Tetomilast: new promise for phosphodiesterase-4 inhibitors?
Journal Article (Journal Article;Review)
INTRODUCTION: Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the treatment of IBD. AREAS COVERED: Peer-reviewed publications, including Phase I and II clinical trials, all other formats included. EXPERT OPINION: Tetomilast may be beneficial in IBD. Small differences in molecules and in recombinant proteins can translate into substantial differences in clinical effects and toxicity in IBD. This is a reasonable approach when exploring new options like tetomilast.
Full Text
Duke Authors
Cited Authors
- Bickston, SJ; Snider, KR; Kappus, MR
Published Date
- December 2012
Published In
Volume / Issue
- 21 / 12
Start / End Page
- 1845 - 1849
PubMed ID
- 23043390
Electronic International Standard Serial Number (EISSN)
- 1744-7658
Digital Object Identifier (DOI)
- 10.1517/13543784.2012.732065
Language
- eng
Conference Location
- England