Jeremy N. Kay | Scholars@Duke

Jeremy N. Kay
Assistant Professor of Neurobiology

We study how neural circuits devoted to specific visual processing tasks arise during development of the retina, and the consequences for circuit function when development goes wrong. The tools of mouse genetics are central to our approach, and we draw on a wide range of molecular, genetic, and imaging methods.

Current Appointments & Affiliations

Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2012
Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2012
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017

Contact Information

Box 3802, Duec, Durham, NC 27710
jeremy.kay@duke.edu
Kay Lab

Background
Education, Training, & Certifications
- Ph.D., University of California - San Francisco 2004
Duke Appointment History
- Investigator Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2012 - 2016
Recognition
In the News
- JUN 24, 2014
  
  Two Neurobiology Faculty Win Pew Scholarships
- FEB 18, 2014
  
  Five Science Faculty Win Sloan Fellowships
Awards & Honors
- Pew Scholars in the Biomedical Sciences. Pew Charitable Trusts. 2014
- Sloan Research Fellowship-Neuroscience. Alfred P. Sloan Foundation. 2014
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Repulsive mechanisms for spatial segregation of developing neural circuits awarded by National Institutes of Health 2017 - 2020
- Muller glial dysfunction in retinal edema awarded by National Institutes of Health 2016 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Molecular & cellular cues for circuit assembly in mouse retina awarded by National Institutes of Health 2016 - 2019
- Molecular control of neuronal position during retinal development awarded by National Institutes of Health 2014 - 2019
- Molecular cues for visual circuit assembly in developing retina awarded by Pew Charitable Trusts 2014 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Cell-cell recognition mechanisms for neural circuit wiring in the retina awarded by Alfred P. Sloan Foundation 2014 - 2016
- NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - O’Koren, Emily G., et al. “Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration..” Immunity, vol. 50, no. 3, Mar. 2019, pp. 723-737.e7. Epmc, doi:10.1016/j.immuni.2019.02.007.
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  - Prigge, Cameron L., and Jeremy N. Kay. “Dendrite morphogenesis from birth to adulthood..” Current Opinion in Neurobiology, vol. 53, Dec. 2018, pp. 139–45. Epmc, doi:10.1016/j.conb.2018.07.007.
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  - Ray, Thomas A., et al. “Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact..” Elife, vol. 7, Apr. 2018. Epmc, doi:10.7554/eLife.34241.
    Full Text Open Access Copy
  - O’Sullivan, Matthew L., et al. “Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development..” Glia, vol. 65, no. 10, Oct. 2017, pp. 1697–716. Epmc, doi:10.1002/glia.23189.
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  - Wang, Jingjing, et al. “Anatomy and spatial organization of Müller glia in mouse retina..” The Journal of Comparative Neurology, vol. 525, no. 8, June 2017, pp. 1759–77. Epmc, doi:10.1002/cne.24153.
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  - Kay, Jeremy N. “Radial migration: Retinal neurons hold on for the ride..” The Journal of Cell Biology, vol. 215, no. 2, Oct. 2016, pp. 147–49. Epmc, doi:10.1083/jcb.201609135.
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  - Redmond, Stephanie A., et al. “Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination..” Neuron, vol. 91, no. 4, Aug. 2016, pp. 824–36. Epmc, doi:10.1016/j.neuron.2016.07.021.
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  - Visser, Jasper J., et al. “An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina..” Elife, vol. 4, Dec. 2015. Epmc, doi:10.7554/eLife.08149.
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  - Lefebvre, Julie L., et al. “Development of dendritic form and function..” Annual Review of Cell and Developmental Biology, vol. 31, Jan. 2015, pp. 741–77. Epmc, doi:10.1146/annurev-cellbio-100913-013020.
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  - Whitney, Irene E., et al. “Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 34, no. 30, July 2014, pp. 10109–21. Epmc, doi:10.1523/JNEUROSCI.0415-14.2014.
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  - Ford, Kevin J., et al. “A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells..” Journal of Neurophysiology, vol. 109, no. 9, May 2013, pp. 2250–59. Epmc, doi:10.1152/jn.01085.2012.
