended for patients suffering from diabetic retinopathy (DR) and age-related macular degeneration ... Full text Link to item Cite

Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials.

Journal Article JAMA Ophthalmol · August 2014 IMPORTANCE: Although anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration (AMD) results in improved vision overall, loss of substantial vision can occur. Understanding the processes that lead to loss of vision m ... Full text Link to item Cite

Paradoxical changes of retinal nerve fiber layer thickness in uveitic glaucoma.

Journal Article JAMA Ophthalmol · July 2014 IMPORTANCE: Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography can aid in the diagnosis and management of glaucoma. We observed a previously unreported phenomenon in eyes with uveitis-associated glaucoma in which p ... Full text Link to item Cite

Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress.

Journal Article Invest Ophthalmol Vis Sci · May 6, 2014 PURPOSE: Retinal pigment epithelial (RPE) cell death is an important feature of the advanced forms of AMD. Complement alternative pathway (AP) activation is associated with RPE cell death in AMD. In this study, we developed a new model to initiate AP activ ... Full text Link to item Cite

Lab-on-a-Disk Immunoassay for Ocular Diagnostics

Journal Article 40th Annual Northeast Bioengineering Conference · 2014 Cite

Fully automatic software for retinal thickness in eyes with diabetic macular edema from images acquired by cirrus and spectralis systems.

Journal Article Invest Ophthalmol Vis Sci · November 15, 2013 PURPOSE: To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral-domain optical coherence tomography (SD-OCT) images obtained from different commercia ... Full text Link to item Cite

Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial.

Journal Article Transl Vis Sci Technol · November 2013 PURPOSE: To determine the impact of segmentation error correction and precision of standardized grading of time domain optical coherence tomography (OCT) scans obtained during an interventional study for macular edema secondary to central retinal vein occl ... Full text Link to item Cite

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.

Journal Article Proc Natl Acad Sci U S A · October 22, 2013 The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification. Herein, we report a previously undescribed role for the AhR signaling pathway as an essential defense mechanism in the pathogenesis of early ... Full text Link to item Cite

A dedicated low-cost fluorescence microfluidic device reader for point-of-care ocular diagnostics

Journal Article Journal of Medical Devices, Transactions of the ASME · June 24, 2013 Microfluidic fluorescence assay devices show great promise as preclinical and clinical diagnostic instruments. Normally, fluorescence signals from microfluidic chips are quantified by analysis of images obtained with a commercial fluorescence microscope. T ... Full text Cite

Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration.

Journal Article Invest Ophthalmol Vis Sci · June 10, 2013 PURPOSE: To characterize longitudinal changes of reticular drusen (RDR) in subjects with geographic atrophy (GA) secondary to age-related macular degeneration in the multicenter, prospective natural history Geographic Atrophy Progression Study. METHODS: Th ... Full text Link to item Cite

All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death.

Journal Article Invest Ophthalmol Vis Sci · April 12, 2013 PURPOSE: Retinal pigment epithelial (RPE) cell death occurs early in the pathogenesis of age-related macular degeneration (AMD) and Stargardt's disease. Emerging evidence suggests that all-trans-retinal (atRal) and alternative complement pathway (AP) activ ... Full text Link to item Cite

Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · December 2012 OBJECTIVE: To report reading center reproducibility during grading of Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA) images obtained during the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Pr ... Full text Link to item Cite

Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis.

Journal Article Invest Ophthalmol Vis Sci · October 25, 2012 PURPOSE: To determine the relative ability of time domain (TD)-optical coherence tomography (OCT) compared with spectral domain (SD)-OCT to assess vitreoretinal interface abnormalities and pharmacologic treatment of symptomatic vitreomacular adhesion (VMA) ... Full text Link to item Cite

Characterization of vitreoretinal interface disorders using OCT in the interventional phase 3 trials of ocriplasmin.

Journal Article Invest Ophthalmol Vis Sci · September 21, 2012 PURPOSE: We determined the reproducibility of a novel optical coherence tomography (OCT) protocol designed to evaluate formally vitreoretinal interface abnormalities on scans obtained during two phase 3 studies of intravitreal ocriplasmin to treat symptoma ... Full text Link to item Cite

Diagnostic yield of vitreous biopsy in presumed sarcoidosis-related posterior segment inflammation.

Journal Article Graefes Arch Clin Exp Ophthalmol · September 2012 PURPOSE: Diagnostic vitrectomy is frequently used to help establish a diagnosis in challenging uveitis cases. The usefulness of this procedure in patients with suspected sarcoidosis with posterior segment involvement, in whom a diagnosis cannot be determin ... Full text Link to item Cite

Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy

Journal Article Clinical Ophthalmology · August 2, 2012 Background: The purpose of this study was to evaluate nepafenac ophthalmic suspension 0.1% (Nevanac®; Alcon Research Ltd) in the prevention of macular edema following cataract surgery in diabetic retinopathy patients. Methods: This was a multicenter, rando ... Full text Cite

Topography of geographic atrophy in age-related macular degeneration.

Journal Article Invest Ophthalmol Vis Sci · July 26, 2012 PURPOSE: To determine the topographic distribution and progression of geographic atrophy (GA) in patients with AMD. METHODS: Fundus autofluorescence images (excitation 488, emission 500-700 nm) from 413 eyes of 413 subjects (median age, 77.0 years; inter q ... Full text Link to item Cite

Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results.

Journal Article Ophthalmology · July 2012 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

The impact of macular edema on visual function in intermediate, posterior, and panuveitis.

Journal Article Ocul Immunol Inflamm · June 2012 PURPOSE: To evaluate the impact of macular edema on visual acuity and visual field sensitivity in uveitis. DESIGN: This study utilized baseline data from the Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized, parallel treatment clinical tria ... Full text Link to item Cite

AMD and imaging

Other Retina Today · March 1, 2012 Cite

Intermediate uveitis

Chapter · January 1, 2012 Full text Cite

Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results.

Journal Article Ophthalmology · January 2012 PURPOSE: To assess long-term visual outcomes and adverse events from a fluocinolone acetonide (FA) sustained drug delivery implant in eyes with chronic macular edema from central retinal vein occlusion (CRVO). DESIGN: Prospective interventional case series ... Full text Link to item Cite

Pars plana vitrectomy, fluocinolone acetonide implantation, and silicone oil infusion for the treatment of chronic, refractory uveitic hypotony.

Journal Article Am J Ophthalmol · November 2011 PURPOSE: To assess the feasibility and outcomes of combining fluocinolone acetonide sustained drug delivery implant insertion, pars plana vitrectomy, and silicone oil infusion to treat patients with chronic, refractory ocular hypotony resulting from uveiti ... Full text Link to item Cite

Therapy for ocular toxoplasmosis.

Journal Article Ocul Immunol Inflamm · October 2011 PURPOSE: To review current evidence for the treatment of ocular toxoplasmosis (OT). DESIGN: Narrative review and expert recommendations. METHODS: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert reco ... Full text Link to item Cite

Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration.

Journal Article Invest Ophthalmol Vis Sci · September 29, 2011 PURPOSE: To determine intraobserver and interobserver longitudinal measurement variability of novel semiautomated software for quantification of age-related macular degeneration-associated geographic atrophy (GA) based on confocal scanning laser ophthalmos ... Full text Link to item Cite

Reticular drusen associated with geographic atrophy in age-related macular degeneration.

