The use of tracheal implants in toxicology and carcinogenesis research.

Published

Journal Article (Review)

Tracheal implants have served as an important experimental pathology tool with which to study the toxic and/or carcinogenic effects of chemicals upon upper respiratory tract epithelium. Initial studies with this method utilized heterotopic rat tracheal transplants which were exposed to compounds of interest, and assessed for toxic and/or carcinogenic endpoints. Grafts containing rodent tissue have proved useful for studying the cellular and biochemical features of neoplastic progression at different time intervals following in vivo exposure to carcinogens. More recent studies have utilized epithelial denuded tracheal implants inoculated with respiratory cell populations, and xenografted into immunodeficient nu/nu mice. This technique permits the study of airway epithelium from a variety of species, including man. The advent of molecular pathology techniques such as in situ hybridization will further expand the uses of tracheal implant technology for studies with xenografted human tissues. Such implants should prove useful for the examination of species- and tissue-specific characteristics of growth and differentiation by providing a bridge between cell culture and whole animal studies.

Full Text

Duke Authors

Cited Authors

  • Everitt, JI; Hesterberg, TW; Boreiko, CJ

Published Date

  • January 1990

Published In

Volume / Issue

  • 60 / 1-2

Start / End Page

  • 27 - 40

PubMed ID

  • 2180131

Pubmed Central ID

  • 2180131

International Standard Serial Number (ISSN)

  • 0300-483X

Digital Object Identifier (DOI)

  • 10.1016/0300-483x(90)90160-i

Language

  • eng

Conference Location

  • Ireland