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Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Publication ,  Journal Article
Scudamore, CL; Soilleux, EJ; Karp, NA; Smith, K; Poulsom, R; Herrington, CS; Day, MJ; Brayton, CF; Bolon, B; Whitelaw, B; White, ES ...
Published in: J Pathol
January 2016

Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis, and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridization (ISH) datasets. This reporting framework will maximize the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders.

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Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2016

Volume

238

Issue

2

Start / End Page

359 / 367

Location

England

Related Subject Headings

  • Translational Research, Biomedical
  • Research Design
  • Publications
  • Practice Guidelines as Topic
  • Pathology
  • Pathology
  • Models, Animal
  • Information Dissemination
  • Humans
  • Animals
 

Citation

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Scudamore, C. L., Soilleux, E. J., Karp, N. A., Smith, K., Poulsom, R., Herrington, C. S., … Arends, M. J. (2016). Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. J Pathol, 238(2), 359–367. https://doi.org/10.1002/path.4642
Scudamore, Cheryl L., Elizabeth J. Soilleux, Natasha A. Karp, Ken Smith, Richard Poulsom, C Simon Herrington, Michael J. Day, et al. “Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.J Pathol 238, no. 2 (January 2016): 359–67. https://doi.org/10.1002/path.4642.
Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, et al. Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. J Pathol. 2016 Jan;238(2):359–67.
Scudamore, Cheryl L., et al. “Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.J Pathol, vol. 238, no. 2, Jan. 2016, pp. 359–67. Pubmed, doi:10.1002/path.4642.
Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ. Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. J Pathol. 2016 Jan;238(2):359–367.
Journal cover image

Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2016

Volume

238

Issue

2

Start / End Page

359 / 367

Location

England

Related Subject Headings

  • Translational Research, Biomedical
  • Research Design
  • Publications
  • Practice Guidelines as Topic
  • Pathology
  • Pathology
  • Models, Animal
  • Information Dissemination
  • Humans
  • Animals