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Tetomilast: new promise for phosphodiesterase-4 inhibitors?

Publication ,  Journal Article
Bickston, SJ; Snider, KR; Kappus, MR
Published in: Expert Opin Investig Drugs
December 2012

INTRODUCTION: Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the treatment of IBD. AREAS COVERED: Peer-reviewed publications, including Phase I and II clinical trials, all other formats included. EXPERT OPINION: Tetomilast may be beneficial in IBD. Small differences in molecules and in recombinant proteins can translate into substantial differences in clinical effects and toxicity in IBD. This is a reasonable approach when exploring new options like tetomilast.

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Published In

Expert Opin Investig Drugs

DOI

EISSN

1744-7658

Publication Date

December 2012

Volume

21

Issue

12

Start / End Page

1845 / 1849

Location

England

Related Subject Headings

  • Thiazoles
  • Phosphodiesterase 4 Inhibitors
  • Pharmacology & Pharmacy
  • Inflammatory Bowel Diseases
  • Humans
  • Anti-Inflammatory Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3211 Oncology and carcinogenesis
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Bickston, S. J., Snider, K. R., & Kappus, M. R. (2012). Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs, 21(12), 1845–1849. https://doi.org/10.1517/13543784.2012.732065
Bickston, Stephen J., Kenneth R. Snider, and Matthew R. Kappus. “Tetomilast: new promise for phosphodiesterase-4 inhibitors?Expert Opin Investig Drugs 21, no. 12 (December 2012): 1845–49. https://doi.org/10.1517/13543784.2012.732065.
Bickston SJ, Snider KR, Kappus MR. Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs. 2012 Dec;21(12):1845–9.
Bickston, Stephen J., et al. “Tetomilast: new promise for phosphodiesterase-4 inhibitors?Expert Opin Investig Drugs, vol. 21, no. 12, Dec. 2012, pp. 1845–49. Pubmed, doi:10.1517/13543784.2012.732065.
Bickston SJ, Snider KR, Kappus MR. Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs. 2012 Dec;21(12):1845–1849.

Published In

Expert Opin Investig Drugs

DOI

EISSN

1744-7658

Publication Date

December 2012

Volume

21

Issue

12

Start / End Page

1845 / 1849

Location

England

Related Subject Headings

  • Thiazoles
  • Phosphodiesterase 4 Inhibitors
  • Pharmacology & Pharmacy
  • Inflammatory Bowel Diseases
  • Humans
  • Anti-Inflammatory Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3211 Oncology and carcinogenesis
  • 1115 Pharmacology and Pharmaceutical Sciences