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Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions.

Publication ,  Journal Article
Liang, S; Yao, J; Bourne, PA; diSant'Agnese, PA; Huang, J; Lei, J-Y
Published in: Am J Clin Pathol
November 2004

The expression of human carcinoma-associated antigen (HCA), a mucin-type glycoprotein, was assessed in 50 esophagogastrectomy specimens. Areas, each from different cases, of Barrett esophagus (n = 36), low-grade dysplasia (n = 38), high-grade dysplasia/carcinoma in situ (n = 26), and esophageal adenocarcinoma (EAC; n = 34) were examined by immunohistochemical stains to 2 anti-HCA monoclonal antibodies, G1 and HAE3. These two antibodies showed similar staining patterns. HCA was overexpressed significantly in EAC and high-grade dysplasia/carcinoma in situ compared with benign esophageal mucosa (P < .001 for both), Barrett esophagus (P < .001 for both), and low-grade dysplasia (P < .025 for both). HCA overexpression did not correlate with the grade of EAC (P > .1). The results suggest that overexpression of HCA might help in diagnosing esophageal dysplasia and cancer. The correlation of HCA with the grade of esophageal dysplasia suggests its possible involvement in the pathogenesis of EAC. HCA also might provide a target for immunotherapy.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

November 2004

Volume

122

Issue

5

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Esophageal Neoplasms
  • Carcinoma in Situ
  • Biomarkers, Tumor
 

Citation

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Chicago
ICMJE
MLA
NLM
Liang, S., Yao, J., Bourne, P. A., diSant’Agnese, P. A., Huang, J., & Lei, J.-Y. (2004). Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. Am J Clin Pathol, 122(5), 747–751. https://doi.org/10.1309/02AP-A6AP-GL43-GCTR
Liang, Songlin, Jorge Yao, Patricia A. Bourne, P Anthony diSant’Agnese, Jiaoti Huang, and Jun-Yi Lei. “Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions.Am J Clin Pathol 122, no. 5 (November 2004): 747–51. https://doi.org/10.1309/02AP-A6AP-GL43-GCTR.
Liang S, Yao J, Bourne PA, diSant’Agnese PA, Huang J, Lei J-Y. Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. Am J Clin Pathol. 2004 Nov;122(5):747–51.
Liang, Songlin, et al. “Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions.Am J Clin Pathol, vol. 122, no. 5, Nov. 2004, pp. 747–51. Pubmed, doi:10.1309/02AP-A6AP-GL43-GCTR.
Liang S, Yao J, Bourne PA, diSant’Agnese PA, Huang J, Lei J-Y. Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. Am J Clin Pathol. 2004 Nov;122(5):747–751.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

November 2004

Volume

122

Issue

5

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Esophageal Neoplasms
  • Carcinoma in Situ
  • Biomarkers, Tumor