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Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients.

Publication ,  Journal Article
Wonkam, A; Makani, J; Ofori-Aquah, S; Nnodu, OE; Treadwell, M; Royal, C; Ohene-Frempong, K; Members of the H3Africa Consortium,
Published in: Cardiovascular journal of Africa
March 2015

Sickle cell disease (SCD) has a high prevalence in sub-Saharan Africa. There are several cardiovascular phenotypes in SCD that contribute to its morbidity and mortality.SCD is characterised by marked clinical variability, with genetic factors playing key modulating roles. Studies in Tanzania and Cameroon have reported that singlenucleotide polymorphisms in BCL11A and HBS1L-MYB loci and co-inheritance of alpha-thalassaemia impact on foetal haemoglobin levels and clinical severity. The prevalence of overt stroke among SCD patients in Cameroon (6.7%) and Nigeria (8.7%) suggests a higher burden than in high-income countries. There is also some evidence of high burden of kidney disease and pulmonary hypertension in SCD; however, the burden and genetics of these cardiovascular conditions have seldom been investigated in Africa.Several H3Africa projects are focused on cardiovascular diseases and present major opportunities to build genome-based research on existing SCD platforms in Africa to transform the health outcomes of patients.

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Published In

Cardiovascular journal of Africa

DOI

EISSN

1680-0745

ISSN

1995-1892

Publication Date

March 2015

Volume

26

Issue

2 Suppl 1

Start / End Page

S50 / S55

Related Subject Headings

  • Research
  • Prevalence
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • General & Internal Medicine
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Anemia, Sickle Cell
  • Africa
 

Citation

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Wonkam, A., Makani, J., Ofori-Aquah, S., Nnodu, O. E., Treadwell, M., Royal, C., … Members of the H3Africa Consortium, . (2015). Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients. Cardiovascular Journal of Africa, 26(2 Suppl 1), S50–S55. https://doi.org/10.5830/cvja-2015-040
Wonkam, Ambroise, Julie Makani, Solomon Ofori-Aquah, Obiageli E. Nnodu, Marsha Treadwell, Charmaine Royal, Kwaku Ohene-Frempong, and Kwaku Members of the H3Africa Consortium. “Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients.Cardiovascular Journal of Africa 26, no. 2 Suppl 1 (March 2015): S50–55. https://doi.org/10.5830/cvja-2015-040.
Wonkam A, Makani J, Ofori-Aquah S, Nnodu OE, Treadwell M, Royal C, et al. Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients. Cardiovascular journal of Africa. 2015 Mar;26(2 Suppl 1):S50–5.
Wonkam, Ambroise, et al. “Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients.Cardiovascular Journal of Africa, vol. 26, no. 2 Suppl 1, Mar. 2015, pp. S50–55. Epmc, doi:10.5830/cvja-2015-040.
Wonkam A, Makani J, Ofori-Aquah S, Nnodu OE, Treadwell M, Royal C, Ohene-Frempong K, Members of the H3Africa Consortium. Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients. Cardiovascular journal of Africa. 2015 Mar;26(2 Suppl 1):S50–S55.

Published In

Cardiovascular journal of Africa

DOI

EISSN

1680-0745

ISSN

1995-1892

Publication Date

March 2015

Volume

26

Issue

2 Suppl 1

Start / End Page

S50 / S55

Related Subject Headings

  • Research
  • Prevalence
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • General & Internal Medicine
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Anemia, Sickle Cell
  • Africa