Diane L. Hatchell | Scholars@Duke

Diane L. Hatchell
Joseph A. C. Wadsworth Distinguished Research Professor Emeritus of Ophthalmology

Isolated islets of Langerhans, transplanted in an immune privileged site, or with immunosupression of the host, have been shown to be successful in restoring normoglycemia in diabetic animals, and in humans to a limited extent. The subretinal space has recently been shown to share immune privilege with the cornea and anterior chamber of the eye. The purposes of the proposed studies are to 1) determine if the subretinal space of the cat eye is an immune privileged site for allogenic transplantation of islets, 2) determine if revascularization and survival of cat islets will be enhanced if they are cotransplanted with cells that are genetically engineered to make vascular endothelial growth factor, or 3) cotransplanted with Sertoli cells that will provide further immunological protection of the islets.

Current Appointments & Affiliations

Joseph A. C. Wadsworth Distinguished Research Professor Emeritus of Ophthalmology, Ophthalmology, Clinical Science Departments 2000
Professor Emeritus of Ophthalmology, Ophthalmology, Clinical Science Departments 2000

Contact Information

1510 Logan Street, Durham, NC 27704
Box 3802 Med Ctr, Durham, NC 27710
dlhatchell@mindspring.com (262) 523-0834

Background
Education, Training, & Certifications
- Ph.D., Marquette University 1968
- M.S., Marquette University 1966
- B.S., University of Wisconsin, Milwaukee 1961
Previous Appointments & Affiliations
- Joseph A. C. Wadsworth Distinguished Research Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 1984 - 2000
- Professor of Ophthamology with Tenure, Ophthalmology, Clinical Science Departments 1984 - 2000
- Professor of Physiology in Cell Biology, Cell Biology, Basic Science Departments 1994 - 2000
- Professor of Physiology, Integrative Immunobiology, Basic Science Departments 1987 - 1988
Academic Positions Outside Duke
- Professor, University of Wisconsin, Milwaukee. 1977 - 1983
Research
Selected Grants
- Subretinal Transplantation Of Islets Of Langerhans awarded by National Institutes of Health 1997 - 1999
- Pathogenesis Of Retinal Ischemic Injury awarded by National Institutes of Health 1995 - 1996
- Pathogenesis Of Retinal Ischemic Injury awarded by National Institutes of Health 1992 - 1996
- Vitrectomy And Proliferative Vitreoretinopathy awarded by National Institutes of Health 1990 - 1991
- Alteration And Renovation awarded by National Institutes of Health 1987 - 1988
- Instrumentation awarded by National Institutes of Health 1986 - 1987
- Regenerative Capacity Of The Cornea awarded by National Institutes of Health 1985 - 1986
- X-Ray Microanalysis And Image Processing System awarded by National Institutes of Health 1985 - 1986
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Maeno, Takatoshi, Makoto Inoue, Sherif N. Embabi, Daijiro Miki, and Diane L. Hatchell. “Islet-like cell clusters: viability, cell types, and subretinal transplantation in pancreatectomized cats.” Lab Anim 40, no. 4 (October 2006): 432–46. https://doi.org/10.1258/002367706778476488.
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  - Budzynski, Ewa, Norbert Wangsa-Wirawan, Lissa Padnick-Silver, Diane Hatchell, and Robert Linsenmeier. “Intraretinal pH in diabetic cats.” Curr Eye Res 30, no. 3 (March 2005): 229–40. https://doi.org/10.1080/02713680590934067.
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  - Inoue, Makoto, Takatoshi Maeno, Daijiro Miki, Sherif Embabi, and Diane L. Hatchell. “Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.” Ophthalmic Res 36, no. 1 (2004): 31–37. https://doi.org/10.1159/000076107.
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  - Inoue, M., T. Maeno, and D. L. Hatchell. “Survival of allografted pancreatic islets in the subretinal space in rats.” Ophthalmic Res 35, no. 1 (2003): 48–53. https://doi.org/10.1159/000068197.
