Skip to main content
Journal cover image

High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study.

Publication ,  Journal Article
Podolanczuk, AJ; Oelsner, EC; Barr, RG; Hoffman, EA; Armstrong, HF; Austin, JHM; Basner, RC; Bartels, MN; Christie, JD; Enright, PL; Newell, JD ...
Published in: Eur Respir J
November 2016

Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between -600 and -250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3-11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8-13.0), lower forced vital capacity (FVC) (mean adjusted difference -82 mL, 95% CI -119--44), lower 6-min walk distance (mean adjusted difference -40 m, 95% CI -1--80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43-2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39-1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur Respir J

DOI

EISSN

1399-3003

Publication Date

November 2016

Volume

48

Issue

5

Start / End Page

1442 / 1452

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Spirometry
  • Smoking
  • Respiratory System
  • Radiography, Thoracic
  • Proportional Hazards Models
  • Middle Aged
  • Matrix Metalloproteinase 7
  • Male
  • Lung Diseases, Interstitial
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Podolanczuk, A. J., Oelsner, E. C., Barr, R. G., Hoffman, E. A., Armstrong, H. F., Austin, J. H. M., … Lederer, D. J. (2016). High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. Eur Respir J, 48(5), 1442–1452. https://doi.org/10.1183/13993003.00129-2016
Podolanczuk, Anna J., Elizabeth C. Oelsner, R Graham Barr, Eric A. Hoffman, Hilary F. Armstrong, John H. M. Austin, Robert C. Basner, et al. “High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study.Eur Respir J 48, no. 5 (November 2016): 1442–52. https://doi.org/10.1183/13993003.00129-2016.
Podolanczuk AJ, Oelsner EC, Barr RG, Hoffman EA, Armstrong HF, Austin JHM, et al. High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. Eur Respir J. 2016 Nov;48(5):1442–52.
Podolanczuk, Anna J., et al. “High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study.Eur Respir J, vol. 48, no. 5, Nov. 2016, pp. 1442–52. Pubmed, doi:10.1183/13993003.00129-2016.
Podolanczuk AJ, Oelsner EC, Barr RG, Hoffman EA, Armstrong HF, Austin JHM, Basner RC, Bartels MN, Christie JD, Enright PL, Gochuico BR, Hinckley Stukovsky K, Kaufman JD, Hrudaya Nath P, Newell JD, Palmer SM, Rabinowitz D, Raghu G, Sell JL, Sieren J, Sonavane SK, Tracy RP, Watts JR, Williams K, Kawut SM, Lederer DJ. High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. Eur Respir J. 2016 Nov;48(5):1442–1452.
Journal cover image

Published In

Eur Respir J

DOI

EISSN

1399-3003

Publication Date

November 2016

Volume

48

Issue

5

Start / End Page

1442 / 1452

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Spirometry
  • Smoking
  • Respiratory System
  • Radiography, Thoracic
  • Proportional Hazards Models
  • Middle Aged
  • Matrix Metalloproteinase 7
  • Male
  • Lung Diseases, Interstitial