Journal Article Invest Ophthalmol Vis Sci · August 24, 2011 PURPOSE: To characterize reticular drusen (RDR) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in a prospective, multicenter, natural history study. METHODS: Confocal scanning laser ophthalmoscopy (cSLO) three- ... Full text Link to item Cite

The role of Bcl-xL in mouse RPE cell survival.

Journal Article Invest Ophthalmol Vis Sci · August 17, 2011 PURPOSE. Retinal pigment epithelial (RPE) cell survival plays a critical role in normal physiology and in retinal diseases, such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). We have previously demonstrated that Bcl-x ... Full text Link to item Cite

Ranibizumab and bevacizumab for neovascular age-related macular degeneration.

Journal Article N Engl J Med · May 19, 2011 BACKGROUND: Clinical trials have established the efficacy of ranibizumab for the treatment of neovascular age-related macular degeneration (AMD). In addition, bevacizumab is used off-label to treat AMD, despite the absence of similar supporting data. METHO ... Full text Link to item Cite

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration.

Journal Article Proc Natl Acad Sci U S A · April 12, 2011 There is no treatment available for vision loss associated with advanced dry age-related macular degeneration (AMD) or geographic atrophy (GA). In a pilot, proof of concept phase 2 study, we evaluated ciliary neurotrophic factor (CNTF) delivered via an int ... Full text Link to item Cite

Evaluation of artifacts associated with macular spectral-domain optical coherence tomography.

Journal Article Ophthalmology · June 2010 PURPOSE: To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements ... Full text Link to item Cite

Combined fluocinolone acetonide intravitreal insertion and glaucoma drainage device placement for chronic uveitis and glaucoma.

Journal Article Am J Ophthalmol · May 2010 PURPOSE: To determine whether a fluocinolone acetonide sustained-release intravitreal drug delivery system can be implanted safely at the same time that a glaucoma drainage device is placed for eyes with uveitis and elevated intraocular pressure (IOP) rece ... Full text Link to item Cite

Retinal thickening in iridocyclitis.

Journal Article Am J Ophthalmol · September 2009 PURPOSE: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. DESIGN: Retrospective, observational case series. METHODS: Records we ... Full text Link to item Cite

Expression and modulation of RPE cell membrane complement regulatory proteins.

Journal Article Invest Ophthalmol Vis Sci · July 2009 PURPOSE: Complement, inflammation, and oxidant injury contribute to age-related macular degeneration (AMD). Membrane complement regulatory proteins (mCRPs) such as CD46, CD55, and CD59, protect host cells from complement attack. The factors that regulate R ... Full text Link to item Cite

Comparison of spectral- and time-domain optical coherence tomography for retinal thickness measurements in healthy and diseased eyes.

Journal Article Am J Ophthalmol · May 2009 PURPOSE: To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses. DESIGN: Retrospective, observational chart ... Full text Link to item Cite

Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006.

Journal Article Retina · February 2009 PURPOSE: To compare the incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide injections during a 6 month period in 2006 to the same period in 2005 and determine the incidence after switching to intravitreal preservative-free tria ... Full text Link to item Cite

In reply

Other Archives of Ophthalmology · January 1, 2009 Full text Cite

Combined fluocinolone acetonide intraocular delivery system insertion, phacoemulsification, and intraocular lens implantation for severe uveitis.

Journal Article Am J Ophthalmol · October 2008 PURPOSE: To determine whether a three-year fluocinolone acetonide sustained drug delivery system can be implanted safely at the same time that phacoemulsification and intraocular lens (IOL) implantation are performed for a visually significant cataract in ... Full text Link to item Cite

Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial results.

Journal Article Arch Ophthalmol · September 2008 OBJECTIVES: To evaluate the safety and efficacy of 0.59-mg and 2.1-mg fluocinolone acetonide (FA) intravitreous implants in noninfectious posterior uveitis. DESIGN: A 3-year, multicenter, randomized, historically controlled trial of the 0.59-mg FA intravit ... Full text Link to item Cite

Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month results.

Journal Article Am J Ophthalmol · August 2008 PURPOSE: To determine treatment outcomes of a long-acting intravitreal fluocinolone acetonide sustained drug delivery implant in eyes with central retinal vein occlusion (CRVO) and chronic refractory macular edema. DESIGN: Prospective, noncomparative, inte ... Full text Link to item Cite

Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitis.

Journal Article Am J Ophthalmol · April 2008 PURPOSE: To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed. DESIGN: Prospective, interventional trial. METHODS: Study subjects comprised a ... Full text Link to item Cite

Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up.

Journal Article Am J Ophthalmol · December 2007 PURPOSE: To assess a response to infliximab therapy in childhood uveitis. DESIGN: Retrospective case series. METHODS: We reviewed the course of 16 children with noninfectious uveitis treated with infliximab at an academic medical center. Outcome measures i ... Full text Link to item Cite

Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.

Journal Article Arch Ophthalmol · November 2007 OBJECTIVE: To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN: Pooled data from 3 multicenter, double-masked, randomized, controll ... Full text Link to item Cite

The importance of Bcl-xL in the survival of human RPE cells.

Journal Article Invest Ophthalmol Vis Sci · August 2007 PURPOSE: In normal eyes and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cell survival is critically important. Bcl-x(L) has been shown to be among the most highly ex ... Full text Link to item Cite

Optical coherence tomography reader agreement in neovascular age-related macular degeneration.

Journal Article Am J Ophthalmol · July 2007 PURPOSE: To determine the interreader and intrareader agreement at the Optical Coherence Tomography (OCT) Reading Center at Duke for images produced for an interventional neovascular age-related macular degeneration (AMD) clinical trial. DESIGN: Retrospect ... Full text Link to item Cite

Caspase-8-mediated apoptosis in human RPE cells.

Journal Article Invest Ophthalmol Vis Sci · July 2007 PURPOSE: Tumor necrosis factor (TNF)-alpha is an important cytokine associated with age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). TNF-alpha activates the extrinsic apoptotic pathway. In many cells, nuclear transcription ... Full text Link to item Cite

Oxidant-mediated Akt activation in human RPE cells.

Journal Article Invest Ophthalmol Vis Sci · October 2006 PURPOSE: To determine whether a model oxidant, hydrogen peroxide (H2O2), influences Akt activation and, if so, whether Akt activation promotes retinal pigment epithelial (RPE) cell survival. METHODS: Cultured human RPE cells were pretreated with medium alo ... Full text Link to item Cite

Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis.

Journal Article Arch Ophthalmol · July 2006 OBJECTIVE: To determine the efficacy of 0.5-mg and 0.1-mg sustained-release fluocinolone acetonide intravitreal implants to inhibit ocular inflammation in a rabbit model of severe uveitis. METHODS: The in vitro pharmacokinetic profile of both the 0.5-mg an ... Full text Link to item Cite

Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study.

Journal Article Ophthalmology · June 2006 PURPOSE: To report the interim 34-week safety and efficacy results of a 3-year study to evaluate an investigational intravitreal fluocinolone acetonide (FA) implant in patients with noninfectious posterior uveitis. DESIGN: Prospective, dose-masked, dose-ra ... Full text Link to item Cite

Ca++-switch induction of RPE differentiation.

