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Xi Chen

Associate Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
2351 Erwin Road AERI3000, Durham, NC 27705

Overview


Dr. Xi Chen is dedicated to being a clinician-scientist who provides great medical and surgical care to patients with vitreoretinal diseases, with a research focus in retinal neurovascular development and disease. Her current research interest is studying human retinal and vascular development and their coordination using advanced imaging techniques.
 
Dr. Chen's basic science training in neural development gives her a unique perspective in her research in human retinal neurovascular development and disease. She hopes to eventually bring the information gathered from the bedside back to the laboratory in order to develop strategies to improve care of premature infants, and pediatric and adult patients with retinal vascular diseases. 

She is very excited to work closely with Dr. Cynthia Toth and Dr. Joseph Izatt, who have pioneered the world in the development of bedside OCT technology and its adaptation for pediatric use. The many gifted clinician-scientists at Duke Eye Center as mentors and role models will also be key to Dr. Chen's research development.
 
Dr. Chen arrived at Duke for fellowship training in vitreoretinal surgery after spending eight years in Boston. She says that she loved her mentors, the staff and the patients at Duke and found the environment to be warm, caring, fun and collaborative. She is grateful to work alongside colleagues and staff who work hard and go out of their way to provide the best possible care to patients.

Current Appointments & Affiliations


Associate Professor of Ophthalmology · 2023 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology

Recent Publications


A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.

Journal Article Sci Rep · January 4, 2024 Extraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural OCT, ... Full text Link to item Cite

Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.

Journal Article Ophthalmol Retina · June 2021 PURPOSE: To report our ability to capture,-grade reliably, and analyze bedside macular OCT images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the Study of Eye Ima ... Full text Link to item Cite

Choroidal neovascularization in a child with infantile primary hyperoxaluria treated with bevacizumab.

Journal Article J AAPOS · April 2021 Fundus manifestations of primary hyperoxaluria include crystalline deposits, focal or diffuse macular hyperpigmentation, and subretinal fibrosis. Choroidal neovascularization has been hypothesized to underlie the pathogenesis of subretinal fibrosis, yet it ... Full text Link to item Cite
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Recent Grants


Engineering three-dimensional perfusable microphysiological models of the human inner blood-retina barrier

ResearchCo Investigator · Awarded by National Eye Institute · 2024 - 2027

Self-aligning, motion-stabilized ocular imaging for eye care in urgent and emergent care settings

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2027

Elucidating perifoveal vascular development in infants

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

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Education, Training & Certifications


Harvard Medical School · 2011 M.D.
Johns Hopkins University, School of Medicine · 2007 Ph.D.
Peking University (China) · 2001 B.S.