The Expanding Clinical Spectrum of Genetic Pediatric Epileptic Encephalopathies.

Journal Article (Journal Article;Review)

Pediatric epileptic encephalopathies represent a clinically challenging and often devastating group of disorders that affect children at different stages of infancy and childhood. With the advances in genetic testing and neuroimaging, the etiologies of these epileptic syndromes are now better defined. The various encephalopathies that are reviewed in this article include the following: early infantile epileptic encephalopathy or Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, West syndrome, severe myoclonic epilepsy in infancy (Dravet syndrome), Landau-Kleffner syndrome, Lennox-Gastaut syndrome, and epileptic encephalopathy with continuous spike-and-wave during sleep. Their clinical features, prognosis as well as underlying genetic etiologies are presented and updated.

Full Text

Duke Authors

Cited Authors

  • Shbarou, R; Mikati, MA

Published Date

  • May 2016

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 134 - 142

PubMed ID

  • 27544470

Electronic International Standard Serial Number (EISSN)

  • 1558-0776

Digital Object Identifier (DOI)

  • 10.1016/j.spen.2016.06.002


  • eng

Conference Location

  • United States