Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Ophthalmology, Duke University 1994 - 1997
  • M.D., University of North Carolina - Chapel Hill 1993
• 

  Previous Appointments & Affiliations

  • Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2019 - 2020
  • Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 2013 - 2020
  • Associate Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2013 - 2019
  • Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2006 - 2013
  • Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 2006 - 2013
  • Assistant Clinical Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 1999 - 2006
  • Assistant Clinical Professor of Pediatrics, Pediatrics, Clinical Science Departments 2001 - 2006
  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 1997 - 1999
• Recognition
• 

  In the News

  • JAN 21, 2021

    January Book: Laura Enyedi, Nandini Gandhi, et al: "The Duke Manual of Pediatric Ophthalmology and Strabismus Surgery"
• Research
• 

  Selected Grants

  • A Randomized, Parallel-Arm, Active Control, Multicenter Study Assessing the Safety and Efficacy of DEXTENZA® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract awarded by Ocular Therapeutix Inc 2022 - 2027
  • A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old (ATS22) awarded by Jaeb Center For Health Research 2021 - 2023
  • Intermittent Exotropia Study (IXT6) A Pilot Randomized Clinical Trial of Base-in Prism Spectacles for Intermittent Exotropia awarded by Jaeb Center For Health Research 2019 - 2023
  • An RCT of Overminus Spectacle Therapy for Intermittent Exotropia awarded by Jaeb Center For Health Research 2018 - 2023
  • Two-Year Follow Up after Treatment of Severe Retinopathy of Prematurity with Low-Dose Bevacizumab (ROP2Y) awarded by Jaeb Center For Health Research 2018 - 2023
  • Binocular Dig Rush Game Treatment for Amblyopia (ATS20) awarded by Jaeb Center For Health Research 2017 - 2022
  • Pediatric Optic Neuritis Prospective Outcomes Study (PON1) awarded by Jaeb Center For Health Research 2016 - 2022
  • Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity (ROP1) awarded by Jaeb Center For Health Research 2015 - 2022
  • Pediatric Cataract Surgery Outcomes Registry (CO2) awarded by Jaeb Center For Health Research 2013 - 2022
  • A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia awarded by Jaeb Center For Health Research 2009 - 2022
  • A Prospective Observational Study of Adult Strabismus awarded by Jaeb Center For Health Research 2015 - 2018
• 

