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Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.

Publication ,  Journal Article
Huang, J; Yao, JL; Zhang, L; Bourne, PA; Quinn, AM; di Sant'Agnese, PA; Reeder, JE
Published in: Am J Pathol
June 2005

Hormonal therapy (androgen ablation and/or inhibition of androgen action) is the treatment of choice for advanced prostate cancer. After an initial response in most patients, tumors invariably progress to an androgen-independent state. It is unclear how prostate cancer cells proliferate without androgen. Recent studies suggest that interleukin-8 may promote androgen-independent proliferation, but the source of interleukin-8 in the prostate is unknown. Using immunohistochemistry, we show that interleukin-8 was expressed by the neuroendocrine tumor cells in human prostate cancer tissue. Expression of the interleukin-8 receptor CXCR1 was negative or low in benign prostatic tissue and was frequently increased in malignant cells of high-grade prostatic intraepithelial neoplasia and prostate cancer; however, CXCR1 was not detected in the neuroendocrine tumor cells, suggesting a paracrine mechanism by which interleukin-8 produced by neuroendocrine tumor cells stimulates androgen-independent proliferation of prostate cancer. Neuroendocrine tumor cells expressed another type of interleukin-8 receptor, CXCR2, suggesting an autocrine mechanism by which interleukin-8 regulates the differentiation or function of the neuroendocrine cells. These results, combined with previous reports that neuroendocrine differentiation is induced by hormonal therapy, suggest that neuroendocrine cells play an important role in promoting androgen-independent growth of prostate cancer through interleukin-8 signaling.

Duke Scholars

Published In

Am J Pathol

DOI

ISSN

0002-9440

Publication Date

June 2005

Volume

166

Issue

6

Start / End Page

1807 / 1815

Location

United States

Related Subject Headings

  • Receptors, Interleukin-8B
  • Receptors, Interleukin-8A
  • Prostatic Neoplasms
  • Pathology
  • Male
  • Interleukin-8
  • Immunohistochemistry
  • Humans
  • Carcinoma, Neuroendocrine
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, J., Yao, J. L., Zhang, L., Bourne, P. A., Quinn, A. M., di Sant’Agnese, P. A., & Reeder, J. E. (2005). Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol, 166(6), 1807–1815. https://doi.org/10.1016/S0002-9440(10)62490-X
Huang, Jiaoti, Jorge L. Yao, Li Zhang, Patricia A. Bourne, Andrew M. Quinn, P Anthony di Sant’Agnese, and Jay E. Reeder. “Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.Am J Pathol 166, no. 6 (June 2005): 1807–15. https://doi.org/10.1016/S0002-9440(10)62490-X.
Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant’Agnese PA, et al. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol. 2005 Jun;166(6):1807–15.
Huang, Jiaoti, et al. “Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.Am J Pathol, vol. 166, no. 6, June 2005, pp. 1807–15. Pubmed, doi:10.1016/S0002-9440(10)62490-X.
Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant’Agnese PA, Reeder JE. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol. 2005 Jun;166(6):1807–1815.
Journal cover image

Published In

Am J Pathol

DOI

ISSN

0002-9440

Publication Date

June 2005

Volume

166

Issue

6

Start / End Page

1807 / 1815

Location

United States

Related Subject Headings

  • Receptors, Interleukin-8B
  • Receptors, Interleukin-8A
  • Prostatic Neoplasms
  • Pathology
  • Male
  • Interleukin-8
  • Immunohistochemistry
  • Humans
  • Carcinoma, Neuroendocrine
  • 42 Health sciences