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Inhaled carbon nanotubes reach the subpleural tissue in mice.

Publication ,  Journal Article
Ryman-Rasmussen, JP; Cesta, MF; Brody, AR; Shipley-Phillips, JK; Everitt, JI; Tewksbury, EW; Moss, OR; Wong, BA; Dodd, DE; Andersen, ME; Bonner, JC
Published in: Nat Nanotechnol
November 2009

Carbon nanotubes are shaped like fibres and can stimulate inflammation at the surface of the peritoneum when injected into the abdominal cavity of mice, raising concerns that inhaled nanotubes may cause pleural fibrosis and/or mesothelioma. Here, we show that multiwalled carbon nanotubes reach the subpleura in mice after a single inhalation exposure of 30 mg m(-3) for 6 h. Nanotubes were embedded in the subpleural wall and within subpleural macrophages. Mononuclear cell aggregates on the pleural surface increased in number and size after 1 day and nanotube-containing macrophages were observed within these foci. Subpleural fibrosis unique to this form of nanotubes increased after 2 and 6 weeks following inhalation. None of these effects was seen in mice that inhaled carbon black nanoparticles or a lower dose of nanotubes (1 mg m(-3)). This work suggests that minimizing inhalation of nanotubes during handling is prudent until further long-term assessments are conducted.

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Published In

Nat Nanotechnol

DOI

EISSN

1748-3395

Publication Date

November 2009

Volume

4

Issue

11

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Pulmonary Fibrosis
  • Pleura
  • Nanotubes, Carbon
  • Nanoscience & Nanotechnology
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Inhalation Exposure
  • Immunity
  • Animals
 

Citation

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Ryman-Rasmussen, J. P., Cesta, M. F., Brody, A. R., Shipley-Phillips, J. K., Everitt, J. I., Tewksbury, E. W., … Bonner, J. C. (2009). Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol, 4(11), 747–751. https://doi.org/10.1038/nnano.2009.305
Ryman-Rasmussen, Jessica P., Mark F. Cesta, Arnold R. Brody, Jeanette K. Shipley-Phillips, Jeffrey I. Everitt, Earl W. Tewksbury, Owen R. Moss, et al. “Inhaled carbon nanotubes reach the subpleural tissue in mice.Nat Nanotechnol 4, no. 11 (November 2009): 747–51. https://doi.org/10.1038/nnano.2009.305.
Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, et al. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol. 2009 Nov;4(11):747–51.
Ryman-Rasmussen, Jessica P., et al. “Inhaled carbon nanotubes reach the subpleural tissue in mice.Nat Nanotechnol, vol. 4, no. 11, Nov. 2009, pp. 747–51. Pubmed, doi:10.1038/nnano.2009.305.
Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, Moss OR, Wong BA, Dodd DE, Andersen ME, Bonner JC. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol. 2009 Nov;4(11):747–751.

Published In

Nat Nanotechnol

DOI

EISSN

1748-3395

Publication Date

November 2009

Volume

4

Issue

11

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Pulmonary Fibrosis
  • Pleura
  • Nanotubes, Carbon
  • Nanoscience & Nanotechnology
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Inhalation Exposure
  • Immunity
  • Animals