Journal Article Exp Eye Res · April 2006 Cultured retinal pigment epithelial (RPE) cells are commonly used as a model of the tissue to study their involvement in visual diseases. Unfortunately, cultured RPE often lose their differentiated phenotype reducing their usefulness as a model of the RPE ... Full text Link to item Cite

Uveitis in the elderly: epidemiological data from the National Long-term Care Survey Medicare Cohort.

Journal Article Ophthalmology · February 2006 PURPOSE: There is a paucity of population-based data on the epidemiology of uveitis in the elderly. In the past 40 years, only 2 U.S. population-based studies have examined the epidemiology of uveitis. The conclusions of these studies on the burden of uvei ... Full text Link to item Cite

Nondegradable intraocular sustained-release drug delivery devices

Chapter · January 1, 2006 Nondegradable sustained-release devices can be either matrix or reservoir systems. In matrix systems, the drug is homogeneously dispersed inside the matrix material, and slow diffusion of the drug through the polymatrix material provides sustained release ... Cite

Intraocular sustained-release drug delivery in Uveitis

Chapter · January 1, 2006 The main goal in the treatment of uveitis is to eliminate intraocular inflammation and thereby relieve discomfort and prevent visually significant complications such as cataract, cystoid macular edema, and hypotony. When anti-inflammatory drugs are given s ... Cite

Drug delivery for proliferative vitreoretinopathy: Prevention and treatment

Chapter · January 1, 2006 Despite improvements in surgical technique, proliferative vitreoretinopathy (PVR) remains a common and significant vision-threatening complication of retinal detachment repair and trauma. A clinically significant form of PVR occurs following approximately ... Cite

Preface

Book · January 1, 2006 Cite

Intraocular drug delivery

Book · January 1, 2006 This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers ... Cite

Diffuse unilateral subacute neuroretinitis in Venezuela.

Journal Article Ophthalmology · December 2005 PURPOSE: To describe the clinical features and management of the largest reported series to date of patients with diffuse unilateral subacute neuroretinitis (DUSN). DESIGN: Observational case series. METHODS: The charts of all patients coded as having DUSN ... Full text Link to item Cite

Steroids in Macular Disease

Chapter · September 27, 2005 Full text Cite

Primary intraocular T-cell-rich large B-cell lymphoma.

Journal Article Arch Pathol Lab Med · August 2005 We report a primary intraocular T-cell-rich large B-cell lymphoma in a 57-year-old woman who underwent 3 diagnostic vitrectomies for a presumed diagnosis of panuveitis. She developed no light perception in the left eye and underwent enucleation. Histopatho ... Full text Link to item Cite

Long-term follow-up results of a pilot trial of a fluocinolone acetonide implant to treat posterior uveitis.

Journal Article Ophthalmology · July 2005 PURPOSE: To investigate the safety and efficacy of a fluocinolone acetonide intravitreal implant in the treatment of noninfectious posterior uveitis. DESIGN: Noncomparative interventional case series, dose randomized, dose masked, prospective. PARTICIPANTS ... Full text Link to item Cite

Human RPE expression of cell survival factors.

Journal Article Invest Ophthalmol Vis Sci · May 2005 PURPOSE: To determine basal and tumor necrosis factor (TNF)-alpha-regulated expression of retinal pigment epithelial (RPE) cell survival factors and whether regulation is dependent on nuclear transcription factor (NF)-kappaB. METHODS: Cultured human RPE ce ... Full text Link to item Cite

Cystoid Macular Edema

Chapter · January 1, 2005 Full text Cite

Evaluation of image artifact produced by optical coherence tomography of retinal pathology.

Journal Article Am J Ophthalmol · January 2005 PURPOSE: To determine the frequency and type of optical coherence tomography (OCT) fast macular thickness map (FMTM) scan artifacts, and whether these artifacts depend on patient diagnosis, demographics, and ocular therapy. DESIGN: Retrospective observatio ... Full text Link to item Cite

Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.

Journal Article Invest Ophthalmol Vis Sci · July 2004 PURPOSE: In many cell types, tumor necrosis factor (TNF)-alpha-induced apoptosis is prevented by production of TNF-alpha-induced antiapoptotic protein, a process mediated by nuclear transcription factor (NF)-kappa B. TNF-alpha is widely expressed in prolif ... Full text Link to item Cite

Prevalence and risk factors for proliferative vitreoretinopathy in eyes with rhegmatogenous retinal detachment but no previous vitreoretinal surgery.

Journal Article Am J Ophthalmol · June 2004 PURPOSE: To determine the prevalence of and risk factors for proliferatative vitreoretinopathy (PVR) in eyes with rhegmatogenous retinal detachment but no previous vitreoretinal surgery. DESIGN: Observational case series. METHODS: Prospective study. SETTIN ... Full text Link to item Cite

Author reply

Other American Journal of Ophthalmology · March 2004 Full text Cite

Author reply

Other American Journal of Ophthalmology · March 2004 Full text Cite

Demographic-related variations in posterior segment ocular sarcoidosis.

Journal Article Ophthalmology · February 2004 OBJECTIVE: To compare the frequency of posterior segment involvement (PSI), the prevalence of specific posterior segment signs, and visual acuity in ocular sarcoidosis by patient race, sex, and age. DESIGN: Retrospective, cross-sectional observational stud ... Full text Link to item Cite

Optical coherence tomography to detect and manage retinal disease and glaucoma.

Journal Article Am J Ophthalmol · January 2004 PURPOSE: To review basic principles of optical coherence tomography, and to describe its use in the diagnosis and management of retinal diseases and glaucoma. DESIGN: Perspective. METHODS: Literature review. RESULTS: Optical coherence tomography is a nonin ... Full text Link to item Cite

Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion.

Journal Article Am J Ophthalmol · September 2003 PURPOSE: To evaluate treatment of cystoid macular edema associated with central retinal vein occlusion with intravitreal triamcinolone acetonide. METHODS: This study included 10 eyes of nine patients with perfused central retinal vein occlusion with visual ... Full text Link to item Cite

B-scan ultrasonography for the detection of macular thickening.

Journal Article Am J Ophthalmol · July 2003 Featured Publication PURPOSE: To report the sensitivity and specificity of B-scan ultrasonography to detect macular thickening. DESIGN: Observational case series. METHODS: Seventy-seven eyes of 40 consecutive patients (age range, 7-80 years) in a retinal specialty practice wer ... Full text Link to item Cite

Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.

Journal Article Invest Ophthalmol Vis Sci · June 2003 Featured Publication PURPOSE: Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA lib ... Full text Link to item Cite

Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.

Journal Article Invest Ophthalmol Vis Sci · March 2003 Featured Publication PURPOSE: The nuclear transcription factor (NF)-kappaB is a central regulator of multiple inflammatory cytokines. The current study was conducted to determine whether infection of human retinal pigment epithelial (RPE) cells by adenovirus carrying a mutant ... Full text Link to item Cite

Modified external needle drainage procedure for rhegmatogenous retinal detachment.

Journal Article Retina · February 2003 Featured Publication PURPOSE: To describe the results of a modified external needle subretinal fluid drainage technique to treat eyes with a rhegmatogenous retinal detachment. METHODS: One hundred eighty-seven consecutive patients with a rhegmatogenous retinal detachment who u ... Full text Link to item Cite

Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

Journal Article Invest Ophthalmol Vis Sci · November 2002 Featured Publication PURPOSE: To evaluate the effects of subretinal and intravitreal delivery of INS37217, a P2Y(2) receptor agonist, on subretinal fluid reabsorption in experimentally induced retinal detachments in rabbits, and to characterize the effects of INS37217 on elect ... Link to item Cite

Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells.

