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Jorg Grandl

Associate Professor of Neurobiology
Neurobiology
Box 3209 Med Ctr, Durham, NC 27710
Bryan Research Building, 311 Research Drive Room 327G, Durham, NC 27710

Research Interests


Our Research Focus

We investigate the biophysics of force-gated ion channels and cellular mechanotransduction. A particular strength of our lab is the development of novel biophysical approaches. Our research is important for understanding physiological processes for the sensing of external forces, such as light touch, and internal forces, such as cellular stiffness. It may help the development of treatments against human diseases, such as chronic pain, inflammatory pain, and itch.

Our Questions

Two main questions drive our work: 1) How do force-gated ion channels work? We want to understand how mechanical energy gates (activates, inactivates and deactivates) ion channels and how compromising specific aspects of gating leads to human diseases. 2) How do force-gated ion channels function in complex cellular environments? We aim to explain how many individual force-gated ion channels function in concert and give rise to complex mechanotransduction in living cells.

Visit the Grandl Lab webpage

Selected Grants


Investigating mechanisms of cell volume regulation in the zebrafish notochord

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Mechanisms of Pancreatic Fibrosis

ResearchInvestigator · Awarded by National Institutes of Health · 2020 - 2025

Mechanisms of Disease associated with mechanically-activated Piezo ion channels

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2020 - 2025

Neurobiology Training Program

Inst. Training Prgm or CMECo-Director · Awarded by National Institutes of Health · 2019 - 2024

Investigating mechanisms of cell volume regulation in the zebrafish notochord

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Mechanisms of Pancreatic Fibrosis

ResearchInvestigator · Awarded by National Institutes of Health · 2020 - 2025

Mechanisms of Disease associated with mechanically-activated Piezo ion channels

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2020 - 2025

Neurobiology Training Program

Inst. Training Prgm or CMECo-Director · Awarded by National Institutes of Health · 2019 - 2024

Mechanisms of mechanically-induced acute pancreatitis

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2023

LUMICKS C-TRAP

EquipmentMinor User · Awarded by National Institutes of Health · 2022 - 2023

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

The mechanism of temperature-activation of TRP ion channels

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2020

Role of S100A4 in Lens Homeostasis and Function

ResearchCollaborator · Awarded by National Institutes of Health · 2016 - 2019

Identifying the physical stimuli for activation and sensitization of Piezo mechanosensitive ion channels

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2019

Basic predoctoral training in neuroscience

Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 1992 - 2018

Identifying the mechanosensitive domains of the Piezo1 ion channel by application of localized force

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017

Structural Biology and Biophysics Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015