Tetomilast: new promise for phosphodiesterase-4 inhibitors?

Journal Article (Journal Article;Review)

INTRODUCTION: Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the treatment of IBD. AREAS COVERED: Peer-reviewed publications, including Phase I and II clinical trials, all other formats included. EXPERT OPINION: Tetomilast may be beneficial in IBD. Small differences in molecules and in recombinant proteins can translate into substantial differences in clinical effects and toxicity in IBD. This is a reasonable approach when exploring new options like tetomilast.

Full Text

Duke Authors

Cited Authors

  • Bickston, SJ; Snider, KR; Kappus, MR

Published Date

  • December 2012

Published In

Volume / Issue

  • 21 / 12

Start / End Page

  • 1845 - 1849

PubMed ID

  • 23043390

Electronic International Standard Serial Number (EISSN)

  • 1744-7658

Digital Object Identifier (DOI)

  • 10.1517/13543784.2012.732065


  • eng

Conference Location

  • England