Non-neoplastic and neoplastic pleural endpoints following fiber exposure.

Journal Article (Journal Article;Review)

Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research.

Full Text

Duke Authors

Cited Authors

  • Broaddus, VC; Everitt, JI; Black, B; Kane, AB

Published Date

  • 2011

Published In

Volume / Issue

  • 14 / 1-4

Start / End Page

  • 153 - 178

PubMed ID

  • 21534088

Pubmed Central ID

  • PMC3118521

Electronic International Standard Serial Number (EISSN)

  • 1521-6950

Digital Object Identifier (DOI)

  • 10.1080/10937404.2011.556049


  • eng

Conference Location

  • England