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  - Miki, Daijiro, Kourosh Dastgheib, Terry Kim, Anne Pfister-Serres, Kimberly A. Smeds, Makoto Inoue, Diane L. Hatchell, and Mark W. Grinstaff. “A photopolymerized sealant for corneal lacerations.” Cornea 21, no. 4 (May 2002): 393–99. https://doi.org/10.1097/00003226-200205000-00012.
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  - Smeds, K. A., A. Pfister-Serres, D. Miki, K. Dastgheib, M. Inoue, D. L. Hatchell, and M. W. Grinstaff. “Erratum: Photocrosslinkable polysaccharides for in situ hydrogel formation (Journal of Biomedical Materials Research (2000) 54 (115-121)).” Journal of Biomedical Materials Research 55, no. 2 (March 19, 2001): 254. https://doi.org/10.1002/1097-4636(200105)55:2<254::AID-JBM1012>3.0.CO;2-5.
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  - Arroyo, J. G., K. Dastgheib, and D. L. Hatchell. “Antithrombotic effect of ticlopidine in an experimental model of retinal vein occlusion.” Jpn J Ophthalmol 45, no. 4 (2001): 359–62. https://doi.org/10.1016/s0021-5155(01)00337-9.
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  - Jumper, J. M., S. N. Embabi, C. A. Toth, I. I. McCuen BW, and D. L. Hatchell. “Electron immunocytochemical analysis of posterior hyaloid associated with diabetic macular edema.” Retina 20, no. 1 (2000): 63–68. https://doi.org/10.1097/00006982-200001000-00012.
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  - Farr, A. K., R. D. Braun, W. T. Cefalu, A. D. Bell-Farrow, Z. Q. Wang, and D. L. Hatchell. “Increased nonenzymatically glycosylated proteins in the vitreous humor of diabetic animals.” Lab Anim Sci 49, no. 1 (February 1999): 58–61.
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  - Smeds, K. A., A. Pfister-Serres, D. L. Hatchell, and M. W. Grinstaff. “Synthesis of a novel polysaccharide hydrogel.” Journal of Macromolecular Science Pure and Applied Chemistry 36 A, no. 7–8 (January 1, 1999): 981–89. https://doi.org/10.1080/10601329908951194.
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  - Giardino, I., A. K. Fard, D. L. Hatchell, and M. Brownlee. “Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.” Diabetes 47, no. 7 (July 1998): 1114–20. https://doi.org/10.2337/diabetes.47.7.1114.
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  - Hatchell, D. L., S. N. Embabi, T. Maeno, P. Saloupis, G. Olson, R. D. Braun, and C. A. Toth. “Transplantation of feline islets of Langerhans in the subretinal space of cat eyes.” Transplant Proc 30, no. 2 (March 1998): 593–95. https://doi.org/10.1016/s0041-1345(97)01421-8.
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  - Garfinkel, M. R., S. S. Yadav, R. C. Harland, D. L. Hatchell, and E. C. Opara. “Glutathione potentiates glucose- stimulated insulin secretion in isolated porcine islets.” Faseb Journal 11, no. 3 (December 1, 1997).
  - Arroyo, J. G., P. B. Jones, N. A. Porter, and D. L. Hatchell. “In vivo photoactivation of caged-thrombin.” Thromb Haemost 78, no. 2 (August 1997): 791–93.
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  - Rao, K. M., D. L. Hatchell, H. J. Cohen, and M. A. De La Paz. “Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy.” Am J Med Sci 313, no. 3 (March 1997): 131–37. https://doi.org/10.1097/00000441-199703000-00002.
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  - Braun, R. D., M. W. Dewhirst, and D. L. Hatchell. “Quantification of erythrocyte flow in the choroid of the albino rat.” Am J Physiol 272, no. 3 Pt 2 (March 1997): H1444–53. https://doi.org/10.1152/ajpheart.1997.272.3.H1444.