Journal Article Am J Vet Res · July 2002 OBJECTIVE: To determine whether a chemokine (RANTES)-like protein expressed by ciliary epithelium plays a role in uveitis. SAMPLE POPULATION: 3 clinically normal horses intradermal, 5 eyes from 5 horses with recurrent uveitis, and 10 normal eyes from 5 age ... Full text Link to item Cite

Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy.

Journal Article Ophthalmology · June 2002 Featured Publication PURPOSE: To determine the yield of diagnostic pars plana vitrectomy in eyes with suspected posterior segment inflammation or malignancy when clinical examination and systemic laboratory testing did not yield a specific diagnosis. DESIGN: Non-comparative in ... Full text Link to item Cite

Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration.

Journal Article Am J Ophthalmol · February 2001 PURPOSE: To evaluate a new procedure for displacement of large, thick submacular hemorrhage in patients with age-related macular degeneration. METHODS: Retrospective review of 11 eyes of 11 patients with age-related macular degeneration and thick submacula ... Full text Link to item Cite

Pharmacokinetics of the ganciclovir implant in the silicone-filled eye.

Journal Article Retina · 2001 PURPOSE: Ganciclovir (GCV) implants are highly effective in delaying the progression of cytomegalovirus (CMV) retinitis. Rhegmatogenous retinal detachments can occur in untreated eyes with CMV retinitis or in eyes treated with anti-CMV therapy, which may i ... Full text Link to item Cite

Management of eyes with both idiopathic macular hole and choroidal neovascularization.

Journal Article Retina · 2001 PURPOSE: To describe the characteristics, treatment, and outcome of five eyes with both choroidal neovascularization (CNV) and macular hole. METHODS: Medical records of five patients with both macular hole and CNV were reviewed. RESULTS: All eyes had full- ... Full text Link to item Cite

Fluocinolone acetonide sustained drug delivery device to treat severe uveitis.

Journal Article Ophthalmology · November 2000 Featured Publication PURPOSE: Uveitis is often a chronic disease requiring long-term medical therapy. In this report, we describe a pilot safety and efficacy trial of a novel sustained drug delivery system containing fluocinolone acetonide to treat patients with severe uveitis ... Full text Link to item Cite

Effect of an intravitreal cyclosporine implant on experimental uveitis in horses.

Journal Article Vet Immunol Immunopathol · October 31, 2000 The purpose of this study was to determine the effects of an intravitreal device releasing cyclosporine A (CsA) on recurrent inflammatory episodes in experimental uveitis. Nine normal horses were immunized peripherally with H37RA-mTB antigen twice, and the ... Full text Link to item Cite

Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device.

Journal Article Invest Ophthalmol Vis Sci · October 2000 Featured Publication PURPOSE: To determine the safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained drug delivery device. METHODS: Nonbiodegradable drug delivery devices containing 2 or 15 mg of a synthetic corticosteroid, fluocinolone acetonide, were ... Link to item Cite

Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel.

Journal Article Am J Ophthalmol · October 2000 PURPOSE: To provide recommendations for the use of immunosuppressive drugs in the treatment of patients with ocular inflammatory disorders. PARTICIPANTS: A 12-person panel of physicians with expertise in ophthalmologic, pediatric, and rheumatologic disease ... Full text Link to item Cite

Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: I. Ophthalmic outcomes submacular surgery trials pilot study report number 1.

Journal Article Am J Ophthalmol · October 2000 PURPOSE: To report complications and changes in vision during 2 years of follow-up of patients with age-related macular degeneration assigned randomly to surgical removal or to laser photocoagulation of subfoveal recurrent neovascular lesions in a pilot tr ... Full text Link to item Cite

Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: II. Quality of life outcomes submacular surgery trials pilot study report number 2.

Journal Article Am J Ophthalmol · October 2000 PURPOSE: To summarize findings from health-related quality-of-life interviews with patients who had recurrent subfoveal choroidal neovascularization secondary to age-related macular degeneration and participated in a randomized pilot trial (focal confluent ... Full text Link to item Cite

Reversible bull's-eye maculopathy associated with intravitreal fomivirsen therapy for cytomegalovirus retinitis.

Journal Article Am J Ophthalmol · August 2000 PURPOSE: To report two cases in which a bull's eye maculopathy developed after intravitreal injection of fomivirsen. METHODS: Case reports. RESULTS: A 50-year-old man with acquired immunodeficiency syndrome (AIDS) and refractory cytomegalovirus retinitis d ... Full text Link to item Cite

Vitrectomy update for macular traction in ocular toxocariasis.

Journal Article Retina · 2000 PURPOSE: To study the results of modern vitrectomy in traction and combined traction-rhegmatogenous retinal detachment involving the macula in cases of ocular toxocariasis. METHODS: This was a cohort study of patients seen in different institutions in the ... Full text Link to item Cite

Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye.

Journal Article Retina · 2000 PURPOSE: To determine the effect of intraocular gas tamponade on drug levels achieved with the intravitreal sustained-release fluocinolone (FL)/5-fluorouracil (5-FU) codrug pellet. METHODS: After insertion of a 10-mg codrug pellet into the right eyes of 43 ... Full text Link to item Cite

Exudative retinal detachment and retinitis associated with acquired syphilitic uveitis.

Journal Article Retina · 2000 PURPOSE: To describe three cases of exudative retinal detachment and focal retinitis associated with acquired syphilitic uveitis. METHODS: Three patients who were referred for evaluation of uveitis were examined. Slit-lamp examination, ophthalmoscopy, B-sc ... Link to item Cite

Long-term effect on the equine eye of an intravitreal device used for sustained release of cyclosporine A.

Journal Article Vet Ophthalmol · 2000 OBJECTIVE: To determine the long-term toxicity of an intravitreal device releasing continuous cyclosporinee A (CsA) in normal eyes of horses by evaluating clinical signs, electroretinography, and histopathology. Animals Studied Ten adult horses with normal ... Full text Link to item Cite

Diagnosis of vitreoretinal adhesions in macular disease with optical coherence tomography.

Journal Article Retina · 2000 PURPOSE: To compare the relative incidence of vitreoretinal adhesions associated with partial vitreous separation within the macula diagnosed with optical coherence tomography (OCT) with that of those diagnosed with biomicroscopy. METHODS: The authors obta ... Link to item Cite

The importance of fluorescein angiography in planning laser treatment of diabetic macular edema.

Journal Article Ophthalmology · November 1999 OBJECTIVE: To test the hypothesis that pretreatment fluorescein angiography (FA) is not necessary for effective laser treatment of patients with clinically significant diabetic macular edema (CSME). DESIGN: Prospective, randomized, controlled treatment sim ... Full text Link to item Cite

Use of the polymerase chain reaction for diagnosis of ocular toxoplasmosis.

Journal Article Ophthalmology · August 1999 OBJECTIVE: To report a cohort of patients in whom polymerase chain reaction (PCR) was performed on vitreous samples and to place in perspective the current role of PCR in the diagnosis of ocular toxoplasmosis. DESIGN: Noncomparative case series. PARTICIPAN ... Full text Link to item Cite

Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy: recommendations of the International AIDS Society-USA panel.

