Tetomilast: new promise for phosphodiesterase-4 inhibitors?
Publication
, Journal Article
Bickston, SJ; Snider, KR; Kappus, MR
Published in: Expert Opin Investig Drugs
December 2012
INTRODUCTION: Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the treatment of IBD. AREAS COVERED: Peer-reviewed publications, including Phase I and II clinical trials, all other formats included. EXPERT OPINION: Tetomilast may be beneficial in IBD. Small differences in molecules and in recombinant proteins can translate into substantial differences in clinical effects and toxicity in IBD. This is a reasonable approach when exploring new options like tetomilast.
Duke Scholars
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Published In
Expert Opin Investig Drugs
DOI
EISSN
1744-7658
Publication Date
December 2012
Volume
21
Issue
12
Start / End Page
1845 / 1849
Location
England
Related Subject Headings
- Thiazoles
- Phosphodiesterase 4 Inhibitors
- Pharmacology & Pharmacy
- Inflammatory Bowel Diseases
- Humans
- Anti-Inflammatory Agents
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 3211 Oncology and carcinogenesis
- 1115 Pharmacology and Pharmaceutical Sciences
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ICMJE
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Bickston, S. J., Snider, K. R., & Kappus, M. R. (2012). Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs, 21(12), 1845–1849. https://doi.org/10.1517/13543784.2012.732065
Bickston, Stephen J., Kenneth R. Snider, and Matthew R. Kappus. “Tetomilast: new promise for phosphodiesterase-4 inhibitors?” Expert Opin Investig Drugs 21, no. 12 (December 2012): 1845–49. https://doi.org/10.1517/13543784.2012.732065.
Bickston SJ, Snider KR, Kappus MR. Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs. 2012 Dec;21(12):1845–9.
Bickston, Stephen J., et al. “Tetomilast: new promise for phosphodiesterase-4 inhibitors?” Expert Opin Investig Drugs, vol. 21, no. 12, Dec. 2012, pp. 1845–49. Pubmed, doi:10.1517/13543784.2012.732065.
Bickston SJ, Snider KR, Kappus MR. Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs. 2012 Dec;21(12):1845–1849.
Published In
Expert Opin Investig Drugs
DOI
EISSN
1744-7658
Publication Date
December 2012
Volume
21
Issue
12
Start / End Page
1845 / 1849
Location
England
Related Subject Headings
- Thiazoles
- Phosphodiesterase 4 Inhibitors
- Pharmacology & Pharmacy
- Inflammatory Bowel Diseases
- Humans
- Anti-Inflammatory Agents
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 3211 Oncology and carcinogenesis
- 1115 Pharmacology and Pharmaceutical Sciences