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  - Braun, R. D., T. C. Fisher, H. J. Meiselman, and D. L. Hatchell. “Decreased deformability of polymorphonuclear leukocytes in diabetic cats.” Microcirculation 3, no. 3 (September 1996): 271–78. https://doi.org/10.3109/10739689609148301.
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  - Arroyo, J. G., R. Machemer, and D. L. Hatchell. “Transmural iontophoresis of fluorescein into rabbit retinal veins.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
  - Braun, R. D., M. W. Dewhirst, D. Papahadjopoulos, and D. L. Hatchell. “Observation and quantification of erythrocyte flow in the choroid of the albino rat.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
  - Smith, D., E. K. Lee, P. Saloupis, J. K. Davis, and D. L. Hatchell. “Role of neutrophils in breakdown of the blood-retinal barrier following intravitreal injection of platelet-activating factor.” Exp Eye Res 59, no. 4 (October 1994): 425–32. https://doi.org/10.1006/exer.1994.1127.
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  - Bullard, S. R., D. L. Hatchell, H. J. Cohen, and K. M. Rao. “Increased adhesion of neutrophils to retinal vascular endothelial cells exposed to hyperosmolarity.” Exp Eye Res 58, no. 6 (June 1994): 641–47. https://doi.org/10.1006/exer.1994.1061.
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  - Steinhorst, U. H., E. P. Chen, S. F. Freedman, R. Machemer, and D. L. Hatchell. “Growth inhibition of human Tenon's capsule fibroblasts and rabbit dermal fibroblasts with non-carcinogenic N-alkylated anthracyclines.” Graefes Arch Clin Exp Ophthalmol 232, no. 6 (June 1994): 347–54. https://doi.org/10.1007/BF00175986.
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  - Hatchell, D. L., C. A. Wilson, and P. Saloupis. “Neutrophils plug capillaries in acute experimental retinal ischemia.” Microvasc Res 47, no. 3 (May 1994): 344–54. https://doi.org/10.1006/mvre.1994.1027.
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  - Kirkman, M. S., D. L. Simel, K. M. Rao, and D. L. Hatchell. “Granulocyte deformability and F-actin content: relationship to diabetes mellitus and retinopathy.” Am J Med Sci 307, no. 2 (February 1994): 86–91. https://doi.org/10.1097/00000441-199402000-00003.
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  - Harris, A. G., T. C. Skalak, and D. L. Hatchell. “Leukocyte-capillary plugging and network resistance are increased in skeletal muscle of rats with streptozotocin-induced hyperglycemia.” Int J Microcirc Clin Exp 14, no. 3 (1994): 159–66. https://doi.org/10.1159/000178824.
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  - Sonkin, P. L., L. W. Kelly, S. H. Sinclair, and D. L. Hatchell. “Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes.” Arch Ophthalmol 111, no. 12 (December 1993): 1647–52. https://doi.org/10.1001/archopht.1993.01090120069024.
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  - Steinhorst, U. H., D. L. Hatchell, E. P. Chen, and R. Machemer. “Ocular toxicity of daunomycin: effects of subdivided doses on the rabbit retina after vitreous gas compression.” Graefes Arch Clin Exp Ophthalmol 231, no. 10 (October 1993): 591–94. https://doi.org/10.1007/BF00936524.
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  - Fulcher, S., G. N. Foulks, M. Wilkerson, L. M. Cobo, L. L. Houston, and D. Hatchell. “Suppression of human corneal epithelial proliferation with breast carcinoma immunotoxin.” Cornea 12, no. 5 (September 1993): 391–96. https://doi.org/10.1097/00003226-199309000-00004.
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  - Sonkin, P. L., S. H. Sinclair, and D. L. Hatchell. “The effect of pentoxifylline on retinal capillary blood flow velocity and whole blood viscosity.” Am J Ophthalmol 115, no. 6 (June 15, 1993): 775–80. https://doi.org/10.1016/s0002-9394(14)73647-5.
