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Sharon Fridovich Freedman

Professor of Ophthalmology
Ophthalmology
Box 3802 Med Ctr, Durham, NC 27710
Albert Eye Research Institute, Durham, NC 27710

Overview


My current research interests include:

Childhood glaucomas - With a large referral practice of children with pediatric glaucomas of all types, Freedman is evaluating existing and new management strategies for treating refractory congenital and childhood glaucomas, including the use of pharmacologic agents, as well as modification of surgical interventions. Freedman has an on-going collaboration with Duke colleagues to study the genetics of pediatric glaucoma. In addition to an active clinical research program, she regularly lectures and directs workshop at national meetings aimed at educating other ophthalmologists about current strategies and controversies in managing children with refractory glaucoma.

Retinopathy of Prematurity - Freedman was the principal investigator at the Duke-UNC Center for the NIH-sponsored, multi-center trial to evaluate early treatment for retinopathy of prematurity (ETROP). Together with colleague David Wallace, she provides eye care and treatment to the many premature children who graduate from the Neonatal Intensive Care units at DUHS. Freedman and Wallace are involved in clinical research involving the computerized evaluation of retinal blood vessels in ROP. Freedman and Wallace collaborate with Cynthia Toth and her Duke research team in applying the new imaging technique of Spectral Domain Optical Coherence Tomography to image children with retinopathy of prematurity and other retinal disorders. Efforts are ongoing to investigate the role of the anti-vascular endothelial growth factor drug, bevasizumab in treating severe ROP.

Strabismus associated with macular translocation surgery - Together with Cynthia Toth, Freedman continues to surgically treat the cyclotorsion and strabismus resulting from macular translocation surgery (now reserved for special cases of macular degeneration that are resistent to injection therapy. She has developed and published on new extraocular muscle surgical techniques to deal with this problem.

Current Appointments & Affiliations


Professor of Ophthalmology · 2007 - Present Ophthalmology, Clinical Science Departments
Chief, Pediatric Ophthalmology · 2008 - Present Ophthalmology, Clinical Science Departments
Professor of Pediatrics · 2007 - Present Pediatrics, Clinical Science Departments

Recent Publications


Quantitative comparison of vascular characteristics of plus disease images published over time: International Classification of Retinopathy of Prematurity.

Journal Article J AAPOS · February 2025 Plus disease was first defined in the original International Classification of retinopathy of prematurity (ICROP) publication in 1984. Over time, the definition of plus disease has evolved, and each ensuing ICROP publication has included example plus disea ... Full text Link to item Cite

In Vivo Assessment of the Pediatric Trabecular Meshwork, Schlemm Canal, and Iridocorneal Angle Using Overhead-Mounted Optical Coherence Tomography.

Journal Article Am J Ophthalmol · January 2025 PURPOSE: To describe the in vivo morphologic characteristics of the trabecular meshwork (TM), Schlemm canal (SC), and iridocorneal angle in pediatric patients with normal eyes, glaucoma, and cataract. DESIGN: Prospective cohort study. STUDY POPULATION: A t ... Full text Link to item Cite

Refractive Change at 5 Years in the Toddler Aphakia and Pseudophakia Study.

Journal Article Ophthalmology · December 16, 2024 PURPOSE: To report refractive change at 5 years of age in children with pseudophakic eyes operated on before 2 years of age. DESIGN: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. PARTICIPANTS: Children who underwent cataract ... Full text Link to item Cite
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Recent Grants


North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2001 - 2030

Analyzing retinal microanatomy in retinopathy of prematurity to improve care

ResearchCo Investigator · Awarded by National Eye Institute · 2021 - 2026

Bevacizumab Treatment for Posterior Zone I Retinopathy of Prematurity (ROP4)

Clinical TrialPrincipal Investigator · Awarded by Jaeb Center For Health Research · 2021 - 2025

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Education, Training & Certifications


Harvard University · 1985 M.D.
Duke University · 1981 B.S.