  External Relationships

  • Novartis pharmaceuticals
  • Tarsus
  • Vyluma
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Freedman, Sharon F., Amra Hercinovic, David K. Wallace, Raymond T. Kraker, Zhuokai Li, Amit R. Bhatt, Charline S. Boente, et al. “Low- and Very Low-Dose Bevacizumab for Retinopathy of Prematurity: Reactivations, Additional Treatments, and 12-Month Outcomes.” Ophthalmology 129, no. 10 (October 2022): 1120–28. https://doi.org/10.1016/j.ophtha.2022.05.019.
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    • Pineles, Stacy L., Robert J. Henderson, Michael X. Repka, Gena Heidary, Grant T. Liu, Amy T. Waldman, Mark S. Borchert, et al. “The Pediatric Optic Neuritis Prospective Outcomes Study: Two-Year Results.” Ophthalmology 129, no. 8 (August 2022): 856–64. https://doi.org/10.1016/j.ophtha.2022.03.021.
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    • Lu, Randy Y., Tammy Yanovitch, Laura Enyedi, Nandini Gandhi, Matthew Gearinger, Alejandra G. de Alba Campomanes, Kara M. Cavuoto, et al. “The flipped-classroom approach to teaching horizontal strabismus in ophthalmology residency: a multicentered randomized controlled study.” J Aapos 25, no. 3 (June 2021): 137.e1-137.e6. https://doi.org/10.1016/j.jaapos.2021.01.008.
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    • Holmes, Jonathan M., Amra Hercinovic, B Michele Melia, David A. Leske, Sarah R. Hatt, Danielle L. Chandler, Trevano W. Dean, et al. “Health-related quality of life in children with untreated intermittent exotropia and their parents.” J Aapos 25, no. 2 (April 2021): 80.e1-80.e4. https://doi.org/10.1016/j.jaapos.2020.10.011.
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    • Holmes, Jonathan M., Amra Hercinovic, B Michele Melia, David A. Leske, Sarah R. Hatt, Danielle L. Chandler, Trevano W. Dean, et al. “Improvement in health-related quality of life following strabismus surgery for children with intermittent exotropia.” J Aapos 25, no. 2 (April 2021): 82.e1-82.e7. https://doi.org/10.1016/j.jaapos.2020.11.021.
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    • Writing Committee for the Pediatric Eye Disease Investigator Group (PEDIG), Jonathan M., Stacy L. Pineles, Michael X. Repka, Grant T. Liu, Amy T. Waldman, Mark S. Borchert, Sangeeta Khanna, et al. “Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months.” Jama Ophthalmol 138, no. 12 (December 1, 2020): 1253–61. https://doi.org/10.1001/jamaophthalmol.2020.4231.
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    • Michalak, Suzanne M., Paramjit K. Bhullar, and Laura B. Enyedi. “The effect of nonmodifiable physician demographics on Press Ganey patient satisfaction scores in ophthalmology.” J Aapos 24, no. 5 (October 2020): 299–301. https://doi.org/10.1016/j.jaapos.2020.05.010.
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    • Hsu, S Tammy, Hoan T. Ngo, Sandra S. Stinnett, Nathan L. Cheung, Robert J. House, Michael P. Kelly, Xi Chen, et al. “Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.” Ophthalmology 126, no. 12 (December 2019): 1703–11. https://doi.org/10.1016/j.ophtha.2019.06.028.
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    • Rotruck, Jill C., Robert J. House, Sharon F. Freedman, Michael P. Kelly, Laura B. Enyedi, S Grace Prakalapakorn, Maria E. Lim, and Mays A. El-Dairi. “Optical Coherence Tomography Normative Peripapillary Retinal Nerve Fiber Layer and Macular Data in Children 0-5 Years of Age.” Am J Ophthalmol 208 (December 2019): 323–30. https://doi.org/10.1016/j.ajo.2019.06.025.
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    • Cabrera, Michelle T., Tammy L. Yanovitch, Nandini G. Gandhi, Leona Ding, and Laura B. Enyedi. “The flipped-classroom approach to teaching horizontal strabismus in ophthalmology residency: a pilot study.” J Aapos 23, no. 4 (August 2019): 200.e1-200.e6. https://doi.org/10.1016/j.jaapos.2019.02.009.
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    • House, Robert J., Jill C. Rotruck, Laura B. Enyedi, David K. Wallace, Ezzeldin Saleh, and Sharon F. Freedman. “Postoperative infection following strabismus surgery: case series and increased incidence in a single referral center.” J Aapos 23, no. 1 (February 2019): 26.e1-26.e7. https://doi.org/10.1016/j.jaapos.2018.09.007.
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    • Pediatric Eye Disease Investigator Group, Aaron M., Aaron M. Writing Committee, Sean P. Donahue, Danielle L. Chandler, Jonathan M. Holmes, Brian W. Arthur, Evelyn A. Paysse, et al. “A Randomized Trial Comparing Bilateral Lateral Rectus Recession versus Unilateral Recess and Resect for Basic-Type Intermittent Exotropia.” Ophthalmology 126, no. 2 (February 2019): 305–17. https://doi.org/10.1016/j.ophtha.2018.08.034.
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    • Hsu, S Tammy, Xi Chen, Hoan T. Ngo, Robert J. House, Michael P. Kelly, Laura B. Enyedi, Miguel A. Materin, et al. “Imaging Infant Retinal Vasculature with OCT Angiography.” Ophthalmol Retina 3, no. 1 (January 2019): 95–96. https://doi.org/10.1016/j.oret.2018.06.017.
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    • Cabrera, Michelle T., Laura B. Enyedi, Leona Ding, and Susan M. MacDonald. “Sexual Harassment in Ophthalmology: A Survey Study.” Ophthalmology 126, no. 1 (January 2019): 172–74. https://doi.org/10.1016/j.ophtha.2018.09.016.
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    • Thompson, Atalie C., Matthew O. Thompson, Maria E. Lim, Sharon F. Freedman, and Laura B. Enyedi. “Microphthalmia, Dermal Aplasia, and Sclerocornea Syndrome: Endoscopic Cyclophotocoagulation in the Management of Congenital Glaucoma.” Journal of Glaucoma 27, no. 1 (January 2018): e7–10. https://doi.org/10.1097/ijg.0000000000000812.
