https://orcid.org/0000-0003-0273-6284
Current Duke Appointments & Affiliations
Professor Emeritus in Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Recent Scholarly Works
The NTP chronic inhalation study does not support an inherent lung cancer hazard of talc: Implications of lung particle overload and maximum tolerated dose.
Journal article Regul Toxicol Pharmacol · June 29, 2026 Interpretation of inhalation carcinogenicity studies for poorly soluble particles requires explicit consideration of lung particle overload in relation to maximum tolerated dose (MTD). In the NTP talc inhalation study, lung tumors occurred in female rats f ... Full text Link to item CiteProgrammable mRNA 3'UTR engineering restores MHC-I and overcomes immune evasion in prostate cancer.
Journal article Nat Biomed Eng · June 16, 2026 Immune-cold tumours such as prostate cancer often resist immune checkpoint therapies (ICT) due to impaired antigen presentation via major histocompatibility complex class I (MHC-I). While MHC-I downregulation is a common immune evasion mechanism, no approv ... Full text Link to item CiteTalc fits the framework of poorly soluble low-toxicity particles - implications for hazard classification.
Journal article Regul Toxicol Pharmacol · May 2026 An extensive toxicology database demonstrates talc exhibits the defining characteristics of poorly soluble, low-toxicity particles (PSLTs), including slow dissolution in biological fluids; macrophage-mediated clearance as the key determinant of lung reside ... Full text Link to item CiteRecent Grants
Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell disease
ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2027Identification and optimization of medical countermeasures for phosgene inhalation injuries
ResearchSignificant Contributor · Awarded by National Institutes of Health · 2024 - 2026The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging
ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education
Cornell University ·
1977
D.V.M.