Journal Article Am J Ophthalmol · March 1999 PURPOSE: To describe the risks, benefits, and recommended use of the ganciclovir implant for the treatment of human immunodeficiency virus-related cytomegalovirus (CMV) retinitis in the era of potent antiretroviral therapy. METHODS: A panel of physicians w ... Full text Link to item Cite

Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor.

Journal Article Invest Ophthalmol Vis Sci · February 1999 PURPOSE: To determine whether nuclear transcription factor-kappaB (NF-kappaB) is activated in human retinal pigment epithelial (hRPE) cells in response to interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), or interferon-gamma (IFN-gamma ... Link to item Cite

Atovaquone for the treatment of toxoplasma retinochoroiditis in immunocompetent patients.

Journal Article Ophthalmology · January 1999 OBJECTIVE: To report the results of a phase I trial to evaluate the safety and efficacy of atovaquone for the treatment of ocular toxoplasmosis in immunocompetent patients. DESIGN: Open label, nonrandomized, prospective, clinical trial. PARTICIPANTS: Seven ... Full text Link to item Cite

Methotrexate treatment for sarcoid-associated panuveitis.

Journal Article Ophthalmology · January 1999 OBJECTIVE: To determine the safety and efficacy of low-dose methotrexate (MTX) for sarcoid-associated panuveitis. DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Twenty eyes from 11 patients were analyzed. Eight patients had sarcoidosis. Th ... Full text Link to item Cite

Management of complications in eyes containing two intraocular lenses.

Journal Article Ophthalmology · November 1998 OBJECTIVE: To describe the management of complications in eyes containing two intraocular lenses (IOLs). DESIGN: A retrospective noncomparative case series. PARTICIPANTS: Eight patients having a dislocated posterior chamber intraocular lens (PC IOL) and a ... Full text Link to item Cite

Intraocular lens changes after short- and long-term exposure to intraocular silicone oil. An in vivo study.

Journal Article Ophthalmology · July 1998 OBJECTIVE: Silicone oil frequently is used as a vitreous substitute after complex vitreoretinal procedures. The authors sought to study the effect of short- and long-term exposure to silicone oil on polymethyl methacrylate (PMMA, MC60BM; Alcon, Ft. Worth, ... Full text Link to item Cite

An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy.

Journal Article Arch Ophthalmol · January 1998 Featured Publication OBJECTIVE: To determine the efficacy and pharmacokinetics of an intravitreal sustained-release triamcinolone acetonide and 5-fluorouracil (TA/5-FU) codrug in the treatment of experimental proliferative vitreoretinopathy (PVR). METHODS: The therapeutic effi ... Full text Link to item Cite

Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis.

Journal Article Ophthalmology · January 1998 Featured Publication OBJECTIVE: Uveitis often is a chronic disease requiring long-term medical therapy. Despite treatment, the disease may be difficult to control and may produce serious, vision-threatening ocular complications. In this study, the authors determined whether an ... Full text Link to item Cite

"Smart" co-drugs. Rapid intravitreal delivery of 5-FU and prolonged delivery of steroid from the same erodible device

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose: The aim of this work was to develop a small implantahle hioerodihle device giving sustained release of 5-FU for 1-2 weeks and sustained release of a steroid for over 2 months. Previous work had indicated that this may be optimal for the treatment ... Cite

Short and long term exposure of intraocular lenses to silicone oil after vitrectomy and silicone oil tamponade

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose: Silicone oil is frequently used as a vitreous substitute after complex vitreoretinal procedures. We sought to study the effect of short and long term exposure to silicone oil on polymethylmethacrylate (PMMA[Alcon MC60BM1), silicone (AMO SI-30NB) a ... Cite

Management of condensation on a foldable acrylic intraocular lens after vitrectomy and fluid-air exchange.

Journal Article Am J Ophthalmol · November 1997 PURPOSE: To describe the management of condensation on the posterior surface of a foldable acrylic intraocular lens during vitrectomy and fluid-air exchange. METHODS: A 70-year-old pseudophakic man with a foldable acrylic intraocular lens and open posterio ... Full text Link to item Cite

Uveitis in the southeastern United States.

Journal Article Curr Eye Res · September 1997 Featured Publication PURPOSE: Previous epidemiologic studies of uveitis have focused on predominantly Caucasian populations, and none have been based in the Southeast. We analyzed the epidemiology of uveitis among a referral population with a high percentage of African America ... Full text Link to item Cite

Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells.

Journal Article Invest Ophthalmol Vis Sci · September 1997 Featured Publication PURPOSE: CD44 is a major hyaluronic acid receptor that exists as a number of isoforms, generated by alternative splicing of 9 "variant" exons in humans (v2 to v10) and 10 exons in rodents. Little is known about the expression and function of CD44 in human ... Link to item Cite

Sustained closure of surgically repaired macular holes after retinal detachment with submacular fluid.

Journal Article Am J Ophthalmol · March 1997 PURPOSE: To examine the behavior of surgically repaired macular holes when subsequent retinal detachment with submacular fluid develops and to correlate these observations with current theories of macular hole formation and closure. METHODS: We reviewed th ... Full text Link to item Cite

Atypical, severe toxoplasmic retinochoroiditis in elderly patients.

Journal Article Ophthalmology · January 1997 BACKGROUND: The diagnosis of toxoplasmic retinochoroiditis is based primarily on characteristic ocular findings, with supportive serologic evidence. Clinical recognition of atypical presentations is critical for timely antiparasitic drug therapy. METHODS: ... Full text Link to item Cite

Clearance of antitransferrin receptor immunotoxin from the rabbit eye.

Journal Article Curr Eye Res · October 1996 PURPOSE: Antitransferrin receptor immunotoxin has potent antiproliferative effects on proliferating human ocular cells in vitro, and shows promise in the treatment of ocular proliferative diseases, such as proliferative vitreoretinopathy, bleb scarring aft ... Full text Link to item Cite

Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy.

Journal Article Invest Ophthalmol Vis Sci · October 1996 PURPOSE: Proliferative vitreoretinopathy (PVR) remains the most common cause of failed retinal detachment (RD) surgery. The authors compared the effectiveness of two intraocular sustained-release codrugs in suppressing PVR in a rabbit model a surgically im ... Link to item Cite

Condensation on polymethylmethacrylate, acrylic polymer, and silicone intraocular lenses after fluid-air exchange in rabbits.

Journal Article Ophthalmology · September 1996 PURPOSE: Condensation occurs rapidly on silicone intraocular lenses (IOLs) after vitrectomy and fluid-air exchange in the presence of a posterior capsulotomy, severely limiting the retinal view. Foldable IOLs made of an acrylic polymer are now available. T ... Full text Link to item Cite

Ocular toxicity following high dose chemotherapy and autologous transplant.

Journal Article Bone Marrow Transplant · July 1996 A 49-year-old woman received an autologous transplant for breast cancer. Six weeks later she noticed visual disturbance of the left eye which correlated with a visual field abnormality. There was a milder degree of visual disturbance in the right eye. Trea ... Link to item Cite

Transferrin-ricin A chain toxin limits the development of experimental proliferative vitreoretinopathy.