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    • Lee, Andrew R., Dilraj S. Grewal, Thomas J. Cummings, Laura B. Enyedi, Nicole A. Larrier, and Prithvi Mruthyunjaya. “Multifocal iris melanoma in a 2-year-old managed with I-125 plaque brachytherapy.” J Aapos 21, no. 5 (October 2017): 410–12. https://doi.org/10.1016/j.jaapos.2017.03.014.
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    • Enyedi, Laura. “Reply.” J Aapos 21, no. 4 (August 2017): 347. https://doi.org/10.1016/j.jaapos.2017.07.002.
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    • Enyedi, Laura B., David K. Wallace, and Guy de L Dear. “A double-masked randomized trial of postoperative local anesthetic for pain control in pediatric strabismus surgery.” J Aapos 21, no. 2 (April 2017): 107–11. https://doi.org/10.1016/j.jaapos.2017.03.005.
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    • White, Cassandra A., James A. Wrzosek, David A. Chesnutt, Laura B. Enyedi, and Michelle T. Cabrera. “A novel method for teaching key steps of strabismus surgery in the wet lab.” J Aapos 19, no. 5 (October 2015): 468-70.e1. https://doi.org/10.1016/j.jaapos.2015.05.020.
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    • Leske, David A., Jonathan M. Holmes, B Michele Melia, and B Michele Pediatric Eye Disease Investigator Group. “Evaluation of the Intermittent Exotropia Questionnaire using Rasch analysis.” Jama Ophthalmol 133, no. 4 (April 2015): 461–65. https://doi.org/10.1001/jamaophthalmol.2014.5622.
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    • Leske, David A., Jonathan M. Holmes, B Michele Melia, and B Michele Pediatric Eye Disease Investigator Group. “Evaluation of the Intermittent Exotropia Questionnaire using Rasch analysis.” Jama Ophthalmol 133, no. 4 (April 2015): 461–65. https://doi.org/10.1001/jamaophthalmol.2014.5622.
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    • Manjunath, V., and L. Enyedi. “Pediatric Myopic Progression Treatments: Science, Sham, and Promise.” Theoretical Chemistry Accounts 2, no. 4 (December 1, 2014): 150–57. https://doi.org/10.1007/s40135-014-0054-4.
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    • Mirzaa, Ghayda M., Laura Enyedi, Gretchen Parsons, Sarah Collins, Livija Medne, Carissa Adams, Thomas Ward, et al. “Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: five novel mutations and review of the literature.” Am J Med Genet A 164A, no. 11 (November 2014): 2879–86. https://doi.org/10.1002/ajmg.a.36707.
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    • Gertsch, Kevin R., David Wallace, J Niklas Ulrich, Laura Enyedi, and Michelle Cabrera. “Computer-assisted quantification of plus disease after treatment of retinopathy of prematurity with intravitreal bevacizumab.” Journal of American Association for Pediatric Ophthalmology and Strabismus 17, no. 1 (February 2013): e15–16. https://doi.org/10.1016/j.jaapos.2012.12.055.
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    • Yanovitch, Tammy, David K. Wallace, Sharon F. Freedman, Laura B. Enyedi, Priya Kishnani, Gordon Worley, Blythe Crissman, Erica Burner, and Terri L. Young. “The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome.” J Aapos 14, no. 6 (December 2010): 472–77. https://doi.org/10.1016/j.jaapos.2010.09.016.
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    • Black, Andrew C., Sarah Jones, Tammy L. Yanovitch, Laura B. Enyedi, Sandra S. Stinnett, and Sharon F. Freedman. “Latanoprost in pediatric glaucoma--pediatric exposure over a decade.” J Aapos 13, no. 6 (December 2009): 558–62. https://doi.org/10.1016/j.jaapos.2009.10.003.
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    • El-Dairi, M. A., S. Holgado, S. G. Asrani, L. B. Enyedi, and S. F. Freedman. “Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children.” Br J Ophthalmol 93, no. 10 (October 2009): 1325–30. https://doi.org/10.1136/bjo.2008.142562.
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    • Scott, Adrienne W., Sina Farsiu, Laura B. Enyedi, David K. Wallace, and Cynthia A. Toth. “Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device.” Am J Ophthalmol 147, no. 2 (February 2009): 364-373.e2. https://doi.org/10.1016/j.ajo.2008.08.010.
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    • Yanovitch, Tammy L., David K. Wallace, Sharon F. Freedman, Laura B. Enyedi, and Terri L. Young. “126: Success rates of adjustable and nonadjustable strabismus surgery in adults.” Journal of American Association for Pediatric Ophthalmology and Strabismus 13, no. 1 (February 2009): e32–e32. https://doi.org/10.1016/j.jaapos.2008.12.097.
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    • Yanovitch, Tammy L., Laura B. Enyedi, Erin O. Schotthoeffer, and Sharon F. Freedman. “Travoprost in children: adverse effects and intraocular pressure response.” J Aapos 13, no. 1 (February 2009): 91–93. https://doi.org/10.1016/j.jaapos.2008.08.006.
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    • El-Dairi, Mays A., Sanjay G. Asrani, Laura B. Enyedi, and Sharon F. Freedman. “Optical coherence tomography in the eyes of normal children.” Arch Ophthalmol 127, no. 1 (January 2009): 50–58. https://doi.org/10.1001/archophthalmol.2008.553.
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    • Morris, Carrie L., Edward G. Buckley, Laura B. Enyedi, Sandra Stinnett, and Sharon E. Freedman. “Safety and efficacy of silicone rod frontalis suspension surgery for childhood ptosis repair.” J Pediatr Ophthalmol Strabismus 45, no. 5 (September 2008): 280–88. https://doi.org/10.3928/01913913-20080901-11.
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    • Muir, Kelly W., Lois Duncan, Laura B. Enyedi, David K. Wallace, and Sharon F. Freedman. “Central corneal thickness: congenital cataracts and aphakia.” Am J Ophthalmol 144, no. 4 (October 2007): 502–6. https://doi.org/10.1016/j.ajo.2007.06.004.
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    • Muir, Kelly W., Lois Duncan, Laura B. Enyedi, and Sharon F. Freedman. “Central corneal thickness in children: Racial differences (black vs. white) and correlation with measured intraocular pressure.” J Glaucoma 15, no. 6 (December 2006): 520–23. https://doi.org/10.1097/01.ijg.0000212284.78045.45.