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  - Costello, M. J., C. W. Lane, D. L. Hatchell, P. Saloupis, and L. M. Cobo. “Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes.” Invest Ophthalmol Vis Sci 34, no. 7 (June 1993): 2174–85.
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  - Steinhorst, U. H., E. P. Chen, D. L. Hatchell, G. P. Samsa, P. T. Saloupis, J. Westendorf, and R. Machemer. “Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.” Invest Ophthalmol Vis Sci 34, no. 5 (April 1993): 1753–60.
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  - Steinhorst, U. H., E. P. Chen, R. Machemer, and D. L. Hatchell. “N,N-dimethyladriamycin for treatment of experimental proliferative vitreoretinopathy: efficacy and toxicity on the rabbit retina.” Exp Eye Res 56, no. 4 (April 1993): 489–95. https://doi.org/10.1006/exer.1993.1062.
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  - Kelly, L. W., C. A. Barden, J. S. Tiedeman, and D. L. Hatchell. “Alterations in viscosity and filterability of whole blood and blood cell subpopulations in diabetic cats.” Exp Eye Res 56, no. 3 (March 1993): 341–47. https://doi.org/10.1006/exer.1993.1044.
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  - Antoszyk, A. N., J. L. Gottlieb, R. Machemer, and D. L. Hatchell. “The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization.” Graefes Arch Clin Exp Ophthalmol 231, no. 1 (1993): 34–40. https://doi.org/10.1007/BF01681698.
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  - Sonkin, P. L., S. F. Freedman, D. Needham, K. M. Rao, and D. L. Hatchell. “Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats.” Exp Eye Res 55, no. 6 (December 1992): 831–38. https://doi.org/10.1016/0014-4835(92)90009-h.
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  - Freedman, S. F., and D. L. Hatchell. “Enhanced superoxide radical production by stimulated polymorphonuclear leukocytes in a cat model of diabetes.” Exp Eye Res 55, no. 5 (November 1992): 767–73. https://doi.org/10.1016/0014-4835(92)90181-q.
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  - Fulcher, S. F., G. N. Foulks, M. Wilkerson, L. M. Cobo, G. J. Jaffe, and D. L. Hatchell. “Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.” Cornea 11, no. 5 (September 1992): 413–17. https://doi.org/10.1097/00003226-199209000-00010.
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  - Wilson, C. A., B. A. Berkowitz, and D. L. Hatchell. “Oxygen kinetics in preretinal perfluorotributylamine.” Exp Eye Res 55, no. 1 (July 1992): 119–26. https://doi.org/10.1016/0014-4835(92)90099-e.
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  - Chen, E. P., U. H. Steinhorst, G. P. Samsa, P. T. Saloupis, and D. L. Hatchell. “The effect of combined daunorubicin and triamcinolone acetonide treatment on a refined experimental model of proliferative vitreoretinopathy.” Invest Ophthalmol Vis Sci 33, no. 7 (June 1992): 2160–64.
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  - Sonkin, P. L., L. E. Chen, A. V. Seaber, and D. L. Hatchell. “Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle.” Angiology 43, no. 6 (June 1992): 462–69. https://doi.org/10.1177/000331979204300602.
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  - Wilkerson, M., S. Fulcher, M. B. Shields, G. N. Foulks, D. L. Hatchell, and L. L. Houston. “Inhibition of human subconjunctival fibroblast proliferation by immunotoxin.” Invest Ophthalmol Vis Sci 33, no. 7 (June 1992): 2293–98.
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  - Berkowitz, B. A., C. A. Wilson, D. L. Hatchell, and R. E. London. “Quantitative determination of the partial oxygen pressure in the vitrectomized rabbit eye in vivo using 19F NMR.” Magn Reson Med 21, no. 2 (October 1991): 233–41. https://doi.org/10.1002/mrm.1910210208.
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  - Wilson, C. A., P. Saloupis, and D. L. Hatchell. “Treatment of experimental preretinal neovascularization using photodynamic thrombosis.” Invest Ophthalmol Vis Sci 32, no. 9 (August 1991): 2530–35.