Journal Article Exp Eye Res · June 1996 This study was designed to determine the safety and efficacy of transferrin-ricin A chain toxin (Tfr-rRA) at preventing retinal detachment in a rabbit model of proliferative vitreoretinopathy (PVR). The toxicity of intravitreal Tfr-rRA (1000-5000 ng) was d ... Full text Link to item Cite

An intravitreal device providing sustained release of cyclosporine and dexamethasone.

Journal Article Curr Eye Res · May 1996 PURPOSE: A device that releases cyclosporine and dexamethasone into the eye for extended periods of time might be beneficial in diseases such as proliferative vitreoretinopathy and uveitis. In this study we examine the pharmacokinetics and toxicity of cycl ... Full text Link to item Cite

Evaluation of a delivery system providing long-term release of cyclosporine.

Journal Article Arch Ophthalmol · March 1996 OBJECTIVES: To examine the clearance of cyclosporine after intravitreal injection and to assess the kinetics and toxic effects of an intravitreal device that provides sustained delivery of cyclosporine. METHODS: Rabbits were divided into two groups to eval ... Full text Link to item Cite

Development of a 1.5 year ganciclovir implant for CMV retinitis

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: To develop an implantable device giving sustained release of ganciclovir (GCV) over 1.5 years. Methods. Short rod like pellets of GCV were prepared by compressing 30 mg of GCV in a 2 mm tablet die. Pellets were then coated in a solution of 98% hyd ... Cite

Efficacy and pharmacokinetics of intravitreal sustained release triamcinolone/5-FU codrug suspension in the treatment of experimental PVR

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose. Last year we described a novel method of delivering a triamcinolone acetonide (TA)/5-FU conjugate as a sustained release suspension for the treatment of PVR in a fibroblast -injection model. Herein, we evaluate the pharmacokinetics and efficacy of ... Cite

Pharmacologic inhibition of experimental proliferative vitreoretinopathy (PVR) using a triamcinolone/5-fluorouracil codrug sustained release pellet

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: We have previously evaluated the efficacy of a novel dexamethasone/5-fluorouracil (5-FU) codrug pellet in the treatment of PVR. This prepararion was not fully effective because of the drug's high solubility and relatively fast release rate. In thi ... Cite

Condensation on polymethylmethacrylate, acrylic polymer and silicone intraocular lenses after vitrectomy and fluid-air exchange

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: Condensation on the posterior surface of intraocular lenses can markedly compromise the retinal view during vitrectomy and fluid-air exchange. In this study, we compared the condensation and subsequent retinal view degradation after vitrectomy and ... Cite

Tissue plasminogen activator for preserving inferior peripheral iridectomy patency in eyes with silicone oil.

Journal Article Ophthalmology · February 1996 PURPOSE: An inferior peripheral iridectomy (IPI) was used to prevent forward migration of silicone oil in vitrectomized eyes; however, in approximately one third of eyes, the IPI closed spontaneously. Occlusion of the IPI by fibrin is believed to be an ear ... Full text Link to item Cite

Cytomegalovirus retinitis associated with Hodgkin's disease.

Journal Article Retina · 1996 BACKGROUND: Patients with intraocular involvement by Hodgkin's disease may present with a variety of ocular abnormalities. Intraocular infections also have been reported in these patients, including two cases of cytomegalovirus retinitis (CMV) diagnosed on ... Full text Link to item Cite

Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer.

Journal Article Ophthalmology · January 1996 PURPOSE: To characterize the ocular toxicity of a bone marrow transplant regimen does not include total body or focal head irradiation. METHODS: Nine patients with advanced breast cancer were referred for visual symptoms after high-dose chemotherapy with c ... Full text Link to item Cite

Hypoxia precedes the development of experimental preretinal neovascularization.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 1996 BACKGROUND: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory me ... Full text Link to item Cite

Treatment of migraine headache after ocular surgery with intravenous metoclopramide hydrochloride.

Journal Article Am J Ophthalmol · January 1996 PURPOSE: To alert ophthalmologists that prolonged or severe postoperative periocular pain and nausea may be caused by migraine. METHODS: We examined two patients who had a history of migraine and had severe episodes of prolonged periocular pain and nausea ... Full text Link to item Cite

Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy.

Journal Article Curr Eye Res · November 1995 We determined whether interleukin-8, monocyte chemotactic protein-1, and macrophage-colony stimulating factor are present in the vitreous of patients with proliferative diabetic retinopathy (PDR) or proliferative vitreoretinopathy (PVR). The levels of thes ... Full text Link to item Cite

Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.

Journal Article Exp Eye Res · May 1995 In retinal pigment epithelium, apically applied epinephrine changes the conductance of specific ions which subsequently affects the membrane voltage and stimulates transepithelial fluid transport. In this investigation, myo-[3H]inositol radiotracer studies ... Full text Link to item Cite

Condensation on the posterior surface of silicone intraocular lenses during fluid-air exchange.

Journal Article Ophthalmology · May 1995 PURPOSE: Posterior chamber foldable silicone intraocular lenses (IOLs) are becoming increasingly prevalent in patients undergoing a pars plana vitrectomy with fluid-air exchange. The authors report an important limitation of foldable silicone IOLs during f ... Full text Link to item Cite

Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells.

Journal Article Exp Eye Res · May 1995 Monocytes and retinal pigment epithelial cells are intimately associated in membranes of eyes with proliferative vitreoretinopathy and in certain types of uveitis. The goal of this study was to determine whether monocytes modulate cytokine expression in re ... Full text Link to item Cite

Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis.

Journal Article Invest Ophthalmol Vis Sci · February 1995 PURPOSE: Uveitis often runs a chronic course requiring long-term therapy. Topical treatment results in poor intravitreal penetration, and systemic therapy is associated with significant side effects. The authors investigated whether an intravitreal sustain ... Link to item Cite

Authors' reply

Journal Article Ophthalmology · January 1, 1995 Full text Cite

Vitrectomy for vitreomacular traction syndrome with macular detachment.

Journal Article Retina · 1995 PURPOSE: To describe the clinical characteristics of the vitreomacular traction syndrome with macular detachment and to report our surgical experience with this condition. METHODS: A retrospective chart and photographic review was performed on nine patient ... Full text Link to item Cite

Removal of optic disc stalks during diabetic vitrectomy.

Journal Article Retina · 1995 BACKGROUND: The morphologic features and clinical consequences of removing residual optic disc stalks during vitrectomy for complications of diabetic retinopathy have not been described. METHODS: Twenty-four residual optic disc stalks that were surgically ... Full text Link to item Cite

Inhibition of proliferating lens epithelium with antitransferrin receptor immunotoxin.

Journal Article J Cataract Refract Surg · September 1994 We investigated the effect of an antitransferrin receptor immunotoxin (454A12-rRA) on proliferating human and baboon lens epithelium in vitro. Human and baboon lens epithelial cells grown in modified TC-199 medium at 35 degrees Celsius in 7% CO2 were seede ... Full text Link to item Cite

Activin expression by cultured human retinal pigment epithelial cells.

Journal Article Invest Ophthalmol Vis Sci · June 1994 PURPOSE: To determine whether human retinal pigment epithelial (hRPE) cells produce activin, a growth factor in the transforming growth factor beta family, and to characterize growth regulatory effects of activin on retinal pigment epithelium. METHODS: mRN ... Link to item Cite

Treatment and pathogenesis of traumatic chorioretinal rupture (sclopetaria).

