Localized force application reveals mechanically sensitive domains of Piezo1.

Published

Journal Article

Piezos are mechanically activated ion channels that function as sensors of touch and pressure in various cell types. However, the precise mechanism and structures mediating mechanical activation and subsequent inactivation have not yet been identified. Here we use magnetic nanoparticles as localized transducers of mechanical force in combination with pressure-clamp electrophysiology to identify mechanically sensitive domains important for activation and inactivation.

Full Text

Duke Authors

Cited Authors

  • Wu, J; Goyal, R; Grandl, J

Published Date

  • October 3, 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 12939 -

PubMed ID

  • 27694883

Pubmed Central ID

  • 27694883

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms12939

Language

  • eng