The Expanding Clinical Spectrum of Genetic Pediatric Epileptic Encephalopathies.
Pediatric epileptic encephalopathies represent a clinically challenging and often devastating group of disorders that affect children at different stages of infancy and childhood. With the advances in genetic testing and neuroimaging, the etiologies of these epileptic syndromes are now better defined. The various encephalopathies that are reviewed in this article include the following: early infantile epileptic encephalopathy or Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, West syndrome, severe myoclonic epilepsy in infancy (Dravet syndrome), Landau-Kleffner syndrome, Lennox-Gastaut syndrome, and epileptic encephalopathy with continuous spike-and-wave during sleep. Their clinical features, prognosis as well as underlying genetic etiologies are presented and updated.
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Related Subject Headings
- Spasms, Infantile
- Neurology & Neurosurgery
- Lennox Gastaut Syndrome
- Landau-Kleffner Syndrome
- Infant
- Humans
- Epilepsies, Myoclonic
- 3213 Paediatrics
- 3209 Neurosciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Spasms, Infantile
- Neurology & Neurosurgery
- Lennox Gastaut Syndrome
- Landau-Kleffner Syndrome
- Infant
- Humans
- Epilepsies, Myoclonic
- 3213 Paediatrics
- 3209 Neurosciences