Journal Article Am J Ophthalmol · February 15, 1994 Eight eyes (seven patients) with traumatic chorioretinal rupture (sclopetaria) from severe ocular trauma were examined. All seven patients were referred with diagnoses of retinal detachment, giant retinal tear, or ruptured globe. Instead, all eyes had larg ... Full text Link to item Cite

Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil.

Journal Article Invest Ophthalmol Vis Sci · February 1994 PURPOSE: To examine the antiproliferative and lysyl hydroxylase suppressing effects of 3'-hydroxyminoxidil and 4'-hydroxyminoxidil, derivatives of minoxidil devoid of the antihypertensive effect, on human retinal pigment epithelial (RPE) cells in culture. ... Link to item Cite

Postoperative fibrin formation and visual outcome after pars plana vitrectomy.

Journal Article Retina · 1994 PURPOSE: To determine whether postvitrectomy fibrin formation was associated with visual outcome, a prospective study of patients undergoing pars plana vitrectomy was performed. METHODS: In 121 patients undergoing vitrectomy at the Medical College of Wisco ... Full text Link to item Cite

Review: implants.

Journal Article J Ocul Pharmacol · 1994 An implantable sustained release device has been developed to treat chronic disorders of the eye. The device, consisting of a central core of drug encased in layers of permeable and impermeable polymers, can be implanted subconjunctivally or intravitreally ... Full text Link to item Cite

Lightning maculopathy. A case report.

Journal Article Retina · 1994 BACKGROUND: Lightning can cause a number of ocular complications. A case involving a patient who developed a cataract and reversible maculopathy in both eyes after being struck by lightning is reported. METHODS: The patient was evaluated for cataract and m ... Link to item Cite

MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.

Journal Article Mol Cell Biol · January 1994 We have characterized constitutive and cytokine-regulated MGSA/GRO alpha, -beta, and -gamma gene expression in normal retinal pigment epithelial (RPE) cells and a malignant melanoma cell line (Hs294T) to discern the mechanism for MGSA/GRO constitutive expr ... Full text Link to item Cite

The antiproliferative effect of a transferrin-toxin on human retinal pigment epithelial cells and rabbit fibroblasts.

Journal Article Invest Ophthalmol Vis Sci · November 1993 PURPOSE: To determine the effect of a rabbit transferrin conjugated to recombinant ricin A chain (Tfr-rRA) and the carboxylic ionophore monensin on proliferating and density-arrested human retinal pigment epithelial cells and rabbit dermal fibroblasts. MET ... Link to item Cite

Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells.

Journal Article Invest Ophthalmol Vis Sci · August 1993 PURPOSE: To characterize mRNA expression and protein production of the cytokine MGSA/gro in human retinal pigment epithelial (RPE) cells and to determine whether expression of MGSA/gro is modulated by serum and the cytokines interleukin 1 beta (IL-1 beta), ... Link to item Cite

An illuminated cannula for subretinal operations.

Journal Article Am J Ophthalmol · June 15, 1993 Full text Link to item Cite

Cataract extraction in the diabetic patient.

Journal Article Semin Ophthalmol · June 1993 Full text Link to item Cite

Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity.

Journal Article Invest Ophthalmol Vis Sci · March 1993 PURPOSE: To examine the antiproliferative and lysyl hydroxylase-suppressing effects of minoxidil on cultured proliferating and density-arrested human retinal pigment epithelial cells (hRPE) and Tenon's capsule fibroblasts (hTCF). METHODS: Proliferating and ... Link to item Cite

Monensin enhances the cytotoxic effect of antitransferrin receptor immunotoxin on cultured RPE cells.

Journal Article Curr Eye Res · January 1993 The effect of monensin on the cytotoxic effect of antitransferrin receptor immunotoxin (IT) was determined on cultured, human retinal pigment epithelial (hRPE) cells. Human RPE cells were treated with 0.1-10,000 ng/ml IT with and without 0.01-0.1 microM mo ... Full text Link to item Cite

Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor.

Journal Article Exp Cell Res · November 1992 The ionic environment of retinal photoreceptors is partially controlled by potassium transporters on retinal glial and retinal pigment epithelial cells (RPE). In this study, serum and epidermal growth factor (EGF) were examined as modulators of potassium t ... Full text Link to item Cite

Progression of nonproliferative diabetic retinopathy and visual outcome after extracapsular cataract extraction and intraocular lens implantation.

Journal Article Am J Ophthalmol · October 15, 1992 Twenty-one patients with symmetric nonproliferative retinopathy who underwent extracapsular cataract extraction and intraocular lens implantation were followed up postoperatively for an average (+/- standard deviation) of 18 +/- 7 months to determine the i ... Full text Link to item Cite

Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.

Journal Article Cornea · September 1992 We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days ... Full text Link to item Cite

Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells.

Journal Article Exp Eye Res · August 1992 mRNA expression and protein production of interleukin-1 alpha, interleukin-1 beta and intracellular and secreted forms of an interleukin-1 receptor antagonist were measured in visually confluent monolayers of unstimulated cultured human retinal pigment epi ... Full text Link to item Cite

Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 1.

Journal Article Arch Ophthalmol · June 1992 Between September 1985 and September 1987, 101 eyes with rhegmatogenous retinal detachment and severe (with a classification of at least C-3) proliferative vitreoretinopathy but without prior vitrectomy were treated with vitrectomy and randomized to either ... Full text Link to item Cite

Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 2.

Journal Article Arch Ophthalmol · June 1992 Between September 1987 and October 1990, 265 eyes with rhegmatogenous retinal detachment and severe (with a classification of at least C-3) proliferative vitreoretinopathy were treated with vitrectomy and randomized to treatment with perfluoropropane gas o ... Full text Link to item Cite

Modulation of macrophage colony stimulating factor in cultured human retinal pigment epithelial cells.

Journal Article Exp Eye Res · April 1992 Steady-state mRNA expression and protein production of macrophage colony stimulating factor were measured in visually confluent monolayers of unstimulated cultured human retinal pigment epithelial cells and after cells were stimulated with recombinant cyto ... Full text Link to item Cite

Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery.

Journal Article Refract Corneal Surg · 1992 BACKGROUND: Postoperative fibrin formation remains a major complication associated with intraocular surgery, especially after vitreoretinal surgery for proliferative vitreoretinopathy, proliferative diabetic retinopathy, trauma, or endophthalmitis. Tissue ... Link to item Cite

Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer.

Journal Article Gynecol Oncol · August 1991 The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular versio ... Full text Link to item Cite

Retinal pigment epithelial cells of the posterior pole have fewer Na/K adenosine triphosphatase pumps than peripheral cells.

Journal Article Invest Ophthalmol Vis Sci · June 1991 The density of Na/K adenosine triphosphatase (ATPase) pumps in retinal pigment epithelial (RPE) cells in different retinal regions was quantified by measuring the binding of 3H-ouabain to RPE in cow and human eyecups. In bovine eyes, pump density was estim ... Link to item Cite

The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium.

