Jorg Grandl
Associate Professor of Neurobiology

Ion channels can be activated (gated) by various stimuli such as chemicals, voltage, pressure and temperature. We develop novel biophysical techniques to identify mechanisms of ion channel function.

Current Research Interests

Molecular and Cellular Mechanisms of Mechanotransduction

Every organ, tissue and cell of the human body is constantly exposed to mechanical forces. Life evolved mechanisms to detect these mechanical forces and translate them into electrical or chemical signals. This process is called mechanotransduction and enables organs, tissues and cells to adequately respond.

The Grandl Lab particularly focuses on rapid mechanotransduction, which is initiated within less than one millisecond and enabled by force-gated ion channels. In order to capture such fast processes we routinely use immortalized cell-lines to express our ion channels of interest and patch-clamp electrophysiology to measure their activity with sub-millisecond precision. A particular strength of our lab is the development of novel biophysical approaches to investigate and ultimately understand mechanotransduction.

Our research contributes to understanding fundamental biology, such as the sense of light touch, and human disease, such as inflammatory pain, chronic pain, and itch. As a consequence the results of our work are of broad interest for the development of treatments of disease.

Two fundamental questions drive our work:

1) How do force-gated ion channels work?

We want to understand how mechanical energy gates (activates, inactivates and deactivates) ion channels and how compromising specific aspects of gating leads to human diseases.

 

2) How are cells sensing mechanical energy?

We aim to explain how many individual force-gated ion channels function in concert and give rise to complex mechanotransduction in living cells.

Current Appointments & Affiliations

Contact Information

  • Box 3209 Med Ctr, Durham, NC 27710
  • Bryan Research Building, 311 Research Drive Room 327G, Durham, NC 27710
  • uri icon Grandl Lab

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.