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  - Kay, Jeremy N., et al. “MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons..” Nature, vol. 483, no. 7390, Mar. 2012, pp. 465–69. Epmc, doi:10.1038/nature10877.
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  - Kay, Jeremy N., et al. “Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate..” Nature Neuroscience, vol. 14, no. 8, July 2011, pp. 965–72. Epmc, doi:10.1038/nn.2859.
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  - Kay, Jeremy N., et al. “Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 31, no. 21, May 2011, pp. 7753–62. Epmc, doi:10.1523/JNEUROSCI.0907-11.2011.
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  - Voinescu, P. Emanuela, et al. “Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position..” The Journal of Comparative Neurology, vol. 517, no. 5, Dec. 2009, pp. 737–50. Epmc, doi:10.1002/cne.22200.
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  - Muto, A., et al. “Forward genetic analysis of visual behavior in zebrafish.” Plos Genetics, vol. 1, no. 5, Dec. 2005, pp. 575–88.
  - Kay, Jeremy N., et al. “Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina..” Development (Cambridge, England), vol. 132, no. 11, June 2005, pp. 2573–85. Epmc, doi:10.1242/dev.01831.
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  - Kay, Jeremy N., et al. “Transient requirement for ganglion cells during assembly of retinal synaptic layers..” Development (Cambridge, England), vol. 131, no. 6, Mar. 2004, pp. 1331–42. Epmc, doi:10.1242/dev.01040.
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  - Kay, J. N., et al. “Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog..” Neuron, vol. 30, no. 3, June 2001, pp. 725–36. Epmc, doi:10.1016/s0896-6273(01)00312-9.
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  - Kay, J. N., and M. Blum. “Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection..” Developmental Neuroscience, vol. 22, no. 1–2, Jan. 2000, pp. 56–67. Epmc, doi:10.1159/000017427.
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  - Kay, J. N., et al. “Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus..” Journal of Neurobiology, vol. 40, no. 3, Sept. 1999, pp. 375–85. Epmc, doi:10.1002/(sici)1097-4695(19990905)40:3<375::aid-neu9>3.0.co;2-a.
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  - Kay, J. N., et al. “Trophic effects of androgen: Development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus.” Journal of Neurobiology, vol. 40, no. 3, 1999, pp. 375–85. Scival, doi:10.1002/(SICI)1097-4695(19990905)40:3<375::AID-NEU9>3.0.CO;2-A.
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- Other Articles
  - Ray, Thomas, et al. Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact. 18 Dec. 2017. Epmc, doi:10.1101/235978.
    Full Text
  - Ray, Thomas A., and Jeremy N. Kay. “Following directions from the retina to the brain..” Neuron, vol. 86, no. 4, May 2015, pp. 855–57. Epmc, doi:10.1016/j.neuron.2015.05.017.
    Full Text
  - Voinescu, P. E., et al. “Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position (The Journal of Comparative Neurology (2009) 517, (737-750)).” Journal of Comparative Neurology, vol. 518, no. 2, 15 Jan. 2010. Scopus, doi:10.1002/cne.22253.
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  - Kay, Jeremy N., and Herwig Baier. “Out-foxing fate; molecular switches create neuronal diversity in the retina..” Neuron, vol. 43, no. 6, Sept. 2004, pp. 759–60. Epmc, doi:10.1016/j.neuron.2004.09.001.
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- Conference Papers
  - Kay, Jeremy N., and Megan Stogsdill. “Starburst amacrine cells orchestrate assembly of retinal direction-selective circuitry.” Investigative Ophthalmology & Visual Science, vol. 56, no. 7, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
    Link to Item
Teaching & Mentoring
Recent Courses
- COMPSCI 394: Research Independent Study 2019
- NEUROBIO 393: Research Independent Study 2019
- NEUROBIO 719B: Cell Biology of the Neuron 2019
- NEUROBIO 790S: Student Seminar (Topics) 2019
- NEUROBIO 793: Research in Neurobiology 2019
- NEUROSCI 494: Research Independent Study 2 2019
- NEUROBIO 719D: Brain Development 2018
- NEUROSCI 150: Research Practicum 2018
- NEUROSCI 493: Research Independent Study 1 2018

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Other Articles

Conference Papers

Recent Courses