Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.

Published

Journal Article

Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal somata and dendrites remain unmyelinated. Utilizing a purified spinal cord neuron-oligodendrocyte myelinating co-culture system, we demonstrate that disruption of dynamic neuron-oligodendrocyte signaling by chemical cross-linking results in aberrant myelination of the somatodendritic compartment of neurons. We hypothesize that an inhibitory somatodendritic cue is necessary to prevent non-axonal myelination. Using next-generation sequencing and candidate profiling, we identify neuronal junction adhesion molecule 2 (JAM2) as an inhibitory myelin-guidance molecule. Taken together, our results demonstrate that the somatodendritic compartment directly inhibits myelination and suggest a model in which broadly indiscriminate myelination is tailored by inhibitory signaling to meet local myelination requirements.

Full Text

Duke Authors

Cited Authors

  • Redmond, SA; Mei, F; Eshed-Eisenbach, Y; Osso, LA; Leshkowitz, D; Shen, Y-AA; Kay, JN; Aurrand-Lions, M; Lyons, DA; Peles, E; Chan, JR

Published Date

  • August 17, 2016

Published In

Volume / Issue

  • 91 / 4

Start / End Page

  • 824 - 836

PubMed ID

  • 27499083

Pubmed Central ID

  • 27499083

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2016.07.021

Language

  • eng

Conference Location

  • United States