https://orcid.org/0000-0003-0273-6284
Current Duke Appointments & Affiliations
Professor Emeritus in Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Recent Scholarly Works
The NTP chronic inhalation study does not support an inherent lung cancer hazard of talc: Implications of lung particle overload and maximum tolerated dose.
Journal article Regul Toxicol Pharmacol · November 2026 Interpretation of inhalation carcinogenicity studies for poorly soluble particles requires explicit consideration of lung particle overload in relation to maximum tolerated dose (MTD). In the NTP talc inhalation study, lung tumors occurred in female rats f ... Full text Link to item CiteIsobaric counterdiffusion of carbon tetrafluoride breathing gas to prevent severe decompression sickness.
Journal article Proc Natl Acad Sci U S A · August 18, 2026 Decompression sickness (DCS) risk limits human undersea operations through tissue inert gas supersaturation and pathological bubble formation. Switching the inert breathing gas prior to decompression to a gas with lower diffusivity could allow faster and s ... Full text Link to item CiteProgrammable mRNA 3'UTR engineering restores MHC-I and overcomes immune evasion in prostate cancer.
Journal article Nat Biomed Eng · June 16, 2026 Immune-cold tumours such as prostate cancer often resist immune checkpoint therapies (ICT) due to impaired antigen presentation via major histocompatibility complex class I (MHC-I). While MHC-I downregulation is a common immune evasion mechanism, no approv ... Full text Link to item CiteRecent Grants
Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell disease
ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2027Identification and optimization of medical countermeasures for phosgene inhalation injuries
ResearchSignificant Contributor · Awarded by National Institutes of Health · 2024 - 2026The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging
ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education
Cornell University ·
1977
D.V.M.