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Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow.

Publication ,  Journal Article
Renaud, JM; Yip, K; Guimond, J; Trottier, M; Pibarot, P; Turcotte, E; Maguire, C; Lalonde, L; Gulenchyn, K; Farncombe, T; Wisenberg, G; Lee, B ...
Published in: J Nucl Med
January 2017

UNLABELLED: Three-dimensional (3D) mode imaging is the current standard for PET/CT systems. Dynamic imaging for quantification of myocardial blood flow with short-lived tracers, such as 82Rb-chloride, requires accuracy to be maintained over a wide range of isotope activities and scanner counting rates. We proposed new performance standard measurements to characterize the dynamic range of PET systems for accurate quantitative imaging. METHODS: 82Rb or 13N-ammonia (1,100-3,000 MBq) was injected into the heart wall insert of an anthropomorphic torso phantom. A decaying isotope scan was obtained over 5 half-lives on 9 different 3D PET/CT systems and 1 3D/2-dimensional PET-only system. Dynamic images (28 × 15 s) were reconstructed using iterative algorithms with all corrections enabled. Dynamic range was defined as the maximum activity in the myocardial wall with less than 10% bias, from which corresponding dead-time, counting rates, and/or injected activity limits were established for each scanner. Scatter correction residual bias was estimated as the maximum cavity blood-to-myocardium activity ratio. Image quality was assessed via the coefficient of variation measuring nonuniformity of the left ventricular myocardium activity distribution. RESULTS: Maximum recommended injected activity/body weight, peak dead-time correction factor, counting rates, and residual scatter bias for accurate cardiac myocardial blood flow imaging were 3-14 MBq/kg, 1.5-4.0, 22-64 Mcps singles and 4-14 Mcps prompt coincidence counting rates, and 2%-10% on the investigated scanners. Nonuniformity of the myocardial activity distribution varied from 3% to 16%. CONCLUSION: Accurate dynamic imaging is possible on the 10 3D PET systems if the maximum injected MBq/kg values are respected to limit peak dead-time losses during the bolus first-pass transit.

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Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

January 2017

Volume

58

Issue

1

Start / End Page

103 / 109

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Myocardial Perfusion Imaging
  • Imaging, Three-Dimensional
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
 

Citation

APA
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ICMJE
MLA
NLM
Renaud, J. M., Yip, K., Guimond, J., Trottier, M., Pibarot, P., Turcotte, E., … deKemp, R. A. (2017). Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow. J Nucl Med, 58(1), 103–109. https://doi.org/10.2967/jnumed.116.174565
Renaud, Jennifer M., Kathy Yip, Jean Guimond, Mikaël Trottier, Philippe Pibarot, Eric Turcotte, Conor Maguire, et al. “Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow.J Nucl Med 58, no. 1 (January 2017): 103–9. https://doi.org/10.2967/jnumed.116.174565.
Renaud JM, Yip K, Guimond J, Trottier M, Pibarot P, Turcotte E, et al. Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow. J Nucl Med. 2017 Jan;58(1):103–9.
Renaud, Jennifer M., et al. “Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow.J Nucl Med, vol. 58, no. 1, Jan. 2017, pp. 103–09. Pubmed, doi:10.2967/jnumed.116.174565.
Renaud JM, Yip K, Guimond J, Trottier M, Pibarot P, Turcotte E, Maguire C, Lalonde L, Gulenchyn K, Farncombe T, Wisenberg G, Moody J, Lee B, Port SC, Turkington TG, Beanlands RS, deKemp RA. Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow. J Nucl Med. 2017 Jan;58(1):103–109.

Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

January 2017

Volume

58

Issue

1

Start / End Page

103 / 109

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Myocardial Perfusion Imaging
  • Imaging, Three-Dimensional
  • Image Interpretation, Computer-Assisted
  • Image Enhancement