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Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus.

Publication ,  Journal Article
Liu, J; Saleem, Z; Wang, B; Go, M; Cheung, NL; White, QW; Ferreira, A; Naithani, R; El-Dairi, M; Freedman, SF
Published in: Sci Rep
December 26, 2025

Virtual reality field (VRF) perimetry is a promising new tool for visual field assessments, offering both monocular and binocular testing modes. We aimed to examine whether ocular misalignment, known as strabismus, influences VRF outcomes between monocular and binocular testing modes, which is currently unknown. Children with non-amblyopic horizontal strabismus were enrolled and completed VRF testing (Olleyes VisuALL) in either the game-based or standard Humphrey visual field (HVF)-equivalent algorithm. Within their respective algorithms, participants completed tests in both monocular and binocular modes. Analyzed parameters included mean deviation (MD), pattern standard deviation (PSD), and foveal sensitivity (FS). Additionally, a masked ophthalmologist graded whether the VRF was abnormal. Twenty-two children (44 eyes) were enrolled with a mean age of 12.1 ± 2.7 years. Regarding MD, participants who took the game-based algorithm compared to the HVF-equivalent yielded better scores (P = 0.048). For PSD, older participants exhibited better scores than younger participants (P = 0.038). Binocular and monocular mode testing were similar across all parameters, and yielded equal rates of abnormal test results (22.7% vs. 22.7%; P = 1.00). Overall, non-amblyopic horizontally strabismic children demonstrated comparable VRF outcomes in both monocular and binocular testing modes, suggesting similar utility between exam options.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 26, 2025

Volume

16

Issue

1

Start / End Page

2308

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, J., Saleem, Z., Wang, B., Go, M., Cheung, N. L., White, Q. W., … Freedman, S. F. (2025). Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus. Sci Rep, 16(1), 2308. https://doi.org/10.1038/s41598-025-32029-3
Liu, Jeffrey, Zara Saleem, Bo Wang, Michelle Go, Nathan L. Cheung, Qiaohui W. White, Adriana Ferreira, Rizul Naithani, Mays El-Dairi, and Sharon F. Freedman. “Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus.Sci Rep 16, no. 1 (December 26, 2025): 2308. https://doi.org/10.1038/s41598-025-32029-3.
Liu J, Saleem Z, Wang B, Go M, Cheung NL, White QW, et al. Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus. Sci Rep. 2025 Dec 26;16(1):2308.
Liu, Jeffrey, et al. “Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus.Sci Rep, vol. 16, no. 1, Dec. 2025, p. 2308. Pubmed, doi:10.1038/s41598-025-32029-3.
Liu J, Saleem Z, Wang B, Go M, Cheung NL, White QW, Ferreira A, Naithani R, El-Dairi M, Freedman SF. Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus. Sci Rep. 2025 Dec 26;16(1):2308.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 26, 2025

Volume

16

Issue

1

Start / End Page

2308

Location

England