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    • Good, William V., and William V. Early Treatment for Retinopathy of Prematurity Cooperative Group. “The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 years.” Br J Ophthalmol 90, no. 11 (November 2006): 1378–82. https://doi.org/10.1136/bjo.2006.098582.
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    • Good, William V., and William V. Early Treatment for Retinopathy of Prematurity Cooperative Group. “The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 years.” Br J Ophthalmol 90, no. 11 (November 2006): 1378–82. https://doi.org/10.1136/bjo.2006.098582.
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    • Muir, Kelly W., Lois Duncan, Laura B. Enyedi, Sandra S. Stinnett, and Sharon F. Freedman. “Central corneal thickness in children: stability over time.” Am J Ophthalmol 141, no. 5 (May 2006): 955–57. https://doi.org/10.1016/j.ajo.2005.11.052.
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    • Holgado, Sandra, Laura B. Enyedi, Cynthia A. Toth, and Sharon F. Freedman. “Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management.” Ophthalmology 113, no. 1 (January 2006): 63–69. https://doi.org/10.1016/j.ophtha.2005.09.022.
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    • Good, William V., Robert J. Hardy, Velma Dobson, Earl A. Palmer, Dale L. Phelps, Michelle Quintos, Betty Tung, and Betty Early Treatment for Retinopathy of Prematurity Cooperative Group. “The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study.” Pediatrics 116, no. 1 (July 2005): 15–23. https://doi.org/10.1542/peds.2004-1413.
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    • Hess, Derek B., Sanjay G. Asrani, Manisha G. Bhide, Laura B. Enyedi, Sandra S. Stinnett, and Sharon F. Freedman. “Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography.” Am J Ophthalmol 139, no. 3 (March 2005): 509–17. https://doi.org/10.1016/j.ajo.2004.10.047.
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    • Dawn, Aerlyn G., Sharon F. Freedman, Paul P. Lee, and Laura B. Enyedi. “Parents' expectations regarding their children's eye care: interview results.” Am J Ophthalmol 136, no. 5 (November 2003): 797–804. https://doi.org/10.1016/s0002-9394(03)00451-3.
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    • Freedman, Sharon F., Sandra Holgado, Laura B. Enyedi, and Cynthia A. Toth. “Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study.” Am J Ophthalmol 136, no. 4 (October 2003): 640–48. https://doi.org/10.1016/s0002-9394(03)00334-9.
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    • Freedman, Sharon F., Matthew D. Gearinger, Laura B. Enyedi, Sandra Holgado, and Cynthia A. Toth. “Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rod.” J Aapos 7, no. 2 (April 2003): 103–7. https://doi.org/10.1016/mpa.2003.S1091853103000107.
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    • Enyedi, Laura B., and Sharon F. Freedman. “Latanoprost for the treatment of pediatric glaucoma.” Survey of Ophthalmology 47 Suppl 1 (August 2002): S129–32. https://doi.org/10.1016/s0039-6257(02)00303-x.
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    • Freedman, S. F., R. E. Rodriguez Rosa, M. C. Rojas, and L. B. Enyedi. “Goniotomy for glaucoma secondary to chronic childhood uveitis.” American Journal of Ophthalmology 133, no. 5 (May 2002): 617–21.
    • Enyedi, L. B., and S. F. Freedman. “Safety and efficacy of brimonidine in children with glaucoma.” J Aapos 5, no. 5 (October 2001): 281–84. https://doi.org/10.1067/mpa.2001.117571.
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    • Buckley, Edward G., Sharon F. Freedman, Laura B. Enyedi, and Cynthia A. Toth. “Surgical Treatment of Incyclotorsion After Macular Translocation.” American Orthoptic Journal 51, no. 1 (January 2001): 16–23. https://doi.org/10.3368/aoj.51.1.16.
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    • Freedman, S. F., J. H. Seaber, E. G. Buckley, L. B. Enyedi, and C. A. Toth. “Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery.” J Aapos 4, no. 2 (April 2000): 75–83. https://doi.org/10.1067/mpa.2000.102925.
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    • Enyedi, L. B., S. F. Freedman, and E. G. Buckley. “The effectiveness of latanoprost for the treatment of pediatric glaucoma.” J Aapos 3, no. 1 (February 1999): 33–39. https://doi.org/10.1016/s1091-8531(99)70092-3.
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    • Enyedi, L. B., S. Dev, and T. A. Cox. “A comparison of the Marcus Gunn and alternating light tests for afferent pupillary defects.” Ophthalmology 105, no. 5 (May 1998): 871–73. https://doi.org/10.1016/S0161-6420(98)95029-1.
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    • Enyedi, L. B., A. Loewenstein, and E. de Juan. “The effect of intraocular pressure on the absorption of air from the vitreous cavity.” Graefes Arch Clin Exp Ophthalmol 236, no. 4 (April 1998): 301–4. https://doi.org/10.1007/s004170050082.
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    • Enyedi, L. B., P. A. Pearson, P. Ashton, and G. J. Jaffe. “An intravitreal device providing sustained release of cyclosporine and dexamethasone.” Curr Eye Res 15, no. 5 (May 1996): 549–57. https://doi.org/10.3109/02713689609000766.
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    • “Caring for the uninsured and underinsured.” Jama 265, no. 19 (May 15, 1991): 2480–84.
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    • Enyedi, L. B., E. de Juan, and A. Gaitan. “Ultrastructural study of Norrie's disease.” Am J Ophthalmol 111, no. 4 (April 15, 1991): 439–45. https://doi.org/10.1016/s0002-9394(14)72378-5.
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  • Other Articles

