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Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Publication ,  Journal Article
Hsu, ST; Ngo, HT; Stinnett, SS; Cheung, NL; House, RJ; Kelly, MP; Chen, X; Enyedi, LB; Prakalapakorn, SG; Materin, MA; El-Dairi, MA; Jaffe, GJ ...
Published in: Ophthalmology
December 2019

PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years; range, 9 weeks-17 years) treated at the Duke University Eye Center. METHODS: We imaged 135 maculae of 89 pediatric patients using the standard Spectralis tabletop and investigational Spectralis with Flex module devices, both equipped with investigational OCTA software (Heidelberg Engineering, Heidelberg, Germany). OCT angiography images of the superficial vascular complex (SVC) and deep vascular complex (DVC) were analyzed for foveal avascular zone (FAZ) area and superficial and deep vessel density. We assessed effects of age, gender, race, axial length (AL), and central subfield thickness on FAZ and vessel density. Patients with both eyes imaged were assessed for agreement between the FAZ and vessel densities of the left and right eyes. MAIN OUTCOME MEASURES: The FAZ area, as well as vessel area density (VAD) and vessel length density (VLD) in the SVC and DVC. RESULTS: The FAZ varied significantly with race; white patients showed a significantly smaller FAZ than black patients (mean difference, 0.11 mm2; P = 0.004). The FAZ did not vary with age, gender, or AL (P > 0.05). In the SVC, VAD and VLD varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender (P > 0.05). The SVC VLD was significantly different between races and ethnicities (P = 0.037), but VAD was not (P < 0.05). In the DVC, VAD and VLD also varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender or race (P > 0.05). There was excellent agreement between the right and left eyes for FAZ (intraclass correlation [ICC], 0.97), SVC VLD (ICC, 1.00), and DVC VLD (ICC, 1.00). CONCLUSIONS: Quantitative studies of pediatric perifoveal vasculature should consider age, race, and AL. In eyes with unilateral disease, the perifoveal vasculature in the unaffected eye may be used as a control comparison because there is excellent agreement between eyes.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

December 2019

Volume

126

Issue

12

Start / End Page

1703 / 1711

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Vessels
  • Prospective Studies
  • Ophthalmology & Optometry
  • Microvessels
  • Male
  • Macula Lutea
  • Infant
  • Humans
 

Citation

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MLA
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Hsu, S. T., Ngo, H. T., Stinnett, S. S., Cheung, N. L., House, R. J., Kelly, M. P., … Vajzovic, L. (2019). Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography. Ophthalmology, 126(12), 1703–1711. https://doi.org/10.1016/j.ophtha.2019.06.028
Hsu, S Tammy, Hoan T. Ngo, Sandra S. Stinnett, Nathan L. Cheung, Robert J. House, Michael P. Kelly, Xi Chen, et al. “Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.Ophthalmology 126, no. 12 (December 2019): 1703–11. https://doi.org/10.1016/j.ophtha.2019.06.028.
Hsu ST, Ngo HT, Stinnett SS, Cheung NL, House RJ, Kelly MP, et al. Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography. Ophthalmology. 2019 Dec;126(12):1703–11.
Hsu, S. Tammy, et al. “Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.Ophthalmology, vol. 126, no. 12, Dec. 2019, pp. 1703–11. Pubmed, doi:10.1016/j.ophtha.2019.06.028.
Hsu ST, Ngo HT, Stinnett SS, Cheung NL, House RJ, Kelly MP, Chen X, Enyedi LB, Prakalapakorn SG, Materin MA, El-Dairi MA, Jaffe GJ, Freedman SF, Toth CA, Vajzovic L. Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography. Ophthalmology. 2019 Dec;126(12):1703–1711.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

December 2019

Volume

126

Issue

12

Start / End Page

1703 / 1711

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Vessels
  • Prospective Studies
  • Ophthalmology & Optometry
  • Microvessels
  • Male
  • Macula Lutea
  • Infant
  • Humans