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  - Berkowitz, B. A., C. A. Wilson, and D. L. Hatchell. “Oxygen kinetics in the vitreous substitute perfluorotributylamine: a 19F NMR study in vivo.” Invest Ophthalmol Vis Sci 32, no. 8 (July 1991): 2382–87.
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  - Wilson, C. A., and D. L. Hatchell. “Photodynamic retinal vascular thrombosis. Rate and duration of vascular occlusion.” Invest Ophthalmol Vis Sci 32, no. 8 (July 1991): 2357–65.
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  - Wilson, C. A., B. A. Berkowitz, and D. L. Hatchell. “Localized steady-state oxygen measurements from the preretinal space of the rabbit eye using 19F NMR.” Nmr Biomed 4, no. 3 (June 1991): 157–59. https://doi.org/10.1002/nbm.1940040308.
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  - Antoszyk, A. N., J. L. Gottlieb, R. C. Casey, D. L. Hatchell, and R. Machemer. “An experimental model of preretinal neovascularization in the rabbit.” Invest Ophthalmol Vis Sci 32, no. 1 (January 1991): 46–52.
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  - Khawly, J. A., P. Saloupis, D. L. Hatchell, and R. Machemer. “Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy.” Graefes Arch Clin Exp Ophthalmol 229, no. 5 (1991): 464–67. https://doi.org/10.1007/BF00166311.
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  - Wilson, C. A., A. J. Royster, J. S. Tiedeman, and D. L. Hatchell. “Exudative retinal detachment after photodynamic injury.” Arch Ophthalmol 109, no. 1 (January 1991): 125–34. https://doi.org/10.1001/archopht.1991.01080010127044.
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  - Wilson, C. A., J. A. Khawly, D. L. Hatchell, and R. Machemer. “Experimental traction retinal detachment in the cat.” Graefes Arch Clin Exp Ophthalmol 229, no. 6 (1991): 568–73. https://doi.org/10.1007/BF00203323.
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  - Foulks, G. N., D. L. Hatchell, A. D. Proia, and G. K. Klintworth. “Histopathology of silicone oil keratopathy in humans.” Cornea 10, no. 1 (January 1991): 29–37.
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  - Hughes, C. L., M. K. Izard, M. A. Morris, and D. L. Hatchell. “Diabetes mellitus not associated with late pregnancy wastage in prosimian primates.” Advances in Contraceptive Delivery Systems 6, no. 3–4 (December 1, 1990): 245–49.
  - Sutherland, F. S., E. Stefansson, D. L. Hatchell, and H. Reiser. “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose.” Acta Ophthalmol (Copenh) 68, no. 6 (December 1990): 715–20. https://doi.org/10.1111/j.1755-3768.1990.tb01701.x.
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  - Gottlieb, J. L., A. N. Antoszyk, D. L. Hatchell, and P. Saloupis. “The safety of intravitreal hyaluronidase. A clinical and histologic study.” Invest Ophthalmol Vis Sci 31, no. 11 (November 1990): 2345–52.
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  - Armstrong, M., D. Needham, D. L. Hatchell, and R. S. Nunn. “Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary.” Angiology 41, no. 4 (April 1990): 253–62. https://doi.org/10.1177/000331979004100401.
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  - Mansour, S. Z., D. L. Hatchell, D. Chandler, P. Saloupis, and M. C. Hatchell. “Reduction of basement membrane thickening in diabetic cat retina by sulindac.” Invest Ophthalmol Vis Sci 31, no. 3 (March 1, 1990): 457–63.
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  - Novack, R. L., E. Stefånsson, and D. L. Hatchell. “The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina.” Exp Eye Res 50, no. 3 (March 1990): 289–96. https://doi.org/10.1016/0014-4835(90)90213-e.
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  - Stefánsson, E., R. L. Novack, and D. L. Hatchell. “Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion.” Invest Ophthalmol Vis Sci 31, no. 2 (February 1990): 284–89.
