Diane L. Hatchell

Isolated islets of Langerhans, transplanted in an immune privileged site, or with immunosupression of the host, have been shown to be successful in restoring normoglycemia in diabetic animals, and in humans to a limited extent. The subretinal space has recently been shown to share immune privilege with the cornea and anterior chamber of the eye. The purposes of the proposed studies are to 1) determine if the subretinal space of the cat eye is an immune privileged site for allogenic transplantation of islets, 2) determine if revascularization and survival of cat islets will be enhanced if they are cotransplanted with cells that are genetically engineered to make vascular endothelial growth factor, or 3) cotransplanted with Sertoli cells that will provide further immunological protection of the islets.

Current Appointments & Affiliations

Joseph A. C. Wadsworth Distinguished Research Professor Emeritus of Ophthalmology · 2000 - Present Ophthalmology, Clinical Science Departments

Professor Emeritus of Ophthalmology · 2000 - Present Ophthalmology, Clinical Science Departments

Recent Publications

Islet-like cell clusters: viability, cell types, and subretinal transplantation in pancreatectomized cats.

Journal Article Lab Anim · October 2006 We investigated a method for isolating sufficient feline islets of Langerhans to restore normoglycaemia following transplantation into the subretinal space of pancreatectomized cats. Collagenase digestate of feline pancreas was maintained in serum-free tis ... Full text Link to item Cite

Intraretinal pH in diabetic cats.

Journal Article Curr Eye Res · March 2005 PURPOSE: To examine intraretinal extracellular H+ concentration([H+]o) in diabetic cats. METHODS: Double-barreled H+-selective microelectrodes were used to measure [H+]o as a function of retinal depth ([H+]o profiles) in four cats with different stages of ... Full text Link to item Cite

Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.

Journal Article Ophthalmic Res · 2004 Survival of pancreatic islet cells transplanted into the subretinal space in rat eyes was studied in relation with apoptosis of infiltrating lymphocytes. Islets isolated from inbred DA rats were transplanted into the subretinal space of fully MHC-mismatche ... Full text Link to item Cite

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Education, Training & Certifications

Marquette University · 1968 Ph.D.

Marquette University · 1966 M.S.

University of Wisconsin, Milwaukee · 1961 B.S.

Diane L. Hatchell

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