Journal Article Exp Cell Res · June 1991 The number and activity of ouabain-sensitive Na/K ATPase pumps expressed by many cell types in vitro, including human retinal pigment epithelial cells (RPE), have been shown to decline with increasing culture density. Cell proliferation also declined as cu ... Full text Link to item Cite

cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

Journal Article Proc Natl Acad Sci U S A · May 1, 1991 A cDNA encoding a receptor antagonist of interleukin 1 (IL-1ra), secreted from human monocytes, has recently been isolated and sequenced [Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E., Brewer, M. T., Hannum, C. H. & Thompson, R. C. (1990) Nat ... Full text Link to item Cite

Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells.

Journal Article Arch Ophthalmol · August 1990 Cultured human retinal pigment epithelial cells were exposed to an immunotoxin composed of a monoclonal antibody, 454A12, directed against transferrin receptors conjugated to a toxin, recombinant ricin A chain. Exposure of proliferating human retinal pigme ... Full text Link to item Cite

Risk factors for postvitrectomy fibrin formation.

Journal Article Am J Ophthalmol · June 15, 1990 We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular fibrin formation and the association of a variety of preoperative and intraoperative variables with the fo ... Full text Link to item Cite

Combined phacoemulsification and pars plana vitrectomy.

Journal Article Arch Ophthalmol · March 1990 Combined phacoemulsification and pars plana vitrectomy were performed in eight eyes with cataract and vitreoretinal disease. Six eyes had tractional retinal detachment and/or nonclearing vitreous hemorrhage, one eye had a retained metallic intraocular fore ... Full text Link to item Cite

Tissue plasminogen activator for postvitrectomy fibrin formation.

Journal Article Ophthalmology · February 1990 Featured Publication The authors injected 25 micrograms of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular fibrin formation that developed after vitrectomy surgery for complicated cas ... Full text Link to item Cite

Magnetic resonance imaging of juxtapapillary plaques in cadaver eyes.

Journal Article The British journal of ophthalmology · January 1990 Adequate treatment of juxtapapillary melanomas with episcleral plaque brachytherapy using lower energy radiation sources may be difficult because of uncertainties regarding the relationship of the plaque to the optic nerve and tumour base. We obtained magn ... Full text Cite

Ferromagnetic hyperthermia and iodine 125 brachytherapy in the treatment of choroidal melanoma in a rabbit model.

Journal Article Arch Ophthalmol · October 1989 Hyperthermia has been combined with conventional radiation methods to achieve enhanced tumor destruction. We combined iodine 125 seeds with ferromagnetic thermoseeds in a single plaque to simultaneously deliver radiation and heat in a rabbit model of choro ... Full text Link to item Cite

Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator.

Journal Article Am J Ophthalmol · August 15, 1989 We injected 25 micrograms of recombinant tissue plasminogen activator into the anterior chamber or the vitreous cavity in seven aphakic patients for pupillary block caused by a complete fibrin pupillary membrane that formed after vitrectomy with fluid-gas ... Full text Link to item Cite

Ab interno sclerostomy with a high-powered argon endolaser. Clinicopathologic correlation.

Journal Article Arch Ophthalmol · August 1989 A high-powered argon blue-green laser coupled to a 300-microns quartz fiberoptic probe was used to create an ab interno sclerostomy in a patient undergoing enucleation for a blind painful eye. Despite the presence of diffuse rubeosis, 360 degrees periphera ... Full text Link to item Cite

Authors' reply

Journal Article Ophthalmology · January 1, 1989 Full text Cite

Photoablation of ocular melanoma with a high-powered argon endolaser.

Journal Article Arch Ophthalmol · January 1989 We studied the use of a 15-W argon blue-green laser in the treatment of choroidal melanoma in a rabbit model. Greene melanoma cells were used to produce 2- to 4-mm thick tumors posteriorly in the suprachoroidal space in pigmented rabbits. Endophotocoagulat ... Full text Link to item Cite

Ouabain-sensitive Na+-K+ ATPase pumps in cultured human retinal pigment epithelium.

Journal Article Exp Eye Res · January 1989 The expression of Na+-K+ ATPase pumps was studied in cultured human retinal pigment epithelium (RPE). Pump site number was measured by quantitation of the specific binding of [3H]ouabain to cultures of varying density. Specific binding of [3H]ouabain was t ... Full text Link to item Cite

Ab interno sclerostomy with a high-powered argon endolaser.

Journal Article Am J Ophthalmol · October 15, 1988 We used a high-energy argon blue-green laser (15-W maximum power output) to create full-thickness sclerostomies from the region of the anterior chamber angle to the subconjunctival space in pigmented rabbits using an ab interno approach. One to four laser ... Full text Link to item Cite

Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator.

Journal Article Arch Ophthalmol · August 1988 Twenty-five micrograms of human recombinant tissue plasminogen activator (tPA) was injected intracamerally into the eyes of three aphakic patients who developed severe intraocular fibrin formation within 24 hours after vitrectomy surgery. Fluid obtained fr ... Full text Link to item Cite

Retinal phototoxicity from the operating microscope. The role of inspired oxygen.

Journal Article Ophthalmology · August 1988 The effect of the inspired oxygen concentration (FIO2) on the production of retinal phototoxicity by the operating microscope was studied in phakic rhesus monkeys. One eye of each monkey was exposed to light under conditions of 99% FIO2, and the other eye ... Full text Link to item Cite

Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy.

Journal Article Arch Ophthalmol · July 1988 We studied the clinical and histopathologic characteristics of the eyes obtained after death from a patient with adult-onset foveomacular pigment epithelial dystrophy. The pigmentation seen in the central fovea corresponded histologically to a hyperplastic ... Full text Link to item Cite

Intravitreal clearance of tissue plasminogen activator in the rabbit.

Journal Article Arch Ophthalmol · July 1988 The clearance of tissue plasminogen activator (t-PA) injected into the midvitreous cavity was studied in the phakic, vitrectomized rabbit eye with and without intravitreal fibrin clots. The quantity and activity of t-PA in the vitreous, serum, and aqueous ... Full text Link to item Cite

Progression of nonproliferative diabetic retinopathy following cataract extraction.

Journal Article Arch Ophthalmol · June 1988 Eight patients experienced progression of nonproliferative diabetic retinopathy following cataract extraction. Six patients underwent an uncomplicated extracapsular cataract extraction with placement of a posterior chamber intraocular lens, and in two pati ... Full text Link to item Cite

Ocular manifestations of preeclampsia.

Journal Article Am J Ophthalmol · March 15, 1987 We performed a prospective, controlled, masked study designed to evaluate the ocular manifestations of preeclampsia in 56 patients, including 25 control, 17 mild preeclamptic, and 14 severe preeclamptic patients. There was a statistically significant corre ... Link to item Cite

Propionibacterium acnes endophthalmitis seven months after extracapsular cataract extraction and intraocular lens implantation.

Journal Article Ophthalmic Surg · December 1986 We present a case of endophthalmitis caused by Propionibacterium acnes seven months following extracapsular cataract extraction and intraocular lens implantation. The markedly delayed clinical course of endophthalmitis associated with this organism appears ... Link to item Cite

Age-related changes of the normal visual field.

Journal Article Arch Ophthalmol · July 1986 We prospectively studied the age-related changes of the visual fields obtained from a selected group of 25 normal patients. The OCTOPUS automated perimeter was used to test both eyes of each patient using Program 32. We calculated the mean threshold sensit ... Full text Link to item Cite