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  - Novack, R. L., E. Stefánsson, and D. L. Hatchell. “Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo.” Graefes Arch Clin Exp Ophthalmol 228, no. 2 (1990): 128–33. https://doi.org/10.1007/BF00935721.
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  - Novack, R. L., E. Stefánsson, and D. L. Hatchell. “Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo.” Graefe’S Archive for Clinical and Experimental Ophthalmology 228, no. 1 (January 1, 1990): 128–33. https://doi.org/10.1007/BF02764306.
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  - Needham, D., M. Armstrong, D. L. Hatchell, and R. S. Nunn. “Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline.” J Cell Physiol 140, no. 3 (September 1989): 549–57. https://doi.org/10.1002/jcp.1041400321.
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  - Twining, S. S., P. M. Wilson, and D. L. Hatchell. “Characterization of corneal proteoglycans under vitamin A deficiency.” Biochim Biophys Acta 992, no. 2 (August 18, 1989): 181–90. https://doi.org/10.1016/0304-4165(89)90008-1.
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  - Juan, E. de, M. S. Humayun, D. L. Hatchell, and D. Wilson. “Histopathology of experimental preretinal neovascularization.” Invest Ophthalmol Vis Sci 30, no. 7 (July 1989): 1495–1503.
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  - Juan, E. de, J. Dickson, and D. L. Hatchell. “Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction.” Graefes Arch Clin Exp Ophthalmol 227, no. 5 (1989): 494–98. https://doi.org/10.1007/BF02172905.
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  - Small, K. W., E. Stefansson, and D. L. Hatchell. “Coronary blood flow in chronic insulin-dependent diabetic dogs.” Acta Diabetol Lat 26, no. 4 (1989): 275–82. https://doi.org/10.1007/BF02624638.
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  - Ghorab, M. el-, A. Capone, B. A. Underwood, D. Hatchell, J. Friend, and R. A. Thoft. “Response of ocular surface epithelium to corneal wounding in retinol-deficient rabbits.” Invest Ophthalmol Vis Sci 29, no. 11 (November 1988): 1671–76.
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  - Royster, A. J., S. K. Nanda, D. L. Hatchell, J. S. Tiedeman, J. J. Dutton, and M. C. Hatchell. “Photochemical initiation of thrombosis. Fluorescein angiographic, histologic, and ultrastructural alterations in the choroid, retinal pigment epithelium, and retina.” Arch Ophthalmol 106, no. 11 (November 1988): 1608–14. https://doi.org/10.1001/archopht.1988.01060140776054.
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  - Newton, C., D. L. Hatchell, G. K. Klintworth, and C. F. Brown. “Topical fibronectin and corneal epithelial wound healing in the rabbit.” Arch Ophthalmol 106, no. 9 (September 1988): 1277–79. https://doi.org/10.1001/archopht.1988.01060140437048.
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  - Eaton, A. M., and D. L. Hatchell. “Measurement of retinal blood vessel width using computerized image analysis.” Invest Ophthalmol Vis Sci 29, no. 8 (August 1988): 1258–64.
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  - Hatchell, D. L., T. McAdoo, S. Sheta, R. T. King, and J. V. Bartolomé. “Quantification of cellular proliferation in experimental proliferative vitreoretinopathy.” Arch Ophthalmol 106, no. 5 (May 1988): 669–72. https://doi.org/10.1001/archopht.1988.01060130731033.
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  - Reiser, H. J., U. G. Whitworth, D. L. Hatchell, F. S. Sutherland, S. Nanda, T. McAdoo, and J. R. Hardin. “Experimental diabetes in cats induced by partial pancreatectomy alone or combined with local injection of alloxan.” Lab Anim Sci 37, no. 4 (August 1987): 449–52.
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  - Nanda, S. K., D. L. Hatchell, J. S. Tiedeman, J. J. Dutton, M. C. Hatchell, and T. McAdoo. “A new method for vascular occlusion. Photochemical initiation of thrombosis.” Arch Ophthalmol 105, no. 8 (August 1987): 1121–24. https://doi.org/10.1001/archopht.1987.01060080123041.