    • Scott, A. W., S. Farsiu, L. B. Enyedi, D. K. Wallace, and C. A. Toth. “Reply.” American Journal of Ophthalmology, June 1, 2009. https://doi.org/10.1016/j.ajo.2009.02.007.
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    • Goldstein, A. O., L. Enyedi, M. Calderon, J. Babb, S. Bennett, A. R. Barnosky, and B. L. Farkas. “Caring for the uninsured and underinsured [1].” Journal of the American Medical Association, 1991. https://doi.org/10.1001/jama.265.19.2480.
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  • Conference Papers

    • Enyedi, L. B., and E. G. Buckley. “Refractive changes following IOL implantation in pediatric patients.” In Investigative Ophthalmology and Visual Science, Vol. 37, 1996.
    • Enyedi, L. B., and E. G. Buckley. “Refractive changes following IOL implantation in pediatric patients.” In Investigative Ophthalmology & Visual Science, 37:2711–2711. LIPPINCOTT-RAVEN PUBL, 1996.
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    • ENYEDI, L. B., P. A. PEARSON, G. J. JAFFE, and P. ASHTON. “PHARMACOKINETICS AND TOXICITY OF AN INTRAVITREAL DEVICE PROVIDING SUSTAINED-RELEASE OF CYCLOSPORINE (CSA) AND DEXAMETHASONE (DEX).” In Investigative Ophthalmology & Visual Science, 35:1906–1906. LIPPINCOTT-RAVEN PUBL, 1994.
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    • PEARSON, P. A., L. B. ENYEDI, G. J. JAFFE, and P. ASHTON. “SUSTAINED DELIVERY OF CYCLOSPORINE (CSA) AND DEXAMETHASONE (DEX) IN THE TREATMENT OF EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY.” In Investigative Ophthalmology & Visual Science, 35:1923–1923. LIPPINCOTT-RAVEN PUBL, 1994.
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