Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.
Publication
, Journal Article
Fulcher, SF; Foulks, GN; Wilkerson, M; Cobo, LM; Jaffe, GJ; Hatchell, DL
Published in: Cornea
September 1992
We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.
Duke Scholars
Published In
Cornea
DOI
ISSN
0277-3740
Publication Date
September 1992
Volume
11
Issue
5
Start / End Page
413 / 417
Location
United States
Related Subject Headings
- Ricin
- Recombinant Fusion Proteins
- Receptors, Transferrin
- Ophthalmology & Optometry
- Mice, Inbred BALB C
- Mice
- Immunotoxins
- Humans
- Epithelial Cells
- Dose-Response Relationship, Drug
Citation
APA
Chicago
ICMJE
MLA
NLM
Fulcher, S. F., Foulks, G. N., Wilkerson, M., Cobo, L. M., Jaffe, G. J., & Hatchell, D. L. (1992). Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea, 11(5), 413–417. https://doi.org/10.1097/00003226-199209000-00010
Fulcher, S. F., G. N. Foulks, M. Wilkerson, L. M. Cobo, G. J. Jaffe, and D. L. Hatchell. “Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.” Cornea 11, no. 5 (September 1992): 413–17. https://doi.org/10.1097/00003226-199209000-00010.
Fulcher SF, Foulks GN, Wilkerson M, Cobo LM, Jaffe GJ, Hatchell DL. Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea. 1992 Sep;11(5):413–7.
Fulcher, S. F., et al. “Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.” Cornea, vol. 11, no. 5, Sept. 1992, pp. 413–17. Pubmed, doi:10.1097/00003226-199209000-00010.
Fulcher SF, Foulks GN, Wilkerson M, Cobo LM, Jaffe GJ, Hatchell DL. Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea. 1992 Sep;11(5):413–417.
Published In
Cornea
DOI
ISSN
0277-3740
Publication Date
September 1992
Volume
11
Issue
5
Start / End Page
413 / 417
Location
United States
Related Subject Headings
- Ricin
- Recombinant Fusion Proteins
- Receptors, Transferrin
- Ophthalmology & Optometry
- Mice, Inbred BALB C
- Mice
- Immunotoxins
- Humans
- Epithelial Cells
- Dose-Response Relationship, Drug