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  - Juan, E. de, D. Wilson, and D. Hatchell. “Breakdown of the blood-retinal barrier in a model of retinal neovascularization.” Invest Ophthalmol Vis Sci 28, no. 7 (July 1987): 1108–15.
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  - Small, K. W., E. Stefánsson, and D. L. Hatchell. “Retinal blood flow in normal and diabetic dogs.” Invest Ophthalmol Vis Sci 28, no. 4 (April 1987): 672–75.
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  - Hatchell, D. L., W. J. O’Brien, J. L. Taylor, and R. A. Hyndiuk. “Herpetic keratitis in experimental vitamin A deficiency.” Invest Ophthalmol Vis Sci 28, no. 2 (February 1987): 238–42.
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  - Foulks, G. N., E. de Juan, D. L. Hatchell, T. McAdoo, and J. Hardin. “The effect of perfluoropropane on the cornea in rabbits and cats.” Arch Ophthalmol 105, no. 2 (February 1987): 256–59. https://doi.org/10.1001/archopht.1987.01060020110040.
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  - Juan, E. de, M. Hardy, D. L. Hatchell, and M. C. Hatchell. “The effect of intraocular silicone oil on anterior chamber oxygen pressure in cats.” Arch Ophthalmol 104, no. 7 (July 1986): 1063–64. https://doi.org/10.1001/archopht.1986.01050190121050.
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  - Stefánsson, E., D. L. Hatchell, B. L. Fisher, F. S. Sutherland, and R. Machemer. “Panretinal photocoagulation and retinal oxygenation in normal and diabetic cats.” Am J Ophthalmol 101, no. 6 (June 15, 1986): 657–64. https://doi.org/10.1016/0002-9394(86)90765-8.
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  - Hatchell, D. L., H. J. Reiser, J. F. Bresnahan, and U. G. Whitworth. “Resistance of cats to the diabetogenic effect of alloxan.” Lab Anim Sci 36, no. 1 (February 1986): 37–40.
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  - Lohr, K. M., R. A. Hyndiuk, D. L. Hatchell, and C. E. Kurth. “Corneal organ cultures in tyrosinemia release chemotactic factors.” J Lab Clin Med 105, no. 5 (May 1985): 573–80.
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  - Twining, S. S., D. L. Hatchell, R. A. Hyndiuk, and K. F. Nassif. “Acid proteases and histologic correlations in experimental ulceration in vitamin A deficient rabbit corneas.” Invest Ophthalmol Vis Sci 26, no. 1 (January 1985): 31–44.
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  - Hatchell, D. L., J. L. Ubels, T. Stekiel, and M. C. Hatchell. “Corneal epithelial wound healing in normal and diabetic rabbits treated with tretinoin.” Arch Ophthalmol 103, no. 1 (January 1985): 98–100. https://doi.org/10.1001/archopht.1985.01050010104029.
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  - Sternberg, P., D. L. Hatchell, G. N. Foulks, and M. B. Landers. “The effect of silicone oil on the cornea.” Arch Ophthalmol 103, no. 1 (January 1985): 90–94. https://doi.org/10.1001/archopht.1985.01050010096027.
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  - Tseng, S. C., D. Hatchell, N. Tierney, A. J. Huang, and T. T. Sun. “Expression of specific keratin markers by rabbit corneal, conjunctival, and esophageal epithelia during vitamin A deficiency.” J Cell Biol 99, no. 6 (December 1984): 2279–86. https://doi.org/10.1083/jcb.99.6.2279.
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  - Hatchell, D. L., and A. Sommer. “Detection of ocular surface abnormalities in experimental vitamin A deficiency.” Arch Ophthalmol 102, no. 9 (September 1984): 1389–93. https://doi.org/10.1001/archopht.1984.01040031131040.
