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Matthew Robert Kappus

Associate Professor of Medicine
Medicine, Gastroenterology
Duke University Hospital, Durham, NC 27617

Current Appointments & Affiliations


Associate Professor of Medicine · 2023 - Present Medicine, Gastroenterology, Medicine

Recent Publications


2025: The Current State of Functional Assessment in Patients Undergoing Liver Transplantation

Journal Article Current Transplantation Reports · December 1, 2026 Purpose of Review: Frailty has emerged as an important factor in liver transplant evaluation, as frailty is common in cirrhosis and is associated with adverse outcomes before and after transplant. No standardized approach to frailty assessment exists in th ... Full text Cite

The Liver Transplant Comorbidity Index (LTCI): A composite index of ambulatory pre-LT factors to identify patients at increased risk of post-LT mortality.

Conference Hepatology · February 1, 2026 BACKGROUND AND AIMS: Frailty is strongly associated with mortality after liver transplantation. However, national guidelines discourage its use as a sole reason to decline a patient for liver transplantation, as some frail patients have acceptable outcomes ... Full text Link to item Cite

Induction of Antigen-Specific T Cell Tolerance by CNP-104 Positively Affects Clinical Response in Primary Biliary Cholangitis (PBC) 9237

Conference The Journal of Immunology · November 1, 2025 Abstract Description PBC is an archetypal autoimmune disease where the dominant autoantigen is mitochondrial PDC-E2. Hitherto, ... Full text Cite
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Recent Grants


P2b Primary Biliary Cholangitis trial CNP-104-CL-202

Clinical TrialPrincipal Investigator · Awarded by COUR Pharmaceuticals Development Company · 2025 - 2030

CMV Vaccine in Orthotopic Liver Transplant Candidates (COLT) Study (Cost Reimbursable)

Clinical TrialPrincipal Investigator · Awarded by University of California - San Francisco · 2024 - 2028

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Education, Training & Certifications


Medical University of South Carolina, College of Medicine · 2009 M.D.