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  - Hatchell, D. L., M. Faculjak, and D. Kubicek. “Treatment of xerophthalmia with retinol, tretinoin, and etretinate.” Arch Ophthalmol 102, no. 6 (June 1984): 926–27. https://doi.org/10.1001/archopht.1984.01040030746036.
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  - Williams, G. A., D. L. Hatchell, B. D. Collier, and J. Knobel. “Clearance from the anterior chamber of RBCs from human diabetics.” Arch Ophthalmol 102, no. 6 (June 1984): 930–31. https://doi.org/10.1001/archopht.1984.01040030750038.
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  - Nelson, J. D., D. B. Lange, R. L. Lindstrom, D. J. Doughman, and D. L. Hatchell. “McCarey-Kaufman (MK) organ culture and MK medium-shifted corneas.” Arch Ophthalmol 102, no. 2 (February 1984): 308–11. https://doi.org/10.1001/archopht.1984.01040030252036.
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  - Ledbetter, S. R., D. L. Hatchell, and W. J. O’Brien. “Secondary aqueous humor stimulates the proliferation of cultured bovine corneal endothelial cells.” Invest Ophthalmol Vis Sci 24, no. 5 (May 1983): 557–62.
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  - Hatchell, D. L., J. J. Magolan, M. J. Besson, A. I. Goldman, H. J. Pederson, and K. J. Schultz. “Damage to the epithelial basement membrane in the corneas of diabetic rabbits.” Arch Ophthalmol 101, no. 3 (March 1983): 469–71. https://doi.org/10.1001/archopht.1983.01040010469029.
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  - Hyndiuk, R. A., S. D. Davis, and D. L. Hatchell. “Experimental Pseudomonas keratitis: Clinical and pathological observations.” Cornea 2, no. 2 (January 1, 1983): 103–14.
  - Haimann, M. H., G. W. Abrams, H. F. Edelhauser, and D. L. Hatchell. “The effect of intraocular irrigating solutions on lens clarity in normal and diabetic rabbits.” Am J Ophthalmol 94, no. 5 (November 1982): 594–605. https://doi.org/10.1016/0002-9394(82)90003-4.
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  - MacRae, S. M., R. L. Engerman, D. L. Hatchell, and R. A. Hyndiuk. “Corneal sensitivity and control of diabetes.” Cornea 1, no. 3 (January 1, 1982): 223–26. https://doi.org/10.1097/00003226-198201030-00008.
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  - McCarey, B. E., D. M. Andrews, D. L. Hatchell, and H. Pederson. “Hydrogel implants for refractive keratoplasty: corneal morphology.” Curr Eye Res 2, no. 1 (1982): 29–38. https://doi.org/10.3109/02713688208998377.
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  - Ledbetter, S. R., D. L. Hatchell, and W. J. O’Brien. “Differential effect of secondary aqueous humor from rabbit and cat on DNA synthesis of cultured bovine corneal endothelial cells.” Curr Eye Res 1, no. 12 (1981): 723–26. https://doi.org/10.3109/02713688108998371.
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- Other Articles
  - Hatchell, D. L., C. A. Toth, C. A. Barden, and P. Saloupis. “Diabetic retinopathy in a cat.” Exp Eye Res, May 1995. https://doi.org/10.1016/s0014-4835(05)80074-0.
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- Conference Papers
  - Grinstaff, M. W., D. Miki, A. Pfister-Serres, K. A. Dastgheib, K. A. Smeds, M. Inoue, and D. L. Hatchell. “Application of photocrosslinkable hyaluronan as a corneal perforation sealant.” In Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 2:717, 1999.
  - Smeds, K. A., D. R. Burnett, D. L. Hatchell, A. Pfister-Serres, and M. W. Grinstaff. “Photocrosslinkable hyaluronic acid for cell encapsulation.” In Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 2:724, 1999.
  - Nelson, C. P., S. N. Embabi, and D. L. Hatchell. “Xenografts of islets of Langerhans in the vitreous cavity.” In Investigative Ophthalmology and Visual Science, Vol. 37, 1996.

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